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Invisibleopenmind
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: morrowasted]
    #27004762 - 10/26/20 02:32 PM (3 years, 3 months ago)

Quote:

morrowasted said:

Ive seen people with no bupe tolerance take the kinds of doses they use for heroin WD- 4mg+, and they were totally wrecked for like 12 to 18 hours. Couldnt function at all. They looked like theyd done 50mg+ of hydrocodone






I bet.

I've never had much of any real "tolerance" to opioids...and the few times I took suboxone ("recreationally", usually up the nose or under the tongue) years ago, the tiniest amount would have me incredibly loaded.

1mg to 2mg was more than plenty to have me loaded all day long...anymore than 3mg and I'd be puking and feeling like crap. One 8mg pill would last me a long time.

I always found the "high" to be very heavy & potent, but it did lack a lot of the euphoria and pleasant feels. It was like all of the "load" but almost none of the "warmth".





-OM

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InvisibleAmanita86
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Registered: 09/26/12
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: openmind]
    #27006370 - 10/27/20 01:29 PM (3 years, 3 months ago)

Do you think that was intentional?  Like a, first step to getting off heroin is getting off the euphoria.

Opiates are a weird thing..


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OfflineFractal420
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: Amanita86]
    #27006535 - 10/27/20 02:53 PM (3 years, 3 months ago)

Well yeah it’s like methadone. If your tolerance to opioids is pretty much zero, it’ll get you high. For maybe 5 days. Then not anymore.

But it’s much quicker at developing tolerance to mu-opioid “recreation” than anything else I know of. But it WILL keep you out of withdrawal once you find your sweet spot.

And for sure it’s safer than a full agonist.
I just wonder if maybe this brand is much more potent due to bioavailability reasons

People who never really took opis, I’ve seen throw up (multiple people) from 1-2mg (of the older brands)


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Invisibletyrannicalrex
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: Fractal420]
    #27006635 - 10/27/20 03:53 PM (3 years, 3 months ago)

I just can not understand why someone would keep taking a rec drug that makes them throw up, dizzy, and sleep a lot. WTF?


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InvisibleHolybullshit
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: morrowasted]
    #27007792 - 10/28/20 07:50 AM (3 years, 2 months ago)

Quote:

morrowasted said:
750ug of buprenorphine would provide decent pain relief for someone woth no opioid tolerance. Probably about what you could expect from 5 to 7.5mg of hydrocodone. But bupe is less euphoric so it might actually be a good idea to use it. Fewer people will abuse it. Obviously some people will

Ive seen people with no bupe tolerance take the kinds of doses they use for heroin WD- 4mg+, and they were totally wrecked for like 12 to 18 hours. Couldnt function at all. They looked like theyd done 50mg+ of hydrocodone




750ug would be more than enough, could even make some totally opioid naive nauseous. Dosing of bupe for pain relief starts at .2mg sublingual.

And bupe for pain relief is becoming more common for exactly the reasons stated.

Its partial agonist activity, resulting in a wonky dose response curve where the lower the dose the more of an agonist it becomes, and the fact that it delivers its effects through beta-arrestin-2 recruitment, make it hard to nail down but experiments seem to indicate 1mg of SL bupe is about equal to 30mg of oral oxycodone...but because of the dose response curve .5mg of bupe might be more like 20mg rather than 15mg.

Spreaking of getting wrecked, since bupe works differently even people with regular opioid tolerance can still get crazy effects off it, at first...I remember the first time I tried bupe, in the middle of WD off a pretty significant habit, and I got straight high, nice little nod and all...of course that only lasts for a couple days and bupe tolerance, at least to the euphoric effects, doesn't go away with a break.

I use to make up and sell suboxone nasal sprays to people with no real opioid tolerance, they would deliver ~.1mg per spray and people went crazy for 'em at first and lots of people would, against my strenuous advice, start taking 4+ sprays up each nostril right off the bat or keep redosing far too often throughout the day...and end up wrapped around a toilet for the next 8 hours.

But most people would only come back for a couple more spray bottles before complaining that it didn't work anymore, even after taking a week off, but all I could tell them was their fun was over and it was a good thing.


Edited by Holybullshit (10/28/20 07:58 AM)


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OfflinePeacefightn
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: Holybullshit]
    #27013627 - 10/31/20 11:19 AM (3 years, 2 months ago)

Let's pray for Timothy the removal of the Government systems and obviously palliative centers in asia.
I find from watching the news a man throwing baby over bridge there is no real man anymore


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OfflineFractal420
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: Peacefightn]
    #27013892 - 10/31/20 01:49 PM (3 years, 2 months ago)

Usually it seems to me if one takes more bupe than they can handle (even 1mg) they will get nauseous, not wrecked.

But opioid naive also will get high at some point below that. It’s a pretty thin margin

It’s very hard to reverse a bupe OD due to extremely high binding, so good thing it almost never happens (and all those scares “with benzos” are ridiculous. I notice no interactions. I think one guy injected bupe and benzos in one shot. And because of that one person there’s always scrutiny when you’re also taking a benzo


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Grinning wide
And comforting me with it's three warm and wild eyes.

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OfflineFractal420
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: Fractal420]
    #27016629 - 11/02/20 01:02 AM (3 years, 2 months ago)

Fuckers ruined my life

Where’s that 8.8 billion

quote]tyrannicalrex said:
I just can not understand why someone would keep taking a rec drug that makes them throw up, dizzy, and sleep a lot. WTF?




That’s really only if you exceed your tolerance.

When you take the right amount: no more pain, no more anxiety, endorphins flood in, and the world is smiling at you and you feel all warm and fuzzy. It’s hard not to love. Also recreational doses (not nodding doses) never made me sleepy.

Honestly it’s perfect if it’s the right amount, Can change your life. At first for the better. Then you rely on it

It’s so good that I won’t ever touch oxycodone again. Also, I mean people are different, some people get mind orgasms thinking about amphetamines. I get a headache

Also, keep in mind these days it’s all street shit. Back in the day you knew the exact dose with no adulterants (rx at least)


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Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



Edited by Fractal420 (11/02/20 01:08 AM)


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Invisibletyrannicalrex
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: Fractal420]
    #27017551 - 11/02/20 01:42 PM (3 years, 2 months ago)

I have taken xanax, vicodin, valium, rohypnol, and codiene "back in the day" at regular prescribed doses. They make me feel awful, sick, itchy, and sleepy. There was NOTHING pleasurable or euphoric about to me at all. I did sort of like valium and codiene, but don't feel much euphoria. They just make me sleep. I am VERY happy my receptors are the way they are in regards to opiates. It's the worst addiction I've ever seen.


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InvisibleHolybullshit
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: tyrannicalrex]
    #27018817 - 11/03/20 07:40 AM (3 years, 2 months ago)

But you do understand that is not the experience of the vast majority of people who take said drugs, right?


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Invisibletyrannicalrex
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Re: OxyContin maker to plead guilty to federal criminal charges, pay $8 billion, and will close the company [Re: Holybullshit]
    #27019143 - 11/03/20 11:05 AM (3 years, 2 months ago)

I don't know if it's a vast majority but a great deal of people who take opiates/opioids do have a very positive reaction to them when taken recreationally. They are extremely addictive and at the same effective for pain management. It's a double edged sword for sure.:sad: I am very glad I don't need them at all nor do I want them and I'm so glad about that. I hope anyone who has a problem with opiates/opioids/heroin gets the help they need to get off of them if they are doing them recreationally and are addicted. If people can do them and function etc...good luck and have fun. Chances are that it's a downward spiral, hopefully not.


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