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OfflineJHPsych
Stranger
Registered: 09/16/20
Posts: 1
Last seen: 3 years, 3 months
Johns Hopkins survey on the interaction between antidepressants and psilocybin * 1
    #26939348 - 09/16/20 04:05 PM (3 years, 4 months ago)

Researchers at Johns Hopkins are conducting a brief online survey about the effects of psilocybin in people who have used a moderate to high dose of psilocybin mushrooms (also called “magic mushrooms”) while taking an antidepressant medication, or within two years of stopping such treatment. Psilocybin is a compound that occurs naturally in certain species of mushrooms, and is currently being studied for its possible antidepressant effects. However, people who are currently using or have recently used antidepressants may react differently to psilocybin, and this interaction is not well understood. Your participation in this research study can help improve our understanding of how psilocybin works in people who have used antidepressant medications.

www.HopkinsPsychedelic.org/adsurvey

Protocol: IRB00254819, Principal Investigator: Roland R. Griffiths, Ph.D.


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Anonymous #1

Re: Johns Hopkins survey on the interaction between antidepressants and psilocybin [Re: JHPsych]
    #26939452 - 09/16/20 05:06 PM (3 years, 4 months ago)

Thanks for doing this research. My response has been recorded.


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OfflineNikon Addict
Another Earthling
Male


Registered: 01/16/18
Posts: 285
Loc: Colorado USA
Last seen: 1 year, 23 days
Re: Johns Hopkins survey on the interaction between antidepressants and psilocybin [Re: JHPsych]
    #26939541 - 09/16/20 05:50 PM (3 years, 4 months ago)

Look, I respect Johns Hopkins, especially their psychedelic research... But there is no way in hell they don't understand the real possibility of someone on an SSRI developing Serotonin Syndrome if they top it off with a psychedelic... I don't understand this... It can be deadly and something like this can give someone the impression it's cool to mix the two... It's not cool to mix the two... Wow is all I've got to say... What a great way to sabotage psychedelic research


--------------------
personal note: "It’s fair to say I’m stepping out on a limb, but I am on the edge and that’s where it happens.”


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Anonymous #1

Re: Johns Hopkins survey on the interaction between antidepressants and psilocybin [Re: Nikon Addict]
    #26939675 - 09/16/20 07:11 PM (3 years, 4 months ago)

I've been taking mushrooms while taking antidepressants for 15 years. I tried quitting the antidepressants for a year once and during that time, mushrooms gave me suicidal thoughts during that time; I've never had them when taking mushrooms while on my antidepressants. Taking antidepressants with mushrooms has never made me feel like I was in any kind of physical danger- certainly not from serotonin syndrome. Not saying it is safe for everyone but it's certainly something that happens. I can understand the motivation for wanting to understand the interactions given that mushrooms as a psychiatric medicine are largely being considered as a treatment for depression and anxiety. Saying that anybody who uses or who has tried antidepressants would exclude a massive patient population that could potentially benefit.

For what it's worth, many people seem to think that SSRIs will just totally block the experience. On high doses the experience is diminished, but I now take the lowest available dose and I'm able to trip on mushrooms quite hard at normal doses.

I would also note that for me taking high doses of SNRI/SSRI drugs made me have visuals- breathing walls, morphing patterns- all the time as a result of bimonthly mushroom use. When I reduced the dose that effect went away entirely.


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Offlinemeowjinx
Stranger
Male
Registered: 05/20/19
Posts: 492
Last seen: 1 year, 6 months
Re: Johns Hopkins survey on the interaction between antidepressants and psilocybin [Re: Nikon Addict]
    #26939949 - 09/17/20 12:15 AM (3 years, 4 months ago)

Quote:

Nikon Addict said:
Look, I respect Johns Hopkins, especially their psychedelic research... But there is no way in hell they don't understand the real possibility of someone on an SSRI developing Serotonin Syndrome if they top it off with a psychedelic... I don't understand this... It can be deadly and something like this can give someone the impression it's cool to mix the two... It's not cool to mix the two... Wow is all I've got to say... What a great way to sabotage psychedelic research




Yep, as someone who's taken SSRI's for a big chunk of his life, I can attest to how dangerous serotonin syndrome can be. I take a regular dosage of my SSRI, never overdo it. But I've been pretty reckless with what drugs I combine it w/ in the past

One time I did some cocaine and amphetamines early in the day. Basically ate nothing while I did a bunch of chores and stuff around my house. I did some shroom work, too. When I was done I decided to relax w/ some Penis Envy shroom tea. I felt amazing and the exhaustion melted away. I felt so good that I decided to eat a couple more grams of shrooms to keep the feeling going, and this was my big mistake

At first I felt fine, but within a few hours I started sweating very profusely, I just felt uncomfortable and out of it and started feeling an irregular heartbeat

I had to lie down, but I was feeling so bad that I was afraid that if I laid down I might pass out and not wake up so I got up and sat in front my SAB station. Next thing I know I wake up, on the floor, and my SAB is in pieces. I had passed out and luckily the SAB broke my fall, although it did cut me up pretty bad. I honestly thought I was dying. I considered going to the ER, but I calmed myself down and eventually it wore off

Moral of the story: don't be stupid and mix drugs the way I did. Yes, it was a combination of a lack of sleep, food, a very large shroom dose, etc. I'm not saying that you absolutely cannot take psychedelics while on SSRIs safely. But Serotonin Syndrome is very real and very dangerous, although it's not nearly as talked about as other types of overdoses, such as from CNS depressants like alcohol/opioids/benzos


Edited by meowjinx (09/17/20 04:35 AM)


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,373
Re: Johns Hopkins survey on the interaction between antidepressants and psilocybin [Re: Nikon Addict]
    #26940086 - 09/17/20 04:15 AM (3 years, 4 months ago)

Quote:

Nikon Addict said:
Look, I respect Johns Hopkins, especially their psychedelic research... But there is no way in hell they don't understand the real possibility of someone on an SSRI developing Serotonin Syndrome if they top it off with a psychedelic... I don't understand this... It can be deadly and something like this can give someone the impression it's cool to mix the two... It's not cool to mix the two... Wow is all I've got to say... What a great way to sabotage psychedelic research




I'm curious why you think taking a survey about SSRIs and psychedelics somehow encourages it? 

Survey-based methodology has been around for quite some time and is a commonly used method of data collection.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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OfflineNikon Addict
Another Earthling
Male


Registered: 01/16/18
Posts: 285
Loc: Colorado USA
Last seen: 1 year, 23 days
Re: Johns Hopkins survey on the interaction between antidepressants and psilocybin [Re: badchad]
    #26940392 - 09/17/20 09:26 AM (3 years, 4 months ago)

Quote:

badchad said:
Quote:

Nikon Addict said:
Look, I respect Johns Hopkins, especially their psychedelic research... But there is no way in hell they don't understand the real possibility of someone on an SSRI developing Serotonin Syndrome if they top it off with a psychedelic... I don't understand this... It can be deadly and something like this can give someone the impression it's cool to mix the two... It's not cool to mix the two... Wow is all I've got to say... What a great way to sabotage psychedelic research




I'm curious why you think taking a survey about SSRIs and psychedelics somehow encourages it? 

Survey-based methodology has been around for quite some time and is a commonly used method of data collection.




It's not the survey itself, it's the nature of the survey... It can give someone the impression it's acceptable to mix SSRI's and psychedelics... The individual might think "Geeez, others do it, there's even a survey, what the hell!!! I'm going for it!!!"

I had a chance to think about it and I appreciate your question... I understand why Johns Hopkins is doing this... There is no safe way to gather this data clinically, and they know it... The moment one person dies, that's it, shut it down, Nixon was right, this shit is dangerous... I'm going to take the survey, I've got it bookmarked... I'm hoping that they get the data they're looking for in order for this research to move forward... I have my own science based theory on why mental illness occurs but I'm a realist, I know it's got to be a drug with "them" I'm grateful that psychedelic research has been resurrected from its literal grave, believe me, there's no one more excited about this than me... Well maybe not no one, but yeah...


--------------------
personal note: "It’s fair to say I’m stepping out on a limb, but I am on the edge and that’s where it happens.”


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Invisiblebadchad
Mad Scientist

Registered: 03/02/05
Posts: 13,373
Re: Johns Hopkins survey on the interaction between antidepressants and psilocybin [Re: Nikon Addict]
    #26940406 - 09/17/20 09:36 AM (3 years, 4 months ago)

Well, I would just add that survey-based research is well-accepted.  It's done across many different areas including all sorts of drug use.  I don't know of any data linking surveys to promotion of a behavior.  Also, bear in mind the questions and survey are reviewed by a large board of doctors, ethicists, etc. (The IRB) to help ensure the survey won't encourage behaviors.


--------------------
...the whole experience is (and is as) a profound piece of knowledge.  It is an indellible experience; it is forever known.  I have known myself in a way I doubt I would have ever occurred except as it did.

Smith, P.  Bull. Menninger Clinic (1959) 23:20-27; p. 27.

...most subjects find the experience valuable, some find it frightening, and many say that is it uniquely lovely.

Osmond, H.  Annals, NY Acad Science (1957) 66:418-434; p.436


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