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Offlinekoods
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419897 - 08/08/21 03:00 PM (2 years, 5 months ago)

Cholera is a bacterial infection


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: koods]
    #27419899 - 08/08/21 03:01 PM (2 years, 5 months ago)

https://en.wikipedia.org/wiki/Antigenic_drift


Antigenic drift is a kind of genetic variation in viruses, arising from the accumulation of mutations in the virus genes that code for virus-surface proteins that host antibodies recognize. This results in a new strain of virus particles that is not effectively inhibited by the antibodies that prevented infection by previous strains. This makes it easier for the changed virus to spread throughout a partially immune population. Antigenic drift occurs in both influenza A and influenza B viruses.


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[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419904 - 08/08/21 03:02 PM (2 years, 5 months ago)

Not to be confused with Antigenic shift or Genetic drift.

Antigenic drift is a kind of genetic variation in viruses, arising from the accumulation of mutations in the virus genes that code for virus-surface proteins that host antibodies recognize. This results in a new strain of virus particles that is not effectively inhibited by the antibodies that prevented infection by previous strains. This makes it easier for the changed virus to spread throughout a partially immune population. Antigenic drift occurs in both influenza A and influenza B viruses.

(Confusion can arise with two very similar terms, antigenic shift and genetic drift. Antigenic shift is a closely related process; it refers to more dramatic changes in the virus's surface proteins. Genetic drift is very different and much more broadly applicable; it refers to the gradual accumulation in any DNA sequence of random mutational changes that do not interfere with the DNA's function and thus that are not seen by natural selection.)

The immune system recognizes viruses when antigens on the surfaces of virus particles bind to immune receptors that are specific for these antigens. These receptors can be antibodies in the bloodstream or similar proteins on the surfaces of immune-system cells. This recognition is quite precise, like a key recognizing a lock. After an infection or after vaccination, the body produces many more of these virus-specific immune receptors, which prevent re-infection by this particular strain of the virus; this is called acquired immunity. However, viral genomes are constantly mutating, producing new forms of these antigens. If one of these new forms of an antigen is sufficiently different from the old antigen, it will no longer bind to the antibodies or immune-cell receptors, allowing the mutant virus to infect people who were immune to the original strain of the virus because of prior infection or vaccination.

In 1940s, Maurice Hilleman discovered antigenic drift, which is the most common way that influenza viruses change.[1][2][3][4] A second type of change is antigenic shift, also discovered by Hilleman,[1][2] where the virus acquires a completely new version of one of its surface-protein genes from a distantly related influenza virus. The rate of antigenic drift is dependent on two characteristics: the duration of the epidemic, and the strength of host immunity. A longer epidemic allows for selection pressure to continue over an extended period of time and stronger host immune responses increase selection pressure for development of novel antigens.[5]


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[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419905 - 08/08/21 03:02 PM (2 years, 5 months ago)

A known process since 1940.


Anything else


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[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419909 - 08/08/21 03:05 PM (2 years, 5 months ago)

Quote:

In human populations, immune (vaccinated) individuals exert selective pressure for single point mutations in the hemagglutinin gene that increase receptor binding avidity, while naive individuals exert selective pressure for single point mutations that decrease receptor binding avidity.[8] These dynamic selection pressures facilitate the observed rapid evolution in the hemagglutinin gene. Specifically, 18 specific codons in the HA1 domain of the hemagglutinin gene have been identified as undergoing positive selection to change their encoded amino acid.[10] To meet the challenge of antigenic drift, vaccines that confer broad protection against heterovariant strains are needed against seasonal, epidemic and pandemic influenza.[11]




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[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


Edited by paradoxlost (08/08/21 03:06 PM)


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419915 - 08/08/21 03:08 PM (2 years, 5 months ago)

So is the answer to first get COVID, then get vaccinated?


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[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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Offlinekoods
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419922 - 08/08/21 03:12 PM (2 years, 5 months ago)

Quote:

paradoxlost said:
Quote:

In human populations, immune (vaccinated) individuals exert selective pressure for single point mutations in the hemagglutinin gene that increase receptor binding avidity, while naive individuals exert selective pressure for single point mutations that decrease receptor binding avidity.[8] These dynamic selection pressures facilitate the observed rapid evolution in the hemagglutinin gene. Specifically, 18 specific codons in the HA1 domain of the hemagglutinin gene have been identified as undergoing positive selection to change their encoded amino acid.[10] To meet the challenge of antigenic drift, vaccines that confer broad protection against heterovariant strains are needed against seasonal, epidemic and pandemic influenza.[11]







This is about influenza viruses


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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InvisibleMr.GuessWork
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419923 - 08/08/21 03:13 PM (2 years, 5 months ago)

probably better to avoid the virulence of infection. I'm sure it's possible to vaccinate against multiple antigens like koods mentioned earlier. there's no good reason to risk all kinds of damage from actual infection in an immune naïve state, and a vaccine should produce a way higher antibody titer than native infection.


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: koods]
    #27419925 - 08/08/21 03:14 PM (2 years, 5 months ago)

Quote:

koods said:
Quote:

paradoxlost said:
Quote:

In human populations, immune (vaccinated) individuals exert selective pressure for single point mutations in the hemagglutinin gene that increase receptor binding avidity, while naive individuals exert selective pressure for single point mutations that decrease receptor binding avidity.[8] These dynamic selection pressures facilitate the observed rapid evolution in the hemagglutinin gene. Specifically, 18 specific codons in the HA1 domain of the hemagglutinin gene have been identified as undergoing positive selection to change their encoded amino acid.[10] To meet the challenge of antigenic drift, vaccines that confer broad protection against heterovariant strains are needed against seasonal, epidemic and pandemic influenza.[11]







This is about influenza viruses





is it retarded to think that such a thing could happen in a coronavirus considering the discussion we just had


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[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: Mr.GuessWork]
    #27419928 - 08/08/21 03:15 PM (2 years, 5 months ago)

Quote:

Mr.GuessWork said:
probably better to avoid the virulence of infection. I'm sure it's possible to vaccinate against multiple antigens like koods mentioned earlier. there's no good reason to risk all kinds of damage from actual infection in an immune naïve state, and a vaccine should produce a way higher antibody titer than native infection.




should and does are two different things.


--------------------
[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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InvisiblebodhisattaMDiscordReddit
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost] * 3
    #27419930 - 08/08/21 03:15 PM (2 years, 5 months ago)

Frantically paradox googles something else. He finds a wiki article about antigenetic drift. This seems to be the thing I'm looking for he thinks to himself. A proverbial nail in the coffin to triumph. Nice work paradox washes over his mind. I DID IT. I didn't even know shit about what I was talking about but I keyboarded so much better that I won muthafukaaaa.

Article talks about influenza not coronaviruses. There's no evidence to suggest that process occurs in other viruses :shrug: just influenza A and B

If we started making mRNA influenza vaccines that wouldn't be a problem anymore anyway. And in fact that's probably the future of influenza vaccines for humans


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:whyyy:


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: bodhisatta]
    #27419931 - 08/08/21 03:17 PM (2 years, 5 months ago)

Quote:

bodhisatta said:
Frantically paradox googles something else. He finds a wiki article about antigenetic drift. This seems to be the thing I'm looking for he thinks to himself. A proverbial nail in the coffin to triumph. Nice work paradox washes over his mind. I DID IT. I didn't even know shit about what I was talking about but I keyboarded so much better that I won muthafukaaaa.

Article talks about influenza not coronaviruses. There's no evidence to suggest that process occurs in other viruses :shrug: just influenza A and B

If we started making mRNA influenza vaccines that wouldn't be a problem anymore anyway. And in fact that's probably the future of influenza vaccines for humans





:wink:

keep moving those goal posts


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[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


Edited by paradoxlost (08/08/21 03:17 PM)


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InvisibleMr.GuessWork
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost]
    #27419946 - 08/08/21 03:27 PM (2 years, 5 months ago)

Quote:

paradoxlost said:
Quote:

Mr.GuessWork said:
probably better to avoid the virulence of infection. I'm sure it's possible to vaccinate against multiple antigens like koods mentioned earlier. there's no good reason to risk all kinds of damage from actual infection in an immune naïve state, and a vaccine should produce a way higher antibody titer than native infection.




should and does are two different things.




it does for the most part. Here's a study comparing various vaccines with natural infection. it looks at efficacy and compares it to neutralization by antibodies.

https://www.nature.com/articles/s41591-021-01377-8


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: Mr.GuessWork]
    #27419984 - 08/08/21 03:54 PM (2 years, 5 months ago)

Quote:

Mr.GuessWork said:
Quote:

paradoxlost said:
Quote:

Mr.GuessWork said:
probably better to avoid the virulence of infection. I'm sure it's possible to vaccinate against multiple antigens like koods mentioned earlier. there's no good reason to risk all kinds of damage from actual infection in an immune naïve state, and a vaccine should produce a way higher antibody titer than native infection.




should and does are two different things.




it does for the most part. Here's a study comparing various vaccines with natural infection. it looks at efficacy and compares it to neutralization by antibodies.

https://www.nature.com/articles/s41591-021-01377-8




the subsequent study i posted refuted the claims in that study that natural immunity decays rapidly until 250 days. The study i showed, indicated miled to moderate symptomatic people (over 80%) of cases, maintained immunity past 250 days


--------------------
[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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Offlineparadoxlost
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: paradoxlost] * 1
    #27419985 - 08/08/21 03:55 PM (2 years, 5 months ago)

Quote:

Another interesting finding of this investigation is the remarkably stable antibody responses among the pre-pandemic and COVID-19 patients to the common human coronaviruses that are acquired in children and adults. These data are most consistent with the generation of long-lived plasma cells and refute the current notion that these antibody responses to human coronaviruses are short lived.




--------------------
[quote]koods said:
Asante, I don’t think we should have any sympathy and should celebrate the deaths of antivax/antimask activists. They are responsible for far more American deaths than al Qaeda ever was. Every time one of them dies ther movement of death is weakened.ut[/quote]

[quote]koods said:
Chasing variants with vaccines is a dumb idea[/quote]


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Offlinemorrowasted
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: koods]
    #27420102 - 08/08/21 05:29 PM (2 years, 5 months ago)

Quote:

koods said:
I don’t know what that means



dude is 100% winging it


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OfflineOutsideOfMyMind
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: budmanman]
    #27420184 - 08/08/21 06:31 PM (2 years, 5 months ago)

Quote:

budmanman said:
They were, and they were buying really dumb shit with the money, poor people don't know how to management money and they didn't have to pay their rent or mortgage if they didn't want to with the stroke of a keyboard, then it dropped to 300 extra instead of 600, so at that point they were making close to the same as before.

Instead of saving up for the impending consequences of the shut down, they blew it on all kinds of shit, a lot of them on crypto, of which were dumb top buyers.



Not all poor people are stupid with their money. I paid off all $10,000 of my credit card debt last year and now I have an 813 credit score. The most recent unemployment benefits enabled me to have $10,000 in the bank now. This is more money than I've had since 2008 before the recession. I'm not rich but god it's so nice having a nice cushion in my account now.


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Edited by OutsideOfMyMind (08/08/21 06:33 PM)


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Invisiblebudmanman
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: OutsideOfMyMind] * 2
    #27420213 - 08/08/21 07:00 PM (2 years, 5 months ago)

People who didn't f their money off are rare. Our own government F's its money on off like its no big deal, its engrained in our society.


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Everything I have ever said is total bogus bs I am full of crud therefore everything I say should never be taken literal.

And I am mentally unstable.


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OfflineOutsideOfMyMind
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) *DELETED* [Re: budmanman]
    #27420225 - 08/08/21 07:11 PM (2 years, 5 months ago)

Post deleted by OutsideOfMyMind

Reason for deletion: Fuck


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Edited by OutsideOfMyMind (08/08/21 07:15 PM)


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Invisiblebudmanman
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Re: COVID-19 aka. SARS-CoV-2 - Main Thread on the Novel Coronavirus Pandemic PART 2 (Delta Wave 2021) [Re: OutsideOfMyMind]
    #27420226 - 08/08/21 07:14 PM (2 years, 5 months ago)

image 404,

your link isn't working for some reason.


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Everything I have ever said is total bogus bs I am full of crud therefore everything I say should never be taken literal.

And I am mentally unstable.


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