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OfflineDH888
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Registered: 08/26/18
Posts: 18
Last seen: 3 years, 2 months
Weird question about Effexor and microdosing
    #27013994 - 10/31/20 02:46 PM (3 years, 2 months ago)

Hello. Happy Halloween! I know nobody has the answer to this question, but I thought I'd ask anyway to see if anyone might have any ideas.

I'm currently taking 150mg of Effexor. I also microdose the Stamets stack of .2g cubensis, 100mg of Niacin, and Lions Mane. I do this 4 days on, and 3 days off. When I used to take Sertraline (zoloft), and Cymbalta, microdosing was basically pointless because I the medication would blunt the effects. Now that I'm on Effexor, I can completely FEEL the mushrooms. I've even been able to have a full trip while on Effexor a few weeks ago. This may sound weird, but I swear it feels like it enhances the mushroom effects.

Does anyone know why this would be? I mean, I'm not complaining! lol. But it seems strange that I would get great effects from the mushrooms while on this med. Either way, so far microdosing has made a HUGE difference. I feel so happy everyday and more in touch with my emotions. I've been living with pretty severe depression for well over ten years, and I haven't felt this good in years. Just curious if anyone has any idea why? Has anyone had any experience mixing Effexor with mushrooms? What was your experience?

Have a safe, trippy, Halloween!


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OfflineDrooler
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Registered: 11/12/20
Posts: 34
Last seen: 1 year, 9 months
Re: Weird question about Effexor and microdosing [Re: DH888]
    #27058396 - 11/26/20 09:44 AM (3 years, 2 months ago)

That certainly does seem strange. Effexor is an SNRI rather than an SSRI, but it's still got the SRI (Serotonin Reuptake inhibitor) aspect that is responsible for largely blunting the effects of mushrooms and LSD. I don't see how blocking the reuptake of norepinephrine could have anything to do with counteracting the effect of SSRIs on psilocybin.

You didn't mention which form of effexor you are talking, if it's immediate release or XR. Effexor does have a short half life of +/- 5 hours, so if you are taking the IR form in the morning, or even one in the morning and one at lunch, it could be that your blood levels have gone down enough that a dose of a psychedelic would be effective in the evening. Even the XR form taken in the morning would still give you substantially lower blood levels in the evening than earlier in the day.

So...my best guess is that the short half-life of effexor is responsible for the difference compared to the SSRIs you mentioned.

I agree, though, the difference is surprising.


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