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OfflineHamHead
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Gilead questions WHO study that cast doubts on drug's COVID-19 benefits * 1
    #26990628 - 10/17/20 08:24 PM (3 years, 3 months ago)

https://www.reuters.com/article/us-health-coronavirus-remdesivir-idUSKBN27032N

"OCTOBER 15, 20204:14 PMUPDATED A DAY AGO
Gilead questions WHO study that cast doubts on drug's COVID-19 benefits
By Deena Beasley, Vishwadha Chander

(Reuters) - Gilead Sciences Inc GILD.O has questioned the findings of a World Health Organization (WHO) study that concluded its COVID-19 drug remdesivir does not help patients who have been admitted to hospital.

The American company told Reuters the data appeared inconsistent, the findings were premature and that other studies had validated the drug’s benefits.

In a blow to one of the few drugs being used to treat people with COVID-19, the WHO said on Thursday its “Solidarity” trial had concluded that remdesivir appeared to have little or no effect on 28-day mortality or length of hospital stays among patients with the respiratory disease.

The antiviral medication was one of the drugs used to treat U.S. President Donald Trump’s coronavirus infection, and has been shown in previous studies to have cut time to recovery, though the European Union is investigating it for possible kidney injury.

The WHO trial was conducted in 11,266 adult patients in more than 30 countries. The evidence was conclusive, the WHO said.

Gilead said other trials of remdesivir, including with 1,062 patients that compared it with a placebo, showed the treatment cut COVID-19 recovery time.

“The emerging (WHO) data appears inconsistent, with more robust evidence from multiple randomized, controlled studies published in peer-reviewed journals validating the clinical benefit of remdesivir,” Gilead told Reuters.

Gilead said it was “unclear if any conclusive findings can be drawn” given what it called differences in how the trial was conducted from site to site and between the patients who received the medicine.

In April, the top U.S. infectious disease official, Anthony Fauci, predicted remdesivir would become “the standard of care”.

Companies such as Gilead are racing to find a treatment for COVID-19. Some 1.1 million people have died and 39.1 million have been reported infected in the pandemic, and the global economy has been thrown into chaos.

Remdesivir was developed for Ebola, which causes fever, bleeding, vomiting and diarrhoea and spreads among humans through bodily fluids.

It was quickly repurposed and has offered some hope for patients, though the WHO's findings may shift the focus of the search for a vaccine to new monoclonal antibodies being developed by companies including Regeneron REGN.O.

The Solidarity trial also evaluated hydroxychloroquine, anti-HIV drug combination lopinavir/ritonavir and interferon, and concluded that they, like remdesivir, did little to help patients survive or leave the hospital more quickly.

The WHO trial's results are yet to be reviewed and were uploaded on the preprint server medRxiv. (bit.ly/3nViYIf)

“PREMATURE”

Gilead say the Solidarity conclusions, lacking scrutiny from other scientists, were premature.

“We are concerned the data from this open-label global trial has not undergone the rigorous review required to allow for constructive scientific discussion, particularly given the limitations of the trial design,” it said.

Remdesivir got emergency use authorization from the U.S. Food and Drug Administration on May 1, and has been authorized for use in several countries.

During the Solidarity study, trials of hydroxychloroquine and lopinavir/ritonavir were stopped in June after they proved ineffective, but the studies of Gilead’s drug and interferon continued in more than 500 hospitals and 30 countries.

WHO chief scientist Soumya Swaminathan said this week the U.N. health agency was now looking at other, emerging treatment options such as monoclonal anti-bodies, immunomodulators and some newer anti-viral drugs.

Regeneron Pharmaceuticals Inc REGN.O is developing a monoclonal antibody that Trump received for his COVID-19 infection.

Eli Lilly and Co LLY.N said on Tuesday a trial of its COVID-19 antibody treatment had been paused by the U.S. government because of a safety concern.

Reporting by Vishwadha Chander, Deena Beasley, Stephanie Ulmer-Nebehay and John Miller in Switzerland, Ludwig Burger in Frankfurt; Editing by Shinjini Ganguli, Devika Syamnath and Timothy Heritage"

I've heard Reuters is a good source for information.


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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Offlinepslyke
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: HamHead]
    #26990688 - 10/17/20 09:01 PM (3 years, 3 months ago)

Reuters tends to not over editorialize the information that they report on. That does not mean that the source information is indeed quality information. More recently, in the interest of getting data quickly into the public domain researchers have been using MedRxiv as a means to get non-peer reviewed information accessible to the research community. While these are extraordinary times, the rigor of science should/must first be evaluated by a group of impartial peers prior to such stock being placed on the findings.

MedRxiv (ahead of press, non-peer reviewed) manuscripts can be of the highest scientific rigor, or they can be motivated by financial or political interests. One should always read them with a critical view.


--------------------
"What appears impenetrable to us does exist, manifesting itself in the deepest wisdom and the most radiant beauty" Einstein

"The conservatives of 70 years ago would be outraged at what has come to pass. It embodies everything they took up arms for to defeat"Asante


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OfflineHamHead
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: pslyke]
    #26998680 - 10/22/20 08:58 PM (3 years, 3 months ago)

https://www.nytimes.com/2020/10/22/us/remdesivir-fda-approved.html

Unreal.

https://www.cnn.com/2020/10/15/health/remdesivir-covid-who-trial-mortality/index.html

https://www.webmd.com/lung/news/20201018/study-remdesivir-does-not-reduce-covid-mortality

https://www.theguardian.com/world/2020/apr/23/high-hopes-drug-for-covid-19-treatment-failed-in-full-trial

https://nationandstate.com/2020/10/22/fda-approves-gileads-remdesivir-to-treat-covid-19-despite-data-showing-drug-doesnt-work/

"Thu, 10/22/2020 – 18:00
Despite reams of data from an international WHO study raising serious questions about its efficacy, the FDA has finally approved the use of Gilead Science’s remdesivir – a powerful antiviral originally developed to treat ebola – for the treatment of COVID-19, making it the first such drug approved to treat the virus in the US.

https://www.india.com/news/world/does-remdesivir-work-in-covid-19-treatment-who-trial-says-no-cut-in-hospital-stay-or-mortality-4174921/

https://www.who.int/emergencies/diseases/novel-coronavirus-2019/globassymptoms.on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments

"Latest update on on treatment arms
Posted on 16 October 2020

The Solidarity Trial published interim results on 15 October 2020. It found that all 4 treatments evaluated (remdesivir, hydroxychloroquine, lopinavir/ritonavir and interferon) had little or no effect on overall mortality, initiation of ventilation and duration of hospital stay in hospitalized patients.

The Solidarity Trial is considering evaluating other treatments, to continue the search for effective COVID-19 therapeutics.

So far, only corticosteroids have been proven effective against severe and critical COVID-19."

Pick a source. I like the last one there, straight from WHO.

These drugs work better before people seek hospitalization, within 3 days of onset of symptoms.


Edited by HamHead (10/22/20 09:01 PM)


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OfflineLeningradCowboy
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: HamHead]
    #26999099 - 10/23/20 04:41 AM (3 years, 3 months ago)

https://worlddoctorsalliance.com/

This is interesting too. Open letter from doctors about covid and pandemia and lockdowns.


--------------------
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FREE HAMHEAD 2020!


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Offlinekoods
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: LeningradCowboy]
    #26999111 - 10/23/20 05:11 AM (3 years, 3 months ago)

Those people are idiots. They’re saying herd immunity has been reached. That’s just not true. Not even close. They are lying or incompetent.

Remdesivir is not that great.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Offlinekoods
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: koods] * 1
    #26999114 - 10/23/20 05:18 AM (3 years, 3 months ago)

I suspect the minoclonal antibodies are highly effective and reversing disease progression if taken early on.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineLeningradCowboy
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: koods]
    #26999120 - 10/23/20 05:24 AM (3 years, 3 months ago)



--------------------
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FREE HAMHEAD 2020!


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OfflineHamHead
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: LeningradCowboy]
    #26999150 - 10/23/20 06:02 AM (3 years, 3 months ago)

Quote:

koods said:
Those people are idiots. They’re saying herd immunity has been reached. That’s just not true. Not even close. They are lying or incompetent.

Remdesivir is not that great.




T-cell immunity is being ignored.

Quote:

LeningradCowboy said:
https://www.facebook.com/100017140411342/videos/726778874570120

Look before taken down. From Belgium.





Wow, 87,000 nurses say no to coronavirus vaccine.

Says PCR test are not accurate, false positives causing panic.


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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Offlinekoods
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: HamHead]
    #26999159 - 10/23/20 06:11 AM (3 years, 3 months ago)

Fire them


--------------------
NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Offlinekoods
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: koods]
    #26999164 - 10/23/20 06:16 AM (3 years, 3 months ago)

Can a mod please ban HamHead until the pandemic is over. His whole purpose here seems to be to undermine harm reduction efforts on a harm reduction site. We don’t have to tolerate this here. He’s not interested in debate, he’s here to spam the forum with disinformation he’s parroting from qanon and other insane conspiracy sites.


--------------------
NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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OfflineHamHead
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: koods] * 1
    #26999471 - 10/23/20 10:49 AM (3 years, 3 months ago)

Quote:

koods said:
Can a mod please ban HamHead until the pandemic is over. His whole purpose here seems to be to undermine harm reduction efforts on a harm reduction site. We don’t have to tolerate this here. He’s not interested in debate, he’s here to spam the forum with disinformation he’s parroting from qanon and other insane conspiracy sites.




Really?

So, 87,000 nurses should all be fired? I guess that's one way to deal with a pandemic. :shrug:

And I should be banned for sharing information? Information found from multiple sources?


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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Offlinechristopera
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: HamHead]
    #26999487 - 10/23/20 10:58 AM (3 years, 3 months ago)

You have become insufferable on this topic.


--------------------
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OfflineLeningradCowboy
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: HamHead] * 1
    #26999489 - 10/23/20 10:58 AM (3 years, 3 months ago)



--------------------
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FREE HAMHEAD 2020!


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OfflineHamHead
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: christopera]
    #26999494 - 10/23/20 11:01 AM (3 years, 3 months ago)

Quote:

christopera said:
You have become insufferable on this topic.




There's only one page in this thread.

I'm posting links to articles.

These are not my opinions. They are of those who preformed these studies.

If there's a problem with data, I don't know what else to say.


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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OfflineHamHead
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Re: Gilead questions WHO study that cast doubts on drug's COVID-19 benefits [Re: LeningradCowboy]
    #26999504 - 10/23/20 11:03 AM (3 years, 3 months ago)

Quote:

LeningradCowboy said:
https://darkoutpost.com/health/doctors-for-truth-tens-of-thousands-medical-professionals-suing-and-calling-for-end-to-covid-tyranny/

More about the nurses against false pandemia




"The Great Barrington Declaration
Earlier this month (October, 2020), three of the world’s most renowned doctors, Dr. Martin Kulldorff, Harvard Medical School Professor, Dr. Sunetra Gupta, Oxford University Epidemiology Professor, and Dr. Jayanta Bhattacharya, Stanford Epidemiology Professor, authored the Great Barrington Declaration.

Since its publication, at the time of writing of this article, it has been signed by 29,202 Medical Practitioners, 10,576 Medical & Public Health Scientists, and 532,027 Concerned Citizens."


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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