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Offlinetregar
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At-home conversion of LSD to 1-acetaldehyde LSD in 1 step (similar to but beyond even ALD-52) like upgraded version of LSD * 2
    #26856505 - 08/01/20 12:33 AM (3 years, 5 months ago)

THH or Tetrahydroharmine + 1-acetaldehyde LSD (similar to ALD-52) combo, like high dose mescaline:

10.19.2021 update:

https://www.shroomery.org/forums/showflat.php/Number/27506721

I've moved on from the 300mg oral THH + sublingual HPBCD DMT, onto a 100% oral alternative, no re-dosing necessary every 1.5 hour like with the HPBCD DMT:

I'm not going to totally abandon the sublingual HPBCD DMT, it can still be taken as a 3rd drug under the tongue to add to the already super potent combo below. 2 to 3 alkaloids are of course more potent than one.

In closing, I'm going to post what I believe to be a revolutionary psychedelic combination, and it's dirt cheap compared to the rare and very expensive cactus...but it's just as long-lasting, profound, highly euphoric, visual, neon-colorful, music-enhancing & super deep head space, with zero-anxiety as two feet of fat bridgesii.

300mg THH + 250ug 1-acetaldehyde LSD report (2oz fresh cold sherry wine morning glory extract can substitute as well :heart:, see post #78 with pics on page 4 )
https://mycotopia.net/topic/110273-new-research-morning-glory-contains-5-stimulating-lsd-like-drugs-soluble-only-in-winealcohol-only-sparingly-soluble-in-water/page-4

1) The combo of 300mg THH + 1-acetaldehyde LSD makes the beauty & aesthetic enhancement way stronger than LSD alone. Same "over the top" beauty enhancement as high dose cactus tea.

2) The music sounds much better than LSD alone, it feels very much like when you combine mescaline with LSD, as THH is like the beta-carboline version of mescaline.

3) The combo is highly visual & neon-colorful with open eyes, with each of the 3 trips spaced two weeks apart experienced so far have seen neon-red-greens, neon-orange-blues, and even neon-purple-yellows, supercolorful just like high-dose cactus tea.

3) Very beautiful combination. :heart: :heart: :heart:

4) This 300mg THH + 250ug 1-acetaldehyde LSD combo is my absolute favorite, have since used it every 2 weeks x 3 times now...prefer it over everything else. No re-doses necessary as the THH has a 10.5 hour half life with peak at 5.25 hours. Very powerful: Lasts all evening, infinitely beautiful. I've consistently reached +5 Shulgin level strength every time, very life changing experience every time. Super deep head space, Divine to the extreme, heavenly mescaline-like spiritual euphoria for hours on end, no words to describe.


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Skip to 3rd page, post #26879016 for how to make this real fast, with 13 comments by me describing how this is vastly different from LSD, like an upgraded version of LSD. 
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To test the 1992 adducts study: LSD blotters can theoretically be converted at home into 1-acetaldehyde LSD or basically equivalent to what ALD-52 is in one step, see sample super highly visual & aesthetic reports in notes (16) and (17):

Dissolve LSD blotter(s) in 1 shot of cold sherry wine (contains 10mg acetaldehyde) with 5 drops of peppermint extract (contains 2 mg water soluble acetaldehyde & isovaleraldehyde & their corresponding acids) for 3 hours in fridge, with swirling once per hour. Researchers achieved 100% new adduct product in 1.5 hour. The sherry is already at ph=4, so no acidic solution needs to be made, like study calls for. They used a stir mantle in fridge, so recommend 3 hours sitting in fridge if not stirring, just hand swirl once an hour.

ALD-52 is know to be even more visual, conceptual & aesthetic compared to the more analytical and less aesthetic LSD, also more forgiving and relaxing mentally compared to LSD which produced brain waves associated with intense concentration & anxiety, reports from Sandoz labs.

Why is ALD-52 possibly more aesthetic than LSD? The adrenal receptors are hit heavily by natural entheogens like mescaline, Ayahuasca with caapi, shrooms, and are believed by some to be responsible for alot of the "aesthetics/euphoria/appreciation of beauty" feeling activity that is experienced while tripping. It is quite possible that ALD-52 agonizes all 3 of the adrenal receptors A2A, A2B, and A2C.

Mescaline for example binds to A2C with "off the chart" rating of 4.00 (max). Anyone who has ever dreamed cactus knows the appreciation for beauty is "thru the roof". See chart below.

LSD only agonizes adrenal A2A (as far as adrenal receptors, see chart below).

See last post #15 of "Potent LSH & penniclavine fresh from morning glory vine & relation to ancient Greece"

https://www.shroomery.org/forums/showflat.php/Number/26838327

The Aztecs and Mayans were known to add the extract from morning glory seeds (same exact alkaloid profile as the Greek claviceps paspali) to a drink containing alcohol (note 2). We know that sherry wine contains average 10mg acetaldehyde per 30ml or shot glass. The Aztecs and Mayans apparently knew about the acetaldehyde adducting properties of wine and alcohol, which as shown in the 1992 adducts study (note 6) will cause acetaldehyde to adduct onto the bottom NH group on the indole of LSH and penniclavine forming something more akin to looking like ALD-52, (at least bottom indole wise).

The table from Sandoz suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD produced brain waves showing a more relaxed mental state. Sample ALD-52 trip reports given in (note 16) and (note 17).

LSA (C16 H17 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSA
LSH (C18 H21 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSH
LSD (C20 H25 N3 O) + acetal (C2 H3 O) at bottom indole NH group = 1-acetal LSD (C22 H27 N3 O2) or ALD-52

2016 Polish morning glory study found 3x higher amounts of LSH in MG seeds direct from grower/producer vs retail (note 7):
Quote:

fresh black seeds from vine: likely 5.00 LSH to 5.00 penniclavine ratio
seeds direct from growers: 1.71 LSH to 5.08 penniclavine ratio
seeds off retail racks: 0.54 LSH to 4.75 penniclavine ratio



Vacuum pack and freeze the fresh picked dark hard black seeds right away to preserve their high potency indefinitely.

Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37).

Note (6) 1992 adducts study: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ Page 8441 "Reaction of Indole with Acetaldehyde: A 0.2% solution of indole in equal amounts of water, ethanol, and acetaldehyde formed a product with 60% yield after 1 hour of reaction at ambient temperature. Omitting the ethanol (50% acetaldehyde in water mixture) had no effect. Decreasing the concentration of acetaldehyde to 0.1% increased the reaction rate and percent yield of product." See pic of the researchers's indole + acetaldehyde adduct product formed at bottom of this post ---> ie before (page 8439) and after (page 8441).

The researchers achieved a new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution."

Note (15) Breakdown of water soluble acetaldehyde & isovaleraldehyde (and their corresponding acids) in peppermint extract: 1mg standard is equivalent to .001ml, 5 drops used in recipe = .25ml, .25ml = 250mg identified compounds, alcohol percent of peppermint extract = 91% alcohol so then 250mg x 0.9% = 23mg leftover of compounds, assuming 9% of this is the acetaldehyde/isovaleraldehyde & their corresponding acids, [see paper "Chemical Composition and Biological Activities of Mentha Species by Brahmi"] then approximately 2mg exists in 5 drops.

Note (16) Sample ALD-52 trip report #1:

"Had the chance in dreams to try ALD-52 around 10 years ago twice, and the blotter had diagrams of the ALD-52 molecule on the back of the blotter, and both times found the 300ug trips experienced in dreams to be PROFOUNDLY VISUAL, remember looking at a living woman's face and seeing it covered & overlayed with colored hieroglyphic symbols. The trip was very strong visually and yet found it relaxed and potently humorous, laughed for at least an hour watching episodes of "Funny or die" at the time.

Also remember seeing a group of Indian Shaman's sitting in a circle floating in mid-air when I walked into the bedroom, potent visuals...miss ALD-52, but the recipe above will transform the morning glory seed's LSH and LSA into similar molecules at least at the bottom indole NH group, which helps significantly in achieving a visually strong trip, sounds are amplified and music heavenly, strong audio heightening qualities, euphoric & stimulating yet relaxed journeys.

Anything longer than around the length of an acetaldehyde molecule (C2 H4 O) attached at the NH indole of the ergoline LSD molecule (especially 1-p-LSD, propionyl = C3 H5 O) may not fit properly into the very specific receptor binding site (as ALD-52 fits, acetyl = C2 H3 O), so cinnamaledehyde (C9 H8 O) and similar very long structures may not have a chance of docking into the receptor site properly."

Note (17) Sample ALD-52 trip report #2:

hxxps://www.reddit.com/r/LSD/comments/4yn8ou/highly_underestimated_ald52/

"Yes, I realize it's not technically LSD but really, it might as well be. I took 300ug thinking it would be mild if anything. Granted it wasn't as intense mentally as LSD can sometimes be, but conceptually and aesthetically it is beautiful beyond anything I ever anticipated. I feel perfect. At one. Better than I've felt in so long. I thought I could never trip again on anything but this is honestly paradigm changing for me. ALD-52 should be considered just as powerful as LSD-25 although it's a lot more relaxed and somewhat forgiving. As it is probably apparent I'm still very deep into this experience and I hope this to be an open discussion to anyone who would like to be involved.

My god, I just went through multiple ego death experiences beyond anything I've ever experienced from LSD before. There are no words. I mean there are plenty of "words" but none of them mean a single thing compared to any of THAT. Dear GOD. I never expected anything like this, but I sure as hell needed it. Even if I'm the only one here to express it to, as that's realistically the truth of nature anyhow. However, anyone who felt compelled to actually read through all this insanity, I just want you to know you're beautiful and you are everything. All things are right and they always will be.

Anyway, as far as the ALD-52, I took 300ug as I said. It was amazing and stronger than I expected, however I don't think 100ug would be very eventful to be perfectly honest. If you're concerned about it being too strong 200 might be worth it but 300 was really a great amount if you ask me. Even if you haven't taken any lysergamides before ALD-52 is rather calm compared to LSD or even mushrooms for the most part. Visually though, at least for me, it was absolutely breathtaking. Colors and textures were shifting like crazy.

Everything was alive and magical. Patterns were forming everywhere. I could lose myself so easily as the visuals seemed to drag my focus in without any effort. As a result, ego death was basically automatic and I reached that point multiple times. The first time I ever experienced ego death on LSD it left me with this beautiful feeling, like a deep inner glow that lasted for months afterwards. It eventually faded and I hadn't felt anything quite like it in years, but ALD-52 brought it back, and I feel like I've awakened from a spiritual coma.

Another thing is LSD sometimes causes my mind to wander uncontrollably unless I take my own initiative to focus, especially during the come up which can also sometimes fill me with restless confusion. Once I peak everything usually evens out, but ALD-52 put me in a state of perfect clarity from beginning to end. The come up was so smooth and comfortable.

I didn't notice the come down because I actually went to sleep when I felt like it was time to do so, which was an interesting surprise. Every time I've taken LSD I've had to let it run its entire course before even attempting to sleep. Often I would have to stay up for the entire day after which is obviously physically and mentally exhausting. But once I felt like the ALD-52 had made its point I went to sleep just like any other day, and woke up the next morning fully rested and mentally clear.

Overall, it felt very natural and I never had a single moment of uncomfortability or confusion. Just pure psychedelic bliss. I mean, I've had some amazing and extremely important experiences on LSD but honestly after the other night, think I prefer ALD-52. It felt like tripping for the first time again."

Note (27) Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
hxxp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max (off the charts), 0.00=min
Quote:

LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69 (sensual & entactogenic)
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69 (novelty, newness)
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)



Explanation of 5-ht1a receptors:

As we go thru day to day life, the 5-ht1a brain serotonin filters (gates, or day to day survival filters as I like to call them) which make up over 80% of brain 5-ht are in place so that we will not be overwhelmed by the perception of the way things would appear to an un-filtered mind, or "Mind at Large" as Aldous Huxley describes it in "Doors of Perception" as "infinite or eternal". He also referred to the visions as coming from "the other world" in his book "Moksha". I prefer to think of it in similar terms as well "the spirit world" or "the other world". Huxley referred to normal day to day mind state as the "reducing valve" due to it's filtering.

5-ht1a inhibition by entheogens (in green above) theoretically cause this filter system to be lifted, and the infinite mind to manifest in combination with oral dmt from traditional psychotria for example with the caapi and/or harmalas providing the 5-ht1a inhibition, just as bufotenine in snuff's provide the 5-ht1a inhibition combined with the dmt in the snuff's, resulting in a 3 hour experience ie both examples of Teamwork on how these entheogens are used traditionally in the Amazon.

Thomas S. Ray's study shows a value of 3.57 at SERT for Ibogaine (4.00 is max). Ibogaine has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine inhibits both serotonin and dopamine reuptake transporters, it is an SDRI or serotonin & dopamine reuptake inhibitor. Tetrahydroharmine (THH) is a serotonin reuptake inhibitor, it is an SRI found in caapi. In other words, both are strong serotonin reuptake inhibitors which inhibit over 80% of brain 5-ht at 5-ht1a.

Dr. Nichols (LSD scientist): "LSD has very strong potency in blocking the action of serotonin. The morpholide lysergamide cousin had only about 1/10th the potency in blocking serotonin. Of the 5 diferent dialkylamides we studied LSD was the most potent and specific serotonin antagonist."

Dr. Nichols "5-ht1a makes up >80% of brain 5-ht...5-ht1a agonism blocks serotonin."

Serotonin blocking is a main effect of all the natural oral entheogens like the semi-synthetic LSD, mescaline, Ayahuasca, mushrooms, 5-meo-dmt & bufotenine (found in snuffs). See 2011 receptorome chart above. Ibogaine inhibits both serotonin and dopamine reuptake transporters (it is an SDRI or serotonin & dopamine reuptake inhibitor).

An example of the importance of adding the serotonin reuptake inhibition properties of 5-meo-dmt for example to dmt (which totally lacks 5-ht1 reuptake properites on it's own) is shown below. This is the same way the snuff's are used in the amazon, as they naturally combine dmt with additives which cause the reuptake of 5-ht like bufotenin for example, this results in a 3 hour experience from the snuff's.

Oroc's experiment of combining 5-meo-dmt with DMT sounds imho very much like a short beautiful transcendental Ayahuasca experience, from his book "Tryptamine Palace":

DMT + tiny amounts of 5-meo-dmt, perhaps similar theoretically to Amazonian snuffs which have a makeup of 7.4% bufotenin (potent 5-ht1a agonist), 0.04% 5-MeO-DMT (potent 5-ht1a agonist) & 0.16% DMT (zero potency as 5-ht1a agonist):

James Oroc "Tryptamine Palace":
Quote:

As an experiment (and in a foreign land) I smoked the last of the Bufo alvarius venom (the story of whose collection is described within the pages of Tryptamine Palace) with some ‘regular’ DMT (extracted from Jurema Preta.). In the vast majority of my early nigerine (DMT) experiences, I encountered visual fields of ‘dots’ that would come together to form images, much like the pointillism style of painting developed by Georges Seurat or the Australian Aboriginal song-line paintings.

With the addition of the 5-MeO-DMT containing toad-venom to the DMT however, the visual characteristic was completely different and totally unique to my experiences so far. On this occasion there was a complete lack of ‘dots’ or ‘points’ of any kind, the fine lines of the constantly changing imagery were like those painted with a single-hair brush on Tibetan thangkas and due to the overwhelming artistry of what I was seeing, I could only think of the vaulted ceiling of the Sistine Chapel in comparison.

Sistene Chapel: This was without a doubt the most ‘visionary’ experience I have ever been fortunate enough to encounter and I lay there with my eyes shut watching the most fantastic parade of the Collective Unconsciousness imaginable, wishing that it would never end, and as I sit here now I can not even describe one tiny corner of it, since every image in the multitude of imagery was in such constant motion that they defied all but a glimpse. And then moments later, like a tent collapsing when its ropes are cut, the vision is gone. Leaving only a struggle of words to explain it, since nothing before or after has come close to this experiences visual majesty.

This experience leads to the interesting question of selectively combining DMT and 5-MeO-DMT for a more visionary and somewhat less overwhelmingly transcendental experience. (Or for the other way around). This combining of the two endogenous entheogens is being tested in changa blends (reportedly at a 90% DMT to 10% 5-MeO-DMT ratio), while many Pharmahuasca urban-shamans are also adding 5-MeO-DMT to their ayahuasca-analogues to transform and deepen that experience. It seems likely to me that the combining of DMT and 5-MeO-DMT in various ratios and manners will only become more popular as the exponentially increasing number of psychonauts search for new psychological terrain to explore.



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Stay true to yourself, Peace, Love & Music.

https://www.friskyradio.com/

Pics:

1) Sherry wine for conversion of LSD to 1-acetaldehyde in only 3 hours, and materials list for conversion of LSH and penniclavine in morning glory seeds to 1-acetaldehyde LSH & penniclavine should you choose to duplicate the 1992 Adducts study given on page 1.

Funnel with cotton balls used to filter morning glory cold water acidified extract should you choose to work with seeds, see here Note (12) on page 2:

https://www.shroomery.org/forums/showflat.php/Number/26838327

2) easy morning glory planter, each 17" wide x 15" beautiful Belize Chata Marsal Clay planter is home to 15 plants, there are 20 vertical rods in each 7 foot round fence for snakevines to climb.

3) Paspalum distichum infected with ergot (likely entheogen used at Eleusis) contains sky high levels of LSH & penniclavine when fresh just like morning glory seeds when fresh off vine.

4) Pic of researcher's new indole product creation BEFORE & AFTER. Acetaldehyde adducts onto bottom of NH group nitrogen of indole, using only water acidified to ph=4 (sherry wine is already at ph=4) and around a 0.1% acetaldehyde solution. Sherry wine contains the acetaldehyde we need, just like the study.

5) LSH or Lysergic acid hydroxyethylamide

6) LSD

7) ALD-52 compared to LSD

8) Graph & table showing levels of LSH in retail store rack seeds, but 3x higher levels LSH in seeds bought directly from producer, not shown possible 6x higher levels from fresh off the vine dark black seeds.

9) Eleusis Telesterian Initiation hall

10) Eleusian Mystery participants

11) 1-(1-hydroxyethyl) penniclavine courtesy of downwardsfromzero

12) 1-(1-hydroxyethyl) penniclavine acetyl courtesy of downwardsfromzero

With LSD, acetaldehyde will also adduct onto the bottom indole NH group nitrogen of the LSD ergoline forming 1-acetaldehyde LSD, containing one more hydrogen at adduct than ALD-52.
































Edited by tregar (10/19/21 08:35 AM)


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Offlinetregar
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar] * 1
    #26856506 - 08/01/20 12:33 AM (3 years, 5 months ago)

Just happened to have been gifted 300ugs of extremely pure acid in dreams, dissolved in 1 shot glass full of Sherry wine with added 5 peppermint extract drops, sits in fridge 3 hours with swirling once per hour till consumed in dreams.

I know the effects of acid vs ALD-52 very well, and the two times I tried ALD-52 over 10 years ago, was astounded by the visuals, see my trip report in note (16) above. I also, like reporter in note (17) at the time found it to be more aesthetic, beautiful and relaxing than the more analytical and less aesthetic acid.

ALD-52 also has "double the anti-serotonin" power of LSD. Anti-serotonin means blockage of serotonin activity via 5-ht1a agonism, which in turn blocks the re-uptake of serotonin, see chart above.

Will report back tomorrow.

The priest at Eleusis added fresh mint (note 22) to their secret entheogenic brew believed to be composed of in theory ground up claviceps paspali infected paspalum distichum grass which grows adjacent to Eleusis in the famous Rharian plain.

Fresh claviceps paspali ergot contains the exact same alkaloid profile as the Aztec morning glory when fresh: sky high levels of LSH (lyseric acid hydroxyethylamide) and penniclavine. Animals became stimulated like with LSD when injected with penniclavine in 1958 [note 8]. Same with LSH, animals became stimulated like with LSD when injected with LSH in 1961 (note 9). As everyone knows, 2 drugs combined is more potent than just one.

Note [8] Ref (1) T. Yui and Y. Takeo, Japan J. Pharmacol. 7, 157 [1958].

Note (9) A. Glasser, Nature 189, 313 (1961)

Note (22) The sources were clear that the kykeon's other ingredient, mint (menthe pulegium) was fresh mint. Mint appears to have played a symbolic role in Eleusinian myth; being Hades' concubine, Mint was "dismembered by the jealous wife Persephone." See Wasson, "The Road to Eleusis", 111.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26856509 - 08/01/20 12:34 AM (3 years, 5 months ago)

I am tripping 300ug on this tonight, will report back tomorrow. Has been in fridge 3 hours with swirling once per hour. Ready to consume in dreams in 1 hour.

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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26856510 - 08/01/20 12:34 AM (3 years, 5 months ago)

Question:
Quote:

I'm wondering if this would work with 1P-LSD, potentially creating an analog of ALD-52?



1p-lsd already has an adduct attached at the bottom NH indole group, it only works with LSD.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26856511 - 08/01/20 12:35 AM (3 years, 5 months ago)

2 hours into it, I can say the experiment was a complete success. It is WAY different from LSD. Did not even notice the come up, way more relaxing mentally as well, I prefer this to LSD, it feels like the 1st time I've tripped. Visuals are profoundly powerful. It feels extremely natural, I see why the Priest now added mint to their sacred entheogenic brew at Eleusis for 2,000 years straight, it has a very low "freak out factor", so I can see why hundreds of people could take this at once. 300ug is definitely a great dose, no less than this.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar] * 1
    #26856517 - 08/01/20 12:42 AM (3 years, 5 months ago)

Your posts are minutes apart, but you talk as if they're hours apart, which is weird. 4 minutes ago, you posted you were going to consume in 1 hour, then 4 minutes later you claim to be 2 hours in. So I guess you must have written all these posts before hand? If so, why post them all in a row like this?

Anyway, I tried ALD52 a number of times, and I always felt it wasn't as good as LSD. It's metallic, not as stimulating, just not as good as LSD IMO. But some rare people prefer it to LSD, but not anyone whose opinion I would trust. It's probably just a prodrug for LSD anyway.

But if you want to hype it and get some sales from it or something, feel free and don't let me stop you. I support RC vendors.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: nooneman] * 1
    #26856547 - 08/01/20 01:11 AM (3 years, 5 months ago)

This has been reposted from dmt nexus, that's why the posts are only minutes apart. I don't like the fact that only certain people are allowed in to the nexus, I believe it should be open to ALL, just like Eleusis, all were allowed to participate. I want to hear comments from all people.

This is the ONLY way I will be taking LSD from now on, deeply impressed, it has more of a cactus/mescaline feel to it, sky high appreciation for beauty, profound visuals, mentally super relaxed. I feel 300ug is only the beginning, going to take this to 400ug next time.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26856560 - 08/01/20 01:28 AM (3 years, 5 months ago)

You have got to try this! It's different from ALD-52 cause it has an extra hydrogen molecule.


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OfflinePandemoon
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26856650 - 08/01/20 04:59 AM (3 years, 5 months ago)

Interesting theory.. :strokebeard:

I like ALD52 very much (I still have a f*cking PAGE of it :smirk: ).

If I ever come across legit lsd25 again I will try this conversion. For now I'm set for a lifetime with several lsd analogs that are modified on the first position. LSD25 is quite expensive here. The legal analogs are a lot cheaper, damn.

But I have some eth-lad also in my stash. Eth-lad is modified on the 6th position, so the first should still allow an acetaldehyde bond, right?
I read that there was 1p-eth-lad around a few years ago, so it should be possible to attach acetaldehyde to the first position..

Eth-lad itself is way more visual than lsd25. If I think about it.. 1A-ETH-LAD, a more calming and even more visual version of eth-lad, sounds too good to be true. :wink:

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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26857232 - 08/01/20 12:32 PM (3 years, 5 months ago)

 

      This is a game changer. Simple kitchen chemistry with available non toxic chemicals to create adducts of LSD with comparable strength and efficacy from morning glory seeds, ergot infected grain or LSD itself.

      I stopped using morning glories years ago because of the sedation and nausea associated with the amount of seeds needed to achieve the level i wish to reach.

Sherry and peppermint oil. Mind blowing stuff.


I cannot wait to try this. it's almost too good to be true. 


--------------------
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Edited by psillyboy (08/05/20 10:37 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: psillyboy]
    #26857253 - 08/01/20 12:50 PM (3 years, 5 months ago)

LSD and ALD-52 are indistinguishable to me, and ALD-52 is a confirmed prodrug of LSD. In vitro, ALD-52 has around 10-fold lower affinity for the 5HT2A receptor compared to LSD, so ALD-52 itself does not contribute to the psychedelic effects (assuming the bulk of the experience is mediated by 5HT2A, which is a safe assumption). LC-MS experiments in rats also confirmed high levels of LSD after dosing with ALD-52. All of those findings are summarized in this article: https://psychedelicreview.com/study-finds-ald-52-1p-lsd-and-1b-lsd-are-prodrugs-of-lsd/ (discussing this original research paper: https://pubmed.ncbi.nlm.nih.gov/31756337/ )

Unless you're just doing this conversion for fun, it seems like a waste of time (and potentially a waste of LSD) to convert LSD into ALD-52 just for the body to turn it back into LSD.

Also, can you explain how ALD-52 was obtained from this procedure, and how that was confirmed? It seems like the reaction of the indole nitrogen with acetaldehyde in acidic water would give the reaction shown below. Protonation of acetaldehyde followed by addition to the indole and dehydration to give the unstable imine, which would revert back to the starting indole and acetaldehyde in the presence of water. However, in the presence of a hydride source, the imine could be reduced to the stable ethylated indole, but is such a reducing agent present in sherry? Even if it is present, the product would be N-ethyl LSD, not N-acetyl LSD (aka ALD-52). It's interesting that the Mayans and Aztecs may have done this with morning glories and such, so I'm just wondering about the data concerning the products that are formed.

EDIT: nevermind, now I see the link to the paper in the original post. Ethanol adds to the imine to give the aminal, so ALD-52 is not produced from this. That's pretty cool that the aminal is stable enough to isolate. I'm guessing it's hydrolyzed in the body to produce LSD, or else that aminal still fits into the 5HT2A receptor, which seems unlikely based on the in vitro data for ALD-52 and other acetylated LSD analogs.



Edited by breeg89 (08/02/20 12:38 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26857254 - 08/01/20 12:53 PM (3 years, 5 months ago)

I managed to stash a few lysergamides which I love.
I am simplifying my approach towards the more minimalistic.
Tiny pipes and lighters and bubble hash replace all the paraphernalia for weed and shatter, vapes and batteries, and the blotters need little extra fuss, unless I need to be more certain about partial doses, which is when I use distilled water and a dropper for 20 blotters and 80 droppers full.

I think extra process with liquor adds a layer of ritual, and that is a dandy thing.
A lot of people thrive on ritual and the sense of molecular command which a laboratory or religious procedure imparts.

There is such a range of variety in psychedelic experience even with just a single variety of a single entheogen, that I don't see myself engaging in this extra molecular decoration, but I will enjoy samples from my stash as it is, or metered with a dropper.

maybe post this to ODD too, lots of free range explorers there (though they are probably here too)?


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26858180 - 08/02/20 05:19 AM (3 years, 5 months ago)

I dosed ALD52 like 100+ times throughout the last 4 or 5 years, in doses between 25ug and350ug.
While ALD52 is very similar to LSD25, I think I can still see a slight difference. To me the visuals are different, especially the tracers. I can clearly see a difference there.

With 200ug+ of ALD52, when I move my hand it shows some very colorfull spirals and fractals in the tracer /smearing.
While with LSD25 it is just a mirroring effect that shows several of my hands. Not nearly as colorfull, just a non colored shadow (or several) of the real hand.
With ALD52 it's much more colorfull and intense, like painting the air with rainbow colors.

100ug or even 150ug don't really show a difference at all to LSD25, but with 300ug and above (my highest dose was 350ug) the differences are even more intense.
With 350ug I can hardly see reality anymore due to all those colorfull reflections of anything I look at.
I think the higher the dose the clearer the differences.

Also, the conversion above doesn't produce ALD52, it produces ALD52 wih an additional hydrogen molecule (if I understood correctly). That's again some different molecule that might show unique effects.

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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Pandemoon]
    #26858368 - 08/02/20 08:20 AM (3 years, 5 months ago)

YES Pandemoon, thanks for your invaluable comments!

Pandemoon said:
Quote:

I dosed ALD52 like 100+ times throughout the last 4 or 5 years, in doses between 25ug and350ug.

While ALD52 is very similar to LSD25, I think I can still see a slight difference. To me the visuals are different, especially the tracers. I can clearly see a difference there.

With 200ug+ of ALD52, when I move my hand it shows some very colorfull spirals and fractals in the tracer /smearing.

While with LSD25 it is just a mirroring effect that shows several of my hands. Not nearly as colorfull, just a non colored shadow (or several) of the real hand.

With ALD52 it's much more colorfull and intense, like painting the air with rainbow colors.

100ug or even 150ug don't really show a difference at all to LSD25, but with 300ug and above (my highest dose was 350ug) the differences are even more intense.

With 350ug I can hardly see reality anymore due to all those colorfull reflections of anything I look at.

I think the higher the dose the clearer the differences.

Also, the conversion above doesn't produce ALD52, it produces ALD52 wih an additional hydrogen molecule (if I understood correctly). That's again some different molecule that might show unique effects.



Yes, as I mentioned above 1-acetaldehyde LSD has an extra hydrogen on the NH group adduct at bottom indole of the ergoline as compared to ALD-52.


emkee_reinvented (bluelight) said:
Quote:

ALD-52 and Al-LAD both were subjectively better then 1p/1cp-LSD as well as LSD. But my memory about that last one are hazy.



tregar said:
Quote:

This is the ONLY way I will be taking LSD from now on, deeply impressed, it has more of a cactus/mescaline feel to it, sky high appreciation for beauty, profound visuals, mentally super relaxed. I feel 300ug is only the beginning, going to take this to 400ug next time.



Anonymous Dissident (bluelight) said:
Quote:

More than anything else in this thread, this comment really got my attention. I absolutely adore mescaline and Tricho cacti, so this couldn't sound more appealing. I will definitely be giving this a try at some point!



Same here Anonymous Dissident, cactus is my absolute favorite, that's why I was surprised the 1-acetaldeyde LSD took me to a state similar to that familiar place, I absolutely ADORE the over the top beauty enhancement & euphoria with cactus, and this new alkaloid took me to that same artistic way of seeing the beauty in the world.

But just like cactus, the 1-acetaldehyde LSD requires higher dosages, I would compare 300ugs of this to a similar state as 300mg mescaline, I believed based on my experience, that 400ugs of this will be the "sweet spot" similar to a state of 400mgs of mescaline. And just like cactus, this is more expensive to experiment with, this requires 4 hits of acid. I don't mind the extra expense, and acid is readily available if you know where to look.

I also believe this would amplify small amounts of cactus quite well, say 300g to 400g of certain cacti fresh, of which I am also well familiar with, as I grow my own in backyard under shadecloth. In the past I've combined acid with small amounts of cactus more times that I can count, to amplify the beauty of the rare cactus. The open & closed eye visions were unbelievable and went on for hours, and the beauty astounding. I believe based on my experience that 1-acetaldehyde LSD will amplify the beauty of small amounts of the rare cactus to an extreme, looking forward to this in the future in dreams.

I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" (but not totally) and towards the adrenal A2A, A2B, and A2C spectrum instead (see chart on page 1 of this thread for explanation), which is the dominance or habitat of mescaline & dmt from hawaiian psychotria when combined with Caapi (again, see receptorome chart).

I also agree with poster in note (17) on page 1 above that 100ug to 200ug of this newly created alkaloid from LSD will be not be very eventful, just like 100mg to 200mg of mescaline is not that eventful, but 300ug is where this shines, just as 300mg of mescaline is a great dosage. I will report back in 2 weeks after dreaming 400ug of this new alkaloid.

This new alkaloid does not feel "man-made" like the semi-synthetic LSD at all, but rather very natural, primitive & infinitely beauty enhancing & euphoric just like cactus. Last night I watched a movie on TV in 4k with lots of beautiful women & scenery, and was astounded at the divine & infinite beauty amidst all the beautiful visuals with open or closed eyes, it cannot be put into words. I also listened to music for an hour and was in heaven.

I did notice the come up, but it was so smooth and relaxing, just like cactus. Again, this experimentation is for people who have acid to spare. If you don't have much acid to spare, recommend you stick with acid.


Edited by tregar (08/02/20 08:33 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Pandemoon]
    #26858763 - 08/02/20 12:13 PM (3 years, 5 months ago)

Quote:

Pandemoon said:


Also, the conversion above doesn't produce ALD52, it produces ALD52 wih an additional hydrogen molecule (if I understood correctly). That's again some different molecule that might show unique effects.

-




True, it does not produce ALD-52, but it's not just ALD-52 with an additional hydrogen. See my pic below which shows the difference between ALD-52 and the theoretical derivative prepared from this sherry procedure. The structure of that derivative is based on the paper posted by the OP: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/



ALD-52 is a confirmed pro-drug of LSD, and the derivative prepared from this procedure is almost certainly a pro-drug as well. That's based on data that modifications at the indole nitrogen (like in ALD-52, 1P-LSD, etc) dramatically reduce binding affinity to the 5HT2A receptor, so if the sherry derivative is active, the current data suggest it must be metabolized to LSD to activate 5HT2A. All of this is discussed in more detail in my earlier post in this thread.

We can speculate that the sherry product does not get metabolized and might bind to receptors that aren't 5HT2A, but in that case the effects should not be classically psychedelic in nature.


Edited by breeg89 (08/02/20 12:29 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26859110 - 08/02/20 03:06 PM (3 years, 5 months ago)

ALD-52 and 1-acetaldehyde LSD are REAL drugs, see here, not some kind of "pro-drug": Perform the experiment I did using 300 to 400ug of acid, it will rock your world in a completely different way than LSD.

Yes, you guys are right about 1p-LSD, it will not fit the "very specific receptor dock" as ALD-52 or 1-aceteldehyde LSD does, even LSD scientist Dr. Nichols said it is too long.

1-acetaldehyde LSD is more stimulating, more like mescaline when it comes to the sky high perception of infinite beauty & euphoria, profound visuals, and relaxing mentally, no thoughts that wander uncontrollably like with LSD.

I was immersed in fine multi colored rainbow reflections that surrounded everything I looked at just like Pandemoon in report saw. It was indeed "like painting the air with rainbows". The beauty was breathtaking. This was different from the "colored specs in the air" I see that flow in front of everything like with acid.

I believe if you combine just 300ug of this with 300 to 400g of fresh cacti (no core) it will make it feel like 600 to 700g of fresh cactus, that's how close I believe the A2A, A2B & A2C receptor binding is between 1-aceteldehyde LSD and mescaline. LSD only binds to A2A in comparison, see chart on page 1 of this thread.

The table from Sandoz (lab where Albert Hofmann discovered LSD) suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD produced brain waves showing a more relaxed mental state. Sample ALD-52 trip reports given in (note 16) and (note 17).

In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower [approximately 1/5] intravenous toxicity (in rabbits), a lower [approximately 1/8] pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD.

Also verified by reading a page on ALD-52 from the book "Ergot alkaloids & related compounds" by Berde that indeed ALD-52 has 2.1 times the "anti-serotonin" properties of LSD, and higher stimulation follows higher anti-serotonin, which may help to explain why our newly formed mystery molecule 1-acetaldehyde LSD is even more stimulating than LSD in the beginning.

The Aztecs and Mayans were known to add the extract from morning glory seeds (same exact alkaloid profile as the Greek claviceps paspali which grows on the grass paspalum distichum adjacent to Eleusis in the famous Rharian plain, both contain sky high amounts of LSH & penniclavine when fresh) to a drink containing alcohol (note 2).

We know that sherry wine contains average 10mg acetaldehyde per 30ml or shot glass. The Aztecs and Mayans apparently knew about the acetaldehyde adducting properties of wine and alcohol, which as shown in the 1992 adducts study (note 6) will cause acetaldehyde to adduct onto the bottom NH group on the indole of LSH and penniclavine forming something more akin to looking like ALD-52, (at least bottom indole wise).

Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37).

Note (6) 1992 adducts study: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ Page 8441 "Reaction of Indole with Acetaldehyde: A 0.2% solution of indole in equal amounts of water, ethanol, and acetaldehyde formed a product with 60% yield after 1 hour of reaction at ambient temperature. Omitting the ethanol (50% acetaldehyde in water mixture) had no effect. Decreasing the concentration of acetaldehyde to 0.1% increased the reaction rate and percent yield of product." See pic of the researchers's indole + acetaldehyde adduct product formed at bottom of this post ---> ie before (page 8439) and after (page 8441).

The researchers achieved a new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution." Sherry wine not only contains avg 10mg acetaldehyde per shot glass, but is already at ph=4.

I will return in 2 weeks with a 400ug 1-acetaldehyde LSD trip experience. It is WAY different from LSD, see reports above.


Edited by tregar (08/02/20 04:19 PM)


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Invisiblebreeg89
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26859147 - 08/02/20 03:22 PM (3 years, 5 months ago)

Quote:

tregar said:


The researchers achieved a new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution." Sherry wine not only contains avg 10mg acetaldehyde per shot glass, but is already at ph=4.






Dude, sherry wine is alcohol, in other words, it has ethanol. In that paper you posted, they state that acetaldehyde alone gave no product:

Quote from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/?page=1 :

"Both of these compounds [N-acetyltryptophan and indole acetic acid] yielded reaction products when treated simultaneously with acetaldehyde and ethanol. No products were detected when either of these reagents was used alone."

In your own post above, you also quoted a part of the paper where they again state that:

"Omitting the ethanol (50% acetaldehyde in water mixture) had no effect."


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26859157 - 08/02/20 03:27 PM (3 years, 5 months ago)

The researchers achieved a new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution." Sherry wine not only contains avg 10mg acetaldehyde per shot glass, but is already at ph=4. You need to read the whole paper, I discovered this paper over 20 years ago.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26859169 - 08/02/20 03:35 PM (3 years, 5 months ago)

Where are you quoting that from? It contradicts the published data in that article you referenced.

I'm not denying LSD mixed with acetaldehyde and acidic water will be active, but it'll be active because it's a solution of LSD, not something new. You need some published analytical data to show the formation of a new product, which would directly contradict the findings from that published article you referenced. This finding can also be rationalized by reversible formation of an unstable imine that just hydrolyzes to give the starting compounds.

If sherry is used as the source of acidic water and acetaldehyde, then ethanol is also present because sherry is wine.


Edited by breeg89 (08/02/20 03:55 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26859219 - 08/02/20 04:21 PM (3 years, 5 months ago)

When the researchers said "Omitting the ethanol (50% acetaldehyde in water mixture) had no effect." WHAT THEY MEAN is that if you take the ethanol out, the reaction STILL WORKS. But you do need ph=4 water solution, and in my experiment, Sherry wine is already at ph=4, and you also need around a 0.1% acetaldehyde solution.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26859367 - 08/02/20 05:42 PM (3 years, 5 months ago)

Quote:

tregar said:
When the researchers said "Omitting the ethanol (50% acetaldehyde in water mixture) had no effect." WHAT THEY MEAN is that if you take the ethanol out, the reaction STILL WORKS. But you do need ph=4 water solution, and in my experiment, Sherry wine is already at ph=4, and you also need around a 0.1% acetaldehyde solution.





Oh wait, I just read that section of the paper. That line is describing the reaction with un-substituted indole, which does not react at the indole nitrogen; it reacts at carbon-3 to form a completely different product (dimeric indole product, shown below, same structure from the paper). True, that reaction does not require ethanol, but it is also irrelevant to LSD because LSD is substituted at carbon-3, so LSD instead reacts at the indole nitrogen through a different process.

For indole derivatives with substituents at carbon-3 (like LSD, tryptophan, tryptamine, DMT, psilocin, etc), the paper uses N-acetyltryptophan and 3-indole acetic acid to show that a different reaction occurs at the indole nitrogen, and they state this reaction only occurs when both acetaldehyde and ethanol are present:

Quote from the paper, page 8439:
"Both of these compounds [N-acetyltryptophan and 3-indole acetic acid] yielded reaction products when treated simultaneously with acetaldehyde and ethanol. No products were detected when either of these reagents was used alone."

Structures of product obtained with un-sub'd indole compared to C3-sub'd indole like LSD:



Edited by breeg89 (08/02/20 06:39 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26859725 - 08/02/20 08:45 PM (3 years, 5 months ago)

Psillyboy and Pandemoon, I love both your posts!

This conversion even works on seed extracts:

69ron (on mint/peppermint added to seed extract):
Quote:

Fact: This conversion, when it works, produces an effect that is very different from LSA. Far more like LSD, and stimulating instead of sedating. When it works, the difference is HUGE, not a tiny difference, the experience is TOTALLY DIFFERENT. I know the effects of LSA and LSD very well. He has used them many times. He guarantees that when the reaction works, there is NO NOTICEABLE LSA left at all in the experience. It becomes almost identical to an LSD experience at low doses. Totally different from LSA."




Kash: (on mint/peppermint added to seed extract):
Quote:

Just took a 40 seed portion of LSA extract that was mixed for 15 minutes with peppermint oil yesterday and tripped his face off with a friend. Was very clean feeling and relaxed. Rainbows and vibrant fractal energy danced all over the skies and throughout his surroundings and music sounded great. The head-space was very acid like but different. Was a bit intense but he was able to keep it together lol. Whole trip was about 8 hrs long.

I have tried a 20 seed extract without peppermint oil and it seemed uncomfortable and sedating with no visuals, while every time he has added peppermint oil he has gotten visuals."




Myself (500ml cold spring water acidified to Ph=4 with DL tartaric acid extract on 400 black hard fresh morning glory seeds right off vine, grown in 3/4 miracle grow + 1/4 cow manure compost) procedure given in (note 12) added 1 shot sherry and 5 drops peppermint extract to cold water seed extract as well:
Quote:

Saw geometric patterns on the surface of everything, with closed eyes, colored vectors spun 360 degrees while traveling from left to right across visual plane. Sounds were not only amplified & music heavenly but audio hallucinations were produced, heavy euphoria component & very strong appreciation for beauty. Remember watching Scarlett Johansson interview on a small television and melting into the seat from her beauty amidst all the breath taking geometrics. Tripped hard as hell in dreams.




The priest at Eleusis added fresh mint (note 22) to their secret entheogenic brew believed to be composed of in theory ground up claviceps paspali infected paspalum distichum grass which grows adjacent to Eleusis in the famous Rharian plain.

Fresh claviceps paspali ergot contains the exact same alkaloid profile as the Aztec morning glory when fresh: sky high levels of LSH (lyseric acid hydroxyethylamide) and penniclavine. Animals became stimulated like with LSD when injected with penniclavine in 1958 [note 8]. Same with LSH, animals became stimulated like with LSD when injected with LSH in 1961 (note 9). As everyone knows, 2 drugs combined is more potent than just one.

Note [8] Ref (1) T. Yui and Y. Takeo, Japan J. Pharmacol. 7, 157 [1958].

Note (9) A. Glasser, Nature 189, 313 (1961)

Note (22) The sources were clear that the kykeon's other ingredient, mint (menthe pulegium) was fresh mint the Preist added to the brew. Mint appears to have played a symbolic role in Eleusinian myth; being Hades' concubine, Mint was "dismembered by the jealous wife Persephone." See Wasson, "The Road to Eleusis", 111.

Pandemoon said:
Quote:

I dosed ALD52 like 100+ times throughout the last 4 or 5 years, in doses between 25ug and 350ug.

While ALD52 is very similar to LSD25, I think I can still see a slight difference. To me the visuals are different, especially the tracers. I can clearly see a difference there.

With 200ug+ of ALD52, when I move my hand it shows some very colorfull spirals and fractals in the tracer /smearing.

While with LSD25 it is just a mirroring effect that shows several of my hands. Not nearly as colorfull, just a non colored shadow (or several) of the real hand.

With ALD52 it's much more colorfull and intense, like painting the air with rainbow colors.

100ug or even 150ug don't really show a difference at all to LSD25, but with 300ug and above (my highest dose was 350ug) the differences are even more intense.

With 350ug I can hardly see reality anymore due to all those colorfull reflections of anything I look at.

I think the higher the dose the clearer the differences.

Also, the conversion above doesn't produce ALD52, it produces ALD52 wih an additional hydrogen molecule (if I understood correctly). That's again some different molecule that might show unique effects.
Yes, as I mentioned above 1-acetaldehyde LSD has an extra hydrogen on the NH group adduct at bottom indole of the ergoline as compared to ALD-52.



myself:
Quote:

2 hours into it, I can say the experiment was a complete success. It is WAY different from LSD. Did not even notice the come up, way more relaxing mentally as well, I prefer this to LSD, it feels like the 1st time I've tripped. Visuals are profoundly powerful. It feels extremely natural, I see why the Priest now added mint to their sacred entheogenic brew at Eleusis for 2,000 years straight, it has a very low "freak out factor", so I can see why hundreds of people could take this at once. 300ug is definitely a great dose, no less than this.

This is the ONLY way I will be taking LSD from now on, deeply impressed, it has more of a cactus/mescaline feel to it, sky high appreciation for beauty, profound visuals, mentally super relaxed. I feel 300ug is only the beginning, going to take this to 400ug next time.

1-acetaldehyde LSD is more stimulating, more like mescaline when it comes to the sky high perception of infinite beauty & euphoria, profound visuals, and relaxing mentally, no thoughts that wander uncontrollably like with LSD.

I was immersed in fine multi colored rainbow reflections that surrounded everything I looked at just like Pandemoon in report saw. It was indeed "like painting the air with rainbows". The beauty was breathtaking. This was different from the "colored specs in the air" I see that flow in front of everything like with acid.

I believe if you combine just 300ug of this with 300 to 400g of fresh cacti (no core) it will make it feel like 500 to 600g of fresh cactus, that's how close I believe the A2A, A2B & A2C receptor binding is between 1-aceteldehyde LSD and mescaline. LSD only binds to A2A in comparison, see chart on page 1 of this thread.




Edited by tregar (08/02/20 09:16 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26860573 - 08/03/20 11:06 AM (3 years, 5 months ago)

OK OK

what part of this is theoretical?


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: redgreenvines] * 2
    #26861624 - 08/03/20 08:47 PM (3 years, 5 months ago)

^ I doubt anyone has ever used analytical techniques to confirm the formation of a new product after subjecting LSD, LSA, etc. to this procedure. The existing data that I've seen only confirmed formation of the mixed aminal/acetal derivative for N-acetyltryptophan and indole-3-acetic acid (see this paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ ). There's a good chance it works with ergoloids, but you still need analytical data to confirm.

I'm guessing the only evidence for LSD, LSA, etc is anecdotal trip reports about perceived differences in the effects compared to the original compounds, which pales in comparison to LC-MS data, especially since these ergoloids obviously are psychoactive without undergoing this reaction.

I've tried to clear up the misinformation about this procedure regarding the products that are formed, the differences in reactivity between un-sub'd indole and 3-sub'd indoles, and the possibility that this reaction just yields a pro-drug of the starting indole. These claims are all based on these published papers:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/

https://psychedelicreview.com/study-finds-ald-52-1p-lsd-and-1b-lsd-are-prodrugs-of-lsd/ (summarizing this published research: https://www.sciencedirect.com/science/article/abs/pii/S0028390819304228 )


Edited by breeg89 (08/03/20 09:04 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26861903 - 08/04/20 02:01 AM (3 years, 5 months ago)

Doubledog said:
Quote:

My friends had some ALD52 blotters few years ago and described it as slightly more visual, and not so stimulating, and as upgraded version of LSD, but with just small difference.

I always explained it in the way that this difference is similar to difference of morphine/acetylmorphine and it is based on different metabolism of molecule.

Btw.
Title of this thread is about acetyl-LSD, but content is mainly about acetaldehyde-LSD. It's confusing.



Thanks for the report Doubledog from your friends, much appreciated. Take this 1-aceteldeyde LSD to the 300ug to 400ug level, it is like mescaline, which shines at the 300mg to 400mg level. Don't worry, there is none of the tenseness or anxiety of LSD, so it is easy to take it higher...but it has plenty of depth mentally. It is extremely visual at the 300ug level in a completely different way from LSD, more like mescaline or DMT in the visuals. This is for people who have plenty of acid to spare, if you do not have much acid to spare, then I recommend sticking with acid. This is just like cactus, it is more expensive to trip with, but well worth it imho, will not take acid any other way from now on. This 1-acetaldehyde LSD imho would combine quite well with 300g to 400g of fresh cactus tea, making it feel more like 600g fresh cactus (no core).

With 300ug conversion: For anyone that does dream this, you may be shocked at how stimulating it is the whole trip, as ALD-52 or 1-acetaldehyde LSD created via this thread has "twice the anti-serotonin power of LSD", and the more anti-serotonin or serotonin blocking (see color receptorome chart on post #1) the more powerful the stimulation, was up till 4:30am in the morning, and had dreamed it at 4pm in afternoon. The girl I was with had to tell me to "stop talking" at one point, as I kept pointing out "how beautiful the scenery was", the stimulation is high, but still mentally relaxing none the less, although a great psychedelic head space, it will take you deep mentally without the anxiety or tenseness of LSD just as Shulgin writes in TIHKAL under ALD-52 section.

It is way more colorful than acid and if you wave your hand in front of you, instead of just seeing multiples of your hand like you would with acid, you will see not only multiple tracers, but inbetween the tracers will be fractals and swirls of color, super fine colored rainbow reflections surrounded almost everything I watched, immensely beautiful. Patterns and textures do indeed shift like crazy with open eyes. It is vastly different from LSD. With closed eyes I saw the most beautiful geometrics, before falling to sleep, saw architecture and gardens like those in Versailles, France with a fast moving groundskeeper zipping about tending to the plants, unbelievable.

Why so different from LSD? I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead (see color chart on page 1 of this thread) which is the high binding dominance or habitat of mescaline & dmt, and psilocin to a lower extent.

benzyme said:
Quote:

I just don't see it...

as with LAH, that acetyl group looks like it would be cleaved with moderate [H+], the carbonyl is obviously nucleophilic. nevermind enzymatic deacetylation; it likely wouldn't even make it to the liver.



This is Happening in the Liver via an enzymatic reaction, there is no cleavage, there is transformation taking place in the liver similar to what is happening in Note (1).

The proof is in the pudding, when someone else dreams this, and reports back. Smile

The Mayans and Aztecs added the extract from morning glory seed to beer/wine, they did not do this with any other entheogen. Sherry wine contains 10mg acetaldehyde per shot glass. The priest at Eleusis added fresh mint to their secret entheogenic brew for over 2,000 years straight, mint contains 2mg water soluble acetaldehyde per 5 drops concentrated extract.

All these ancient people were not stupid, they were quite clever, there was a reason they did what they did. Fresh morning glory contains LSH and penniclavine in sky high amounts, as does the claviceps paspali which infects the paspalum distichum grass which grows next to Eleusis in the famous Rharian plain, Both contain the exact same alkaloids. If you do this same experiment I did with LSH, it also transforms the molecule.

Note (1) Here's an example: If you soak coca leaf tea bags in wine, and the wine drunk, the cocaine is converted into coca-ethylene in the liver...cocaethyelene is orally potent, it has a "higher like" rating than even cocaine when human tests were done in 1994. This was the basis behind the famous commerical "Vin Mariani wine" back in the 1860's popular with both Popes, Thomas Edison, and scores of other famous people. I don't see any cleavage taking place with this molecule but rather addition/transformation. This "in-vivo" liver transformation of the molecule was not even discovered till 1994.

How can you all call me wrong, when none of you have even tried this? I will report back in 2 weeks with a 400ug experience. This is not a rat taking LSD mixed with a shot of sherry and 5 drops peppermint in the lab, this is a human experiment, let your liver do the work, you will see the light.

Still do this the way the study outlined, by letting all sit in fridge for 3 hours with swirling once per hour like I did. The Sherry is already at ph=4 so no acidic solution necessary.


Edited by tregar (08/04/20 04:13 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26864036 - 08/05/20 08:44 AM (3 years, 5 months ago)

DMT Nexus banned me till the year 2294, account deleted.

They also deleted the entire original thread with comments from everyone.

My friend said:
Quote:

Don't worry about those guys, a lot of online communities are full of people trying to use their "superior knowledge" to flaunt it over others. As far as I'm, concerned, any and all discussion on psychedelic topics should be encouraged. If someone disagrees, great, they should then respectfully state their reasons for disagreeing and then assert their own views. There is no reason to disrespect others.




Even downwardsfromzero (chemical genius) at the old deleted thread agrees with the results of the study, I even had pics of the "indole before" and "indole after" from the study, but it was all deleted.

Downwardsfromzero (my only supporter) had even reposted the study in a downloadable form, all gone now of course.

You can see all of the diagrams downwardsfromzero made if you go to this older thread, see post #1 and look at the section of chemical diagrams among the 22 pics:

[no sense posting link, all pics, study tables & graphs deleted from all my threads by moderators, no idea why]

All I did was propose a theory and my results, and was suspended for life.


Edited by tregar (08/05/20 01:02 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26864585 - 08/05/20 01:09 PM (3 years, 5 months ago)

I'm off to weight room to relieve some stress, been a bodybuilder since age 22. Weight = 220 lbs, 12% body fat. It's the only thing that keeps me sane.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26864680 - 08/05/20 02:03 PM (3 years, 5 months ago)

At the nexus, where my thread was removed and I was banned for life, I was very kind and simply proposed my theory based on study and my results, I used the scientific method. Apparently one of the dudes in the thread who claimed to be some kind of big shot big pharma attempted to tear it apart piece by piece, then it just went downhill from there after 3 other Elitist backed up the big pharma dude and told me that what I experienced was "impossible." He trolled me after every post and was extremely rude to me. He claimed everything is a "pro-drug" and impossible for it to have it's own effects. He told me "I must follow his direction." I feel better after lifting weights now and jamming to music in the gym.

I know it has not yet been 2 weeks, but tonight I will be performing an experiment with 400ug of 1-acetaldehyde LSD taken 1/2 hour of taking 400g of fresh cactus tea (equivalent of around 400mg mescaline with particular cacti) and will report back around midnight, then I will take a long vacation from the forum until Winter, I will leave it up to you gals and guys to take it from here should you choose to duplicate the study as well.

I have a strong feeling the 400ug of 1-acetaldehyde LSD will make this 400g of fresh cactus feel like around 700g of fresh cactus, or around 700mg of mescaline.

I have hundreds of experiences in the past combining 400g of fresh home grown cactus with regular acid in all amounts, so I am very experienced.

4 hits of acid have been dissolved into 1/2 shot of sherry wine (5mg acetaldehyde, natural ph=4 which is what study calls for), along with 5 drops of peppermint extract, swirled mixture once per hour, as it sat in fridge for 3 hours.


Edited by tregar (08/05/20 02:59 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26865073 - 08/05/20 05:12 PM (3 years, 5 months ago)

As expected, 3 hours in, this is way different from my past experiences combining cactus with acid. Some will prefer the "electricity" of acid. But I prefer this, it has no anxiety or tenseness, no wandering thoughts, it's deep mentally, a real gem. It did indeed make it feel like around 700g fresh of the rare cactus. It is more colorful, more natural, the patterns and shifting of textures is magical. There does not seem to be the "extreme tolerance" of normal acid. Extremely beautiful experience, beyond description. I am humbled. In a whole nother world with the music. The rainbow reflections of color surround everything. When I move my hand, I see fractals and patterns inside the tracers.
,
I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead (see chart on page 1 of this thread for explanation), which is the dominance or habitat of mescaline & dmt & psilocin (see color chart post #1).


Edited by tregar (08/05/20 05:48 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26865609 - 08/05/20 10:40 PM (3 years, 5 months ago)

It's good to know that people at the nexus also realized the misinformation and potential pitfalls in this procedure. There might be a common theme here -- people with chemistry knowledge have a problem with your claims.

I have no problem with your hypothesis that this procedure yields a new N-sub'd indole product that potentially binds to adrenal receptors. The problem is that it's just a speculative hypothesis with no analytical data to support it. The notion that subjective anecdotal evidence from someone in an altered state of mind passes for conclusive scientific data is absurd. You're not an LC-MS man.

Can you provide objective evidence for your claim that adrenal receptors modulate perception of "beauty/aesthetic" (please don't cite Fear and Loathing in Las Vegas)? Adrenal receptors are important for many biological processes, but classical psychedelic-like effects are not among them, as far as I know. I agree -- data confirm that DMT, mescaline, psilocin, etc bind adrenal receptors, but where's the evidence that this contributes to the psychedelic state? In fact, data demonstrate that 5-HT2A is the key functional target for classical psychedelics, as 5-HT2A antagonists block the psychedelic effects of classical 5-HT2A-agonizing psychedelics.

Here's some data suggesting that this is a pro-drug (from https://psychedelicreview.com/study-finds-ald-52-1p-lsd-and-1b-lsd-are-prodrugs-of-lsd/ and https://www.sciencedirect.com/science/article/abs/pii/S0028390819304228 ):

-the finding that ALD-52, 1P-LSD, and 1B-LSD show 5-10-fold reduced 5-HT2A binding affinity compared to LSD in vitro.

-the finding that giving rats ALD-52 or 1P-LSD produced high concentrations of LSD in the blood.

-the finding that giving rats ALD-52, 1P-LSD, or 1B-LSD initiated the characteristic psychedelic head-twitch response (despite dramatically reduced 5-HT2A binding affinity in vitro).

These results indicate that substitutions at the indole nitrogen of LSD reduce affinity for 5-HT2A, yet the compounds are still psychedelic, and LSD is produced after they're administered in vivo. What conclusion can we draw from that? I'd wager they are metabolized to LSD, which is a psychedelic. Plus, the mixed aminal/acetal compound resulting from your acetaldehyde procedure is prone to hydrolysis (see my chemdraw pics on page 1), suggesting it is metabolized in vivo to yield LSD (either via hydrolysis in the stomach or enzymatically).

People don't need to care about the science surrounding this, but they should be properly informed about what they're subjecting their LSD to if they choose to do this, especially given the possibility that they're just making a pro-drug.


Edited by breeg89 (08/06/20 12:24 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26865694 - 08/06/20 12:32 AM (3 years, 5 months ago)

Thankfully, this discussion is also being continued at bluelight with important comments from Administrator Xorkoth. Of whom I grew up reading his countless amazing posts (over 14,000!)

https://www.bluelight.org/xf/threads/theoretical-at-home-conversion-of-lsd-to-ald-52-1-acetyl-lsd-in-1-step.890589/


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26865779 - 08/06/20 03:19 AM (3 years, 5 months ago)

All you need is 1/2 shot of sherry wine (contains 5mg acetaldehyde at ph=4, what study calls for) and some peppermint extract (Adam's extract). Just drop 4 (100ug hits, old or new) into the 1/2 shot glass full of sherry wine, then add 5 peppermint extract drops. Let sit in fridge for 3 hours with swirling once per hour, then consume. Go to the grocery store and buy some Sherry wine and peppermint extract.

This conversion works very well, it is nothing like LSD, like an UPGRADED VERSION OF LSD, profound visuals, music sounds even more heavenly than with acid...no tenseness or anxiety. Deep mental headspace. It has more of a mescaline feel to it (very strong) that's why it potentiates cactus so well. I will return in the winter.

This is the ONLY WAY I will take acid from now on for the rest of my life, unbelievable, so incredibly beautiful and visual....remember this is how the ancient Aztec and Mayans would take LSH from fresh morning glory, they added fresh off the vine mg seed water extract to wine, the ancient Greek priest would add ground up claviceps paspali (same exact alkaloid profile as morning glory when fresh, sky high levels of LSH & penniclavine) from paspalum distichum grass to brew with mint in it, which also contains 2mg acetaldehyde per 5 drops concentrated extract. Before falling to sleep I had colored visions of architecture and gardens, pristine as if just newly created, mind-blowing.

Myself earlier:
Quote:

As expected, 3 hours in, this is way different from my past experiences combining cactus with acid. Some will prefer the "electricity" of acid. But I prefer this, it has no anxiety or tenseness, no wandering thoughts, it's deep mentally, a real gem. It did indeed make it feel like around 700g fresh of the rare cactus. It is more colorful, more natural, the patterns and shifting of textures is magical. There does not seem to be the "extreme tolerance" of normal acid. Extremely beautiful experience, beyond description. I am humbled. In a whole nother world with the music. The rainbow reflections of color surround everything. When I move my hand, I see fractals and patterns inside the tracers.

I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead (see chart on page 1 of this thread for explanation), which is the dominance or habitat of mescaline & dmt & psilocin (see color chart post #1).




Edited by tregar (08/06/20 12:24 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26865859 - 08/06/20 06:20 AM (3 years, 5 months ago)

shouldn't this thread really be in ODD?


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: redgreenvines]
    #26867433 - 08/06/20 10:10 PM (3 years, 5 months ago)

:whathesaid:


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26867626 - 08/07/20 04:01 AM (3 years, 5 months ago)

One last thing before I leave for a few months, as mentioned earlier, I grow my own cactus under shadecloth, and I have taken 400g of fresh cactus with acid (in all different dosages) hundreds of times in the past for over 15 years. I grow ALOT of cactus.

400g of the particular kind of cactus I grow is equivalent to around 400mg of mescaline.

When you convert your LSD to 1-acetaldehyde LSD, you will want to use at least 300ug, preferably 400ug of acid (or around 4 x 100ug hits). This stuff shines at 300 to 400ug, no less than this, just as mescaline shines at 300mg to 400mg.

When I tripped 2 days ago on 400g of fresh cactus + 400ug of 1-acetaldehyde LSD, I also did not mention that I watched the movie "To the stars" with Kara Hayward & Jordana Sprio, two very beautiful women....when I watched the new movie off Hulu, I had never seen such infinite beauty in my life, this was the most powerful trip of my life, and I've tripped hundreds of times. The beauty seen on screen was overwhelming, the colors & shifting of patterns & textures were insane, I was in 7th Heaven. There were super-fine colored rainbow reflections that surrounded everything I watched.

On acid, I will see "colored specs" that flow in front of everything, the rainbow reflections with 1-acetaldehyde LSD are much prettier....but this is way different from acid, very powerful color enhancement just like with cactus....this is why the 1-acetaldehyde potentiates cactus so well. The beauty was "thru the roof" when I watched the women on screen. The mental space was not wandering thoughts or tense or anxiety ridden like with acid....it was mentally deep without any of the side effects of acid, just like the table at Sandoz labs, where Albert Hofmann discovered ALD-52 as well describes.

It is not a sacrilege to convert LSD to this, as Albert Hofmann discovered ALD-52 as well. But this 1-acetaldehyde LSD has one more hydrogen on the adduct than ALD-52. The Mayans and Aztecs as mentioned above also converted LSH from fresh morning glory to this, as they would add the water extract from the seeds to a wine as well (see my notes on page 1). The priest at Eleusis would add the ground up claviceps paspali (which infected the pasplaum distichum grass growing adjacent to Eleusis in the famous Rarian plain) to a brew containing fresh mint. Mint contains water soluble acetaldehyde as well at 2mg per 5 drops concentrated extract. Claviceps paspali contains the exact same alkaloid profile as fresh morning glory (sky high levels of LSH and penniclavine).

What I'm trying to say is don't be afraid to take this to 400ug, this stuff is out of this world incredible at 400ug, this is the dosage I will always use, no less. It also does not have "the extreme tolerance of normal acid"

I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead which is the dominance or habitat of mescaline & dmt & psilocin (see color chart post #1).

You will find that 400ug of 1-acetaldehyde LSD is more similar to the natural mescaline/dmt visuals and extreme color enhancement, euphoria, and over the top beauty enhancement. I can't stop thinking about the trip the other night, mesmerizing.

This is how I prepared the 1-acetaldehyde LSD: Simply fill a shot glass 1/2 full with fridge cold sherry wine (contains 5mg acetaldehyde at ph=4 which is what 1992 adducts study calls for), then drop 4 hits of 100ug acid into the glass, then stick in fridge with a foil cover over top, then 1 hour later add 5 drops of peppermint extract, then swirl the shotglass x once per hour, let it sit in fridge for 3 hours total, as the study found new product creation at 1.5 hour, but you want to leave it in fridge for 3 hours total with swirling once per hour since we are not using a stir mantel in the fridge like the study. I have performed this experiment twice already, with outstanding results, it was WAY different from LSD, like an upgraded version of LSD.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26868968 - 08/07/20 07:27 PM (3 years, 5 months ago)

Just to make sure we are on the same page here. We are talking about peppermint extract (for making cookies) not peppermint oil, Correct?


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: psillyboy]
    #26869471 - 08/08/20 04:10 AM (3 years, 5 months ago)

Yes psillyboy, it's the Adam's peppermint extract.

I won't really be leaving for several months, I will just be more silent and mostly just read posts instead and respond with a sentence or two, won't be posting much.

I feel I've achieved what I wanted to with the morning glory LSH thread and discovery of 1-acetaldehyde LSD, this all started with a post by another member who has disappeared since! Crazy how one person can start an avalanche of ideas.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26870384 - 08/08/20 05:39 PM (3 years, 5 months ago)

In conclusion, my personal observations, as I have taken acid hundreds of times in the past not only by itself, but in combination with 400g of fresh boiled cactus tea (I grow my own cactus under shade cloth) over 200 times in over 15 years, I keep a trip diary.

I also grow around 30 ipomoea tricolor heavenly blue morning glory plants, 15 to each 17" wide x 15" tall planter with 7 foot tall round welded wire fence (from garden store) in each, equivalent growing area of a 7 foot tall x 4 foot wide fence, grown in 3/4 miracle grow + 1/4 cow manure compost, produces extremely potent LSH & penniclavine containing seeds, that I pick when seeds are dark and hard and immediately vacuum pack and store in freezer to keep their high potency indefinitely. Each planter produces 3,000 seeds (5 seeds per pod), 6000 seeds total divided by 400 seeds per trip = 15 high potency trips. Even just small amounts of these seeds also potentiate normal LSD in combination, producing outstanding visions and transcendence beyond just normal LSD.

This same conversion I describe in this thread also works with the LSH & penniclavine in the seeds, converting them to 1-acetaldehyde LSH & penniclavine. As I described earlier with supporting references, the ancient Aztec and Mayans and Priest at Eleusis for 2,000 years straight used this same conversion on LSH from the seeds, and LSH from the ground up claviceps paspali (ancient Greece) growing on the paspalum distichum grass adjacent to Eleusis to serve to hundreds of people at once, it has a low "freak out factor" (like with mescaline), so I can see why hundreds could take this at once.

1) You know how acid has that sudden drop off then you are back to sobriety? Instead, this lasts longer than acid and has a warm gentle transition back over a longer period.

2) 1-acetaldehyde LSD is way more colorful than acid, similar to mescaline.

3) 1-acetaldehyde LSD does not have the "visual choppiness" of acid, but is flowing in the visuals.

4) LSD produces tracers with multiples of shadows of the hand, this produces not only tracers, but colored fractals and mosaics inside the tracers.

5) LSD produces "colored specs that flow in front of everything", this produces instead "fine colored rainbow reflections" that surround everything.

6) Music sounds good on acid, but music sounds great on this, like a whole nother world, similar to mescaline.

7) With 1-acetaldehyde LSD, everything was indeed alive and magical. Patterns were forming everywhere, the shifting of textures is magical. I could lose myself so easily as the visuals seemed to drag my focus in without any effort. As a result, ego death was basically spontaneous. Taking this 2 times already, made it feel like the first time I've ever tripped. My 2nd trip with 400ug 1-acetaldehyde LSD in combination with 400g fresh cactus tea was the most infinitely beautiful & powerful trip I have ever experienced in my life.

8] Sometimes LSD causes my mind to wander uncontrollably unless I take my own drive to focus, but with 1-acetaldehyde LSD there is no wandering thoughts, no tenseness or anxiety like with acid, this is deep mentally, a real gem, pure psychedelic bliss.

9) 400ug of 1-aceteldehyde LSD makes 400g of fresh boiled cactus pieces (no core, approximately 400mg mescaline) feel instead like 700mg of mescaline. I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead which is the dominance or habitat of mescaline & dmt & psilocin (see color chart post #1).

10) You can take this more often as it does not have the "extreme tolerance" of normal LSD which mainly works thru the 5-ht2a receptor (see color chart post #1), just like with cactus which you can take more often.

11) It is not a sacrilege to convert LSD to 1-acetaldehyde LSD cause Albert Hofmann also discovered ALD-52 at Sandoz labs. This is different from ALD-52 cause it has one extra hydrogen on the acetaldehyde adduct at the bottom indole NH group nitrogen. The table from Sandoz suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD-52 produced brain waves showing a more relaxed mental state. It also has "twice the anti-serotonin or serotonin blocking power" of normal LSD.

12) Before falling to sleep, I saw closed eye colored visions of architecture and gardens like those in Versailles, France.

13) LSD is more "analytical" and not as aesthetic, this feels more natural and is extremely aesthetic (beauty enhancing) like with mescaline.
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Final note:

Don't forget that menthol in peppermint extract also causes cytochrome P450 enzyme inhibition in the liver, which is involved in the metabolism of exogenous chemicals. This may have a potential effect in preventing the breakdown of 1-acetaldehyde LSD. Peppermint extract also contains 2mg water soluble acetaldehyde per 5 drops, sherry wine contains 5mg acetaldehyde per 15ml or 1/2 shot glass.

So if you choose to duplicate the experiment based on the 1992 adducts study as I did, it would be wise to keep the peppermint extract with the 1/2 shot of sherry wine. I always add the 5 drops Adam's peppermint extract to the cold sherry wine shot glass containing the 4 LSD blotters about 1 hour later, with 3 hours total soak time, with swirling once per hour. Keep shot glass in fridge, as acetaldehyde boils off at room temp.

I know that from now on this is the only way I will take 400ug of LSD, as the "upgraded 1-acetaldehyde LSD cousin."
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I did not discover this conversion, it was given to me by an ancient spiritually prominent Shaman in a vision, true story, see here:

Discovered 1992 adducts study the same week after receiving a 20 minute visit or "schooling" from an ancient powerful and spiritually prominent Aztec Shaman who appeared out of the shadows on a wall cast by a Christmas tree, this after girl and I both took 10 hits each of 15 year old decomposed acid given to me by a dear friend, true story. The acid had a sick feeling for the 1st two hours, but then it worked and skyrocketed us to higher divine plane.

The Shaman sat on a throne made of spirit animals (birds, otters, Jaguars, macaws, toucans) that morphed into other spiritual animals continuously. The Shaman stared intently into my eyes as if downloading information to me. What's even more amazing, is that the girl who was with me also saw the EXACT same vision on the wall.

The Shaman wore a huge beautiful headdress made of feathers, to the left and right of him stood female centaurs, half naked female above, half animal below. He showed me the rise and fall of several civilizations throughout time. I saw the great pyramid of the Aztec empire in the distance. The animated vision was beyond 4k, and highly detailed.

Behind the female centaurs were snakevines growing out of the ground. Before the Shaman left, he motioned to me with his eyes to look out the window in the living room to the patio, where I had an empty garden plot, he was trying to tell me to plant entheogenic plants. His point in showing me the rise and fall of the different civilizations was I believe he was trying to tell me "that if humanity is survive, the only hope is a Spiritual solution."

Don't forget that to the Aztecs, the morning glory plant was more important to them then their other 2 classical plants, peyote and mushrooms. Two sources given for this comment below.

Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37)."

Note (4) Psychotomimetics of the Convolvulaceae pg 93: "This particular plant seems to have been more important to the Aztecs in divinity then Peyotl or Teonanacatl, two of their other classical sacred plants."

Note (5) Jonathan Ott "Pharmacotheon": "Ololiuhqui was far more prominent as an entheogen here in Mesoamerica than those mushrooms; the mushrooms are mentioned only here and there by a few competent chroniclers; yet almost an entire book was devoted to denouncing mainly the ololiuhqui idolatry. The annals of the Inquisition contain many times more autos de fe for ololiuhqui than for mushrooms."

Note (22) The sources were clear that the kykeon's other ingredient, mint (menthe pulegium) was fresh mint. Mint appears to have played a symbolic role in Eleusinian myth; being Hades' concubine, Mint was "dismembered by the jealous wife Persephone." See Wasson, "The Road to Eleusis", 111.

In Ipomoea Tricolor vine: from Tryptophan-->chanoclavine-->agroclavine-->elymoclavine-->lysergic acid-->ergometrine-->LSH, which then decomposes over time into LSA.

2016 Polish morning glory study found 3x higher amounts of LSH in MG seeds direct from grower/producer vs retail:
Quote:

fresh black seeds from vine: likely 5.00 LSH to 5.00 penniclavine ratio
seeds direct from growers: 1.71 LSH to 5.08 penniclavine ratio
seeds off retail racks: 0.54 LSH to 4.75 penniclavine ratio
Vacuum pack & freeze freshly picked seeds to preserve potency indefinitely.



LSH (lysergic acid hydroxyethylamide) decomposes in neutral water solutions, and quickly in alkaline solutions, and also if heated, but it is quite stable in acidic environments (just like the solution recipe I give). Traditionally (e.g. as reported from Wasson) they only soaked the mushed seeds briefly in water, then strained and immediately drank. Even Hermes and Nogal (both extracted 400 to 500 seeds into cold acidic water using a squirt of lemon juice) both reported EXTREMELY VISUAL MG trip reports:

(1) Hermes (the Lycaeum):
Quote:

Cold water extract with squirt of lemon juice: Saw strong 4D lattice-like open eye visuals and warping and melting of furniture with only 400 seeds. There are around 32 to 36 seeds to a gram. I see amazing three and seemingly four-dimensional shapes morphing and bifurcating. Often I get religious and esoteric themed visuals, like fractal cherub wings and winged eyes like those in some of Alex Grey's work. Eyes are all over everything. I see pyramids and sphinxes and Gigeresque biomechanical forms. I see amazing geometric lattice structures. I watch mathematical space-filling algorithms doing their thing, all of this with nothing more than 500 seeds.



(2) Nogal (the Nook):
Quote:

Yes I know of someone who tried the CWE method with the Heavenly Blue variety, except with the substitution of a coffee grinder in place of a stone metate (I think that's what is called but I could be wrong), and a squirt of lemon in the water, with around 400-500 seeds. Closed and open eyed visuals were extremely breath taking. Some of the most prominent visions were of Aztec/Mayan glyphic patterns, a menacing and demonic technicolor nymph made of light who tried to seduce the viewer, and this bizare trail of energy spheres which each contained a different stylized animal form (again definately of Aztec/Mayan origin).



(3) Erowid report:
Quote:

400 older dried seeds is similar to a little less than one hit LSD. 400 fresh off vine is like about 2 or three hits.



Myself: 500ml cold spring water acidified to Ph=4 with DL tartaric acid extract on 400 fresh off the vine dark hard heavenly blue morning glory seeds that I grew in 3/4 miracle grow + 1/4 cow manure compost, fed 1 tablespoon miracle grow crystals dissolved into 1 gallon watering can w/spout once per month only, 22 years ago, added 1 shot of sherry & 5 drops peppermint extract, let sit in fridge 3 hours with swirling once per hour:
Quote:

Saw geometric patterns on the surface of everything, with closed eyes, colored vectors spun 360 degrees while traveling from left to right across visual plane. Sounds were not only amplified & music heavenly but audio hallucinations were produced, heavy euphoria component & very strong appreciation for beauty. Remember watching Scarlett Johansson interview on a small television and melting into the seat from her beauty amidst all the breath taking geometrics. Tripped hard as hell in dreams.



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I am not a shaman, but I have been thru alot of the stuff Shaman's have gone thru, I have lost both my twin girls at birth, so I have no children, my beloved pet Shitzu died at only age 4 from continuous bladder stones for 6 months, he was unable to pee so many times, we had to rush him to vet, where he was put down. He visited both of us in a dream 2 days later to tell us he was alright in Heaven with a big smile on his face.

I have nearly died several times, once I was hit head on by a truck when driver ran a yield sign, I barely survived with numerous injuries.

I once took alot of acacia bark with Ayahuasca instead of the normal hawaiian psychotria I use, and went into a serious serotonin syndrome shock, for 1.5 hours I sweated my ass off sitting in the bathtub, I told my wife goodbye while my dog watched in a sad state..by some miracle I pulled out of it, I believe it was the high levels of maoi's in the acacia that interacted with the rima's in the Ayahuasca, bad combination. My forehead was pouring sweat for 1.5 hours, I was in severe shock and trembling, and knew I was gonna die.

Lost everything in a 100 year severe flood, my home and all my belongings, I had just gotten married and all the newlywed gifts perished...right after that I moved to an apartment complex, and 5 months later all my belongings again burnt to the ground after a dude had threw a lit blunt into the apartment complex after his girlfriend dumped him.

Had it not been for the policeman banging on the door of the apartment, we would have surely burned in the flames, as we were on the 3rd floor & asleep as I worked 2nd shift at the time. We ran down the steps in only our bare feet and suffered smoke inhalation.

Have been thru some %!%%, similar to a Shaman, who lives on the outskirts of society. Lifting weights, walking in nature with my dog, going to the waterpark with a season pass every summer, and reading the bible is all that keeps me sane some days.
-----------------------------------------------------------------------
Stay true to yourself, Peace, Love & Music.

https://www.friskyradio.com/

Pics:

1) Sherry wine for conversion of LSD to 1-acetaldehyde in only 3 hours, and materials list for conversion of LSH and penniclavine in morning glory seeds to 1-acetaldehyde LSH & penniclavine should you choose to duplicate the 1992 Adducts study given on page 1.

Funnel with cotton balls used to filter morning glory cold water acidified extract should you choose to work with seeds, see here Note (12) on page 2:

https://www.shroomery.org/forums/showflat.php/Number/26838327

2) easy morning glory planter, each 17" wide x 15" beautiful Belize Chata Marsal Clay planter is home to 15 plants, there are 20 vertical rods in each 7 foot round fence for snakevines to climb.

3) Paspalum distichum infected with ergot (likely entheogen used at Eleusis) contains sky high levels of LSH & penniclavine when fresh just like morning glory seeds when fresh off vine.

4) Pic of researcher's new indole product creation BEFORE & AFTER. Acetaldehyde adducts onto bottom of NH group nitrogen of indole, using only water acidified to ph=4 (sherry wine is already at ph=4) and around a 0.1% acetaldehyde solution. Sherry wine contains the acetaldehyde we need, just like the study.

With LSD, acetaldehyde will also adduct onto the bottom indole NH group nitrogen of the LSD ergoline forming 1-acetaldehyde LSD, containing one more hydrogen at adduct than ALD-52.












Instructions:

Note (1): Make sure your sherry wine is cold before you use it, it contains 5 mg acetaldehyde per 15ml or 1/2 shot glass. Acetaldehyde boils off at 68 degrees F, or slightly below room temp, so keep 1/2 shot glass of it in fridge at all times until you consume.

Note (2): Menthol is largest ingredient in peppermint extract and causes cytochrome P450 enzyme inhibition in the liver, which is involved in the metabolism of exogenous chemicals. This may have a potential effect in preventing the breakdown of 1-acetaldehyde LSD. Peppermint extract also contains 2mg water soluble acetaldehyde per 5 drops

1) Fill a shot glass up 1/2 way with dry sherry wine.

2) Drop 3 to 4 hits of 100ug acid into shot glass.

3) Put a foil cover on shot glass and let sit in fridge.

4) 1 hour later add 5 drops of Adam's peppermint extract.

5) Swirl the shot glass once per hour, the researchers used a stir mantel in the fridge, and achieved 100% new product creation in 1.5 hour, but since we are not using a stir mantle, swirl once per hour.

6) After 3 hours sitting in fridge, consume, sit back & enjoy the brand new experience of 1-acetaldhyde LSD, or what is similar to ALD-52 with one extra hydrogen.

THIS THREAD IS BEING CONTINUED HERE, IT HAS BEEN MOVED TO ODD SECTION:

https://www.shroomery.org/forums/showflat.php/Number/26872226


Edited by tregar (08/10/20 06:56 AM)


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OfflineSabnock
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar] * 1
    #26870727 - 08/08/20 10:01 PM (3 years, 5 months ago)

Even though we sometimes don't see eye to eye Tregar, i do applaud your convictions, observations, experimentation and postings. Don't let the Nexus get ya down, there's some good there but they're far from great ime, just do your thing, experiment around, make some observations, speculate/hypothesize as to what's going on, and share with like-minded folks wherever possible. I've been paying attention to your notes and i will continue keeping them in mind for my own future experimentation/exploration.


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Invisiblebreeg89
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Sabnock]
    #26874178 - 08/10/20 09:50 PM (3 years, 5 months ago)

The problem is the mis-representation of parts of the literature that are cited. At least get the structure right for the hypothetical product -- it's not ALD-52 with an extra hydrogen -- it's a mixed aminal/acetal, the structure of which is shown in the very paper that's cited ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ ). I'll re-post these structures to clarify:



Not just an extra hydrogen. It's an extra hydrogen plus an ethyl group on the oxygen. Again, structure is drawn in the cited paper. This is not my speculation -- this is confirmed by LC-MS and 1H NMR for simple 3-sub'd indoles (but NOT LSD or more complex ergoloids).


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26874833 - 08/11/20 10:59 AM (3 years, 5 months ago)

The Axe said:
Quote:

I've seen teks on the web for mushrooms that don't seem plausible at all, like lemon tek, but on the other hand I've seen other simple teks with lye or food grade lime seem like they do strip off part of a chain. I'm just wondering, other than subjectively, how to confirm whether there's an acetyl attached to the LSD-25 or whether something else is going on with acetyl during metabolism.



Well said The Axe, let's not forget the possibility that acetaldehyde could be adducting onto the NH group nitrogen of the ergoline indole of LSD "in vivo" in the liver to convert this to 1-acetaldehyde LSD. After all, the Aztecs and Mayans added the morning glory extract to wine/liquor, and the 1992 adducts paper is entitled:

"Tryptophan analogues form adducts by cooperative reaction with aldehydes and alcohols or with aldehydes alone: possible role in ethanol toxicity."

Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37)."

Here's an example: If you soak coca leaf tea bags in wine, and the wine drunk, the cocaine is converted into coca-ethylene in the liver...cocaethyelene is orally potent, it has a "higher like" rating than even cocaine when human tests were done in 1994. This was the basis behind the famous commerical "Vin Mariani wine" back in the 1860's popular with both Popes, Thomas Edison, and scores of other famous people. I don't see any cleavage taking place with this molecule but rather addition/transformation. This "in-vivo" liver transformation of the molecule was not even discovered till 1994 !

Perhaps this same "in vivo" transformation of LSD to 1-acetaldehyde LSD takes place in the liver via an enzymatic reaction that has not yet been discovered. I know the effects of LSD and 1-acetaldehyde LSD very well, as I have taken acid hundreds of times, and the 2 times I tried 1-acetaldehyde first at 300ug and 2nd time at 400ug were completely different, in fact I prefer the 1-acetaldehyde LSD by a long shot, it's the only way I will take acid for the rest of my life, I don't mind the extra expense of using 3 or 4 tabs at once for the conversion, it's cheap and plentiful in dreams. You have nothing to loose, my grocery store carried just one brand of Sherry wine, seen in the 1st pic of linked thread with 13 pics, "Taylor brand sherry" and the peppermint extract was right down a few isles.

Like I mentioned earlier, I've taken acid in all different amounts with 400g of fresh cactus tea (I grow lots of cactus under shade cloth) for over 15 years, and it always feels just like "acid + cactus", but when I took the 400ug of 1-acetaldehyde LSD with 400g of fresh cactus, for the 1st time in my life it felt like 700mg of mescaline, it was THE most profoundly infinitely beautiful and powerful trip of my entire life, I can't stop thinking about even 1 week later, big time life changing. I had complete control of my faculties, no tenseness or anxiety like with acid, no wandering thoughts, it was deep mentally, real gem, I would wave my hand and see not only tracers, but fractals inside the tracers, the beauty of the 2 women on screen from the new hulu movie "to the stars" was overwhelming, I was in heaven, the colors were out of this world impossible and breath-taking for hours on end...I thanked Heaven for this remarkable experience, the most profound of my life. Just my 2 cents.

Normalperson said:
Quote:

what's the worst that could happen? lose a couple of tabs and be stuck with a bottle of shitty wine? or maybe i would like the wine and become a wino? I'll try it out soon.



I laughed my ass off reading that.


Edited by tregar (08/13/20 08:04 PM)


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Offlinedownwardsfromzero
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26878705 - 08/13/20 02:23 PM (3 years, 5 months ago)

Some of you may remember from my commentary at the Nexus my considerable scepticism that an aldehyde adduct on the nitrogen atom of a primary amide would form in any appreciable quantity simply by mixing the two ingredients in solution.

This reference:
Quote:

1. The condensation of aldehydes with amides
Rup Kishore Mehra, Kantilal C. Pandya; 1938; DOI 10.1007/BF03045405; Print ISSN 0370-0089



via here: Herbpedia
forces me to rethink my view in that respect.

That isn't particularly relevant to this thread, what with LSD-25 being a tertiary amide and all. Instead I respectfully will echo the point constructively made by breeg89 - the scientific value of anecdotal reports regarding qualitative differences in subjective experience resulting from a particular method of preparation serves only as a stimulus for investigating what is actually going on.

What if it were as simple as the fact that the LSD has gone into solution and is protected from oxidation by the sherry/mint tea components? And tregar, you've already noted the metabolic effect of menthol on the CYPxxx enzymes - what if that is what is making the trip smoother by preventing the formation of the more 'jangly' 13-OH-LSD, for example?

It would be most helpful to think through all the potential confounding possibilities and ways of controlling for them, because this effect seems to be pretty interesting. Preparing a sample of the putative 1-(1-hydroxy [or ethoxy]ethyl)LSD for analysis would be only one step for the scientific community. Working out what it does in the human body would be a whole other ball game.


--------------------
Writhing and groaning


Edited by downwardsfromzero (08/21/20 05:08 AM)


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OfflineSabnock
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: downwardsfromzero]
    #26878795 - 08/13/20 03:20 PM (3 years, 5 months ago)

One must also take into consideration the influence of various compounds on the Psychedelic in question. It's not necessarily that a compound is turning into a different compound, it could just be that something that is being mixed with the compound is altering it's characteristics/flavor/feel, the quality/nature of the experience/effects. It's more easily done than one would think.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Sabnock]
    #26879016 - 08/13/20 06:08 PM (3 years, 5 months ago)

Downwardsfromzero and Sabnock so glad to see you both! What is gonna take for you guys to stop talking about it, and JUST TRY IT !!! So far, NO ONE has duplicated my experiment. Downwardsfromzero worked with me to draw up chemical diagrams at the Nexus in the fresh morning glory LSH thread before they suspended my account until the year 2294 for posting the current thread you are reading. :crazy2: Nexus. I just so happen to be a 220lb bodybuilder with 12% bodyfat, been lifting weights since age 22...and a bunch of pencil necks canned my post. They even deleted ALL THE PICS and study tables and graphs to all of my posts over there that belonged to me for the last 12 years, making all my posts useless.:mad2:

Dragonrider, we have proof a new product is being created...look at this from Vecktor (advanced chemist):
Quote:

Tregar you have probably rediscovered something that has long been a curiosity....the morning glory extract treated with acetaldehyde-methanol without the water showed a clear difference in the alkaloid profile, with a shift to several new non polar spots which couldn't be identified. IIRC Erhlichs was used to develop the plates so these were indole compounds.


So glad to hear Vecktor, thanks. It takes time for the new product to form when there is water involved--->the researchers achieved a 100% new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution, with a 1.5 hour soak time with stirring. It just so happens that sherry wine is already at ph=4 just like the study calls for! Researchers said "the lower the PH, the faster the reaction."

Typerwritermonky said:
Quote:

Uhh tregar have you ever taken 1-acetylhyde-LSD on its own or only in combination with other substances?  This is interesting, but I still feel like 400ug of LSD-25 is a strong enough experience to question what in the world is going on.



Yes, I have taken this on it's own at 300ug, at 400ug and again tomorrow will be taking it at 400ug.

I have taken LSD hundreds of times over 15 years, and I am very familiar with acid vs this new alkaloid 1-acetaldehyde LSD, which I have found to be COMPLETELY different! You all have got to try this, it is one incredible substance at the 300 to 400ug level, not at all like LSD when taken at 300ug to 400ug.

I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead which is the dominance or habitat of mescaline & dmt & psilocin (see receptorome chart on post #1).

It feels more like mescaline or Ayahuasca at 400ug then 400ug of acid, way different, way more colorful, come up is relaxing like with cactus, profound visuals that look more like mescaline visuals than acid visuals, way more euphoric and beauty enhancing like with mescaline, not analytical at all like with LSD. Love, love, love this stuff, only way I will take acid for the rest of my life.

This has one more hydrogen molecule than ALD-52, so it's even different from ALD-52. This is one very beautiful substance.
-----------------------------------------------------------------------
I have made 1-acetaldehyde LSD twice so far from 3 LSD blotters and then 4 LSD blotters the 2nd time, it is extraordinary, easy to do in one step and based on the 1992 adducts study with indole see below note (6).

This is absolutely no "pro-drug" it has effects all on it's own, COMPLETELY different from LSD from beginning to end of trip, see my 13 comments further below on how this is way different from LSD in profound ways, like an upgraded version of LSD.

I know that from now on this is the only way I will take 400ug of LSD for the rest of my life, as the "upgraded 1-acetaldehyde LSD cousin." My absolute favorite.

Don't bash me until you try this with 3 or 4 hits of acid yourself, it is based on pure science, and really works. With LSD, acetaldehyde will adduct onto the bottom indole NH group nitrogen of the LSD ergoline forming 1-acetaldehyde LSD, containing one more hydrogen at adduct than ALD-52.

The main recipe is based on the 1992 indole adducts study which creates a new 1-acetaldehyde (similar to ALD-52 but contains one more hydrogen molecule) alkaloid from LSD. The peppermint extract in the recipe contains menthol as the main ingredient which shuts off the cytochrome P450 enzyme inhibition in the liver, which is involved in the metabolism of exogenous chemicals. This has the potential effect in vivo of preventing the breakdown of 1-acetaldehyde LSD.

The same conversion described in this thread also works with the LSH (lysergic acid hydroxyethylamide) & penniclavine in morning glory seeds, converting them to 1-acetaldehyde LSH & 1-acetaldehyde penniclavine. As described below with supporting references in Notes, the ancient Aztec and Mayans and Priest at Eleusis for 2,000 years straight used this same conversion on LSH from the seeds, and LSH from the ground up claviceps paspali (ancient Greece) growing on the paspalum distichum grass adjacent to Eleusis to serve to hundreds of people at once, it has a low "freak out factor" (like with mescaline), so I can see why hundreds could take this at once. Fresh morning glory and fresh claviceps paspali ergot both contain the exact same alkaloid profile.

Researchers showed in 1961 that Claviceps paspali ergot produces high amounts of LSH in culture "Production of a new lysergic acid derivative (LSH or Lysergic acid hydroxyethylamide) by a strain of Claviceps paspali, Stevens & Hall".

See pics on how this also converts penniclavine (highest alkaloid in morning glory seeds) for example to the 1-(1-hydroxyethyl) penniclavine courtesy of downwardsfromzero (chemical genius) who drew up diagrams for all this stuff as he worked along with me, in 13 pics in the fresh morning glory LSH thread here at Shroomery.

Instructions:

Note (1): Make sure your sherry wine is cold before you use it, it contains 5 mg acetaldehyde per 15ml or 1/2 shot glass. Acetaldehyde boils off at 68 degrees F, or slightly below room temp, so keep 1/2 shot glass of it in fridge at all times until you consume.

Note (2): There is a less than ten dollar wine preservation canister available that will prevent oxidation of the wine, instead a bottle of sherry wine will last several months instead of just 7 days. This way the natural precious high levels of acetaldehyde in the sherry wine will not oxidize to acetic acid over time. The canister replaces the air that seeps into an open bottle with a balanced mixture of carbon dioxide, nitrogen and argon to keep wine fresh: just look up "private preserve wine preservation system", less than ten dollars. Seen it at amazon.

Note (3): Menthol is largest ingredient in peppermint extract and causes cytochrome P450 enzyme inhibition in the liver, which is involved in the metabolism of exogenous chemicals. This may have a potential effect in preventing the breakdown of 1-acetaldehyde LSD. Peppermint extract also contains 2mg water soluble acetaldehyde per 5 drops

1) Fill a shot glass up 1/2 way with dry sherry wine. Sherry wine is already at ph=4 which is what study calls for, and contains the acetaldehyde (5mg avg. per 15ml) we need like the study.

2) Drop 3 hits of 100ug acid into shot glass.

3) Put a foil cover on shot glass and let sit in fridge.

4) 1 hour later add 5 drops of Adam's peppermint extract.

5) Swirl the shot glass once per hour, the researchers used a stir mantel in the fridge, and achieved 100% new product creation in 1.5 hour, but since we are not using a stir mantle, swirl once per hour.

6) After 3 hours sitting in fridge, consume, sit back & enjoy the brand new experience of 1-acetaldehyde LSD, or what is similar to ALD-52 with one extra hydrogen at the bottom indole NH group.
--------------------------------------------------------------------
LSA (C16 H17 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSA
LSH (C18 H21 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSH
LSD (C20 H25 N3 O) + acetal (C2 H3 O) at bottom indole NH group = 1-acetal LSD (C22 H27 N3 O2) or ALD-52
--------------------------------------------------------------------
Note (6) 1992 adducts study: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ Page 8441 "Reaction of Indole with Acetaldehyde: A 0.2% solution of indole in equal amounts of water, ethanol, and acetaldehyde formed a product with 60% yield after 1 hour of reaction at ambient temperature. Omitting the ethanol (50% acetaldehyde in water mixture) had no effect. Decreasing the concentration of acetaldehyde to 0.1% increased the reaction rate and percent yield of product." See pic of the researchers's indole + acetaldehyde adduct product formed at bottom of this post ---> ie before (page 8439) and after (page 8441).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/

The researchers achieved a 100% new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution, with a 1.5 hour soak time with stirring.

Note (15) Breakdown of water soluble acetaldehyde & isovaleraldehyde (and their corresponding acids) in peppermint extract: 1mg standard is equivalent to .001ml, 5 drops used in recipe = .25ml, .25ml = 250mg identified compounds, alcohol percent of peppermint extract = 91% alcohol so then 250mg x 0.9% = 23mg leftover of compounds, assuming 9% of this is the acetaldehyde/isovaleraldehyde & their corresponding acids, [see paper "Chemical Composition and Biological Activities of Mentha Species by Brahmi"] then approximately 2mg exists in 5 drops.
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In conclusion, my personal observations, as I have taken acid hundreds of times in the past not only by itself, but in combination with 400g of fresh boiled cactus tea (I grow my own cactus under shade cloth) over 200 times in over 15 years, I keep a trip diary.

I also grow around 30 ipomoea tricolor heavenly blue morning glory plants, 15 to each 17" wide x 15" tall planter with 7 foot tall round welded wire fence (from garden store) in each, equivalent growing area of a 7 foot tall x 4 foot wide fence, grown in 3/4 miracle grow + 1/4 cow manure compost, produces extremely potent LSH & penniclavine containing seeds, that I pick when seeds are dark and hard and immediately vacuum pack and store in freezer to keep their high potency indefinitely. Each planter produces 3,000 seeds (5 seeds per pod), 6000 seeds total divided by 400 seeds per trip = 15 high potency trips. Even just small amounts of these seeds also potentiate normal LSD in combination, producing outstanding visions and transcendence beyond just normal LSD.

1) You know how acid has that sudden drop off then you are back to sobriety? Instead, this lasts longer than acid and has a warm gentle transition back over a longer period.

2) 1-acetaldehyde LSD is way more colorful than acid, similar to mescaline.

3) 1-acetaldehyde LSD does not have the "visual choppiness" of acid, but is flowing in the visuals.

4) LSD produces tracers with multiples of shadows of the hand, this produces not only tracers, but colored fractals and mosaics inside the tracers.

5) LSD produces "colored specs that flow in front of everything", this produces instead "fine colored rainbow reflections" that surround everything.

6) Music sounds good on acid, but music sounds great on this, like a whole nother world, similar to mescaline.

7) With 1-acetaldehyde LSD, everything was indeed alive and magical. Patterns were forming everywhere, the shifting of textures is magical. I could lose myself so easily as the visuals seemed to drag my focus in without any effort. As a result, ego death was basically spontaneous. Taking this 2 times already, made it feel like the first time I've ever tripped. My 2nd trip with 400ug 1-acetaldehyde LSD in combination with 400g fresh cactus tea was the most infinitely beautiful & powerful trip I have ever experienced in my life.

8] Sometimes LSD causes my mind to wander uncontrollably unless I take my own drive to focus, but with 1-acetaldehyde LSD there is no wandering thoughts, no tenseness or anxiety like with acid, this is deep mentally, a real gem, pure psychedelic bliss.

9) 400ug of 1-aceteldehyde LSD makes 400g of fresh boiled cactus pieces (no core, approximately 400mg mescaline) feel instead like 700mg of mescaline. I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead which is the dominance or habitat of mescaline & dmt & psilocin (see color chart post #1 of old long thread).

10) You can take this more often as it does not have the "extreme tolerance" of normal LSD which mainly works thru the 5-ht2a receptor (see color chart post #1), just like with cactus which you can take more often.

11) It is not a sacrilege to convert LSD to 1-acetaldehyde LSD cause Albert Hofmann also discovered ALD-52 at Sandoz labs. This is different from ALD-52 cause it has one extra hydrogen on the acetaldehyde adduct at the bottom indole NH group nitrogen. The table from Sandoz suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD-52 produced brain waves showing a more relaxed mental state. It also has "twice the anti-serotonin or serotonin blocking power" of normal LSD.

12) Before falling to sleep, I saw closed eye colored visions of architecture and gardens like those in Versailles, France.

13) LSD is more "analytical" and not as aesthetic, this feels more natural and is extremely aesthetic (beauty enhancing) like with mescaline.
-----------------------------------------------------------------------------
Final notes when working with mg seeds instead of LSD:

Penniclavine is found in extremely high amounts in the mg seeds & in claviceps paspali infected wild grass Paspalum distichum L, with the labile LSH a close second in both of them and binds to 5-ht1a, 5-ht2a, 5-ht6, 5-ht7, adrenal A2A, A2C, A2D, and most of the dopamine receptors.

We don't have radioligand binding data for LSH, we only know it is similar to LAE-32 in TIHKAL, in which human experiments were done, at 1.5mg it was stimulating & "LSD like".

LSD only binds to A2A in comparison (when in comes to adrenal receptors, note 11). When Yui & Takeo injected penniclavine & agroclavine into lab animals in 1958 they noticed the animals became stimulated like with LSD. Penniclavine is a metabolite of agroclavine. Glasser in 1961 noticed animals also became stimulated when injected with LSH. Dr. Glasser said some of the mice even stood on their hine legs and pressed on the noses of the mice in front of them, very peculiar.

Animal tests all point to LSH being an active psychedelic and it is indeed the closest thing to LSD found in nature, far closer than d-ergine (LSA). Owsley claims Hoffman himself told him that LAOH is very LSD-like. I totally agree.

As everyone knows, 2 drugs combined is more potent than just one.

A 2014 forensics paper from Paulke found no LSH in HBWR seeds, but only found LSA & iso-LSA (83-84%) & ergometrine (10-17%) & rest: lysergol, elymoclavine & chanoclavine. We know that MG has centuries of Shamanic use, while HBWR has no history of Shamanic use. HBWR only has history of medicinal use.

Sandgrease: "HBWR has more of a sedative effect compared to MG."

Nogal: "HBWR is more body related while MG seeds have effects more similar to LSD."
-----------------------------------------------------------------------
I did not discover this conversion, it was given to me by an ancient spiritually prominent Shaman in a vision, true story, see here:

Discovered 1992 adducts study the same week after receiving a 20 minute visit or "schooling" from an ancient powerful and spiritually prominent Aztec Shaman who appeared out of the shadows on a wall cast by a Christmas tree, this after girl and I both took 10 hits each of 15 year old decomposed acid given to me by a dear friend, true story. The acid had a sick feeling for the 1st two hours, but then it worked and skyrocketed us to higher divine plane.

The Shaman sat on a throne made of spirit animals (birds, otters, Jaguars, macaws, toucans) that morphed into other spiritual animals continuously. The Shaman stared intently into my eyes as if downloading information to me. What's even more amazing, is that the girl who was with me also saw the EXACT same vision on the wall.

The Shaman wore a huge beautiful headdress made of feathers, to the left and right of him stood female centaurs, half naked female above, half animal below. He showed me the rise and fall of several civilizations throughout time. I saw the great pyramid of the Aztec empire in the distance. The animated vision was beyond 4k, and highly detailed.

Behind the female centaurs were snakevines growing out of the ground. Before the Shaman left, he motioned to me with his eyes to look out the window in the living room to the patio, where I had an empty garden plot, he was trying to tell me to plant entheogenic plants. His point in showing me the rise and fall of the different civilizations was I believe he was trying to tell me "that if humanity is survive, the only hope is a Spiritual solution."

Don't forget that to the Aztecs, the morning glory plant was more important to them then their other 2 classical plants, peyote and mushrooms. Two sources given for this comment below.

Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37)."

Note (4) Psychotomimetics of the Convolvulaceae pg 93: "This particular plant seems to have been more important to the Aztecs in divinity then Peyotl or Teonanacatl, two of their other classical sacred plants."

Note (5) Jonathan Ott "Pharmacotheon": "Ololiuhqui was far more prominent as an entheogen here in Mesoamerica than those mushrooms; the mushrooms are mentioned only here and there by a few competent chroniclers; yet almost an entire book was devoted to denouncing mainly the ololiuhqui idolatry. The annals of the Inquisition contain many times more autos de fe for ololiuhqui than for mushrooms."

Note (22) The sources were clear that the kykeon's other ingredient, mint (menthe pulegium) was fresh mint. Mint appears to have played a symbolic role in Eleusinian myth; being Hades' concubine, Mint was "dismembered by the jealous wife Persephone." See Wasson, "The Road to Eleusis", 111.

In Ipomoea Tricolor vine: from Tryptophan-->chanoclavine-->agroclavine-->elymoclavine-->lysergic acid-->ergometrine-->LSH, which then decomposes over time into LSA.

2016 Polish morning glory study found 3x higher amounts of LSH in MG seeds direct from grower/producer vs retail:
Quote:

fresh black seeds from vine: likely 5.00 LSH to 5.00 penniclavine ratio
seeds direct from growers: 1.71 LSH to 5.08 penniclavine ratio
seeds off retail racks: 0.54 LSH to 4.75 penniclavine ratio



Vacuum pack & freeze freshly picked seeds to preserve potency indefinitely.

LSH (lysergic acid hydroxyethylamide) decomposes in neutral water solutions, and quickly in alkaline solutions, and also if heated, but it is quite stable in acidic environments (just like the solution recipe I give). Traditionally (e.g. as reported from Wasson) they only soaked the mushed seeds briefly in water, then strained and immediately drank. Even Hermes and Nogal (both extracted 400 to 500 seeds into cold acidic water using a squirt of lemon juice) both reported EXTREMELY VISUAL MG trip reports:

(1) Hermes (the Lycaeum):
Quote:

Cold water extract with squirt of lemon juice: Saw strong 4D lattice-like open eye visuals and warping and melting of furniture with only 400 seeds. There are around 32 to 36 seeds to a gram. I see amazing three and seemingly four-dimensional shapes morphing and bifurcating. Often I get religious and esoteric themed visuals, like fractal cherub wings and winged eyes like those in some of Alex Grey's work. Eyes are all over everything. I see pyramids and sphinxes and Gigeresque biomechanical forms. I see amazing geometric lattice structures. I watch mathematical space-filling algorithms doing their thing, all of this with nothing more than 500 seeds.



(2) Nogal (the Nook):
Quote:

Yes I know of someone who tried the CWE method with the Heavenly Blue variety, except with the substitution of a coffee grinder in place of a stone metate (I think that's what is called but I could be wrong), and a squirt of lemon in the water, with around 400-500 seeds. Closed and open eyed visuals were extremely breath taking. Some of the most prominent visions were of Aztec/Mayan glyphic patterns, a menacing and demonic technicolor nymph made of light who tried to seduce the viewer, and this bizare trail of energy spheres which each contained a different stylized animal form (again definately of Aztec/Mayan origin).



(3) Erowid report:
Quote:

400 older dried seeds is similar to a little less than one hit LSD. 400 fresh off vine is like about 2 or three hits.



Myself: 500ml cold spring water acidified to Ph=4 with DL tartaric acid extract on 400 fresh off the vine dark hard heavenly blue morning glory seeds that I grew in 3/4 miracle grow + 1/4 cow manure compost, fed 1 tablespoon miracle grow crystals dissolved into 1 gallon watering can w/spout once per month only, 22 years ago, added 1 shot of sherry & 5 drops peppermint extract, let sit in fridge 3 hours with swirling once per hour:
Quote:

Saw geometric patterns on the surface of everything, with closed eyes, colored vectors spun 360 degrees while traveling from left to right across visual plane. Sounds were not only amplified & music heavenly but audio hallucinations were produced, heavy euphoria component & very strong appreciation for beauty. Remember watching Scarlett Johansson interview on a small television and melting into the seat from her beauty amidst all the breath taking geometrics. Tripped hard as hell.



-----------------------------------------------------------------------
I am not a shaman, but I have been thru alot of the stuff Shaman's have gone thru, I have lost both my twin girls at birth, so I have no children, my beloved pet Shitzu died at only age 4 from continuous bladder stones for 6 months, he was unable to pee so many times, we had to rush him to vet, where he was put down. He visited both of us in a dream 2 days later to tell us he was alright in Heaven with a big smile on his face.

I have nearly died several times, once I was hit head on by a truck when driver ran a yield sign, I barely survived with numerous injuries.

I once took alot of acacia bark with Ayahuasca instead of the normal hawaiian psychotria I use, and went into a serious serotonin syndrome shock, for 1.5 hours I sweated my ass off sitting in the bathtub, I told my wife goodbye while my dog watched in a sad state..by some miracle I pulled out of it, I believe it was the high levels of maoi's in the acacia that interacted with the rima's in the Ayahuasca, bad combination. My forehead was pouring sweat for 1.5 hours, I was in severe shock and trembling, and knew I was gonna die.

Lost everything in a 100 year severe flood, my home and all my belongings, I had just gotten married and all the newlywed gifts perished...right after that I moved to an apartment complex, and 5 months later all my belongings again burnt to the ground after a dude had threw a lit blunt into the apartment complex after his girlfriend dumped him.

Had it not been for the policeman banging on the door of the apartment, we would have surely burned in the flames, as we were on the 3rd floor & asleep as I worked 2nd shift at the time. We ran down the steps in only our bare feet and suffered smoke inhalation.

Have been thru some %!%%, similar to a Shaman, who lives on the outskirts of society. Lifting weights, walking in nature with my dog, going to the waterpark with a season pass every summer, and reading the bible is all that keeps me sane some days.
-----------------------------------------------------------------------
Stay true to yourself, Peace, Love & Music.

https://www.friskyradio.com/


Edited by tregar (09/04/20 04:42 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26879045 - 08/13/20 06:27 PM (3 years, 5 months ago)

I will leave you with this...by the way I will be taking 1-acetaldehyde LSD again at 400ug this Friday for the 3rd time, this time in combination with 400g of fresh boiled cactus tea, as it's been 2 weeks.

This conversion also works on morning glory and HBWR seed extracts as explained earlier in this thread, the Mayans and Aztecs added the fresh or dried morning glory seed extracts to a drink containing wine or liquor, see notes section of this thread.

Downwardsfromzero:
Quote:

As I've mentioned, my most successful plant-derived lysergamide experience - in dreams, of course - albeit with HBWR, coincided with intake of a fairly large quantity of brandy which, in all likelihood, produced a significant level of acetaldehyde within my body, exposing the plant lysergamides to the correct conditions (as reported in the Austin & Fraenkel-Conrat PNAS paper) within my stomach for the putative 1-(1-hydroxyethyl) or, rather, it seems, the 1-(1-ethoxyethyl) derivative to be formed. In this case, the effects were clearly stimulating, unlike the sedative effects usually reported for HBWR. I see that brandy weighs in fairly well on the acetaldehyde content scale as well.

The neon-electric zingyness of LSD was all but absent, although there was a fractal overlay with eyes open. The overall feel was more earthy and organic. A wise, stern-but-kind voice within gave me most useful advice for several hours. This also contrasted with the 8 hours solid 'LMAO' that LSD so often provides. The divinatory use of this type of material makes absolute sense. I count this among the more significant entheogenic experiences of my life.



Norman at mycotopia also mentioned his powerful and very enjoyable experience when he extracted HBWR with wine and consumed. He said it was better then any other kind of extraction method by far.

And don't forget the comments by 69ron and Kash further up in this thread who combined the seed extracts with peppermint extract which contains 2mg acetaldehyde per 5 drops, they said the experiences turned into stimulating instead of sedating experiences, and were profoundly visual compared to normal extracts.

Krystle Cole from the book "Lysergic":
Quote:

"Isn't Ergot what Socrates used to take at Eleusis?" I thought it was kind of cool to be taking something that the founders of our democracy used to take, but that our current democracy has made illegal.

LSD chemist Todd Skinner replied "Yes, except for he did a water infusion of the ergot, instead of alcohol." Todd had prepared 6 jugs of ergot wine and stored them for many years.

Krystle Cole's "ergot wine" experience (several pages long) in the book "Lysergic", reported that she saw constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head.



It was so powerful that it was the only time Krystle said Todd would say a Prayer before ingesting, he never said a Prayer with any other substance.

How is this for alchemy? The Greek Priest & ancient Aztec & Mayans were not the only ones to transform their brews. Dr. Shulgin in an issue of the "Entheogen Review" in the "Questions to Dr. Shulgin section" describes how harmaline gains 2 hydrogen atoms from Vitamin C doner (same way Santo Daime brew their Ayahuasca for long periods with added vitamin C) transforming all the sleepy dreamy harmaline in their brews into the stimulating, euphoric & colorfully visual anti-serotonin alkaloid tetrahydroharmine, via an Alchemy process, Note (27). All of their brews shown in table 1 had zero mg harmaline left.

In a similar way LSH & LSA & LSD in the thread's recipe brew are transforming to their stimulating doubly anti-serotonin, highly visual + audial, very euphoric + more colorful, zero anxiety, tenseness & wandering thoughts, more aesthetic beauty enhancing cousins 1-acetaldehyde LSH & 1-acetaldehyde LSA & 1-acetaldehyde LSD via the donation of acetaldehyde under proper acidic conditions.

Remember ALD-52 was shown by Sandoz labs to have "double the anti-serotonin power of LSD" and the more serotonin blocking, the more stimulating. The liver-produced Coca-ethylene from cocaine in coca leaf tea bags (5mg per tea bag) soaked in wine (and the wine drunk) is another example of a powerful anti-serotonin alkaloid which is highly stimulating. Cocaethylene has a higher affinity for the dopamine transporter than does cocaine. Cocaethylene produces euphoria and has a longer duration of action than cocaine.

Note (27) Callaway, James C. (June 2005). "Various alkaloid profiles in decoctions of Banisteriopsis caapi." See wikipedia page on tetrahydroharmine in references at bottom, Page 154: "The average ratio of THH to harmine in the Santo Daime brews was consistently near 1:1, from all sources (Table 2), while the ratio was closer to 1:5 in a large survey of the source plant material (B. caapi)." Page 154 describes the process of conversion under acidic conditions with chemical diagrams.

Here are just a few of the other topics I have posted about:

1) How to convert the research chemical 4-aco-dmt (which I don't like) to 4-ho-dmt (actual psilocin)

2) Was the first to show how to complex the nbome's with the super cheap HPBCD (hydroxy propyl beta cyclodextrin) to create a bioavailable form of the drug that could be absorbed readily under tongue. HPBCD is the basis behind the highly popular "Febreze" to trap odors and dispose of them as well. Nearly all the suppliers of nbome's in the world took my idea and marketed them as such. I regret that decision as I hate the man-made drug 25i-nbome. I flushed all mine down the toilet.

3) How to create a 100% nausea free Ayahuasca brew to the stomach & intestines using cotton ball in a funnel filtering. The cotton ball and funnel are the best invention since the toothbrush. Yes, Coffee filters are useless as they allow nothing through.

What I'm trying to say is that I would not post about this 1-acetaldehyde LSD if it did not work. Why would I invest so much time and effort to convey this discovery if it had no merit?

Vecktor:
Quote:

Tregar you have probably rediscovered something that has long been a curiosity....the morning glory extract treated with acetaldehyde-methanol without the water showed a clear difference in the alkaloid profile, with a shift to several new non polar spots which couldn't be identified. IIRC Erhlichs was used to develop the plates so these were indole compounds.




Edited by tregar (08/13/20 06:30 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26879203 - 08/13/20 08:23 PM (3 years, 5 months ago)

:eek:


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Sabnock] * 1
    #26879292 - 08/13/20 09:52 PM (3 years, 5 months ago)

Quote:

Sabnock said:
One must also take into consideration the influence of various compounds on the Psychedelic in question. It's not necessarily that a compound is turning into a different compound, it could just be that something that is being mixed with the compound is altering it's characteristics/flavor/feel, the quality/nature of the experience/effects. It's more easily done than one would think.




Very true. It could also be purely placebo -- it could be the ritual of the preparation itself that's altering the experience.  Without analytical data and blinded dosing, it's all just speculation. The blinded dosing is critical because even if analytical data confirm the formation of the indole N-adduct, chemistry principles suggest the product is a prodrug, so without a blinded study, you can't rule out the possibility that perceived differences in the effects are entirely subjective.


Edited by breeg89 (08/13/20 09:59 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26881399 - 08/15/20 10:24 AM (3 years, 5 months ago)

namaste said:
Quote:

Might have a go this weekend, all depends on my fragile mental health.  Been eating doses 25+ years.  Lots of work drama, we shall see.



You will find that your mental health will thank you after trying this at 300ug, just yesterday (Friday night) again took 400ug of the 1-actealdehyde LSD with 400g of fresh boiled cactus tea, once again, was blown away by the power of this.

Namaste, thanks for trying this out...you will find this is easy on your mental health...There is Zero anxiety, zero tenseness, zero wandering thoughts, no "neural overload" feeling like with normal LSD...deep mental space, pure psychedelic bliss. Replacing the "electricity" of LSD with calm, profound beauty enhancement to the nth degree and visuals way beyond normal LSD.

The comeup is smooth and relaxing like with cactus, no sudden drop off like with acid as it lasts much longer than acid with a warm gentle transition back to reality over a long period of time. Like a long warm hug and embrace.

With closed eyes, high speed movies played in color in the visual plain, flowers, animals, beautiful people, vast meadows and gardens, grand architecture including palaces and interior decorations within them. I climbed the steps of one of these palaces surrounded by art carvings of animals to the left and right of all the steps leading up to the entrance. Mind blowing visions.

With open eyes, colors were once again out of this world and impossible for hours on end, the beauty was infinite as patterns formed everywhere and inside the tracers when I moved my hand I once again saw colored fractals inside them, extremely powerful visuals and transcendence. I never see fractals inside tracers on normal LSD, just shadows of the hand.

This is the only way I will take acid from now on till I die. Extremely beautiful experience with none of the side effects of normal acid.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26881508 - 08/15/20 11:36 AM (3 years, 5 months ago)

namaste said:
Quote:

Might have a go this weekend, all depends on my fragile mental health.  Been eating doses 25+ years.  Lots of work drama, we shall see.



You will find that your mental health will thank you after trying this at 300ug, just yesterday (Friday night) again took 400ug of the 1-actealdehyde LSD with 400g of fresh boiled cactus tea, once again, was blown away by the power of this.

Namaste, thanks for trying this out...you will find this is easy on your mental health...There is Zero anxiety, zero tenseness, zero wandering thoughts, no "neural overload" feeling like with normal LSD...deep mental space, pure psychedelic bliss. Replacing the "electricity" of LSD with calm, profound beauty enhancement to the nth degree and visuals way beyond normal LSD.

The comeup is smooth and relaxing like with cactus, no sudden drop off like with acid as it lasts much longer than acid with a warm gentle transition back to reality over a long period of time. Like a long warm hug and embrace.

With closed eyes, high speed movies played in color in the visual plain, flowers, animals, beautiful people, vast meadows and gardens, grand architecture including palaces and interior decorations within them. I climbed the steps of one of these palaces surrounded by art carvings of animals to the left and right of all the steps leading up to the entrance. Mind blowing visions.

With open eyes, colors were once again out of this world and impossible for hours on end, the beauty was infinite as patterns formed everywhere and inside the tracers when I moved my hand I once again saw colored fractals inside them, extremely powerful visuals and transcendence. I never see fractals inside tracers on normal LSD, just shadows of the hand.

This is the only way I will take acid from now on till I die. Extremely beautiful experience with none of the side effects of normal acid.

Hey Traeger
Quote:

Got a good mindset going.  300 sounds reasonable, 400 excessive as I usually go with 100-200.  Just picked up a bottle of cooking Sherry and a bottle of peppermint extract.  Blast off at 7pm central time. These are the Ric and Morty blotters, pretty confident that they're at least 100mcg.


Yes, Namaste! Thanks for trying this...300ug is PLENTY! My calculations are off, 400ug is not necessary, this I discovered after my 3rd experiment with this. Mine are extremely pure 100ug, they were run thru the purification chromatography column twice according to where they came from.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: downwardsfromzero]
    #26882779 - 08/16/20 05:14 AM (3 years, 5 months ago)

Quote:

What is gonna take for you guys to stop talking about it, and JUST TRY IT !!!


Thanks to you, I've located my I tricolor seeds and they're sprouting as best they can (a bit old). Fingers crossed I'll be testing the Eleusinian formula later this year.

As for trying this specific version relevant to this thread - obtaining actual LSD is out of the question for me at the moment although I do have a small amount of a closely related 1-acylated ergoloid that I'm willing to put through the process as some kind of active control.

That boils down to a question of time scheduling.

I wonder how this method might impact the effects of other things - that is to say, what would happen if DMT or psilocin was dissolved in peppermint sherry (and how about Crème de Menthe?), or even a non-indole such as mescaline?

Gathering of experiential data is a bit of a minefield - some minds are more forgiving of persistent alteration than others - and appropriate tolerance and integration breaks, out of necessity, have their place.

I'm eager to contribute my own experiential data to this question but the actual process is heavily constrained by logistical factors. In the meantime, my ongoing output of questions and nuances is done in the hope of inspiring directed experimentation in those with the opportunity to do so.


--------------------
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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: downwardsfromzero]
    #26882863 - 08/16/20 07:04 AM (3 years, 5 months ago)

namaste said:
Quote:

The Love is soaking, got a little zesty, overswirled and spilt a tiny bit.  Have you considered sending to EC for a MC/GS?  I think it's the only way to actually prove the molecular structure has been altered.


Yes, be careful, just swirl lightly, and put a saran wrap or foil on cover of shot glass to prevent spill over.

We have proof already that the conversion is happening with morning glory seed extract, see here:

Vecktor (advanced chemist):
Quote:

Tregar you have probably rediscovered something that has long been a curiosity....the morning glory extract treated with acetaldehyde-methanol without the water showed a clear difference in the alkaloid profile, with a shift to several new non polar spots which couldn't be identified. IIRC Erhlichs was used to develop the plates so these were indole compounds.


So glad to hear Vecktor, thanks. It takes time for the new product to form when there is water involved--->the researchers achieved a 100% new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution, with a 1.5 hour soak time with stirring. It just so happens that sherry wine is already at ph=4 just like the study calls for. Researchers said "the lower the PH, the faster the reaction."

Breeg89 said:
Quote:

the finding that ALD-52, 1P-LSD, and 1B-LSD show 5-10-fold reduced 5-HT2A binding affinity compared to LSD in vitro.

the finding that giving rats ALD-52 or 1P-LSD produced high concentrations of LSD in the blood.

the finding that giving rats ALD-52, 1P-LSD, or 1B-LSD initiated the characteristic psychedelic head-twitch response (despite dramatically reduced 5-HT2A binding affinity in vitro).



1. Like I said, 1-acetaldehyde LSD does not work thru the 5-ht2a receptor, but rather shifts the receptorome or radio ligand binding "away from 5-ht2a" and towards the adrenal A2A, A2B & A2C receptor binding which is the dominace or habitat of mescaline, dmt, and psilocin, see color chart on page 1. That's why 1-acetaldehyde LSD is more colorful, zero anxiety & tenseness, more visual, amazing mental headspace.

2. This is not an experiment done with rats, this is a human experiment. We are not giving a rat a shot of sherry wine with LSD dissolved with 5 drops of peppermint extract, did you forget to read my post earlier which shows that menthol is the highest ingredient in peppermint extract, which shuts down the cytochrome P450 enzyme in the liver which is involved in the metabolism of external chemicals? This has the potential effect of preventing the breakdown of 1-acetaldehyde LSD.

3. This works, I have taken acid HUNDREDS of times in 15 years, there is no mistaking 1-acetaldehyde LSD with acid, completely different, see my 13 comments on how this is different from LSD further up.

downwardsfromzero said:
Quote:

Thanks to you, I've located my I tricolor seeds and they're sprouting as best they can (a bit old). Fingers crossed I'll be testing the Eleusinian formula later this year.

As for trying this specific version relevant to this thread - obtaining actual LSD is out of the question for me at the moment although I do have a small amount of a closely related 1-acylated ergoloid that I'm willing to put through the process as some kind of active control.

That boils down to a question of time scheduling.

I wonder how this method might impact the effects of other things - that is to say, what would happen if DMT or psilocin was dissolved in peppermint sherry (and how about Crème de Menthe?), or even a non-indole such as mescaline?

Gathering of experiential data is a bit of a minefield - some minds are more forgiving of persistent alteration than others - and appropriate tolerance and integration breaks, out of necessity, have their place.

I'm eager to contribute my own experiential data to this question but the actual process is heavily constrained by logistical factors. In the meantime, my ongoing output of questions and nuances is done in the hope of inspiring directed experimentation in those with the opportunity to do so.



Thanks downwardsfromzero! I'm so glad to see you back with another post!

Typewritermonkey said:
Quote:

Tregar is it the same potency as LSD, or less potent?  Because 300-400ug of LSD-25 to me is a very huge dosage.



See below...

Thanks for trying this in the future Typewritermonky! Here is another trip report with ALD-52 vs LSD (not from me) which will help others understand the differences, and why a higher dosage is necessary:

Quote:

hxxps://www.reddit.com/r/LSD/comments/4yn8ou/highly_underestimated_ald52/

"Yes, I realize it's not technically LSD but really, it might as well be. I took 300ug thinking it would be mild if anything. Granted it wasn't as intense mentally as LSD can sometimes be, but conceptually and aesthetically it is beautiful beyond anything I ever anticipated. I feel perfect. At one. Better than I've felt in so long. I thought I could never trip again on anything but this is honestly paradigm changing for me. ALD-52 should be considered just as powerful as LSD-25 although it's a lot more relaxed and somewhat forgiving. As it is probably apparent I'm still very deep into this experience and I hope this to be an open discussion to anyone who would like to be involved.

My god, I just went through multiple ego death experiences beyond anything I've ever experienced from LSD before. There are no words. I mean there are plenty of "words" but none of them mean a single thing compared to any of THAT. Dear GOD. I never expected anything like this, but I sure as hell needed it. Even if I'm the only one here to express it to, as that's realistically the truth of nature anyhow. However, anyone who felt compelled to actually read through all this insanity, I just want you to know you're beautiful and you are everything. All things are right and they always will be.

Anyway, as far as the ALD-52, I took 300ug as I said. It was amazing and stronger than I expected, however I don't think 100ug would be very eventful to be perfectly honest. If you're concerned about it being too strong 200 might be worth it but 300 was really a great amount if you ask me. Even if you haven't taken any lysergamides before ALD-52 is rather calm compared to LSD or even mushrooms for the most part. Visually though, at least for me, it was absolutely breathtaking. Colors and textures were shifting like crazy.

Everything was alive and magical. Patterns were forming everywhere. I could lose myself so easily as the visuals seemed to drag my focus in without any effort. As a result, ego death was basically automatic and I reached that point multiple times. The first time I ever experienced ego death on LSD it left me with this beautiful feeling, like a deep inner glow that lasted for months afterwards. It eventually faded and I hadn't felt anything quite like it in years, but ALD-52 brought it back, and I feel like I've awakened from a spiritual coma.

Another thing is LSD sometimes causes my mind to wander uncontrollably unless I take my own initiative to focus, especially during the come up which can also sometimes fill me with restless confusion. Once I peak everything usually evens out, but ALD-52 put me in a state of perfect clarity from beginning to end. The come up was so smooth and comfortable.

I didn't notice the come down because I actually went to sleep when I felt like it was time to do so, which was an interesting surprise. Every time I've taken LSD I've had to let it run its entire course before even attempting to sleep. Often I would have to stay up for the entire day after which is obviously physically and mentally exhausting. But once I felt like the ALD-52 had made its point I went to sleep just like any other day, and woke up the next morning fully rested and mentally clear.

Overall, it felt very natural and I never had a single moment of uncomfortability or confusion. Just pure psychedelic bliss. I mean, I've had some amazing and extremely important experiences on LSD but honestly after the other night, think I prefer ALD-52. It felt like tripping for the first time again.




A few more comments from reddit, there are actual "fan clubs" devoted to ALD-52 over there, but keep in mind 1-acetaldehyde LSD has one more hydrogen atom on adduct than ALD-52, so it is even different from that:

Quote:


It's practically extinct! ALD52 is my favorite thing over even LSD and the site I used to get it from shut down.
-----------------------
ALD-52 is probably most similar to LSD relative to the other analogues (of which I have only tried ALD-52). The headspace is markedly psychedelic, it lasts 12 hours and the visuals are prominent enough. They seemed to take on a more flowing characteristic than LSD, to where I'd see objects form within the patterns.

I find it has a more mellow vibe than LSD, I'm more content to sit back and relax whereas 1p is supposedly closer to the electricity of LSD.

For what it's worth, I found the come down of ALD-52 to be better than LSD... it just felt more refreshing, like a warm hug and it tapers off gently whereas LSD is more of a sudden drop off into sobriety, but the actual peak of LSD feels more... alive to me. like my consciousness is oscillating at a super high vibration.
-----------------------
I find it's also less prone to creating anxiety. Becuase of this, I feel like I can take much higher doses and go much deeper. I took 5 tabs and experienced absolutely no anxiety at all. I don't think I would have been able to to do the same with LSD-25.
-------------------------
Hmmm. I seem to get much more euphoria from ALD over LSD or 1p. But yes, the anxiety levels are consistently low with this chemical. ALD is an absolute gem.
-------------------------
Agree. I feel like it's a subtle power, not as forceful as 1p. But there's genuine depth to it.
-------------------------
I'll be the first to admit it may be placebo, but I also favor ALD-52 for this reason.
-------------------------
I dosed ALD52 like 100+ times throughout the last 4 or 5 years, in doses between 25ug and 350ug.

While ALD52 is very similar to LSD25, I think I can still see a slight difference. To me the visuals are different, especially the tracers. I can clearly see a difference there.

With 200ug+ of ALD52, when I move my hand it shows some very colorfull spirals and fractals in the tracer /smearing.

While with LSD25 it is just a mirroring effect that shows several of my hands. Not nearly as colorfull, just a non colored shadow (or several) of the real hand.

With ALD52 it's much more colorfull and intense, like painting the air with rainbow colors.

100ug or even 150ug don't really show a difference at all to LSD25, but with 300ug and above (my highest dose was 350ug) the differences are even more intense.

With 350ug I can hardly see reality anymore due to all those colorfull reflections of anything I look at.

I think the higher the dose the clearer the differences.




namaste said:
Quote:

Might have a go this weekend, all depends on my fragile mental health.  Been eating doses 25+ years.  Lots of work drama, we shall see.


You will find that your mental health will thank you after trying this at 300ug, just yesterday (Friday night) again took 400ug of the 1-actealdehyde LSD with 400g of fresh boiled cactus tea, once again, was blown away by the power of this.

Namaste, thanks for trying this out...you will find this is easy on your mental health...There is Zero anxiety, zero tenseness, zero wandering thoughts, no "neural overload" feeling like with normal LSD...deep mental space, pure psychedelic bliss. Replacing the "electricity" of LSD with calm, profound beauty enhancement to the nth degree and visuals way beyond normal LSD.

The comeup is smooth and relaxing like with cactus, no sudden drop off like with acid as it lasts much longer than acid with a warm gentle transition back to reality over a long period of time. Like a long warm hug and embrace.

With closed eyes, high speed movies played in color in the visual plain, flowers, animals, beautiful people, vast meadows and gardens, grand architecture including palaces and interior decorations within them. I climbed the steps of one of these palaces surrounded by art carvings of animals to the left and right of all the steps leading up to the entrance. Mind blowing visions.

With open eyes, colors were once again out of this world and impossible for hours on end, the beauty was infinite as patterns formed everywhere and inside the tracers when I moved my hand I once again saw colored fractals inside them, extremely powerful visuals and transcendence. I never see fractals inside tracers on normal LSD, just shadows of the hand.

This is the only way I will take acid from now on till I die. Extremely beautiful experience with none of the side effects of normal acid.


Edited by tregar (08/16/20 10:15 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26885466 - 08/17/20 05:51 PM (3 years, 5 months ago)

We now have confirmation :thumbup: from another person here at Shroomery that this works (see other drug discussion or ODD part of forum):

Namaste said:
Quote:

I think you're on to something here.  It was extremely chill.  Soft around the edges.  When I started coming down, it felt like 10 years of therapy.

I remembered good times, felt compassion.  Listened to music I haven't listened to in years.  Thought about friends, was at peace in a way that I haven't felt before.

The stars formed into animated constellations.  My Bodhi statue began to juggle.  I saw the Perseidies meteors not just out of the corner of my eyes but right over my face while lying in a hammock.  Saw the entire movement from start to finish.  They looked like giant arrows.

Stayed awake all day, went out to visit friends.  It was very happy nostalgia.  Sometimes larger doses make me totally black out.  Not this time, I was awake and aware.  No primal fear or paranoia.

TWM
I used McCormick brand peppermint, not spearmint, and Holland House brand Sherry.  It did feel 'altered', seems to extend the duration too.  Felt like I was still peaking seven hours after dropping.  Sometimes I get a cracked out, confused feeling, not this time.

Haven't seen neon colors like that since the one and only time I was puddled.

Sunday's are generally filled with dread and depression for the following week.  Experienced none of that.  Just a long lasting afterglow.  Still in a great mood now.  I did get a pretty severe headache but I also drink like it's my job, and I am on a SSRI.

Been thinking about Ephesus and Pergamon, not sure if thats subliminal or coincidence.  :shrug:

Going to wait 3-4 months and repeat.

Give this a go!



Thank you Namaste!:smile: :smile: :smile: Namaste converted 300ug.

Just add Sherry wine and peppermint extract (any brand will do, even McCormick's) to your wife's grocery list. Peppermint extract is found in the spices and extracts isle. Your wife will look at you like WTF? Just tell her you are doing an experiment like the ancient Aztecs and Mayans in South America and Greek Priest used to do at Eleusis in Greece for over 2,000 years. When she tells you "don't ever say that I don't do anything for you". Just tell her "thanks!"

Taylor brand sherry is virtually everywhere, it's the only brand of Sherry wine my grocery store carries. One bottle will last you a lifetime. It is at ph=4 like the 1992 adducts study calls for, and it contains average 5mg acetaldehyde per 15ml or 1/2 shot glass like we use in the experiment, just like what the study requires (around a 0.1% acetaldehyde solution).

There is a picture of the Sherry wine in pic #1 on post #1, right behind two of the home grown cactus I grew and cut from top of existing cactus. I have found out I like to take 300 to 400ug of the 1-acetaldehyde LSD with 400g fresh (no core) of the cactus (equivalent of 400mg mescaline) cause it makes it feel like 700mg of mescaline. Whereas LSD + cactus just feels like "acid + cactus" nothing too terribly special of a combination, but the 1-acetaldehyde LSD with cactus--->now that is something very special.

Below the pic of the Taylor brand sherry and cactus you will see "double morning glory planters". Each planter is 17" wide x 15" tall with 7 foot tall round welded fence, each contain 15 plants. When I first brought the planter and fence home, my wife looked at me like I was crazy, like the scene in "Close encounters of the 3rd kind" where Richard Dreyfus raids his neighbors's chicken coop for a piece of fence to build a replica of the "Wyoming Devil's Tower." This same experiment also works with cold water acidified extracts of morning glory seeds, transforming the LSH and penniclavine to 1-acetaldehyde LSH & penniclavine. I did this same thing over 22 years ago with mg seeds.

The ancient Aztec and Mayan also normally added the fresh or dried morning glory extract to wine or liquor as well, notes Shultes on page 515 of "Encyclopedia of Psychoactive Plants" by Ratsch. The ancient Greek Priest would add fresh mint to the entheogenic brew consisting of fresh claviceps paspali which contains high levels of LSH when fresh as well, transforming the LSH to 1-aceteldehyde LSH, as mint contains 2mg acetaldehyde per 5 drops mint or peppermint extract.

The ancient Aztec & Mayan & Greek Priest were not the only ones to transform their brews...Dr. Shulgin shows how the beta-carboline harmaline transforms into tetrahydroharmine when a vitamin C doner is added to long standing boiling brew...as it donates 2 hydrogen atoms at the indole "N" position, transforming to "NH" as the sleepy dreamy harmaline transforms to the stimulating, euphoric and colorfully visual alkaloid tetrahydroharmine or thh in an issue of "Entheogen Review" questions and answers section with Dr. Shulgin.

This is done by the Santo Daime vegetal group, as none of their brews contain any leftover harmaline (they brew for long periods with added vitamin C) see paper on this at bottom of references under wikipedia entry for tetrahydroharmine by Dr. Callaway 2005. See page 154 with chemical diagrams showing addition at indole N (nitrogen) position to "NH": https://catbull.com/alamut/Bibliothek/various%20alkaloid%20profiles%20in%20aya%20decoction.pdf

Notice the similarity of what is happening above at the nitrogen N position of the indole on the betacarboline harmaline --> transformation to tetrahydroharmine as what is theoretically happening at the nitrogen NH group position of the bottom indole of the ergoline LSD as well, via the donation of acetaldehyde under proper ph=4 acidic conditions over a several hour period with sitting/stirring once per hour.

From Sandoz Labs, where Albert Hofmann also discovered ALD-52:
Quote:

Sandoz labs suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD-52 produced brain waves showing a more relaxed mental state.

It was also found to display "twice the anti-serotonin or serotonin blocking power" of normal LSD.

ALD-52 is listed as having a lower (approximately 1/5) intravenous toxicity (in rabbits), a lower approximately one eighth pyretogenic effect, and double the "antiserotonin" effect as compared with LSD. Human experiments have not been well documented.




I have made 1-acetaldehyde LSD at the 300ug dosage, 400ug dosage, and again at the 400ug dosage, all spaced about 2 weeks apart...

There is Zero anxiety, zero tenseness, zero wandering thoughts, no "neural overload" feeling like with normal LSD...deep mental headspace, pure psychedelic bliss. Replacing the "electricity" of LSD with calm, profound beauty enhancement to the nth degree and visuals beyond normal LSD.

LSD feels "man-made" to me and is "analytical" and not very aesthetic, whereas 1-acetaldehyde LSD feels very natural, primitive and infinitely aesthetic (beauty enhancing) like with cactus.

The comeup is smooth and relaxing like with cactus, no sudden drop off like with acid as it lasts much longer than acid with a warm gentle transition back to reality over a long period of time. Like a long warm hug and embrace.

With closed eyes, high speed movies played in color in the visual plain, flowers, animals, beautiful people, vast meadows and gardens, grand architecture including palaces and interior decorations within them. I climbed the steps of one of these palaces surrounded by art carvings of animals to the left and right of all the steps leading up to the entrance. Mind blowing visions.

With open eyes, colors were once again out of this world and impossible for hours on end, the beauty was infinite as patterns formed everywhere and inside the tracers when I moved my hand I once again saw colored fractals inside them, extremely powerful visuals and transcendence. I never see fractals inside tracers on normal LSD, just shadows of the hand.

Appreciation of the beauty of the two on-screen actresses from "to the stars" (new movie on hulu) was euphorically over the top, similar to tripping on cactus. Like being in Heaven, beauty is perceived as being infinite and divine.

This is the only way I will take acid from now on till I die. Extremely beautiful experience with none of the side effects of normal acid.

I did not discover this study, I was directed to it via a vision from a spiritually prominent Shaman, see story further up in post #1. He wanted humanity to know about it.


Edited by tregar (08/18/20 04:10 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26887706 - 08/19/20 04:14 AM (3 years, 5 months ago)

Namaste said:
Quote:

I think you're on to something here.  It was extremely chill.  Soft around the edges.  When I started coming down, it felt like 10 years of therapy.

I remembered good times, felt compassion.  Listened to music I haven't listened to in years.  Thought about friends, was at peace in a way that I haven't felt before.

The stars formed into animated constellations.  My Bodhi statue began to juggle.  I saw the Perseidies meteors not just out of the corner of my eyes but right over my face while lying in a hammock.  Saw the entire movement from start to finish.  They looked like giant arrows.

Stayed awake all day, went out to visit friends.  It was very happy nostalgia.  Sometimes larger doses make me totally black out.  Not this time, I was awake and aware.  No primal fear or paranoia.

TWM
I used McCormick brand peppermint, not spearmint, and Holland House brand Sherry.  It did feel 'altered', seems to extend the duration too.  Felt like I was still peaking seven hours after dropping.  Sometimes I get a cracked out, confused feeling, not this time.

Haven't seen neon colors like that since the one and only time I was puddled.

Sunday's are generally filled with dread and depression for the following week.  Experienced none of that.  Just a long lasting afterglow.  Still in a great mood now.  I did get a pretty severe headache but I also drink like it's my job, and I am on a SSRI.

Been thinking about Ephesus and Pergamon, not sure if thats subliminal or coincidence.  :shrug:

Going to wait 3-4 months and repeat.

Give this a go!


Namaste thanks a million for your report, you are the 2nd person on the planet besides myself to give this a go.

So cool Namaste that you watched the meteor shower outside, as the Perseidies are active every year from July 14 to August 24, according to NASA. You also mention that you saw "neon colors like you have not seen in ages" and that "you did not experience the depression which sometimes follows days later".

That's another thing I love about this 1-acetaldehyde LSD, it is extremely colorful, way more colorful than acid, more similar to mescaline in that respect. For hours with open eyes I see impossible out of this world neon colors, reminds me of Ayahuasca or Mescaline with the colors. I have made this at 300ug, 400ug, and again at 400ug, all spaced around 2 weeks apart. I also do not experience the typical mood drop 2 days later, but still feel pretty darn good days later...I also like the fact that it last around double the time that acid does, I am also still peaking way past 4 hours later..I get "double the fun" out of this compared to acid. I never liked the way acid ended so abruptly, I prefer how this last way longer, just like cactus which lasts way longer than acid. I am taking this again for the 4rth time tonight, as I work all weekend, and today and tomorrow is my "weekend" as I work long shifts.

I have a strong suspicion that  1-acetaldehyde LSD does not work thru the 5-ht2a receptor, but rather shifts the receptorome or radio ligand binding "away from 5-ht2a" and towards the adrenal A2A, A2B & A2C receptor binding which is the dominace or habitat of mescaline, dmt, and psilocin, see color chart on page 1. That's why 1-acetaldehyde LSD is more colorful, zero anxiety & tenseness, more visual, amazing mental headspace.

LSD feels "man-made" to me and is "analytical" and not very aesthetic, whereas 1-acetaldehyde LSD feels very natural, primitive and infinitely aesthetic (beauty enhancing) like with cactus. LSD induces "intense concentration" and "anxiety" whereas this produces "over the top" appreciation for beauty and profound visuals similar to how mescaline takes these same qualities to the nth level.

TWM said:
Quote:

Also tregar, please do not take my posts as "doubt".  I have followed your posts immanently since 2012 when you discovered HPBCD coupling with 25i's for oral.  And as an amazing discovery as that was, and revolutionzed the world - it was ended up being only a scientific discovery because those series were awful.

But regardless, here I am immanently following all your posts, and this one.  And I hope that if this legitimate, you will let me help you realize that with empirical and concrete evidence.  Empirical in the sense that I have a distinct gift for psychedelic sensitivity as well as many powers to concretely prove this if possible.

I am very excited to host this experiment as soon as possible.


I look forward to hearing your results, glad you have 500ug soaking (you said you were going to take 1/2 of it), just use 5 drops of the McCormick's brand peppermint extract or whatever you can find at grocery store.

Note (1): Make sure your sherry wine is cold before you use it, it contains 5 mg acetaldehyde per 15ml or 1/2 shot glass. Acetaldehyde boils off at 68 degrees F, or slightly below room temp, so keep 1/2 shot glass of it in fridge at all times until you consume. It is also at ph=4 which is what 1992 adducts study calls for, researchers said "the lower the ph, the faster the reaction."

Note (2): Menthol is largest ingredient in peppermint extract and causes cytochrome P450 enzyme inhibition in the liver, which is involved in the metabolism of exogenous chemicals. This may have a potential effect in preventing the breakdown of 1-acetaldehyde LSD. Peppermint extract also contains 2mg water soluble acetaldehyde per 5 drops.

See my comments above how Dr. Shulgin explains how the betacarboline harmaline converts to tetrahydroharmine via the donation of 2 hydrogen atoms from "vitamin C doner" via stirring and boiling for many hours, same way Santo Daime brew their Ayahuasca for long periods with added vitamin C, tables and charts & link to paper given above with chemical diagram explaining the chemical conversion process via the addition at the indole "N" position, changing to "NH".

See my story on Post #1 (page 1) about how a Shaman lead me to the 1992 adducts study in a 20 minute vision, He wanted all of humanity to know about this, as this is the way the Aztecs would prepare their morning glory seed extract, normally adding it to liquor for the conversion to happen either externally or "in vivo" in the liver.

Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37)."


Edited by tregar (08/19/20 04:44 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26888233 - 08/19/20 11:36 AM (3 years, 5 months ago)

If you don't hear from me again, it's because my other love is bodybuilding, been lifting weights since age 22, 220lbs, 12% bodyfat, competed in several competitions. I believe in physical, mental & spiritual health all working together. Better living thru chemistry. You may have seen me, been on cover of Twinlab's "Ironman" in my early 30's, posed with 2 women on the cover. Was a professional lifeguard for a decade.

Stay true to yourself, peace, love & music

http://friskyradio.com

Not me below, but showing Ironman magazine so you know what it looks like.


Edited by tregar (08/19/20 11:51 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26888776 - 08/19/20 04:33 PM (3 years, 5 months ago)

Once again, I overshot. 300ug is all you need of this, PLENTY STRONG for any occasion.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26889250 - 08/19/20 10:14 PM (3 years, 5 months ago)

Namaste said:
Quote:

Haha

Thanks for sharing the recipe.  I really do believe that there is a conversion into a new substance, that it's acting on different receptors.  That was one of the best trips of my life and I dose several times/year.

Blessed be




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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26889461 - 08/20/20 05:25 AM (3 years, 5 months ago)

I go back and forth between shrooms and acid every month or two. I have been on an acid kick lately and have a three day camping trip next week. If I can get the supplies together before then, I will definitely give this a go. My tabs are supposedly 150 ug but I have sincere doubts so considering going with 2.5 tabs. Will definitely report back if I make it happen.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Sharp-Inflation]
    #26894867 - 08/23/20 07:16 AM (3 years, 5 months ago)

Thanks for trying this out Sharp-Inflation.

Before I leave, just wanted to say:

gannetsarewe said:
Quote:

So has anybody else tried this. I don't want to waste my scarce acid or have to drink the rest of my bottle of sherry wine, not sure which is worse.



You're acid will not be wasted, when dissolved into wine, it does not disappear or disintegrate. It will remain 100% active, only it will be converted to a completely different substance after 3 hours with far reaching different activity from normal LSD. 1 bottle of sherry wine will last a lifetime, as will the peppemint extract. Read again above what Dr. Shulgin saids happens at the indole N position of the betacarboline harmaline, converting to "NH" with the donation of 2 hydrogens from vitamin C doner, transforming into tetrahydroharmine over several hours in acidic conditions. Here we are doing the same thing, only using "acetaldehyde donor" at the indole NH position.

If you don't want to believe me then listen to Namaste (he took acid hundreds of times in the past, just like myself, his full trip report is below with 300ug of 1-acetaldehyde LSD):
Quote:

Thanks for sharing the recipe. I really do believe that there is a conversion into a new substance, that it's acting on different receptors. That was one of the best trips of my life and I dose several times/year.

Blessed be

I think you're on to something here. It was extremely chill. Soft around the edges. When I started coming down, it felt like 10 years of therapy.

I remembered good times, felt compassion. Listened to music I haven't listened to in years. Thought about friends, was at peace in a way that I haven't felt before.

The stars formed into animated constellations. My Bodhi statue began to juggle. I saw the Perseidies meteors not just out of the corner of my eyes but right over my face while lying in a hammock. Saw the entire movement from start to finish. They looked like giant arrows.

Stayed awake all day, went out to visit friends. It was very happy nostalgia. Sometimes larger doses make me totally black out. Not this time, I was awake and aware. No primal fear or paranoia.

TWM
I used McCormick brand peppermint, not spearmint, and Holland House brand Sherry. It did feel 'altered', seems to extend the duration too. Felt like I was still peaking seven hours after dropping. Sometimes I get a cracked out, confused feeling, not this time.

Haven't seen neon colors like that since the one and only time I was puddled.

Sunday's are generally filled with dread and depression for the following week. Experienced none of that. Just a long lasting afterglow. Still in a great mood now. I did get a pretty severe headache but I also drink like it's my job, and I am on a SSRI.

Been thinking about Ephesus and Pergamon, not sure if thats subliminal or coincidence. 🤷

Going to wait 3-4 months and repeat.

Give this a go!



Krystle Cole from the book "Lysergic":
Quote:

"Isn't Ergot what Socrates used to take at Eleusis?" I thought it was kind of cool to be taking something that the founders of our democracy used to take, but that our current democracy has made illegal.

LSD chemist Todd Skinner replied "Yes, except for he did a water infusion of the ergot, instead of alcohol." Todd had prepared 6 jugs of ergot wine and stored them for many years.

Krystle Cole's "ergot wine" experience (several pages long) in the book "Lysergic", reported that she saw constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head.



Even LSD chemist Todd Skinner added ergot to wine, then consumed. He knew alkaloid conversion was taking place as well, years before I caught onto it.


Edited by tregar (08/23/20 07:34 AM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26895230 - 08/23/20 11:19 AM (3 years, 5 months ago)

Just got my supplies ready for my camping trip this week. My girl got the only brand of sherry they had plus the peppermint extract. Will be using this tek on ~375 ug of acid (2.5 tabs of supposedly 150 ug acid) for my camping trip Thursday. Plan to just be in nature with my girl who will be on shrooms. Lots of good music and those cool little packets that make fire change colors. That combined with some nice weather should make for an excellent setting for this experiment. Looking forward to reporting back on how it goes.



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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Sharp-Inflation]
    #26895694 - 08/23/20 04:49 PM (3 years, 5 months ago)

Mods should consider locking this thread since it's double posted in ODD and entirely hypothetical.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26901053 - 08/26/20 05:43 PM (3 years, 5 months ago)

Just read Sherry wine goes bad once opened after several weeks, good thing it's only $6 a bottle, will just have to keep several un-opened bottles on hand in the fridge, thank goodness it is cheap. Apparently the acetaldehyde in the wine converts to acetic acid in the wine once exposed to oxygen over time, not good for our experiments. Keep this in mind everyone.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26902808 - 08/27/20 05:54 PM (3 years, 4 months ago)

Sharp-inflation said:
Quote:

Just got my supplies ready for my camping trip this week. My girl got the only brand of sherry they had plus the peppermint extract. Will be using this tek on ~375 ug of acid (2.5 tabs of supposedly 150 ug acid) for my camping trip Thursday. Plan to just be in nature with my girl who will be on shrooms. Lots of good music and those cool little packets that make fire change colors. That combined with some nice weather should make for an excellent setting for this experiment. Looking forward to reporting back on how it goes.




Way to go sharp-inflation! Can't wait to hear your report!

I saw this nine dollar wine preservation canister, will prevent oxidation of the wine, instead a bottle of sherry wine will last several months instead of just a few weeks. This way the natural precious high levels of acetaldehyde in the sherry wine will not oxidize to acetic acid over time.


https://www.amazon.com/Private-Preserve-25300-True-1026/dp/B00IB7PHSE/ref=asc_df_B00IB7PHSE/?tag=hyprod-20&linkCode=df0&hvadid=198078681519&hvpos=&hvnetw=g&hvrand=2079867634529355252&hvpone=&hvptwo=&hvqmt=&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=1026651&hvtargid=pla-352081173838&psc=1

Replaces the air that seeps into an open bottle with a balanced mixture of carbon dioxide, nitrogen and argon to keep wine fresh: just look up "private preserve wine preservation system", less than ten dollars. Seen it at amazon.

I quote studies above from Dr. Shulgin, Dr. Callaway, and the 1992 indole adducts study, all support my theory, and the real world results speak for themselves. There is even the possibility of "in vivo" transformation in the liver just as cocaine from coca leaf tea bags (5mg cocaine per tea bag) + soaked in ethanol in wine = transforms to the orally potent cocaethylene when drunk. Last longer and even more euphoric than cocaine, IN VIVO REACTION was not discovered till 1994, even though "Vin Mariani coca leaf wine" was created in 1896. Drunk by both popes, Thomas Edison and scores of other famous people for decades until made illegal. After all, the 1992 indole adducts paper "Tryptophan analogues form adducts by cooperative reaction with aldehydes and alcohols or with aldehydes alone: possible role in ethanol toxicity" discusses this distinct possibility.

There is no mistaking 1-acetaldehyde LSD for LSD, completely different, like an upgraded version of LSD. Have a strong suspicion that it does not work thru the 5-ht2a receptor, but rather the A2A, A2B and A2C receptors, which are the dominance or habitat of mescaline, dmt in Ayahuasca, and psilocin. Give this a shot, will only cost you around six dollars for the bottle of Sherry wine which will last several months with a ten dollar wine preservation canister and two dollars for the peppermint extract, really works extremely well.
-------------------------------------------------------------------------------------------------------------------------------------
If you don't want to believe me then listen to Namaste (he took acid hundreds of times in the past, just like myself, his full trip report is below with 300ug of 1-acetaldehyde LSD):

Quote:

"Thanks for sharing the recipe. I really do believe that there is a conversion into a new substance, that it's acting on different receptors. That was one of the best trips of my life and I dose several times/year.

Blessed be

I think you're on to something here. It was extremely chill. Soft around the edges. When I started coming down, it felt like 10 years of therapy.

I remembered good times, felt compassion. Listened to music I haven't listened to in years. Thought about friends, was at peace in a way that I haven't felt before.

The stars formed into animated constellations. My Bodhi statue began to juggle. I saw the Perseidies meteors not just out of the corner of my eyes but right over my face while lying in a hammock. Saw the entire movement from start to finish. They looked like giant arrows.

Stayed awake all day, went out to visit friends. It was very happy nostalgia. Sometimes larger doses make me totally black out. Not this time, I was awake and aware. No primal fear or paranoia.

TWM
I used McCormick brand peppermint, not spearmint, and Holland House brand Sherry. It did feel 'altered', seems to extend the duration too. Felt like I was still peaking seven hours after dropping. Sometimes I get a cracked out, confused feeling, not this time.

Haven't seen neon colors like that since the one and only time I was puddled.

Sunday's are generally filled with dread and depression for the following week. Experienced none of that. Just a long lasting afterglow. Still in a great mood now. I did get a pretty severe headache but I also drink like it's my job, and I am on a SSRI.

Been thinking about Ephesus and Pergamon, not sure if thats subliminal or coincidence. 🤷

Going to wait 3-4 months and repeat.

Give this a go! "



--------------------------------------------------------------------------------------------------------------------------------

I'm taking this 1-acetaldehyde LSD at the waterpark in Nature this Saturday, it lasts way longer than LSD, beautiful relaxing comeup like with cactus, way more neon colorful & visual, but no "intense concentration", "tenseness", or "anxiety" like with normal LSD, instead of feeling "man-made" or "analytical" like with LSD it feels very natural, primitive and infinitely "beauty-enhancing" like with mescaline, great for outdoors.

It has a fantastic headspace without the anxiety & tenseness of LSD, you keep complete control of all your faculties while achieving a more visual & colorful experience, once again very similar to tripping on cactus, made for outdoors. Mescaline works it's magic thru the adrenal A2A, A2B & A2C receptors, and does not even target 5-ht2a (see my color radioligand binding chart beginning of this thread). I believe this 1-acetaldehyde LSD is similar in it's receptorome binding activity. Not only do you see multiples of shadows of your hand when you move it like on acid, but I see colored neon fractals inside the tracers, this never happens with normal LSD.

This is one beautiful substance. The neon colors for hours on end are breath-taking, normal LSD is just not very colorful or aesthetic (beauty-enhancing) like this substance, if you have taken mescaline or cactus, you know exactly what I am talking about when describing the colors and infinite beauty-enhancement.

A family member of Albert Hofmann (discoverer of LSD) is in contact with me, and he is very interested in this procedure, this is what he told me recently:
Quote:

Awesome! Thank you!
Please do keep us apprised of your research. Have you gotten a response from xxxxx?
I know Paul Daley would be interested in Eleusis theories, and now that Picard is out...
hmmmm...
Have you seen a reference to the ergot derived 'grail' sacrament discussed by Krystal Cole - i guess it was something Skinner came up with (?) perhaps with Leonard's help (?).
I'm no expert on these subjects, and only saw a reference to this once. I was waiting for the movie :wink:



He is referring to how Todd Skinner remarked in the book "Lysergic" how if you add ergot to wine, and let it sit for a while, that it "changes the alkaloid composition over time". Those were Todd's exact words. There is a long trip report (several pages long) in the book "Lysergic" by Krystle Cole. Krystle said the ergot wine experience was so visual, strong and powerful, that it was "the only time Todd would say a prayer before ingesting". She said he never said a prayer when taking any other substance. Krystle reported that she saw constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head. Todd had prepared 6 jugs of the "ergot wine."

p.s. I have an entheogenic library of 150 books, that's how I also found the info about how the Greek priest at Eleusis would add "fresh mint" to their entheogenic brew for 2,000 years straight and the ancient Aztec and Mayan would normally add the fresh or dried morning glory seed extract to liquor before consuming. Both these substances contain water soluble acetaldehyde. If the priest were using claviceps paspali infected paspalum distichum grass (known to grow in the famous Rharian plain adjacent to Eleusis), then the LSH was being converted to 1-acetaldehyde LSH, and I can see how hundreds of people could take this at once, as it has a "low freak out factor" like with mescaline.

The Aztecs were simply in theory converting the high levels of LSH in fresh morning glory to 1-acetaldehyde LSH as well. Claviceps paspali was found in 1961 to produce high levels of LSH when fresh as well, both have an almost identical alkaloid composition ie high levels of the psychoactive LSH and penniclavine, see the on-line 2016 Polish morning glory study with tables and charts of high levels of LSH and penniclavine in morning glory, break through modern findings. When Glasser and Yao and Takeo injected LSH & penniclavine (separately) into rabbits and rodents, they acted as if they had been injected with LSD, both substances were highly stimulating, see TIHKAL for LAE-32 human experiments which is nearly identical to LSH, LAE-32 is highly active at 1.5mg.

Please see the story in page #2 post #26870384 about how girl and I had a 20 minute vision where an ancient Aztec Shaman visited us or "schooled us" on how they used to prepare the morning glory as well, he led me to the 1992 indole adducts paper. This vision we saw form out of the shadows cast by a Christmas tree on a wall after we each took 10 hits of 15 year old decomposed acid. That's why I did not discover this, I was led to this by the Shaman, he wanted all of humanity to know that this was the way the Aztecs would prepare their morning glory seed extracts. He showed me the rise and fall of several civilizations his message "the only hope for humanity if it is to survive, is a Spiritual Solution." He advocated to us both the "growing of entheogenic plants" starting with my barren patio garden I had outside.


Edited by tregar (08/27/20 06:11 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26903730 - 08/28/20 08:45 AM (3 years, 4 months ago)

Ballz_Trippington said:
Quote:

Man, between corresponding with Albert Hoffman's relatives, modeling for body building magazines (which has zero to do with this thread - really mind boggling that you even mentioned it) and collecting reading an entheogenic library I'm very surprised you find the time to do this bathtub LSD alchemy...


You're funny Ballz_Trippington. It's because we have no kids!:grin: Page 1 post #1 explains why we have no kids, all the time in the world for entheogens, lifting weights, and don't forget I grow an entire half a yard full of cactus under shadecloth, which I trim from top every summer to supply my needs. Wait till you try this 1-acetaldehyde at 300ug + 400g of fresh boiled cactus tea, makes 400mg of the beautiful mescaline feel like 700mg of mescaline, whereas cactus + acid just feels like "cactus + acid" nothing too terribly special. But 1-acetaldehyde LSD + cactus, now THAT is something very special, that one trip with the two combined resulted in the most powerful, visual, neon colorful, euphoric experience of my life a month ago. It was the most powerful experience of my life, and I've tripped hundreds of times over 20 years. Music sounded like it was from another world, completely Alien and beyond Heavenly. I listened to music for hours.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26912480 - 09/01/20 05:56 PM (3 years, 4 months ago)

Note (1): Make sure your sherry wine is cold before you use it, it contains 5 mg acetaldehyde per 15ml or 1/2 shot glass. Acetaldehyde boils off at 68 degrees F, or slightly below room temp, so keep 1/2 shot glass of it in fridge at all times until you consume.

Note (2): There is a less than ten dollar wine preservation canister available that will prevent oxidation of the wine, instead a bottle of sherry wine will last several months instead of just 7 days. This way the natural precious high levels of acetaldehyde in the sherry wine will not oxidize to acetic acid over time. The canister replaces the air that seeps into an open bottle with a balanced mixture of carbon dioxide, nitrogen and argon to keep wine fresh: just look up "private preserve wine preservation system", less than ten dollars. Seen it at amazon.
---------------------------------------------------------------------------------------------------
I took 300ug of 1-acetaldehyde LSD at the waterpark this past Saturday, and had the time of my life outdoors amidst all the bikinis, river, trees, gardens, rides, lazy tube rides. I would never have been able to take 300ug of normal LSD out in public. This was more visual, stronger visual trip, lasted longer than LSD, way more colorful, but instead felt like I had taken mescaline instead, easy to handle yourself out in public. You keep control of all your faculties, just like with cactus. Instead of the "intense concentration" and "anxiety" and "electricity" of normal LSD at 300ug, enjoyed instead infinite beauty enhancement similar to around 400mg of mescaline, headspace was deep. This stuff is made for outdoors just like with cactus.

It has a fantastic headspace without the anxiety & tenseness of LSD, you keep complete control of all your faculties while achieving a more visual & colorful experience, once again very similar to tripping on cactus, made for outdoors. Mescaline works it's magic thru the adrenal A2A, A2B & A2C receptors, and does not even target 5-ht2a (see my color radioligand binding chart beginning of this thread). I believe this 1-acetaldehyde LSD is similar in it's receptorome binding activity. Not only do you see multiples of shadows of your hand when you move it like on acid, but I see colored neon fractals inside the tracers, this never happens with normal LSD.


Edited by tregar (09/01/20 05:59 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26913222 - 09/02/20 06:23 AM (3 years, 4 months ago)

1) You know how acid has that sudden drop off then you are back to sobriety? Instead, this lasts longer than acid and has a warm gentle transition back over a longer period.

2) 1-acetaldehyde LSD is way more colorful than acid, similar to mescaline.

3) 1-acetaldehyde LSD does not have the "visual choppiness" of acid, but is flowing in the visuals.

4) LSD produces tracers with multiples of shadows of the hand, this produces not only tracers, but colored fractals and mosaics inside the tracers.

5) LSD produces "colored specs that flow in front of everything", this produces instead "fine colored rainbow reflections" that surround everything.

6) Music sounds good on acid, but music sounds great on this, like a whole nother world, similar to mescaline.

7) With 1-acetaldehyde LSD, everything was indeed alive and magical. Patterns were forming everywhere, the shifting of textures is magical. I could lose myself so easily as the visuals seemed to drag my focus in without any effort. As a result, ego death was basically spontaneous. Taking this 2 times already, made it feel like the first time I've ever tripped. My 2nd trip with 400ug 1-acetaldehyde LSD in combination with 400g fresh cactus tea was the most infinitely beautiful & powerful trip I have ever experienced in my life.

8] Sometimes LSD causes my mind to wander uncontrollably unless I take my own drive to focus, but with 1-acetaldehyde LSD there is no wandering thoughts, no tenseness or anxiety like with acid, this is deep mentally, a real gem, pure psychedelic bliss.

9) 400ug of 1-aceteldehyde LSD makes 400g of fresh boiled cactus pieces (no core, approximately 400mg mescaline) feel instead like 700mg of mescaline. I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead which is the dominance or habitat of mescaline & dmt & psilocin (see color chart post #1).

10) You can take this more often as it does not have the "extreme tolerance" of normal LSD which mainly works thru the 5-ht2a receptor (see color chart post #1 of old long thread), just like with cactus which you can take more often.

11) It is not a sacrilege to convert LSD to 1-acetaldehyde LSD cause Albert Hofmann also discovered ALD-52 at Sandoz labs. This is different from ALD-52 cause it has one extra hydrogen on the acetaldehyde adduct at the bottom indole NH group nitrogen. The table from Sandoz suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD-52 produced brain waves showing a more relaxed mental state. It also has "twice the anti-serotonin or serotonin blocking power" of normal LSD.

12) Before falling to sleep, I saw closed eye colored visions of architecture and gardens like those in Versailles, France.

13) LSD is more "analytical" and not as aesthetic, this feels more natural and is extremely aesthetic (beauty enhancing) like with mescaline.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26915838 - 09/03/20 03:16 PM (3 years, 4 months ago)

How can ALD52 be only a prodrug to LSD25 if scientists showed that human brains act differently on ALD52 compared to LSD25?
I think it's well studied that ALD52 has a different effects' profile than LSD25.

To me it feels slightly different. Can surely be placebo, but I think it's smoother, a bit more stmulating and a "warmer feeling" overall, and more colofull visuals.

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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: Pandemoon]
    #26916531 - 09/03/20 10:20 PM (3 years, 4 months ago)

^ What study are you referring to that showed different effects with ALD-52 vs LSD?


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: breeg89]
    #26920003 - 09/05/20 07:11 PM (3 years, 4 months ago)

As mentioned before, I've taken LSD hundreds of times over the past 25 years, and this 1-acetaldehyde LSD x 5 times spaced around 2 weeks apart, and I vastly prefer 1-acetaldehyde LSD to normal LSD. There is a world of difference between the two. I've also taken Ayahuasca over 65 times over 2 decades, and home grown cactus nearly 200 times over 20 years. I am very experienced. I keep a trip diary.

The table from Sandoz suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD-52 produced brain waves showing a more relaxed mental state. It also has "twice the anti-serotonin or serotonin blocking power" of normal LSD.

This is the same way the ancient Aztec would take morning glory extract, adding it to liquor, then consuming, see my notes above, the Greek Priest at Eleusis would also add fresh mint to their theoretical kykeon composed of claviceps paspali infected paspalum distichum grass, both morning glory and claviceps paspali ergot contain high levels of LSH and penniclavine when fresh, this process converts those to 1-acetaldehyde LSH and 1-acetaldehyde penniclavine.

To Make: simply soak 3 x 100ug LSD blotters in 1/2 shot of cold sherry wine in the fridge in a large shot glass for 3 hours with foil lid to prevent spill over....one hour later add 5 drops of peppermint extract, and swirl the shot glass once per hour. Consume after 3 hours. The sherry wine contains 5mg acetaldehyde per 15ml or 1/2 shot glass, and is at ph=4 which is what the 1992 indole adducts study calls for, including the long soak time. Acetaldehyde boils off (has a green apple smell) at 68 degree F, so keep shot glass in fridge at all times till consumed. Peppermint extract also contains 2mg acetaldehyde per 5 drops.

This conversion is also supported not only by the 1992 indole adduct study, but by the studies given above from Dr. Shulgin and Dr. Callaway (2005). See link to studies above. This could also be happening "in vivo" in the liver as cocaine converts to cocaethylene in the liver when you soak coca leaf tea bags in wine (5mg cocaine per coca leaf tea bag), then consume the wine. Cocaethylene is more euphoric than cocaine and lasts 3 times as long, this was not even discovered till 1994 even though Vin Mariani coca wine was invented in 1896.

1-acetaldehyde LSD has many similarities to ALD-52, especially the various out of this world neon-colors I've seen on it at 300ug that I've never seen in my life, except on high dose caapi + 35g hawaiian psychotria & mescaline. I've done Ayahuasca over 65 times, and the neon colors seen on higher dose Ayahuasca & mescaline are indeed similar to 1-acetaldehyde LSD.

Have a wine preservation canister to keep the six dollar bottle of sherry wine good for months instead of 7 days, I just spray it into the open bottle to replace the oxygen with carbon dioxide/argon/nitrogen so the high levels of acetaldehyde in the Sherry wine will not oxidize to acetic acid (gives a vinegar taste to wine) over time.

As mentioned above, I had the time of my life taking 300ug of 1-acetaldehyde LSD outdoors at the waterpark this last Saturday, incredible neon-colorful visual experience with zero anxiety outdoors. The bikinis stood out in neon colors, the gardens, trees, lazy river tube rides were just breath-taking. Ranks up there with one of the best outdoor trips of my life.

If I would have taken even just 200ug of normal LSD outdoors, I would have been all-consumed with "intense concentration", "anxiety", and "paranoia" & "analytical thoughts" outside, but not with this stuff, instead felt similar to 400mg of mescaline, had complete control of all my faculties, and enjoyed infinite beauty enhancement instead & awesome visuals, similar to mescaline, 1-acetaldehyde LSD is great outdoors.

I also agree with 2nd comment below, that there is zero anxiety at 300ug. Here are two comments from reddit that I found that are similar to what I've experienced, having taken 1-acetaldehyde LSD x 5 times allready, spaced around 2 weeks apart. Keep in mind that 1-acetaldehyde LSD has one more hydrogen atom on NH group adduct than ALD-52.
-----------------
I am very fond of ALD-52 as well! For me, the headspace was very much like #25; however, I felt like the former of the two had potential for a really crazy headspace. ALD-52 also had me seeing three different colors that I'd never seen in my life. I saw red-greens, orange-blues, and of course the fucking purple-yellows.
-----------------
NoticesMemesOwO:
ALD is MUCH calmer than 1P in every way. 1P tends to have a shitload of anxiety on the come up and tachycardia for me and my group of friends. Its very visual but also very scary at times. especially at high doses. ALD is the best IMO. I prefer it over the real thing honestly. At high doses it was very tame, had a great visual set, and no anxiety at all. very welcoming in the way it gets you. I would pick ALD all day long, and i could take or leave 1P in all honesty.
-----------------


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26929465 - 09/11/20 07:06 AM (3 years, 4 months ago)

I am taking this again for the 6th time (been taking it spaced 2 weeks apart) at 300ug, and my wife is going to take it for the first time at 175ug.

The first thing you will notice when you take this, is that there is a slow gentle relaxing come up like with mescaline. I agree with Namaste who said he was still peaking 7 hours later, the peak is way past the 4 hours commonly felt with LSD. This lasts way longer than LSD. It does not feel "man-made" or "analytical" at all like LSD, but rather very primitive & natural like with mescaline, infinitely beauty enhancing just like with mescaline, extremely neon colorful, zero anxiety, no wandering thoughts or tenseness, but has a deep headspace, a real gem, perhaps deeper headspace than LSD I feel due to it's having double the anti-serotonin blocking power of LSD. The more serotonin-blocking power, the further the reach into the divine infinite space, and the more "away from the day-to-day survival filters" (see color chart on page 1 for explanation with comments from LSD scientist Dr. Nichols) just as 5-meo-dmt has extremely high serotonin-blocking power, similar head space. You do indeed see neon red-green, neon orange-blue, and neon purple-yellow colors all night long with 1-acetaldehyde LSD, just as commenter below saids.

I also agree with 2nd comment below, that there is zero anxiety at 300ug. Here are two comments from reddit that I found that are similar to what I've experienced, having taken 1-acetaldehyde LSD x 5 times allready, spaced around 2 weeks apart. Keep in mind that 1-acetaldehyde LSD has one more hydrogen atom on NH group adduct than ALD-52.
-----------------
I am very fond of ALD-52 as well! For me, the headspace was very much like #25; however, I felt like the former of the two had potential for a really crazy headspace. ALD-52 also had me seeing three different colors that I'd never seen in my life. I saw red-greens, orange-blues, and of course the fucking purple-yellows.
-----------------
NoticesMemesOwO:
ALD is MUCH calmer than 1P in every way. 1P tends to have a shitload of anxiety on the come up and tachycardia for me and my group of friends. Its very visual but also very scary at times. especially at high doses. ALD is the best IMO. I prefer it over the real thing honestly. At high doses it was very tame, had a great visual set, and no anxiety at all. very welcoming in the way it gets you. I would pick ALD all day long, and i could take or leave 1P in all honesty.

1992 adducts study: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ Page 8441 "Reaction of Indole with Acetaldehyde: A 0.2% solution of indole in equal amounts of water, ethanol, and acetaldehyde formed a product with 60% yield after 1 hour of reaction at ambient temperature. Omitting the ethanol (50% acetaldehyde in water mixture) had no effect. Decreasing the concentration of acetaldehyde to 0.1% increased the reaction rate and percent yield of product." See pic of the researchers's indole + acetaldehyde adduct product formed ---> ie before (page 8439) and after (page 8441).

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/

The researchers achieved a 100% new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution, with a 1.5 hour soak time with stirring.

The Sherry wine supplies 5mg acetaldehyde per 15ml or 1/2 shot glass, and is at ph=4 already like the study calls for, new 300ug 1-acetaldehyde LSD formed from 300ug LSD in 3 hours sitting in the fridge with stirring once per hour due to adduction at NH group nitrogen at indole of ergoline LSD with acetaldehyde, just as study explains.





----------------------------------------------------------------------------------------------------------------------------
Also see Namaste's trip report with 300ug:

Quote:

Thanks for sharing the recipe. I really do believe that there is a conversion into a new substance, that it's acting on different receptors. That was one of the best trips of my life and I dose several times/year.

Blessed be

I think you're on to something here. It was extremely chill. Soft around the edges. When I started coming down, it felt like 10 years of therapy.

I remembered good times, felt compassion. Listened to music I haven't listened to in years. Thought about friends, was at peace in a way that I haven't felt before.

The stars formed into animated constellations. My Bodhi statue began to juggle. I saw the Perseidies meteors not just out of the corner of my eyes but right over my face while lying in a hammock. Saw the entire movement from start to finish. They looked like giant arrows.

Stayed awake all day, went out to visit friends. It was very happy nostalgia. Sometimes larger doses make me totally black out. Not this time, I was awake and aware. No primal fear or paranoia.

TWM
I used McCormick brand peppermint, not spearmint, and Holland House brand Sherry. It did feel 'altered', seems to extend the duration too. Felt like I was still peaking seven hours after dropping. Sometimes I get a cracked out, confused feeling, not this time.

Haven't seen neon colors like that since the one and only time I was puddled.

Sunday's are generally filled with dread and depression for the following week. Experienced none of that. Just a long lasting afterglow. Still in a great mood now. I did get a pretty severe headache but I also drink like it's my job, and I am on a SSRI.

Been thinking about Ephesus and Pergamon, not sure if thats subliminal or coincidence. 🤷

Going to wait 3-4 months and repeat.

Give this a go!



-----------------------------------------------------------------------------------------------------------------------------------------------
Krystle Cole from the book "Lysergic":
Quote:

Isn't Ergot what Socrates used to take at Eleusis?" I thought it was kind of cool to be taking something that the founders of our democracy used to take, but that our current democracy has made illegal.

LSD chemist Todd Skinner replied "Yes, except for he did a water infusion of the ergot, instead of alcohol." Todd had prepared 6 jugs of ergot wine and stored them for many years.

Krystle Cole's "ergot wine" experience (several pages long) in the book "Lysergic", reported that she saw constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head.



Even LSD chemist Todd Skinner added ergot to wine, then consumed. He saids in the book that alkaloid conversion was taking place as well, years before I caught onto it.

See my Double 5 foot high morning glory planters which will produce around 6000 fresh potent seeds very high in LSH & penniclavine total: https://www.shroomery.org/forums/showflat.php/Number/26838327/page/2

-----------------------------------------------------------------
To Make: simply soak 3 x 100ug LSD blotters in 1/2 shot of cold sherry wine in the fridge in a large shot glass for 3 hours with foil lid to prevent spill over....one hour later add 5 drops of peppermint extract, and swirl the shot glass once per hour. Consume after 3 hours. The sherry wine contains 5mg acetaldehyde per 15ml or 1/2 shot glass, and is at ph=4 which is what the 1992 indole adducts study calls for, including the long soak time. Acetetaldehyde boils off (has a green apple smell) at 68 degree F, so keep shot glass in fridge at all times till consumed. Peppermint extract also contains 2mg acetaldehyde per 5 drops.

Have a nine dollar "wine preservation canister" to keep the six dollar bottle of sherry wine good for months instead of 7 days, I just spray it into the open bottle to replace the oxygen with carbon dioxide/argon/nitrogen so the high levels of acetaldehyde in the Sherry wine will not oxidize to acetic acid (gives a vinegar taste to wine) over time.


Edited by tregar (09/11/20 07:31 PM)


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26946602 - 09/20/20 05:45 PM (3 years, 4 months ago)

Wife enjoyed her trip on the 1-acetaldehyde LSD last Friday as well. She sat outside and watched as the clouds in the sky formed Egyptian architecture and pyramids she said. We both saw numerous animals form in the clouds. Intensely visual & colorful, very strong trip for both of us...when we came inside, we listened to dance music from friskyradio.com streaming over the bluetooth while we watched 4k walking tours of Spain beaches on You tube. She and I felt like we were still peaking nearly 6 hours later. The trips were extremely strong, and very long lasting.

Music sounded INCREDIBLE, reminded me of listening to music on mescaline, like a whole nother world. Music sounds good on acid, but music sounds great on this! She remarked that the music sounded so good and 3-dimensional, like it was coming to her from all directions. We both could not stop talking about the music, neon colors and infinite beauty seen all night. She took 175ug and I took 300ug, just an over the top breath-taking experience all night. One of the best trips of our lives she and I both agreed. Give this a shot if you can.

We both experienced zero anxiety, no wandering thoughts or tenseness, a fantastic deep head space, she remarked as well that it felt quite different from normal LSD. She has taken mescaline at 400mg several times before, and she remarked as well that it felt similar to the beauty enhancement and neon colors of mescaline. We both found it to be very natural and primitive feeling like with cactus rather than the man-made analytical feel of LSD.

It's very amazing how the choppiness of the visuals with LSD are replaced instead with flowing visuals, no choppiness. She also saw the "fine rainbow reflections of color" that surrounded everything as I did. She also remarked about the "cartoon quality" of human faces seen, which is a trait of mescaline, rather than of LSD, which tends to make everyone look like a cartoon version of themselves. She also remarked that this is the only way she wants to take LSD from now on, as the 1-acetaldehyde LSD cousin.

* Sherry wine (naturally high in acetaldehyde)= $6
* Wine preservation canister = $9 (will keep a bottle of Sherry wine good for countless months, so the acetaldehyde in the wine does not oxidize to acetic acid)
* peppermint extract = $2

My 5 year old Shitzu needs cataract surgery in both eyes (4 grand in medical costs) so he does not go blind next week, so I will not be around much for many weeks. Will need intensive care (40 drops per eye for weeks spaced several hours per day while he wears a cone on head), and many return opthamology appointments...Work, weight-lifting, etc. all take up time.


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Re: Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step [Re: tregar]
    #26961617 - 09/30/20 08:40 AM (3 years, 3 months ago)

Namaste said:
Quote:

Thank you for sharing this information. I'm about six weeks out from my next session.

Hope your pupper heals up quickly.



Thanks Namaste. The surgery with puppy was done yesterday, it went fine, so relieved, go to pick him up this morning from the ICU. Now begins the intensive healing process for weeks, and 32 drops per eye daily. Glad you are about 6 weeks out from next time!

Please don't forget this is not an experiment being done with rats. This is the simultaneous ingestion of LSD with Sherry wine, which contains high levels of acetaldehyde and peppermint drops, which also contains the alcohol menthol and 2mg acetaldehyde per 5 drops.

The indole adducts paper points to the possibility of this adduction to indole with aldehydes even occurring in vivo in the liver. The liver production of this new aldehyde + indole adduct can then go on to reach the brain in-tact.

Most of the ethanol in the body is broken down in the liver by an enzyme called alcohol dehydrogenase (ADH), which transforms ethanol into a compound called acetaldehyde. This acetaldehyde can then bond or adduct to the nitrogen NH group indole of LSD, forming 1-acetaldehyde LSD or what is beyond even ALD-52, as it contains one additional hydrogen atom.

Coca leaf when soaked in wine is converted to coca-ethylene by the liver with an "in-vivo" conversion as well, this was discovered in 1994 even though the popular Vin Mariani coca wine was invented in 1896. coca-ethylene lasts twice as long as cocaine, is orally potent, and even more euphoric than cocaine.

The nitrogen NH group of the indole part of LSD is very prone to adduction with aldehydes, just as the 1992 adducts paper explains with indoles of all types.

Please keep an open mind about the in-vivo creation of this product by the liver, which then goes on to easily reach the brain.
-------------------------------------------

THH or Tetrahydroharmine + 1-acetaldehyde LSD (similar to ALD-52) combo, like high dose mescaline:

10.19.2021 update:

https://www.shroomery.org/forums/showflat.php/Number/27506721

I've moved on from the 300mg oral THH + sublingual HPBCD DMT, onto a 100% oral alternative, no re-dosing necessary every 1.5 hour like with the HPBCD DMT:

I'm not going to totally abandon the sublingual HPBCD DMT, it can still be taken as a 3rd drug under the tongue to add to the already super potent combo below. 2 to 3 alkaloids are of course more potent than one.

In closing, I'm going to post what I believe to be a revolutionary psychedelic combination, and it's dirt cheap compared to the rare and very expensive cactus...but it's just as long-lasting, profound, highly euphoric, visual, neon-colorful, music-enhancing & super deep head space, with zero-anxiety as two feet of fat bridgesii.

300mg THH + 250ug 1-acetaldehyde LSD report (2oz fresh cold sherry wine morning glory extract can substitute as well :heart:, see post #78 with pics on page 4 )
https://mycotopia.net/topic/110273-new-research-morning-glory-contains-5-stimulating-lsd-like-drugs-soluble-only-in-winealcohol-only-sparingly-soluble-in-water/page-4

1) The combo of 300mg THH + 1-acetaldehyde LSD makes the beauty & aesthetic enhancement way stronger than LSD alone. Same "over the top" beauty enhancement as high dose cactus tea.

2) The music sounds much better than LSD alone, it feels very much like when you combine mescaline with LSD, as THH is like the beta-carboline version of mescaline.

3) The combo is highly visual & neon-colorful with open eyes, with each of the 3 trips spaced two weeks apart experienced so far have seen neon-red-greens, neon-orange-blues, and even neon-purple-yellows, supercolorful just like high-dose cactus tea.

3) Very beautiful combination. :heart: :heart: :heart:

4) This 300mg THH + 250ug 1-acetaldehyde LSD combo is my absolute favorite, have since used it every 2 weeks x 3 times now...prefer it over everything else. No re-doses necessary as the THH has a 10.5 hour half life with peak at 5.25 hours. Very powerful: Lasts all evening, infinitely beautiful. I've consistently reached +5 Shulgin level strength every time, very life changing experience every time. Super deep head space, Divine to the extreme, heavenly mescaline-like spiritual euphoria for hours on end, no words to describe.


Edited by tregar (10/19/21 08:35 AM)


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