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morrowasted
Worldwide Stepper


Registered: 10/30/09
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Loc: House of Mirrors
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Re: THEY are trying to give me diabetes [Re: gopher]
#26940193 - 09/17/20 06:35 AM (3 years, 4 months ago) |
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in terms of OTC stuff, N-Acetyl-L-Tyrosine (NALT)
pharmaceutical levodopa is used for parkinsons, it is a dopamine prodrug
I've tried NALT it though and personally it makes me feel shitty.
dopamine does a lot of things other than make you feel "reward". just increasing the amount of dopamine you have isn't a fantastic strategy for feeling reward. a better idea is to try to increase the number of dopamine receptors in the specific circuit involved in reward, or at least inhibit the reduction of those receptors through dopamine-stimulating drug use. NMDA antagonists like magnesium, agmatine sulfate, and ketamine appear to do this. I made a thread about it, lemme see if I can dig it up
Here it is
Quote:
Pathology of tolerance development to d1 receptor activation in the nucleus accumbens:
↑Extracellular Dopamine -> D1 receptor agonism -> NMDA receptor activation -> ↑ Intracellular Ca2+ ion -> ↑Intracellular cAMP -> PKA activation -> ↑pCREB (CREB phosphorylation) -> ↑ΔFosB accumulation -> HDAC1 overexpression -> c-Fos downregulation.

As you can see, induction of c-Fos is NMDAr-dependent. This is the rationale behind the use of NMDA receptor antagonists for the attenuation of D1-mediated psychostimulant tolerance.
commonly available NMDAr antagonists used for this purpose include magnesium l-threonate, agmatine, ketamine, and memantine. DXM, PCP, and alcohol also do this but they're not good choices.
Agmatine is my personal favorite of these. I don't use it to prevent tolerance, though. It makes me feel increasingly focused over time. also great for lifting weights
Amphetamine and Dopamine-Induced Immediate Early Gene Expression in Striatal Neurons Depends on Postsynaptic NMDA Receptors and Calcium
Of course, the best way to avoid developing a tolerance to a substance is not to use it.
Edited by morrowasted (09/17/20 07:09 AM)
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poofdargon
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Registered: 08/06/20
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Re: THEY are trying to give me diabetes [Re: morrowasted]
#26940243 - 09/17/20 07:38 AM (3 years, 4 months ago) |
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Quote:
morrowasted said:
Quote:
poofdargon said: I was referring to the multiple orgasms without losing your erection.
It is badass if youre actually having sex 
Not saying it gives you priapism where you literally cant get rid of your erection. It just makes it so that the erection doesnt immediately go away after you nut, and if you wanna keep fucking you can. And you can nut again. Continuing to have sex immediately after nutting is an interesting experience. It feels very different. The penis is so sensitive at that point its like you feel half an orgasm the entire time youre having sex. Then the actual orgasms get successively more intense
I would like to add that does not happen (in my case it’s like that for me but without any drug it’s just how my body is) as you say. Usually it’s the bad sort of sensitivity where you can’t be touched because it hurts. It’s definitely not half an orgasm the whole time and it’s very uncomfortable. While I could technically nut again it would not be pleasurable, and each orgasm I have after is less pleasurable. Hence why I say it’s a nightmare.
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morrowasted
Worldwide Stepper


Registered: 10/30/09
Posts: 31,377
Loc: House of Mirrors
Last seen: 4 days, 11 minutes
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Re: THEY are trying to give me diabetes [Re: poofdargon]
#26940249 - 09/17/20 07:40 AM (3 years, 4 months ago) |
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Sucks that that is your experience, it isn't mine at all
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The Blind Ass
Bodhi



Registered: 08/16/16
Posts: 26,657
Loc: The Primordial Mind
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Re: THEY are trying to give me diabetes [Re: morrowasted]
#26940257 - 09/17/20 07:44 AM (3 years, 4 months ago) |
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Dopey mean. Dopamine. Exercise always does the trick. Same for learning something difficult & new & then integrating it. Ex. New Language, new mathematics, & building something from scratch etc etc.
-------------------- Give me Liberty caps -or- give me Death caps
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poofdargon
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Re: THEY are trying to give me diabetes [Re: morrowasted]
#26940280 - 09/17/20 08:00 AM (3 years, 4 months ago) |
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Quote:
morrowasted said: Sucks that that is your experience, it isn't mine at all
I wouldn’t say it sucks. Sex felt more like a condition to manage than something to enjoy.
-------------------- You think yourself immune to madness? Are you certain it has yet to take hold? I'm gonna be the greatest music star in all of Riboflavin. -Grup
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gopher
Coffee Bean Extraordinaire



Registered: 11/22/17
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Loc: Canada
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Re: THEY are trying to give me diabetes [Re: poofdargon]
#26940295 - 09/17/20 08:13 AM (3 years, 4 months ago) |
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https://pubmed.ncbi.nlm.nih.gov/12820816/
Quote:
Atypical antipsychotic treatment may unmask or precipitate hyperglycemia. Although such cases attributed to clozapine or olanzapine are more numerous than those associated with risperidone, the number for risperidone-associated hyperglycemia is relatively higher than that observed with the conventional neuroleptic haloperidol.
-------------------- For most of the normies out there, an operating system is just a bootloader for Google Chrome. Since Disney has obtained tremendous value from the public domain, knows how important the public domain is, and is firmly determined to never contribute anything to it. My pronouns are He and Him, and my adjectives are Fat and Jazzy
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poofdargon
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Re: THEY are trying to give me diabetes [Re: gopher]
#26940367 - 09/17/20 09:10 AM (3 years, 4 months ago) |
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Not what we are getting at in the moment in time.
-------------------- You think yourself immune to madness? Are you certain it has yet to take hold? I'm gonna be the greatest music star in all of Riboflavin. -Grup
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