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HamHead
Hard Ass Motherfucker
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Re: Hydroxychloroquine sulfate [Re: HamHead] 1
#26857897 - 08/01/20 09:49 PM (3 years, 7 months ago) |
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-------------------- The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February. https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF This online first version has been peer-reviewed, accepted and edited, but not formatted and finalized with corrections from authors and proofreaders https://www.icandecide.org/
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ONE OZ SLUG
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Posts: 17,839
Loc: TX
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Re: Hydroxychloroquine sulfate [Re: HamHead] 3
#26857920 - 08/01/20 10:02 PM (3 years, 7 months ago) |
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Not really sure what you're trying to prove by posting these articles nobody (including yourself) will read. The only you even give a shit about HCQ is because your daddy Trump said it might be a cure. In spite of the articles touting its benefits, it would seem the very doctors and other qualified personnel have been reporting the exact opposite. I'm going to listen to the people who actually work in this field, not some halfassed journalist. If there's anything I've learned from this thread, is that google is not your friend.
Edited by ONE OZ SLUG (08/01/20 11:06 PM)
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Ice9
3X Ban Lotto Champion
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Re: Hydroxychloroquine sulfate [Re: ONE OZ SLUG] 1
#26857959 - 08/01/20 10:27 PM (3 years, 7 months ago) |
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I'll leave this and ask a simple question:
article
Question: Do you understand the difference between a journal impact score, the allegations of pay for publication out other major publishers (Elsevier) and how trust worthy information is? Quick follow up (I know that's 2 questions) What's the difference between a double blind placebo controlled study and an epidemiological study?
I have I guess, unless you google, you have no idea.
-------------------- The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable man. -- George Brenard Shaw
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HamHead
Hard Ass Motherfucker
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Posts: 6,107
Loc: Galactic sector ZZ9 Plura...
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Re: Hydroxychloroquine sulfate [Re: Ice9] 1
#26858018 - 08/01/20 11:33 PM (3 years, 7 months ago) |
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Quote:
Ice9 said: I'll leave this and ask a simple question:
article
Question: Do you understand the difference between a journal impact score, the allegations of pay for publication out other major publishers (Elsevier) and how trust worthy information is? Quick follow up (I know that's 2 questions) What's the difference between a double blind placebo controlled study and an epidemiological study?
I have I guess, unless you google, you have no idea.
https://www.nejm.org/doi/full/10.1056/NEJMoa2016638
"METHODS We conducted a randomized (comes into question), double-blind, placebo-controlled trial across the United States and parts of Canada testing hydroxychloroquine as postexposure prophylaxis. We enrolled adults who had household or occupational exposure to someone with confirmed Covid-19 at a distance of less than 6 ft for more than 10 minutes while wearing neither a face mask nor an eye shield (high-risk exposure) or while wearing a face mask but no eye shield (moderate-risk exposure). Within 4 days after exposure, we randomly assigned participants to receive either placebo or hydroxychloroquine (800 mg once, followed by 600 mg in 6 to 8 hours, then 600 mg daily for 4 additional days). The primary outcome was the incidence of either laboratory-confirmed Covid-19 or illness compatible with Covid-19 within 14 days."
First, dosage. 800mg+600mg=1,400mg Within 24hours or less, which is a little too much even when treating a malaria infection. Then, 600mg for 4 additional days equals 2,400mg. Yay, I maths, see! 2,400mg+1,400mg=3,800mg
Weight Based Dosage In Adults And Pediatric Patients
13 mg/kg (10 mg/kg base), not to exceed 800 mg (620 mg base) followed by 6.5 mg/kg (5 mg/kg base), not to exceed 400 mg (310 mg base), at 6 hours, 24 hours and 48 hours after the initial dose.
And to treat malaria, 800mg+400mg=1,200mg. Then, it says 400mg at 24 and 48 hours, which is an additional 800mg. So, 800mg+400mg@6h+400mg@24hr+400mg@48h=2,000mg.
It's no wonder people are having problems with dosages used. IMO, it's too much when only 200mg once per day for 5 days on Zelenko protocol, which includes zinc, something this trial leaves out which has been proven be a vital key when using a zinc ionophore such as HCQ.
SETTING Recruitment was performed primarily with the use of social media outreach as well as traditional media platforms. Participants were enrolled nationwide in the United States and in the Canadian provinces of Quebec, Manitoba, and Alberta. Participants enrolled themselves through a secure Internet-based survey using the Research Electronic Data Capture (REDCap) system.
Not randomized.
These trials leave out zinc. Do they not understand zinc ionophore?
-------------------- The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February. https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF This online first version has been peer-reviewed, accepted and edited, but not formatted and finalized with corrections from authors and proofreaders https://www.icandecide.org/
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HamHead
Hard Ass Motherfucker
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Posts: 6,107
Loc: Galactic sector ZZ9 Plura...
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Re: Hydroxychloroquine sulfate [Re: HamHead] 1
#26866965 - 08/06/20 06:01 PM (3 years, 7 months ago) |
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Oh, here's a gem, for those smart enough to understand what's happening.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350140/
"Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery
Abstract Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DENV) is a global public health problem, and we lack an antiviral drug for DENV. Here, we evaluated the anti-DENV potential of treatment with HCQ. Immunofluorescence assays demonstrated that HCQ could inhibit DENV serotype 1–4 infection in vitro. RT-qPCR analysis of HCQ-treated cells showed induced expression of interferon (IFN)-related antiviral proteins and certain inflammatory cytokines. Mechanistic study suggested that HCQ activated the innate immune signaling pathways of IFN-β, AP-1, and NFκB. Knocking down mitochondrial antiviral signaling protein (MAVS), inhibiting TANK binding kinase 1 (TBK1)/inhibitor-κB kinase ɛ (IKKɛ), and blocking type I IFN receptor reduced the efficiency of HCQ against DENV-2 infection. Furthermore, HCQ significantly induced cellular production of reactive oxygen species (ROS), which was involved in the host defense system. Suppression of ROS production attenuated the innate immune activation and anti-DENV-2 effect of HCQ. In summary, HCQ triggers the host defense machinery by inducing ROS- and MAVS-mediated innate immune activation against DENV infection and may be a candidate drug for DENV infection."
Oh, jeez, it's so abstract, don't get lost.
What's up?
Want me to pull up some shit about Dengue vaccines used in hundreds of thousands of children?
And people have the nerve to come at me about empathy.
Fauci has no empathy.
Gates has no empathy.
-------------------- The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February. https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF This online first version has been peer-reviewed, accepted and edited, but not formatted and finalized with corrections from authors and proofreaders https://www.icandecide.org/
Edited by HamHead (08/06/20 06:02 PM)
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The Blind Ass
Bodhi
Registered: 08/16/16
Posts: 27,364
Loc: The Primordial Mind
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Re: Hydroxychloroquine sulfate [Re: HamHead]
#26866973 - 08/06/20 06:06 PM (3 years, 7 months ago) |
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You should go back and Major in bio w/ a track that emphasizes biomed and or research. Then you can rise through the ranks and take over the CDC p and save the world from the evil mask pandemic and then you’ll be able to tell everyone I told you so and stuff...
You’re already heavily invested, may as well go all the way baby!
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HamHead
Hard Ass Motherfucker
Registered: 03/17/15
Posts: 6,107
Loc: Galactic sector ZZ9 Plura...
Last seen: 2 years, 10 months
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Go back?
As if I went to begin with?
Pfft.
I worked. I learned skills.
It's only been these past 4 months or so that I've been in this rabbit hole.
Ass with the rest of you.
How many paths have you gone down?
-------------------- The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February. https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF This online first version has been peer-reviewed, accepted and edited, but not formatted and finalized with corrections from authors and proofreaders https://www.icandecide.org/
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morrowasted
Worldwide Stepper
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Re: Hydroxychloroquine sulfate [Re: HamHead]
#26867119 - 08/06/20 07:31 PM (3 years, 7 months ago) |
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Speak for yourself, Ive been treating, much less learning about, viral pneumonias for longer than 4 months
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ONE OZ SLUG
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Registered: 05/22/13
Posts: 17,839
Loc: TX
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Re: Hydroxychloroquine sulfate [Re: HamHead]
#26867423 - 08/06/20 09:55 PM (3 years, 7 months ago) |
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You just don't stop, do you?
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HamHead
Hard Ass Motherfucker
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Posts: 6,107
Loc: Galactic sector ZZ9 Plura...
Last seen: 2 years, 10 months
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Re: Hydroxychloroquine sulfate [Re: ONE OZ SLUG] 1
#26867426 - 08/06/20 09:57 PM (3 years, 7 months ago) |
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Quote:
morrowasted said: Speak for yourself, Ive been treating, much less learning about, viral pneumonias for longer than 4 months
Stand corrected. You have been assisting doctors who are treating patients. You have no say in their treatments.
I know it hurts.
You'll be OK.
Quote:
ONE OZ SLUG said: You just don't stop, do you?
No.
Not until evidence can no longer be ignored.
-------------------- The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February. https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF This online first version has been peer-reviewed, accepted and edited, but not formatted and finalized with corrections from authors and proofreaders https://www.icandecide.org/
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ONE OZ SLUG
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Registered: 05/22/13
Posts: 17,839
Loc: TX
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Re: Hydroxychloroquine sulfate [Re: HamHead]
#26867428 - 08/06/20 09:59 PM (3 years, 7 months ago) |
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I'm more of a results guy, but you do you
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HamHead
Hard Ass Motherfucker
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Posts: 6,107
Loc: Galactic sector ZZ9 Plura...
Last seen: 2 years, 10 months
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Re: Hydroxychloroquine sulfate [Re: ONE OZ SLUG] 1
#26867446 - 08/06/20 10:22 PM (3 years, 7 months ago) |
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Quote:
ONE OZ SLUG said: I'm more of a results guy, but you do you
Same.
Quick to see, like those lethal HCQ doses given to critically ill patients.
-------------------- The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February. https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF This online first version has been peer-reviewed, accepted and edited, but not formatted and finalized with corrections from authors and proofreaders https://www.icandecide.org/
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morrowasted
Worldwide Stepper
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Re: Hydroxychloroquine sulfate [Re: HamHead] 1
#26867489 - 08/06/20 11:02 PM (3 years, 7 months ago) |
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Quote:
Stand corrected. You have been assisting doctors who are treating patients. You have no say in their treatments.
Nope. Nurses treat patients.
Literally just google nurses treat patients (we all know you're capable of using google). It is standard nomenclature. In the environment I work in, doctors actually do very little other than prescribe drugs, intubate patients, and insert central venous catheters.
By the way, you don't even assist doctors. You sit at home all day trying to pick arguments about a drug you almost certainly had never even heard of before it become a partisan talking point. The utter void of meaning that characterizes your existence would pitiable, if only you didn't go so far out of your way to be so insufferably annoying to people who actually contribute something valuable to the world.
You don't even know where the nursing scope of practice is defined (yeah, go ahead and google it and try to pretend that you do), much less what is actually includes.
Edited by morrowasted (08/06/20 11:12 PM)
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The Blind Ass
Bodhi
Registered: 08/16/16
Posts: 27,364
Loc: The Primordial Mind
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Re: Hydroxychloroquine sulfate [Re: morrowasted] 1
#26867497 - 08/06/20 11:09 PM (3 years, 7 months ago) |
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HamHead speaks of what he does not know as if he knows it. I imagine I’d have a hard time trusting him if he had to properly administer meds, intubate, or hook up a central venous catheter - just to name a few things...
-------------------- Give me Liberty caps -or- give me Death caps
Edited by The Blind Ass (08/06/20 11:17 PM)
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morrowasted
Worldwide Stepper
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Posts: 31,400
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Quote:
The Blind Ass said: HamHead speaks of what he does not know as if he knows it. I imagine I’d have a hard time trusting him if he had to administer meds, intubate, or hook up a mainline.
I would pay good money to watch this guy attempt to pass even prereqs for nursing school.
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Ice9
3X Ban Lotto Champion
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Re: Hydroxychloroquine sulfate [Re: morrowasted] 1
#26869675 - 08/08/20 08:28 AM (3 years, 7 months ago) |
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Quote:
morrowasted said:
Quote:
The Blind Ass said: HamHead speaks of what he does not know as if he knows it. I imagine I’d have a hard time trusting him if he had to administer meds, intubate, or hook up a mainline.
I would pay good money to watch this guy attempt to pass even prereqs for nursing school.
Does he even have a high school diploma? The whole randomized bit in the study I linked about recruiting through facebook. The doctors did not select patients, i.e. randomized. When you perform a randomized trial you put out an advert seeking patients in the listed range, and take who shows up. You do no not abduct people of the street, conduct studies on patients currently in hospital without written consent (self-selection).
I do hope HamHead achieves his dream of a three way bath in HCQ now with zinc with Donald Trump and Alex Jones. It would be a beautiful moment.
-------------------- The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable man. -- George Brenard Shaw
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koods
Ribbit
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Re: Hydroxychloroquine sulfate [Re: HamHead]
#26869851 - 08/08/20 10:31 AM (3 years, 7 months ago) |
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Quote:
HamHead said: Oh, here's a gem, for those smart enough to understand what's happening.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350140/
"Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery
Abstract Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DENV) is a global public health problem, and we lack an antiviral drug for DENV. Here, we evaluated the anti-DENV potential of treatment with HCQ. Immunofluorescence assays demonstrated that HCQ could inhibit DENV serotype 1–4 infection in vitro. RT-qPCR analysis of HCQ-treated cells showed induced expression of interferon (IFN)-related antiviral proteins and certain inflammatory cytokines. Mechanistic study suggested that HCQ activated the innate immune signaling pathways of IFN-β, AP-1, and NFκB. Knocking down mitochondrial antiviral signaling protein (MAVS), inhibiting TANK binding kinase 1 (TBK1)/inhibitor-κB kinase ɛ (IKKɛ), and blocking type I IFN receptor reduced the efficiency of HCQ against DENV-2 infection. Furthermore, HCQ significantly induced cellular production of reactive oxygen species (ROS), which was involved in the host defense system. Suppression of ROS production attenuated the innate immune activation and anti-DENV-2 effect of HCQ. In summary, HCQ triggers the host defense machinery by inducing ROS- and MAVS-mediated innate immune activation against DENV infection and may be a candidate drug for DENV infection."
Oh, jeez, it's so abstract, don't get lost.
What's up?
Want me to pull up some shit about Dengue vaccines used in hundreds of thousands of children?
And people have the nerve to come at me about empathy.
Fauci has no empathy.
Gates has no empathy.
I asked this before: Do you have any research where they actually studied if HCQ has any benefit treating dengue?
--------------------
NotSheekle said “if I believed she was 16 I would become unattracted to her”
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Ice9
3X Ban Lotto Champion
Registered: 03/20/14
Posts: 11,672
Loc: daterapeville,USA
Last seen: 5 hours, 9 minutes
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Re: Hydroxychloroquine sulfate [Re: HamHead] 1
#26869985 - 08/08/20 12:09 PM (3 years, 7 months ago) |
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Quote:
HamHead said: Oh, here's a gem, for those smart enough to understand what's happening.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350140/
"Hydroxychloroquine-Inhibited Dengue Virus Is Associated with Host Defense Machinery
Abstract Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implications remain controversial. Infection with dengue virus (DENV) is a global public health problem, and we lack an antiviral drug for DENV. Here, we evaluated the anti-DENV potential of treatment with HCQ. Immunofluorescence assays demonstrated that HCQ could inhibit DENV serotype 1–4 infection in vitro. RT-qPCR analysis of HCQ-treated cells showed induced expression of interferon (IFN)-related antiviral proteins and certain inflammatory cytokines. Mechanistic study suggested that HCQ activated the innate immune signaling pathways of IFN-β, AP-1, and NFκB. Knocking down mitochondrial antiviral signaling protein (MAVS), inhibiting TANK binding kinase 1 (TBK1)/inhibitor-κB kinase ɛ (IKKɛ), and blocking type I IFN receptor reduced the efficiency of HCQ against DENV-2 infection. Furthermore, HCQ significantly induced cellular production of reactive oxygen species (ROS), which was involved in the host defense system. Suppression of ROS production attenuated the innate immune activation and anti-DENV-2 effect of HCQ. In summary, HCQ triggers the host defense machinery by inducing ROS- and MAVS-mediated innate immune activation against DENV infection and may be a candidate drug for DENV infection."
Oh, jeez, it's so abstract, don't get lost.
What's up?
Want me to pull up some shit about Dengue vaccines used in hundreds of thousands of children?
And people have the nerve to come at me about empathy.
Fauci has no empathy.
Gates has no empathy.
Direct from your article, it's a header in fact
HCQ inhibits DENV infection in vitro.
I know latin is hard, but any researcher will tell you in vitro studies do not have a high rate of success when moved to in vivo. Keep posting irrelevant studies. If that one worked HCQ would be a front-line treatment for DENV since it was performed in 2015. It did not because the results did not translate to animal models most likely.
Please keep trying and not understanding how science works. Remember the Dunning-Kruger graph I posted for you, remember where you stand on that graph.
-------------------- The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable man. -- George Brenard Shaw
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mndfreeze
Shroomery Secret Service
Registered: 04/22/02
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Re: Hydroxychloroquine sulfate [Re: Ice9] 4
#26870050 - 08/08/20 12:44 PM (3 years, 7 months ago) |
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Hamhead is currently on vacation from the pub. Be totally ok if you guys just let these fall off into oblivion and moved on.
-------------------- Nothing says love like grannies prolapsed anus! quote]Urb said: I know... Its fucked up... Ill fix it minyana..[/quote]
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ONE OZ SLUG
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Registered: 05/22/13
Posts: 17,839
Loc: TX
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Re: Hydroxychloroquine sulfate [Re: mndfreeze] 1
#26870164 - 08/08/20 02:15 PM (3 years, 7 months ago) |
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