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OfflineBaby_Hitler
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy] * 2
    #27035334 - 11/12/20 02:05 PM (3 years, 2 months ago)

Why don't they just make the minks wear tiny little masks?


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InvisiblefeeversM
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Baby_Hitler]
    #27035355 - 11/12/20 02:23 PM (3 years, 2 months ago)

Quote:

Baby_Hitler said:
Why don't they just make the minks wear tiny little masks?



Looks like you just found your new invention idea.


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OfflineSeriously_trippin
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
    #27035433 - 11/12/20 03:15 PM (3 years, 2 months ago)

Quote:

LeningradCowboy said:
Quote:

Seriously_trippin said:




The Denmark government is in the process of exterminating all minks in the country and it better work




https://www.theguardian.com/environment/2020/nov/09/denmark-drops-plans-for-mass-mink-cull-after-covid-mutation-fears

Denmark just announced that it cancelled the culling of minks.
Covid-19 has been founded on minks all so in Sweden and America.

"Frederik Waage, law professor at the University of Southern Denmark, told Danish national paper Berlingske the cull order was “illegal”."

"The American Veterinary Medical Association said at least 8,000 minks have died of infection with Sars-CoV-2 on farms in Utah. And nearly 3,400 mink are reported to have died from the coronavirus at a mink farm in Wisconsin. It added that the infection seems to be deadlier among older minks."

It looks like we are going to have A LOT of different strains soon.



Well that is truly terrifying


--------------------
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Invisiblebreeg89
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Registered: 05/04/11
Posts: 3,120
Loc: mass
Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Seriously_trippin]
    #27035780 - 11/12/20 06:36 PM (3 years, 2 months ago)

Apparently the spike protein gene is the second most highly mutated gene in the sars-cov-2 genome. Mutations have even been identified in the spike protein domain that binds the human ACE receptor for infection, and this domain is also important for recognition by antibodies. Here's the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318555/

A laboratory evolution experiment also successfully bred sars-cov-2 spike mutants that evade neutralizing antibodies. The mutations they discovered were also identified in sars-cov-2 samples from patients, suggesting that sars-cov-2 will mutate to evade vaccine-induced immunity. Here's the preprint: https://www.biorxiv.org/content/10.1101/2020.07.21.214759v1

Hopefully these mutations will severely hinder fitness and/or we will retain at least partial immunity to these mutants and experience only mild symptoms.


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Offlinekoods
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: breeg89]
    #27035878 - 11/12/20 07:51 PM (3 years, 2 months ago)

OP are you a antivaxxer?


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineSeriously_trippin
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
    #27035899 - 11/12/20 08:01 PM (3 years, 2 months ago)

Quote:

koods said:
OP are you a antivaxxer?



The Pfizer vaccine is still our best hope next universal mask wearing for now but it seems important to squash that problem not to deligitimzie vaccines


--------------------
R.I.P
Zombi3, Blue Helix
Modest Mouse
Zappa
Slothie
That Kid With The face
ShLong
Le Canard
split_by_nine
& Big Worm Forever
Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many :heart:


Edited by Seriously_trippin (11/12/20 08:02 PM)


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Offlinekoods
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: Seriously_trippin]
    #27035928 - 11/12/20 08:24 PM (3 years, 2 months ago)

op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.


--------------------
NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Invisiblebreeg89
i'll tell ya hwhat

Registered: 05/04/11
Posts: 3,120
Loc: mass
Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
    #27035954 - 11/12/20 08:52 PM (3 years, 2 months ago)

Yeah herd immunity and vaccines both put selective pressure on the virus to mutate and evade the immune response. The difference is vaccines provide immunity without overwhelming hospitals and causing mass casualty.


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OfflineSeriously_trippin
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
    #27035990 - 11/12/20 09:46 PM (3 years, 2 months ago)

Quote:

koods said:
op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.



I agree with this full heartedly it drives me up the wall to hear people arguing about a mask when close to 2k people die a day from covid right now. Wear a mask, it's no hoax and we aren't saying this because of msm.malot of us have people in their lives or close family like mother, father brothers sisters etc. Wear a mask please if not for that reason do it so every state in the country didn't have to shut down more then twice a year


--------------------
R.I.P
Zombi3, Blue Helix
Modest Mouse
Zappa
Slothie
That Kid With The face
ShLong
Le Canard
split_by_nine
& Big Worm Forever
Etched in the sands of time in the shroomery and ever so beloved and deeply missed by many :heart:


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines developed may not work on this [Re: koods]
    #27036000 - 11/12/20 09:58 PM (3 years, 2 months ago)

Quote:

koods said:
op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.




Quote:

koods said:
OP are you a antivaxxer?



Quote:

koods said:
op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.




Your arguments fail. And here we go again. Attacking person.

I work with risk groups. My parents are in risk group.
They are going to take the vaccine.
I would like it to be effective and Safe.
Even in long run.
Not something put up in hurry and cutting corners and time to get the deal.
I have lost member from my family tree because of this too.

I belive we need vaccines for some diseases.
But on this case I smell money, lots of it.
Even more when this virus has ability to mutate.
(Can we now agree it has ability to mutate?)

And one thing that is unclear still is who is going to pay this vaccine that is going to be seasonal. And now that the new strains start to surface it is even more clear that there is not going to be one magic bullet.

Ideas for this Koodz?

I want this shit handled as much as the next person.
But want it handled properly
Not the way that makes most money to corporations.

And as far as the public health measures go:

I dont party lot like you tried to suggest. And the reason that I want this handled properly is not to get back in clubs like you tried to say. I do my social distancing/isolation. Keep care of my hand hygiene. When at work or training periods I happily wear the gear needed to keep my clients SAFE.
These are the tools that were used in Finland to stop the first wave and they work.

I sincerely dont understand your problem with people when your arguments fail. Stop running your mouth and you may learn something new.

EDIT: Still not living in America but in Finland. If you want to comment on the situation here please first take some time to edugate your self how things are actually going in here.


--------------------
From tundra with love!


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Edited by LeningradCowboy (11/12/20 10:00 PM)


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: breeg89]
    #27036004 - 11/12/20 10:02 PM (3 years, 2 months ago)

Quote:

breeg89 said:
Apparently the spike protein gene is the second most highly mutated gene in the sars-cov-2 genome. Mutations have even been identified in the spike protein domain that binds the human ACE receptor for infection, and this domain is also important for recognition by antibodies. Here's the study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318555/

A laboratory evolution experiment also successfully bred sars-cov-2 spike mutants that evade neutralizing antibodies. The mutations they discovered were also identified in sars-cov-2 samples from patients, suggesting that sars-cov-2 will mutate to evade vaccine-induced immunity. Here's the preprint: https://www.biorxiv.org/content/10.1101/2020.07.21.214759v1

Hopefully these mutations will severely hinder fitness and/or we will retain at least partial immunity to these mutants and experience only mild symptoms.




Thank you for the data and links:heart:


--------------------
From tundra with love!


FREE HAMHEAD 2020!


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Offlinewhitecarnist
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Registered: 08/30/20
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
    #27036155 - 11/13/20 12:02 AM (3 years, 2 months ago)

Quote:

koods said:
op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.



This is the worst advice. If we all got infected during the spring and summer we would be done with it now.


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: whitecarnist]
    #27036197 - 11/13/20 12:31 AM (3 years, 2 months ago)

Is that an monologue :lol:

As I said I think I regonize that tune :hi:

:puppet:


--------------------
From tundra with love!


FREE HAMHEAD 2020!


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Offlinekoods
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: whitecarnist]
    #27036743 - 11/13/20 09:56 AM (3 years, 2 months ago)

Quote:

whitecarnist said:
Quote:

koods said:
op has been poo pooing every public health measure proposed this entire pandemic. He’s a full on herd immunity proponent. Of course if this mutation is escapes immunity then herd immunity is out the window. Wear a mask.



This is the worst advice. If we all got infected during the spring and summer we would be done with it now.




And we would have had 4 million dead with a massively outstripped hospital capacity and no effective treatments. I can’t believe people are still pushing this garbage. Look at Sweden where they had to euthanize patients.


--------------------
NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
    #27037761 - 11/13/20 09:08 PM (3 years, 2 months ago)

Hey you cant go there. Conspiracy not allowed in pub:lol:


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From tundra with love!


FREE HAMHEAD 2020!


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy]
    #27037783 - 11/13/20 09:22 PM (3 years, 2 months ago)

https://www.euronews.com/2020/11/13/coronavirus-should-we-be-worried-about-denmark-s-covid-19-mutation

"In the months since, infections in mink have been reported in Italy, Spain, Sweden and the United States."

"The mink variant has raised concerns because of its effect on antigenicity, which means the capacity to induce an immune response. Since vaccines are all about inducing immunity, the fear is that COVID-19 vaccines would not protect against this strain of the virus."

"The worst-case scenario is that multiple new strains develop from animal-to-human and human-to-animal transmission, which could in theory require multiple vaccines. Given how long it takes to develop a vaccine, the fear is that COVID-19 keeps mutating and never goes away.

But - and it is a very big but - there is at present no evidence that this new strain is any less susceptible to the vaccines currently in development."

Did they know at this point that the mutation in spike protein does exactly this?


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Invisiblebreeg89
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Registered: 05/04/11
Posts: 3,120
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: LeningradCowboy] * 1
    #27037868 - 11/13/20 10:39 PM (3 years, 2 months ago)

Article summarizing some new preliminary data on this: https://www.nature.com/articles/d41586-020-03218-z

Evidence suggests that these mink mutations do not facilitate spread of the virus, do not increase virulence, and should not hinder the efficacy of the emerging vaccines. But there is evidence that a combination of three amino acid mutations and two deletions in the spike protein observed in five mink farms and 12 people in Denmark confers some resistance to neutralizing antibodies. That's why all these minks are being killed (and for good reason).

In any case, the "non-mink" strains are obviously susceptible to Pfizer's current vaccine -- that is clear from the 90% efficacy, so there's still no reason not to take it. Side effects are reportedly no worse than a flu vaccine or a hangover.


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Offlinekoods
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: breeg89]
    #27037887 - 11/13/20 10:53 PM (3 years, 2 months ago)

I would suspect that a change in the spike protein that was significant enough to not bind to antibodies would also seriously hinder its ability to bind to and infect human cells.

Did all these people catch this mutated virus from minks? Maybe it doesn’t spread human to human. A lot of mutations like this are dead ends, where the animal can act as a reservoir for the virus but the virus itself is has much more limited ability to be passed on to another person. MERS is an example of this kind of virus.


Edited by koods (11/13/20 11:01 PM)


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Invisiblebreeg89
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Registered: 05/04/11
Posts: 3,120
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods] * 1
    #27037923 - 11/13/20 11:23 PM (3 years, 2 months ago)

Yeah the human ACE2 receptor and antibodies tend to bind the same portion of the spike protein, so mutations that evade antibodies would likely alter ACE2 binding.

There is evidence that antibody-resistant spike mutants show a similar replication rate as the control wild-type virus. BUT this study used an artificial chimeric virus unrelated to sars-cov-2 that was engineered to express the spike protein. This is just a model system. You can't draw definitive conclusions from the results because the genome is entirely different, aside from the spike protein gene. https://www.biorxiv.org/content/10.1101/2020.07.21.214759v1.full (preprint, but i think it has been published in a peer-reviewed journal now)


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OfflineLeningradCowboy
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Re: New mutation of covid-19 in Denmark: The vaccines develobed may not work on this [Re: koods]
    #27037929 - 11/13/20 11:26 PM (3 years, 2 months ago)

You clearly have not read those links in this thread koodz?

There was 214 cases of that new strain on humans last time I checked. And this is not todays information.

And they cancelled the killing btw.


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