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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
Posts: 1,962
Loc: Siperia underground
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New mutation of covid-19 in Denmark: The vaccines develobed may not work on this
#27032373 - 11/10/20 09:59 PM (3 years, 2 months ago) |
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https://www.bbc.com/news/world-europe-54818615
New strain of covid-19 is passed to humans from minks in Denmark.
"Prime Minister Mette Frederiksen said the mutated virus posed a "risk to the effectiveness" of a future Covid-19 vaccine."
This can make the vaccine development take big leap backwards as it seems that there is not going to be single magic bullet against this one.
Known mutations of covid-19
https://nextstrain.org/ncov/global
Opinions please
Edited by LeningradCowboy (11/11/20 01:20 PM)
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
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https://www.bmj.com/content/371/bmj.m4338
"One strain of mutated SARS-CoV-2, found in 12 humans in Denmark, appeared in laboratory tests to exhibit “decreased susceptibility” to antibodies from previously infected people, the country’s State Serum Institute said in a preliminary report.1 This variant, if it spread, might be less easily controlled by covid-19 vaccines currently under development, the report warned."
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whitecarnist
Stranger
Registered: 08/30/20
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Completely irrelevant.It's probably even weaker now.
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Loaded Shaman
Psychophysiologist



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Re: New mutation of covid-19 in Denmark [Re: whitecarnist] 2
#27032584 - 11/11/20 12:47 AM (3 years, 2 months ago) |
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Lol didn't McDonald's just make the news regarding something with minks?
Quote:
whitecarnist said: Completely irrelevant.It's probably even weaker now.
Oh cool good to know the brand new guy 100% knows for fact the veracity and severity of these claims.
--------------------
  "Real knowledge is to know the extent of one’s ignorance." — Confucius
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whitecarnist
Stranger
Registered: 08/30/20
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Re: New mutation of covid-19 in Denmark [Re: Loaded Shaman]
#27032593 - 11/11/20 12:53 AM (3 years, 2 months ago) |
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I'll be honest, I'm posting only because I need 10 posts.
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Loaded Shaman
Psychophysiologist



Registered: 03/02/15
Posts: 8,006
Loc: Now O'Clock
Last seen: 28 days, 3 hours
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist]
#27032598 - 11/11/20 12:55 AM (3 years, 2 months ago) |
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Quote:
whitecarnist said: I'll be honest, I'm posting only because I need 10 posts.
Understandable just a heads up don't spam or try to be overly witty until you're here a bit; a lot of the top dogs will fuck with you and give you a low rating, even if it's not warranted, via an argument, from which you'll never recover, lol.
As such, for being honest, I started you off with a 5/5 shroom review (check under your name now!).
Welcome! 
PM anytime.
--------------------
  "Real knowledge is to know the extent of one’s ignorance." — Confucius
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
Posts: 1,962
Loc: Siperia underground
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist] 1
#27032660 - 11/11/20 02:00 AM (3 years, 2 months ago) |
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Quote:
whitecarnist said: Completely irrelevant.It's probably even weaker now.
Who´s you are? Kinda recognize that negative undertone though
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
Posts: 1,962
Loc: Siperia underground
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist]
#27032671 - 11/11/20 02:12 AM (3 years, 2 months ago) |
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Quote:
whitecarnist said: Completely irrelevant.It's probably even weaker now.
https://www.who.int/csr/don/06-november-2020-mink-associated-sars-cov2-denmark/en/
"Initial observations suggest that the clinical presentation, severity and transmission among those infected are similar to that of other circulating SARS-CoV-2 viruses. However, this variant, referred to as the "cluster 5" variant, had a combination of mutations, or changes that have not been previously observed. The implications of the identified changes in this variant are not yet well understood. Preliminary findings indicate that this particular mink-associated variant identified in both minks and the 12 human cases has moderately decreased sensitivity to neutralizing antibodies. Further scientific and laboratory-based studies are required to verify preliminary findings reported and to understand any potential implications of this finding in terms of diagnostics, therapeutics and vaccines in development. In the meantime, actions are being taken by Danish authorities to limit the further spread of this variant of the virus among mink and human populations."
Specialists of that are do not agree with you though
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
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https://www.foreigner.fi/articulo/coronavirus/denmark-says-about-200-infected-with-mink-coronavirus-mutation/20201106172650008914.html
This is going to be bad for the vaccine.
"At least 214 people have been infected with a variant of the coronavirus that appeared in minks in June, said the Danish State Serum Institute (SSI) on Friday."
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Texas Honey Badger
No fucks given



Registered: 07/12/18
Posts: 57,774
Loc: Spicemaster Texas
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Re: New mutation of covid-19 in Denmark [Re: whitecarnist]
#27033175 - 11/11/20 10:36 AM (3 years, 2 months ago) |
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Quote:
whitecarnist said: I'll be honest, I'm posting only because I need 10 posts.
For what??
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Jokeshopbeard
Humble Student

Registered: 11/30/11
Posts: 26,088
Loc: Deep in the system
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You need 10 posts for ODD.
-------------------- Let it be seen that you are nothing. And in knowing that you are nothing... there is nothing to lose, there is nothing to gain. What can happen to you? Something can happen to the body, but it will either heal or it won't. What's the big deal? Let life knock you to bits. Let life take you apart. Let life destroy you. It will only destroy what you are not. --Jac O'keeffe
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Texas Honey Badger
No fucks given



Registered: 07/12/18
Posts: 57,774
Loc: Spicemaster Texas
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Re: New mutation of covid-19 in Denmark [Re: Jokeshopbeard] 1
#27033254 - 11/11/20 11:25 AM (3 years, 2 months ago) |
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That is pretty special
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
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Explanation why one of these 5 different mutations is resistant to antibodies from normal covid-19. And speculation why the vaccines in development right now might not be effective against this strain of covid-19
https://www.theguardian.com/commentisfree/2020/nov/10/the-covid-carrying-danish-mink-are-a-warning-sign-but-is-anyone-heeding-it
"Mink ACE2 is slightly different from human ACE2, so mink-to-mink transmission may have favoured a mutated virus with a change to its spike protein key that better fits the mink ACE2 lock. As the antibodies that humans generate to fight off Covid-19 target the spike protein on the external surface of the virus, this mink-adapted virus, which has a mutation in its spike protein, may be better able to circumvent our defences.
Danish researchers report that one of the variants of the virus found in mink isn’t as easily defeated by the antibodies that humans produce against Covid-19. One risk is that people who have recovered from Covid-19 may have antibodies that are less able to fight off the mink strain of the virus, leaving them open to reinfection. And most of the vaccines under development, on which we are pinning so much hope, are intended to induce antibodies that target the spike protein in the virus that causes Covid-19 in humans. While it’s too early to say for certain, one possibility is that these vaccines could be less effective against the mink virus, because it has a different spike protein."
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koods
Ribbit



Registered: 05/26/11
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Immunity is not all or nothing. A virus can mutate away from immunity but very unlikely that it would drift so far the vaccine wouldn’t work.
Just like a flu vaccine, partial immunity may not prevent infection, but would limit the course of the infection and prevent serious illness. Partial immunity gives your immune system a head start.
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NotSheekle said “if I believed she was 16 I would become unattracted to her”
Edited by koods (11/11/20 06:14 PM)
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
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Re: New mutation of covid-19 in Denmark [Re: koods]
#27034246 - 11/11/20 09:50 PM (3 years, 2 months ago) |
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Did you read that last article? Antibodies from normal covid-19 do not react to proberly to 1 of the 5 strains founded in minks.
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LeningradCowboy
Yes, my name is you?



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And flu vaccine is new every season. The vaccine is made by educated guess how the virus is going to mutate from last season.
This is how flu vaccine development works, this is not my opinion how it works. This is how it works.
Some years they guess it right and the vaccine is effective, some years they dont and it is not.
https://www.fpca.net/flu-vaccine-the-educated-guess/
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breeg89
i'll tell ya hwhat

Registered: 05/04/11
Posts: 3,120
Loc: mass
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Yeah, different spike protein sequence could be bad news. Hopefully Denmark can stay on top of this.
Vaccines designed to promote an immune response against the spike protein are inevitably going to select for resistant mutants with different spike protein sequences anyway. We just have to hope those mutations dramatically hinder fitness. Seems like we will probably be getting seasonal covid vaccines to fight the new strains as they emerge from selective pressure.
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Seriously_trippin
Cosmic Guru Ganesh



Registered: 07/12/13
Posts: 14,471
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
#27034324 - 11/11/20 11:00 PM (3 years, 2 months ago) |
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Quote:
LeningradCowboy said: https://www.bbc.com/news/world-europe-54818615
New strain of covid-19 is passed to humans from minks in Denmark.
"Prime Minister Mette Frederiksen said the mutated virus posed a "risk to the effectiveness" of a future Covid-19 vaccine."
This can make the vaccine development take big leap backwards as it seems that there is not going to be single magic bullet against this one.
Known mutations of covid-19
https://nextstrain.org/ncov/global
Opinions please
The Denmark government is in the process of exterminating all minks in the country and it better work
-------------------- R.I.P Zombi3, Blue Helix Modest Mouse Zappa Slothie That Kid With The face ShLong Le Canard split_by_nine & Big Worm Forever Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many
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LeningradCowboy
Yes, my name is you?



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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
#27034347 - 11/11/20 11:29 PM (3 years, 2 months ago) |
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I really dont think it is going to stop this mutation of spreading. Can stop new ones from forming though.
It has all ready been founded in 214 humans. And these are not todays numbers.
North Jutland is in isolation now. The area of most mink production on Denmark.
https://www.thelocal.dk/20201105/denmark-tightens-north-jutland-restrictions-in-response-to-coronavirus-mutation
https://coronasmitte.dk/en/restrictions-in-north-jutland
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LeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Seriously_trippin]
#27035261 - 11/12/20 01:12 PM (3 years, 2 months ago) |
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Quote:
Seriously_trippin said:
The Denmark government is in the process of exterminating all minks in the country and it better work
https://www.theguardian.com/environment/2020/nov/09/denmark-drops-plans-for-mass-mink-cull-after-covid-mutation-fears
Denmark just announced that it cancelled the culling of minks. Covid-19 has been founded on minks all so in Sweden and America.
"Frederik Waage, law professor at the University of Southern Denmark, told Danish national paper Berlingske the cull order was “illegal”."
"The American Veterinary Medical Association said at least 8,000 minks have died of infection with Sars-CoV-2 on farms in Utah. And nearly 3,400 mink are reported to have died from the coronavirus at a mink farm in Wisconsin. It added that the infection seems to be deadlier among older minks."
It looks like we are going to have A LOT of different strains soon.
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Baby_Hitler
Errorist




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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy] 2
#27035334 - 11/12/20 02:05 PM (3 years, 2 months ago) |
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Why don't they just make the minks wear tiny little masks?
-------------------- Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ Ƹ̵̡Ӝ̵̨̄Ʒ (•_•) <) )~ ANTIFA / \ \(•_•) ( (> SUPER / \ (•_•) <) )> SOLDIERS / \
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feevers


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Loc:
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Baby_Hitler]
#27035355 - 11/12/20 02:23 PM (3 years, 2 months ago) |
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Quote:
Baby_Hitler said: Why don't they just make the minks wear tiny little masks?
Looks like you just found your new invention idea.
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Seriously_trippin
Cosmic Guru Ganesh



Registered: 07/12/13
Posts: 14,471
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
#27035433 - 11/12/20 03:15 PM (3 years, 2 months ago) |
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Quote:
LeningradCowboy said:
Quote:
Seriously_trippin said:
The Denmark government is in the process of exterminating all minks in the country and it better work
https://www.theguardian.com/environment/2020/nov/09/denmark-drops-plans-for-mass-mink-cull-after-covid-mutation-fears
Denmark just announced that it cancelled the culling of minks. Covid-19 has been founded on minks all so in Sweden and America.
"Frederik Waage, law professor at the University of Southern Denmark, told Danish national paper Berlingske the cull order was “illegal”."
"The American Veterinary Medical Association said at least 8,000 minks have died of infection with Sars-CoV-2 on farms in Utah. And nearly 3,400 mink are reported to have died from the coronavirus at a mink farm in Wisconsin. It added that the infection seems to be deadlier among older minks."
It looks like we are going to have A LOT of different strains soon.
Well that is truly terrifying
-------------------- R.I.P Zombi3, Blue Helix Modest Mouse Zappa Slothie That Kid With The face ShLong Le Canard split_by_nine & Big Worm Forever Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many
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breeg89
i'll tell ya hwhat

Registered: 05/04/11
Posts: 3,120
Loc: mass
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Seriously_trippin]
#27035780 - 11/12/20 06:36 PM (3 years, 2 months ago) |
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Apparently the spike protein gene is the second most highly mutated gene in the sars-cov-2 genome. Mutations have even been identified in the spike protein domain that binds the human ACE receptor for infection, and this domain is also important for recognition by antibodies. Here's the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318555/
A laboratory evolution experiment also successfully bred sars-cov-2 spike mutants that evade neutralizing antibodies. The mutations they discovered were also identified in sars-cov-2 samples from patients, suggesting that sars-cov-2 will mutate to evade vaccine-induced immunity. Here's the preprint: https://www.biorxiv.org/content/10.1101/2020.07.21.214759v1
Hopefully these mutations will severely hinder fitness and/or we will retain at least partial immunity to these mutants and experience only mild symptoms.
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koods
Ribbit



Registered: 05/26/11
Posts: 106,049
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: breeg89]
#27035878 - 11/12/20 07:51 PM (3 years, 2 months ago) |
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OP are you a antivaxxer?
--------------------
NotSheekle said “if I believed she was 16 I would become unattracted to her”
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Seriously_trippin
Cosmic Guru Ganesh



Registered: 07/12/13
Posts: 14,471
Last seen: 1 hour, 30 minutes
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
#27035899 - 11/12/20 08:01 PM (3 years, 2 months ago) |
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Quote:
koods said: OP are you a antivaxxer?
The Pfizer vaccine is still our best hope next universal mask wearing for now but it seems important to squash that problem not to deligitimzie vaccines
-------------------- R.I.P Zombi3, Blue Helix Modest Mouse Zappa Slothie That Kid With The face ShLong Le Canard split_by_nine & Big Worm Forever Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many
Edited by Seriously_trippin (11/12/20 08:02 PM)
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koods
Ribbit



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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Seriously_trippin]
#27035928 - 11/12/20 08:24 PM (3 years, 2 months ago) |
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op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.
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NotSheekle said “if I believed she was 16 I would become unattracted to her”
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breeg89
i'll tell ya hwhat

Registered: 05/04/11
Posts: 3,120
Loc: mass
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
#27035954 - 11/12/20 08:52 PM (3 years, 2 months ago) |
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Yeah herd immunity and vaccines both put selective pressure on the virus to mutate and evade the immune response. The difference is vaccines provide immunity without overwhelming hospitals and causing mass casualty.
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Seriously_trippin
Cosmic Guru Ganesh



Registered: 07/12/13
Posts: 14,471
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
#27035990 - 11/12/20 09:46 PM (3 years, 2 months ago) |
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Quote:
koods said: op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.
I agree with this full heartedly it drives me up the wall to hear people arguing about a mask when close to 2k people die a day from covid right now. Wear a mask, it's no hoax and we aren't saying this because of msm.malot of us have people in their lives or close family like mother, father brothers sisters etc. Wear a mask please if not for that reason do it so every state in the country didn't have to shut down more then twice a year
-------------------- R.I.P Zombi3, Blue Helix Modest Mouse Zappa Slothie That Kid With The face ShLong Le Canard split_by_nine & Big Worm Forever Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
Posts: 1,962
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Re: New mutation of covid-19 in Denmark: The vaccines developed may not work on this [Re: koods]
#27036000 - 11/12/20 09:58 PM (3 years, 2 months ago) |
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Quote:
koods said: op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.
Quote:
koods said: OP are you a antivaxxer?
Quote:
koods said: op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.
Your arguments fail. And here we go again. Attacking person.
I work with risk groups. My parents are in risk group. They are going to take the vaccine. I would like it to be effective and Safe. Even in long run. Not something put up in hurry and cutting corners and time to get the deal. I have lost member from my family tree because of this too.
I belive we need vaccines for some diseases. But on this case I smell money, lots of it. Even more when this virus has ability to mutate. (Can we now agree it has ability to mutate?)
And one thing that is unclear still is who is going to pay this vaccine that is going to be seasonal. And now that the new strains start to surface it is even more clear that there is not going to be one magic bullet.
Ideas for this Koodz?
I want this shit handled as much as the next person. But want it handled properly Not the way that makes most money to corporations.
And as far as the public health measures go:
I dont party lot like you tried to suggest. And the reason that I want this handled properly is not to get back in clubs like you tried to say. I do my social distancing/isolation. Keep care of my hand hygiene. When at work or training periods I happily wear the gear needed to keep my clients SAFE. These are the tools that were used in Finland to stop the first wave and they work.
I sincerely dont understand your problem with people when your arguments fail. Stop running your mouth and you may learn something new.
EDIT: Still not living in America but in Finland. If you want to comment on the situation here please first take some time to edugate your self how things are actually going in here.
-------------------- From tundra with love!
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Edited by LeningradCowboy (11/12/20 10:00 PM)
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
Posts: 1,962
Loc: Siperia underground
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: breeg89]
#27036004 - 11/12/20 10:02 PM (3 years, 2 months ago) |
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Quote:
breeg89 said: Apparently the spike protein gene is the second most highly mutated gene in the sars-cov-2 genome. Mutations have even been identified in the spike protein domain that binds the human ACE receptor for infection, and this domain is also important for recognition by antibodies. Here's the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318555/
A laboratory evolution experiment also successfully bred sars-cov-2 spike mutants that evade neutralizing antibodies. The mutations they discovered were also identified in sars-cov-2 samples from patients, suggesting that sars-cov-2 will mutate to evade vaccine-induced immunity. Here's the preprint: https://www.biorxiv.org/content/10.1101/2020.07.21.214759v1
Hopefully these mutations will severely hinder fitness and/or we will retain at least partial immunity to these mutants and experience only mild symptoms.
Thank you for the data and links
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whitecarnist
Stranger
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
#27036155 - 11/13/20 12:02 AM (3 years, 2 months ago) |
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Quote:
koods said: op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.
This is the worst advice. If we all got infected during the spring and summer we would be done with it now.
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LeningradCowboy
Yes, my name is you?



Registered: 08/01/15
Posts: 1,962
Loc: Siperia underground
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: whitecarnist]
#27036197 - 11/13/20 12:31 AM (3 years, 2 months ago) |
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Is that an monologue 
As I said I think I regonize that tune 
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koods
Ribbit



Registered: 05/26/11
Posts: 106,049
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: whitecarnist]
#27036743 - 11/13/20 09:56 AM (3 years, 2 months ago) |
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Quote:
whitecarnist said:
Quote:
koods said: op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.
This is the worst advice. If we all got infected during the spring and summer we would be done with it now.
And we would have had 4 million dead with a massively outstripped hospital capacity and no effective treatments. I can’t believe people are still pushing this garbage. Look at Sweden where they had to euthanize patients.
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LeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
#27037761 - 11/13/20 09:08 PM (3 years, 2 months ago) |
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Hey you cant go there. Conspiracy not allowed in pub
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LeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
#27037783 - 11/13/20 09:22 PM (3 years, 2 months ago) |
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https://www.euronews.com/2020/11/13/coronavirus-should-we-be-worried-about-denmark-s-covid-19-mutation
"In the months since, infections in mink have been reported in Italy, Spain, Sweden and the United States."
"The mink variant has raised concerns because of its effect on antigenicity, which means the capacity to induce an immune response. Since vaccines are all about inducing immunity, the fear is that COVID-19 vaccines would not protect against this strain of the virus."
"The worst-case scenario is that multiple new strains develop from animal-to-human and human-to-animal transmission, which could in theory require multiple vaccines. Given how long it takes to develop a vaccine, the fear is that COVID-19 keeps mutating and never goes away.
But - and it is a very big but - there is at present no evidence that this new strain is any less susceptible to the vaccines currently in development."
Did they know at this point that the mutation in spike protein does exactly this?
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breeg89
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy] 1
#27037868 - 11/13/20 10:39 PM (3 years, 2 months ago) |
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Article summarizing some new preliminary data on this: https://www.nature.com/articles/d41586-020-03218-z
Evidence suggests that these mink mutations do not facilitate spread of the virus, do not increase virulence, and should not hinder the efficacy of the emerging vaccines. But there is evidence that a combination of three amino acid mutations and two deletions in the spike protein observed in five mink farms and 12 people in Denmark confers some resistance to neutralizing antibodies. That's why all these minks are being killed (and for good reason).
In any case, the "non-mink" strains are obviously susceptible to Pfizer's current vaccine -- that is clear from the 90% efficacy, so there's still no reason not to take it. Side effects are reportedly no worse than a flu vaccine or a hangover.
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koods
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: breeg89]
#27037887 - 11/13/20 10:53 PM (3 years, 2 months ago) |
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I would suspect that a change in the spike protein that was significant enough to not bind to antibodies would also seriously hinder its ability to bind to and infect human cells.
Did all these people catch this mutated virus from minks? Maybe it doesn’t spread human to human. A lot of mutations like this are dead ends, where the animal can act as a reservoir for the virus but the virus itself is has much more limited ability to be passed on to another person. MERS is an example of this kind of virus.
Edited by koods (11/13/20 11:01 PM)
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breeg89
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods] 1
#27037923 - 11/13/20 11:23 PM (3 years, 2 months ago) |
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Yeah the human ACE2 receptor and antibodies tend to bind the same portion of the spike protein, so mutations that evade antibodies would likely alter ACE2 binding.
There is evidence that antibody-resistant spike mutants show a similar replication rate as the control wild-type virus. BUT this study used an artificial chimeric virus unrelated to sars-cov-2 that was engineered to express the spike protein. This is just a model system. You can't draw definitive conclusions from the results because the genome is entirely different, aside from the spike protein gene. https://www.biorxiv.org/content/10.1101/2020.07.21.214759v1.full (preprint, but i think it has been published in a peer-reviewed journal now)
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LeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
#27037929 - 11/13/20 11:26 PM (3 years, 2 months ago) |
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You clearly have not read those links in this thread koodz?
There was 214 cases of that new strain on humans last time I checked. And this is not todays information.
And they cancelled the killing btw.
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koods
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
#27038032 - 11/14/20 12:46 AM (3 years, 2 months ago) |
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sounds like it won’t be a problem
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koods
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
#27038036 - 11/14/20 12:51 AM (3 years, 2 months ago) |
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Sounds like they need to work on a mink vaccine as well. The mink are going with the herd immunity approach actually
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NotSheekle said “if I believed she was 16 I would become unattracted to her”
Edited by koods (11/14/20 12:52 AM)
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