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Offlinemorrowasted
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LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020]
    #26996684 - 10/21/20 04:25 PM (3 years, 3 months ago)

https://www.sciencedirect.com/science/article/pii/S0924977X20309111

Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study

Quote:

There is a popular interest in microdosing with psychedelics such as LSD. This practice of using one-tenth of a full psychedelic dose according to a specific dosing schedule, anecdotally enhances mood and performance. Nonetheless, controlled research on the efficacy of microdosing is scarce. The main objective of the present dose-finding study was to determine the minimal dose of LSD needed to affect mood and cognition. A placebo-controlled within-subject study including 24 healthy participants, was conducted to assess the acute effects of three LSD doses (5, 10, and 20 mcg) on measures of cognition, mood, and subjective experience, up until 6 h after administration. Cognition and subjective experience were assessed using the Psychomotor Vigilance Task, Digit Symbol Substitution Test, Cognitive Control Task, Profile of Mood States, and 5-Dimensional Altered States of Consciousness rating scale. LSD showed positive effects in the majority of observations by increasing positive mood (20 mcg), friendliness (5, 20 mcg), arousal (5 mcg), and decreasing attentional lapses (5, 20 mcg). Negative effects manifested as an increase in confusion (20 mcg) and anxiety (5, 20 mcg). Psychedelic-induced changes in waking consciousness were also present (10, 20 mcg). Overall, the present study demonstrated selective, beneficial effects of low doses of LSD on mood and cognition in the majority of observations. The minimal LSD dose at which subjective and performance effects are notable is 5 mcg and the most apparent effects were visible after 20 mcg.




I've never understood the claims that microdosing LSD was somehow making people in silicon valley into creative geniuses. It makes me happy, sociable, distractable/unfocused, cognitively slow, and a little high strung. That's it.


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OfflineReynardTheFox
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: morrowasted]
    #26996741 - 10/21/20 05:17 PM (3 years, 3 months ago)

Quote:

morrowasted said:
https://www.sciencedirect.com/science/article/pii/S0924977X20309111

Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study

Quote:

There is a popular interest in microdosing with psychedelics such as LSD. This practice of using one-tenth of a full psychedelic dose according to a specific dosing schedule, anecdotally enhances mood and performance. Nonetheless, controlled research on the efficacy of microdosing is scarce. The main objective of the present dose-finding study was to determine the minimal dose of LSD needed to affect mood and cognition. A placebo-controlled within-subject study including 24 healthy participants, was conducted to assess the acute effects of three LSD doses (5, 10, and 20 mcg) on measures of cognition, mood, and subjective experience, up until 6 h after administration. Cognition and subjective experience were assessed using the Psychomotor Vigilance Task, Digit Symbol Substitution Test, Cognitive Control Task, Profile of Mood States, and 5-Dimensional Altered States of Consciousness rating scale. LSD showed positive effects in the majority of observations by increasing positive mood (20 mcg), friendliness (5, 20 mcg), arousal (5 mcg), and decreasing attentional lapses (5, 20 mcg). Negative effects manifested as an increase in confusion (20 mcg) and anxiety (5, 20 mcg). Psychedelic-induced changes in waking consciousness were also present (10, 20 mcg). Overall, the present study demonstrated selective, beneficial effects of low doses of LSD on mood and cognition in the majority of observations. The minimal LSD dose at which subjective and performance effects are notable is 5 mcg and the most apparent effects were visible after 20 mcg.




I've never understood the claims that microdosing LSD was somehow making people in silicon valley into creative geniuses. It makes me happy, sociable, distractable/unfocused, cognitively slow, and a little high strung. That's it.



That was my experience too. Minus the cognitive slowing.


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"Every actual State is corrupt. Good men must not obey laws too well" - Ralph Waldo Emerson

"If I am the devil's child, I will live then, by the devil" - Ralph Waldo Emerson


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InvisibleAchuma
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: ReynardTheFox]
    #26996834 - 10/21/20 06:43 PM (3 years, 3 months ago)

microdosing psilocin works better for me.  LSD has too many different types of effect for me to consider microdosing on it to be useful.


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Invisiblenooneman
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: morrowasted]
    #26996969 - 10/21/20 08:24 PM (3 years, 3 months ago)

I find anything less than 50ug to not be worthwhile. But then again, I much prefer larger doses overall rather than microdoses in general. Still, I have had some great times microdosing mushrooms.


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InvisibleHolybullshit
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: nooneman]
    #26997500 - 10/22/20 08:23 AM (3 years, 3 months ago)

That's not exactly a microdose, I think you might be conflating it with low dosing to obtain threshold affects and still going out into public. You shouldn't generally be having a "great time" when micro-dosing, the affects should be fairly subtle. And not just subtle compared to a full dose.


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OfflineskOsH
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: Holybullshit]
    #26997532 - 10/22/20 08:52 AM (3 years, 3 months ago)

I've found that it depends on what I am focusing on, whether or not a microdose benefits me.

I'd like to see the same study but with microdosing followed by some nootropic substances and lion's mane


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InvisiblePsychoReactive
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: Achuma]
    #26997888 - 10/22/20 12:39 PM (3 years, 3 months ago)

Quote:

Achuma said:
microdosing psilocin works better for me.  LSD has too many different types of effect for me to consider microdosing on it to be useful.



How much psilocin do you take? Is this the one you extract yourself? Not dried mushrooms?


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Invisiblebreeg89
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: PsychoReactive]
    #27000704 - 10/24/20 12:52 AM (3 years, 3 months ago)

I'm just glad to see a blinded study to show that micro-dosing is not just placebo.


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OfflineCountHTML
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: breeg89]
    #27000722 - 10/24/20 01:24 AM (3 years, 3 months ago)

I would be interested in a study looking at how microdosing LSD in particular may or may not improve functioning in adults with ADHD. I suspect the cognitive gains may mainly be for these individuals and may be nil for those without pre existing attention deficits.


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InvisibleprettyMushy
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: CountHTML]
    #27003652 - 10/25/20 08:57 PM (3 years, 3 months ago)

I'm ADHD and i find it improves my cognitive abilities.  My problem solving skills go through the roof and i find myself not making as many mistakes when programming.


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OfflineTankie_J
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: morrowasted]
    #27007531 - 10/28/20 02:00 AM (3 years, 2 months ago)

Quote:

morrowasted said:

I've never understood the claims that microdosing LSD was somehow making people in silicon valley into creative geniuses. It makes me happy, sociable, distractable/unfocused, cognitively slow, and a little high strung. That's it.




This is what got me to read the whole article.

We are INDIVIDUALS. Effects are going to be different with every single person. Sure there are going to be general similarities, but on an individual basis it’s going to be different. Especially under a controlled study!

Smokers who smoke are asked not to smoke 2hrs before dose. — In the smokers natural life setting this isn’t going to be the case.

Users of any substance, Cannabis, for example, are asked to not use 2 weeks prior — Real life? They are detoxing at this point. Anxieties are likely higher, etc.

Questionnaires?

Blood sample every half hour?

This has to have an affect on results.

What I’m getting at is, that it’s a real possibility that there are far better results with micro and/or low dosing outside of a controlled study.

These guys in Silicon Valley are nerdin’ out and living in their flow states. Fuckin props.

This study shows us that at low doses there are actual effects. Let’s not forget the importance of set and setting.  :trippy:

— Tankie


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OfflineFractal420
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: Tankie_J]
    #27009568 - 10/29/20 02:09 AM (3 years, 2 months ago)

Supposed to be sub threshold. So under 25ug

Most lsd trips I’ve had (less so ALD and such) have had elements of anxiety. If not all of the lsd25 trips


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Invisibleilus
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: Fractal420]
    #27011100 - 10/29/20 08:24 PM (3 years, 2 months ago)

This was my experience also.  I would not recommend LSD for microdosing.  Psilocybin is a whole different ballgame and I have had very positive experiences with it.


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OfflineFractal420
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: ilus]
    #27012120 - 10/30/20 01:12 PM (3 years, 2 months ago)

I recommend like 3-4mg of 4hoDipt. Seriously. Amazing and will change your whole attitude


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Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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OfflineFailboat
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: Fractal420]
    #27012558 - 10/30/20 06:01 PM (3 years, 2 months ago)

I would expect that microdosing would be more practical for those who dose heavily often as the would be less sensitive to various effects given their tolerance, especially behavioral. Subjects accustomed  to 500+mcg doses weekly may find a dose of <100mcg to be rather modest and beneficial. There needs much more comprehensive research to state anything particularly definitive. Mucho mas.


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OfflineFractal420
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Re: LSD microdoses improve attention and mood, impair working memory, and increase anxiety [2020] [Re: Failboat]
    #27016642 - 11/02/20 01:16 AM (3 years, 2 months ago)

4mg 4hoDipt microdose successful! Awesome anti-depressant effects and it’s like a therapy session, I still think I took too much cause it’s supposed to be sub-threshold but I just took a pinch

Def just as good as microdosing lsd or mush, I’d say better than lsd for this purpose


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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