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OfflineRamblin-Man
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Using RIMA to beat Psychedelic Tolerance
    #26880829 - 08/14/20 10:29 PM (3 years, 5 months ago)

Recently discovered RIMAs based on harmalas — especially Tetrahydroharmine. Harmaline/harmine etc.

These make the psychedelic experience extremely powerful. I’ve taken it with 🍄 and it pushed the experience into the DMT zone.

Could you potentially dose an RIMA like TTH daily and experience full trips more often — like days apart? In other words, would something like TTH allow a person to trip constantly?


Edited by Ramblin-Man (08/14/20 10:48 PM)


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OfflinePrimalSoup
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Ramblin-Man]
    #26880892 - 08/14/20 11:44 PM (3 years, 5 months ago)

Just upping the dose sufficiently will allow you to experience full-on trips daily, if you can stand it.  But you have to have a really good reason to want to do that, and you have to be able to have the time to do it, etc. :cookiemonster:


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InvisibleKaruna
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Ramblin-Man]
    #26904440 - 08/28/20 03:11 PM (3 years, 5 months ago)

I feel as if psychedelics have have a high natural tolerance to reduce their potential for abuse and increase their potential for beneficial use, trying to cheat that system and trip constantly probably falls into the realm of the former.

I understand this may not be the answer you want or can even hear right now but feel like it's worth saying nonetheless.

There's been times during a trip where I wish I could be tripping forever and others I've been fearful at the same prospect. Tripping constantly isn't an ideal in my opinion, having access to the same mind state while sober is.


Edited by Karuna (08/28/20 03:27 PM)


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OfflineSabnock
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Karuna] * 2
    #26904714 - 08/28/20 06:00 PM (3 years, 5 months ago)

Idk, i took oral DMT daily/near daily for 4 years straight, best time of my life, learned so much, experienced a lot, was never abuse or escape or addiction, was merely about exploration, learning, seeking, experimenting, remembering and realizing things about myself and reality. I do feel like one can overuse them if not using them for the right purposes/reasons but so long as one is using them responsibly, maturely, wisely and for the right reasons, diving into it for a good long while is actually quite useful. It's a pity imo that you can't do that with other Psychedelics.


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OfflineTheEschatologist
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Re: Using RIMA to beat Psychedelic Tolerance *DELETED* [Re: Sabnock]
    #26906044 - 08/29/20 01:43 PM (3 years, 5 months ago)

Post deleted by TheEschatologist

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OfflineSabnock
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Re: Using RIMA to beat Psychedelic Tolerance [Re: TheEschatologist]
    #26906065 - 08/29/20 01:55 PM (3 years, 5 months ago)

Quote:

TheEschatologist said:
Someone correct me if I'm wrong but I don't think you can really build tolerance to RIMAs, so yeah the tripping every day thing would probably work. You'd probably have to combine it with psilo or dmt extract to fully trip each time. I haven't tried it so don't know how much you'd have to increase dosages over consecutive days. Personally I think I'd probably get tired after like a week and would benefit from taking breaks, like a week on week off schedule or something like that. Maybe I'll give it a shot in future. Take care OP, don't get lost down the rabbit hole :lol:




Can't build tolerance to RIMA's, or to DMT, but you can take Psilocin and other Psychedelics.


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InvisibleShenmue
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Sabnock]
    #26906069 - 08/29/20 01:58 PM (3 years, 5 months ago)

why would you even want to trip daily? Mushrooms are already perfect in design :yesnod: ..


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OfflineSabnock
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Shenmue]
    #26906220 - 08/29/20 03:26 PM (3 years, 5 months ago)

Quote:

Shenmue said:
why would you even want to trip daily? Mushrooms are already perfect in design :yesnod: ..




If you have to ask, you haven't thoroughly explored what they have to offer. There's lots to learn and figure out.


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InvisibleShenmue
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Sabnock]
    #26906529 - 08/29/20 07:26 PM (3 years, 5 months ago)

Are you terence mckennas long lost son or something? :lol:


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OfflineSabnock
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Shenmue] * 1
    #26906611 - 08/29/20 08:17 PM (3 years, 5 months ago)

Quote:

Shenmue said:
Are you terence mckennas long lost son or something? :lol:




Are you an ignoramus? Quite possibly.


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OfflineBeerus
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Sabnock]
    #27904875 - 08/15/22 08:57 PM (1 year, 5 months ago)

Quote:

Sabnock said:
Can't build tolerance to RIMA's, or to DMT, but you can take Psilocin and other Psychedelics.




It is possible to get Serotonin Syndrome, and therefore death from TTH. I do not recommend taking this stuff so often.


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OnlineNorthernerM
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Beerus]
    #27905086 - 08/16/22 02:05 AM (1 year, 5 months ago)

You need a serotonin agonist as well as the TTH to cause serotonin syndrome. Just don't so that.


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OfflineSabnock
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Re: Using RIMA to beat Psychedelic Tolerance [Re: Beerus] * 3
    #27905592 - 08/16/22 12:59 PM (1 year, 5 months ago)

Quote:

Beerus said:
Quote:

Sabnock said:
Can't build tolerance to RIMA's, or to DMT, but you can take Psilocin and other Psychedelics.




It is possible to get Serotonin Syndrome, and therefore death from TTH. I do not recommend taking this stuff so often.




Well i think you're referring to THH (TetraHydroHarmine)? That's not a RIMA, that's a weak SRI (Serotonin reuptake inhibitor) and is found in the B. Caapi "Ayahuasca" vine alongside Harmine and Harmaline (the RIMA's aka reversible inhibitors of MAO-A). You're not going to get Serotonin Syndrome, or die, from consuming Harmalas/MAO-A inhibitors even in combination with Serotonergic agonists like DMT or Psilocin or any number of other Serotonergic Psychedelics. THH being a weak SRI is nothing compared to a potent SSRI like Prozac or Zoloft for example, and Caapi in itself contains both RIMA's and THH and even in high dosages has a good safety factor, the problem with SRI's come in the form of the potent/strong SSRI's. Also it should be noted that i do not take THH, i don't necessarily get any benefit from THH and thus do not find it necessary, i use Harmine/Harmaline, in particular Syrian Rue.

Serotonin Syndrome occurs when there's too much Serotonin in the system, i've had Serotonin Syndrome before from pharmaceutical SSRI's, not a pleasant experience, but so long as you are not taking a potent/strong SSRI, or some sort of Serotonin releasing agent (SRA), with a stiff dose of an MAO-A inhibitor, you're not going to get Serotonin Syndrome. So taking a Serotonergic agonist isn't going to cause Serotonin Syndrome, neither is the MAO-A inhibition, but if you were to consume a potent SSRI with MAO-A inhibition it could potentially cause Serotonin Syndrome, hence why that is not advised. However there are some studies, and some psychiatrists who have used certain combinations of SSRI's with reversible MAOI's like Moclobemide for example, where it was tolerated and had a positive and safe outcome but the dosages and the types of medicines as well as the professionals working with them are to be taken into account there, and again, such combinations are ill advised without some sort of professional guidance.

So things like MDMA or even 5-MEO-DMT, which have monoamine reuptake inhibitive properties (in particular the Serotonin reuptake), shouldn't be mixed with MAO-A inhibitors.

And care should also be taken with the CYP1A2 and CYP2D6 inhibition of the Harmalas since many medications are metabolized by CYP1A2 or CYP2D6, which some medications metabolized by those enzymes can actually be taken with those enzymes inhibited but dosage of medications metabolized by those enzymes would need to be lowered/reduced for equal effect compared to without the CYP inhibition and resulting potentiation through increased bioavailability.

With that said, i've been consuming Harmalas on a regular basis since 2012, with and without Psychedelics, and i've been just fine, and Harmalas in themselves are pretty safe and are not going to cause death unless it's mixed with the wrong things, in which case i would argue it would be the mixed in things themselves, like an SSRI for example, that would be to blame for any Serotonin Syndrome regardless of the fact of the MAO-A inhibition being also present, seeing as how i've gotten Serotonin Syndrome from SSRI's alone and they're what increases Serotonin concentrations in the synaptic cleft whereas MAO-A inhibition only increases background concentrations of Serotonin as well as Noradrenaline and to a lesser extent Dopamine (since MAO-B and COMT primarily handle Dopamine), so it's the SSRI's really at fault here for Serotonin Syndrome, not so much MAO-A inhibition although that can certainly contribute if mixed with an SSRI.


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