Home | Community | Message Board


Zamnesia.com
Please support our sponsors.

Feedback and Administration >> Shroomery News Service

Welcome to the Shroomery Message Board! You are experiencing a small sample of what the site has to offer. Please login or register to post messages and view our exclusive members-only content. You'll gain access to additional forums, file attachments, board customizations, encrypted private messages, and much more!

Kraken Kratom Shop: Red Vein Kratom

Jump to first unread post. Pages: 1
Offlineicetech
 User Gallery


Registered: 08/21/17
Posts: 3,304
Loc: FSM's loving noodles.
Last seen: 11 hours, 17 minutes
LSD for pain... new study. * 1
    #26902437 - 08/27/20 03:48 PM (28 days, 11 hours ago)

https://newatlas.com/science/trial-lsd-microdoses-acute-pain-study-results/

P.S. in news we already knew :smile:

An incredible, first-of-its-kind trial testing the pain-killing properties of LSD microdoses has delivered the compelling suggestion that tiny, non-psychedelic doses of this infamous drug could serve as an effective analgesic.

Back in the 1960s, during the original heyday of psychedelic science, one of the more fascinating research areas for LSD was its unexpected efficacy as an analgesic. Researcher Eric Kast was one of the pioneer investigators on the topic, publishing over a dozen key papers exploring the ways pain perception is influenced by LSD.

Kast’s work was primarily with active psychedelic doses of LSD, and he consistently found the drug produced effective, and protracted, analgesic effects. Unfortunately, Kast’s work with LSD ended, as most psychedelic research did, when access to the drug was restricted in the late 1960s.

Decades later, as the freeze on psychedelic research begins to thaw, the idea of LSD as a pain-reliever still sits on the fringes of psychedelic science. No modern clinical researcher has returned to Kast’s ideas, however, anecdotal cases have begun to emerge highlighting some people self-medicating with LSD microdoses to treat chronic pain.

This new study, led by researchers from Maastricht University with assistance from the Beckley Foundation, is the first clinical trial to revisit this topic in more than 50 years. Unlike Kast’s prior work, this new research focused on microdoses of LSD rather than larger, actively psychedelic doses.

“From a medical point of view, controlled research on the efficacy of LSD in pain management should focus on non-hallucinogenic, low doses of LSD, which are more manageable and thus preferable over treatment with high doses of LSD that produce full-blown psychedelic effects,” the researchers explain in their paper.

The double-blind, placebo-controlled trial recruited 24 healthy subjects, each of whom took part in four separate experimental sessions, separated by at least five days. Three different LSD microdoses were tested (five, 10, and 20 micrograms) alongside a placebo.

During each experimental session, the subjects completed a Cold Pressor Test (CBT) at two time points following dosing: 90 minutes after and five hours after. The test basically involves plunging one’s hand into a tank of water at 3 °C (37.4 °F). Pain tolerance is measured by combining the amount of time one can hold their hand in the cold water, with a series of subjective ratings regarding painfulness.

The researchers described the results of the study as “remarkable”, with the 20-µg-dose group revealing prolonged improvements to pain tolerance compared to both lower doses and placebo. The results were sustained across both time points suggesting the analgesic effect is just as prominent five hours later as it is within the first 90 minutes.

“The current data consistently indicated that LSD 20 µg significantly reduced pain perception as compared with placebo, whereas lower doses of LSD did not,” the researchers write. “LSD 20 µg significantly increased pain tolerance (i.e. immersion time) by about 20%, while decreasing the subjective levels of experienced painfulness and unpleasantness.”

So what exactly is going on here? Is LSD just distracting people from the acute pain, or is it actually inhibiting pain signaling through a more direct pharmacological mechanism?

Kast hypothesized 50 year ago these analgesic effects were the result of LSD reorienting attention away from pain sensations to a more encompassing psychedelic experience. While that hypothesis certainly is reasonable when high LSD doses are administered, it doesn’t really explain the results seen in this new microdose trial.

The researchers do note a small correlation between increasing levels of psychedelic disassociation and greater pain relief in their results, but the association was weak. They estimate it accounting for no more than six percent of the variance in analgesic results.

A variety of possible alternate hypotheses are presented in the new study, from pharmacologically influencing specific brain receptors known to mediate pain sensation, to triggering a condition called hypertension-associated hypoalgesia whereby blood pressure rises can lead to a diminished perception of pain.

“… an extended dose-finding study is needed to determine the dose at which analgesic effects of LSD are optimal, i.e. when efficacy is maximal and mental interference is minimal,” propose the researchers. “Such a study could potentially explore the trade-off between increments in treatment efficacy and psychedelic symptoms in a low to medium dose range (i.e. 20–50 µg LSD).”

Perhaps the most intriguing finding in the study is the observation that the analgesic effect seen in the 20-µg LSD group is comparable to what prior studies have seen with in the same cold water pain test for opioids such as oxycodone and morphine.

Needless to say, a great deal more research is needed before these results can be extrapolated into any real-world clinical treatment. Will these LSD microdose results translate into pain relief for chronic pain sufferers? Or is this kind of analgesic best for certain types of acute pain? What are the safety issues surrounding long-term use? Does a tolerance eventually build to low-dose LSD?

At the very least these promising results suggest further clinical trials are necessary as modern researchers slowly catch up with where the science was half a century ago.


--------------------


Edited by icetech (08/27/20 03:51 PM)


Post Extras: Print Post  Remind Me! Notify Moderator
Offlinesk8fast
Tripping skater
 User Gallery


Registered: 08/02/10
Posts: 352
Last seen: 11 days, 5 hours
Re: LSD for pain... new study. [Re: icetech]
    #26915762 - 09/03/20 04:12 PM (21 days, 11 hours ago)

One time i busted my elbow skating on lsd i fell on it twice hard and it was bleeding and swollen but i didn't feel any pain it was just completely numb to the touch, i thought forsure it was broken and i was gonna be in pain when I came down but i could move it fine with no pain when I came down. it was just a wound and the swelling had gone down, it wasnt broken and I didn't have any pain. I was pretty amazed at the absence of pain and that it was not broken, my friends that saw it who were not tripping thought it might have been broken from how much it swelled.

Edit: my dose was definitely not a microdose i was on 1 and a half tabs


Edited by sk8fast (09/03/20 04:15 PM)


Post Extras: Print Post  Remind Me! Notify Moderator
Offlineicetech
 User Gallery


Registered: 08/21/17
Posts: 3,304
Loc: FSM's loving noodles.
Last seen: 11 hours, 17 minutes
Re: LSD for pain... new study. [Re: sk8fast]
    #26915952 - 09/03/20 06:43 PM (21 days, 8 hours ago)

That's crazy.. and between bmx and skating way back.. i have some fucked up joints.. worth it.


--------------------


Post Extras: Print Post  Remind Me! Notify Moderator
Jump to top. Pages: 1

Kraken Kratom Shop: Red Vein Kratom

Feedback and Administration >> Shroomery News Service

Similar ThreadsPosterViewsRepliesLast post
* Father of LSD turns 100 veggie 4,029 19 12/06/08 05:36 PM
by Shr00mZ
* DEA Retraction of Pain FAQ Angers, Scares Doctors and Patients 12/3/04 motamanM 3,095 4 12/06/04 05:34 PM
by Asante
* American chemist found guilty of making LSD [UK] veggie 7,724 17 04/24/05 07:39 PM
by theocean06
* LSD faces an acid test as a pain killer veggie 2,411 7 02/18/06 06:13 PM
by Koala Koolio
* Internet developers and LSD IAmTheWalrus212 976 0 04/25/05 05:50 PM
by IAmTheWalrus212
* MindMed Announces First-Ever Clinical Trial Combining MDMA and LSD sonoramo 704 5 09/03/20 04:05 PM
by sk8fast
* 'Special K' for chronic pain veggie 1,383 4 03/09/16 11:16 PM
by delta9RSD
* Pot Laws Pain Some Elders veggie 1,655 2 07/02/05 05:25 AM
by veggie

Extra information
You cannot start new topics / You cannot reply to topics
HTML is disabled / BBCode is enabled
Moderator: motaman, karode13, Alan Rockefeller, naum, Mostly_Harmless
638 topic views. 1 members, 11 guests and 5 web crawlers are browsing this forum.
[ Print Topic ]
Search this thread:
Everything Mushrooms
Please support our sponsors.

Copyright 1997-2020 Mind Media. Some rights reserved.

Generated in 0.035 seconds spending 0.003 seconds on 13 queries.