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Offlinesonoramo
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Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market
    #26874696 - 08/11/20 09:24 AM (3 years, 5 months ago)

Original story link

Sounds a lot like psilo-windowpane. Anyone know how to make this stuff at home? Film-strip tek?

Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market

Kaitlin Domangue
August 11, 2020

Revive Therapeutics is introducing dissolvable, oral psilocybin film-strips to their portfolio. The move comes by way of a sponsored research partnership agreement with the Reed Research Group out of the University of Wisconsin-Madison.

Psilocybin is a compound that is found in hallucinogenic mushrooms, sometimes called magic mushrooms. It has been used for thousands of years across many cultures. Australian cave paintings are said to have been created in 10,000 BCE and are said to suggest the culture’s use of psilocybin mushrooms. Other Spanish rock paintings indicate that prehistoric people used magic mushrooms (or at least knew of their existence) around 4,000 BCE.

Three controlled trials exploring the use of psilocybin mushrooms for mood and anxiety have suggested that using magic mushrooms (properly dosed) may reduce the symptoms of depression in anxiety relating to psychiatric distress associated with cancer. The study shows that participants experienced relief for at least six months after taking just one dose! “A small, open-label study in patients with treatment-resistant depression showed reductions in depression and anxiety symptoms 3 months after two acute doses. For addiction, small, open-label pilot studies have shown promising success rates for both tobacco and alcohol addiction.”

Revive Therapeutics has determined tannin-chitosan composite as the number one candidate for their strips. The film strips will undergo further testing before being made available, but they will have dosages that range from 1 mg to 20 mg. There’s a number of benefits to using dissolvable oral strips, including a faster time to the bloodstream and the ease of use for patients who may not be able to swallow (plus there is no need for water). This drug delivery technology aspires to produce both natural and synthetic extract of psilocybin in a number of ways, including topical gels, transdermal patches, and oral foams.

The CEO of Revive Therapeutics, Michael Frank, said “We are very pleased about the progress we have achieved to date and this technical milestone for our drug delivery technology specifically in the development of an orally dissolvable thin film strip for psilocybin, which will be used in future human clinical studies. This is the first time that we have applied our drug delivery technology to oral thin films and we see great promise in delivering psychedelic-based medicines to treat various diseases and disorders that would benefit from such a delivery method and in partnering with life sciences companies seeking to add unique offerings in their product pipeline.  We look forward to unveiling the final prototype in the coming weeks.”
Would you try to DIY psilo-windowpane?
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Invisibletyrannicalrex
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: sonoramo]
    #26875054 - 08/11/20 12:42 PM (3 years, 5 months ago)

Just use one of those gummy teks and make it really thin?


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Invisiblebreeg89
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: tyrannicalrex]
    #26875860 - 08/11/20 08:12 PM (3 years, 5 months ago)

It's good to see psilocybin getting so much traction. These types of alternative dosing formulations could be good to mitigate first-pass metabolism in the liver too.

For a home-brew, maybe take an ethanol or vinegar psilocybin extract and use it to make some thin gelatin strips like the dude above said.

psilocybin extraction: https://www.erowid.org/plants/mushrooms/mushrooms_journal1.shtml

Always remember, methanol is TOXIC and causes BLINDNESS and/or DEATH in small doses.


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OfflineFractal420
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: breeg89]
    #26876463 - 08/12/20 07:59 AM (3 years, 5 months ago)

I actually worry about pharma getting too firm a hold on psilo and then trying to crack down on DIY

I dunno if it’d be easy to make strips from natural mush without a lab. I do like the idea of pure psilocybin tho (not even psilocin - at least to start with)

I feel like psilocybin has more magical effects and psilocin is more intense


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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Invisibletyrannicalrex
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: Fractal420]
    #26876479 - 08/12/20 08:08 AM (3 years, 5 months ago)

https://psychedelicreview.com/psilocin-active-component-magic-mushrooms/

Psilocybin is inactive but rapidly converted in the body into psilocin.

PSILOCYBIN AND PSILOCIN ARE TWO DIFFERENT MOLECULES FOUND IN MAGIC MUSHROOMS.

Psilocybin is a Means for Ingesting Psilocin
Although psilocybin receives most of the credit for affecting mood and perception, psilocin is probably the molecule actually responsible for producing the psychoactive effects. Consider these facts:

Psilocin is psychoactive but not stable.2,3 It degrades quickly in the presence of air, heat, and/or light. This makes sense because the 4-hydroxy group on the tryptamine is susceptible to oxidation.
Psilocybin is not psychoactive. But, it is far more stable than silicon. Unlike psilocin (which has 4-hydroxy group on the tryptamine ring system), psilocybin has a phosphate ester in this position. That phosphate ester protects the molecule from degradation (e.g., oxidation), making psilocybin more stable than psilocin.
Psilocybin is easily converted into psilocin. When psilocybin is ingested (e.g., by eating mushrooms or mushroom preparations) it is rapidly converted into psilocin. The conversion of psilocybin into psilocin can occur under either acidic conditions and/or enzymatic dephosphorylation by alkaline phosphatase enzymes.
Overall, the most reasonable theory is that a person ingests psilocybin (e.g., by eating mushrooms containing psilocybin) as a means of administering psilocin. In other words, a person takes psilocybin, which is converted into psilocin, which produces the observed psychoactive effects.

Psilocin is Different From Psilocybin
Practically speaking, taking psilocybin provides a means for administering a psilocin equivalent. A user takes one molecule of psilocybin and (after some metabolism and chemistry) receives one molecule of psilocin, which provides the majority of the psychoactive effects.

However, although psilocybin can be viewed as a psilocin equivalent, the two are not exactly the same. To be clear, they are different molecules. Accordingly, the effects of administering psilocybin will not be exactly the same as administering psilocin.


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Offlinerider420
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: sonoramo]
    #26876510 - 08/12/20 08:43 AM (3 years, 5 months ago)

  Wow a sugar coated pill! For a drug that will destroy your sugar coated illusions. This is the irony you get from people designing and selling drugs they have never used themselves.

  Psilocybin should never be given to anyone who can't drink or swallow, it should only be used when the patient is at their healthiest or in remission.  The morons who are making strips don't have a clue as to how the drug works or what it does instead they are treating it like most pain relieving medicines that need to act right away and at any time.

  I hope doctors aren't moronic enough to follow the advise of pharmaceutical companies, sometimes I make myself laugh. :myfaceismelting:


  BTW if you think highly processed drugs are a good ideal then you must then think that fentanyl, heroine or morphine is less harmful then smoking opium. Or does the reality of life sometimes seep in?


Edited by rider420 (08/12/20 08:50 AM)


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OfflineRapjack
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: rider420]
    #26876549 - 08/12/20 09:25 AM (3 years, 5 months ago)

Quote:

rider420 said:
  Psilocybin should never be given to anyone who can't drink or swallow, it should only be used when the patient is at their healthiest or in remission. 




Hospice / end of life care is a great use for psilocybin strips. A trip can, as you say "destroy sugar coated illusions" in terminal patients with dying bodies but sound minds and make them at peace with dying. The last months or years of someone's life is vastly improved and they can be in the present with their loved ones.

I'm surprised how quickly they came out with this, it seems only a few months ago that the article announcing the research was posted. Maybe they had it mostly figured out by then.


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Offlinerider420
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: Rapjack]
    #26876796 - 08/12/20 12:14 PM (3 years, 5 months ago)

Quote:

Rapjack said:
Quote:

rider420 said:
  Psilocybin should never be given to anyone who can't drink or swallow, it should only be used when the patient is at their healthiest or in remission. 




Hospice / end of life care is a great use for psilocybin strips. A trip can, as you say "destroy sugar coated illusions" in terminal patients with dying bodies but sound minds and make them at peace with dying. The last months or years of someone's life is vastly improved and they can be in the present with their loved ones.

I'm surprised how quickly they came out with this, it seems only a few months ago that the article announcing the research was posted. Maybe they had it mostly figured out by then.




If a person can't take a pill the best method is by intravenous injection:
Injecting psilocybin liquid rectally by means of an enema is second only to intravenous injection for having the drug reach the brain quickly. This area of the body has a significant surface area for absorption. This method reduces nausea and vomiting associated with eating mushrooms.


"This drug delivery technology aspires to produce both natural and synthetic extract of psilocybin in a number of ways, including topical gels, transdermal patches, and oral foams."


FYI: Cannabis is a great drug no one has ever died from its use! Hundreds of people have died from synthetic THC.


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OfflineO_Dweeds
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: Rapjack]
    #26876801 - 08/12/20 12:17 PM (3 years, 5 months ago)

Anyone who has used mushrooms to help with stopping opiates knows this is a miracle medicine. Seeing it's already being made into film form looks as it's right around the corner to being used in a medical detox setting.


--------------------
Oxygen. Water. Neil Young

Our word "planet" comes from the Greek word planetes, meaning "wanderer."

"There ain't no revolution, only evolution, but every time I'm in Georgia I eat a peach for peace."
Gregg Allman


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OfflineO_Dweeds
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: rider420]
    #26876807 - 08/12/20 12:23 PM (3 years, 5 months ago)

Quote:

rider420 said:
Quote:

Rapjack said:
Quote:

rider420 said:
  Psilocybin should never be given to anyone who can't drink or swallow, it should only be used when the patient is at their healthiest or in remission. 




Hospice / end of life care is a great use for psilocybin strips. A trip can, as you say "destroy sugar coated illusions" in terminal patients with dying bodies but sound minds and make them at peace with dying. The last months or years of someone's life is vastly improved and they can be in the present with their loved ones.

I'm surprised how quickly they came out with this, it seems only a few months ago that the article announcing the research was posted. Maybe they had it mostly figured out by then.




If a person can't take a pill the best method is by intravenous injection:
Injecting psilocybin liquid rectally by means of an enema is second only to intravenous injection for having the drug reach the brain quickly. This area of the body has a significant surface area for absorption. This method reduces nausea and vomiting associated with eating mushrooms.


"This drug delivery technology aspires to produce both natural and synthetic extract of psilocybin in a number of ways, including topical gels, transdermal patches, and oral foams."


FYI: Cannabis is a great drug no one has ever died from its use! Hundreds of people have died from synthetic THC.




Completely agree, after seeing how horrific "synthetic-thc" can be any synthetic should be completely understood before giving out to other people as if it was the organic molecule.
It's a shame JWH is even compared to naturally occurring THC, definitely slowed down many people who are still realizing the endless benefits of cannabis.


--------------------
Oxygen. Water. Neil Young

Our word "planet" comes from the Greek word planetes, meaning "wanderer."

"There ain't no revolution, only evolution, but every time I'm in Georgia I eat a peach for peace."
Gregg Allman


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Offlinesuperreggie
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: O_Dweeds]
    #26876844 - 08/12/20 12:45 PM (3 years, 5 months ago)

Whenever I hear about things like  'ancient' cave paintings about 10,000 years ago and prehistorical peoples 4000 years ago... I just can't help but think how incredibly recent that is. And the fact that there's evidence of mushroom use associated with that art is just a super obvious sign of the fact that, I don't know... maybe this whole explosion of tool making that allows me 4000 years later to communicate this concept to you tapping letters on a keyboard and publishing them on the internet miiiight just be somehow connected to the mushroom use.


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OfflineO_Dweeds
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: superreggie]
    #26877594 - 08/12/20 09:30 PM (3 years, 5 months ago)

Quote:

superreggie said:
Whenever I hear about things like  'ancient' cave paintings about 10,000 years ago and prehistorical peoples 4000 years ago... I just can't help but think how incredibly recent that is. And the fact that there's evidence of mushroom use associated with that art is just a super obvious sign of the fact that, I don't know... maybe this whole explosion of tool making that allows me 4000 years later to communicate this concept to you tapping letters on a keyboard and publishing them on the internet miiiight just be somehow connected to the mushroom use.





The internet "network" is a copy of the mycellium network connected to all plant life allowing everything to be in constant communication with each-other. We all are energy and we all produce & contain DMT, allowing us to be in constant communication/connection, showing we all come from the same place, and eventually we all return to the same place. ALL ONE.


--------------------
Oxygen. Water. Neil Young

Our word "planet" comes from the Greek word planetes, meaning "wanderer."

"There ain't no revolution, only evolution, but every time I'm in Georgia I eat a peach for peace."
Gregg Allman


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OfflineFractal420
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Re: Revive Therapeutics First to Bring Oral Psilocybin Strips to the Market [Re: O_Dweeds]
    #26884322 - 08/17/20 06:15 AM (3 years, 5 months ago)

Quote:

Completely agree, after seeing how horrific "synthetic-thc" can be any synthetic should be completely understood before giving out to other people as if it was the organic molecule.
It's a shame JWH is even compared to naturally occurring THC, definitely slowed down many people who are still realizing the endless benefits of cannabis




Luckily, synthetic psilo and it’s (Many) analogs have been explored since TIHKAL and they’re much, much safer than the full agonist synthetic cannabinoids (which isn’t even correct - they’re cannabamimetics). ALSO these pure tryptamines can show you what psilocin is like and you can compare it to a mushroom trip, and I’d say it’s actually a lot more magical when there’s a prodrug (either psilocybin or 4aco) compared to just psilocin by itself. I’m not sure why. I find psilocin by itself pretty intense and def body-oriented. A lot more geometry and a calmer, more enjoyable experience for me with either mushroom tea or 4aco vs just psilocin


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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