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napoleon
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Is there any scientific literature on shroom tolerance? 1
#26850520 - 07/28/20 07:02 PM (3 years, 5 months ago) |
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So I've heard 3-5 days, 7-14 days, 2 weeks, 2-4 weeks etc etc
I did 5 grams of cube last week (6 nights ago)and I want to do a 7.5 gram level trip tonight and according to this psychedelic tolerance calculator it says I should do 9.2 grams to reach 7.5 from 5 grams 6 nights prior.
Just curious of any of those studies John Hopkins and others have been doing have touched on psilocybin tolerance?
Edited by napoleon (07/28/20 07:08 PM)
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napoleon
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Re: Is there any scientific literature on shroom tolerance? [Re: napoleon] 1
#26855919 - 07/31/20 05:44 PM (3 years, 5 months ago) |
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bump
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PrimalSoup
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Re: Is there any scientific literature on shroom tolerance? [Re: napoleon] 1
#26856239 - 07/31/20 08:49 PM (3 years, 5 months ago) |
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Did you look?
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if you stand too close to the machine it'll start to eat youPrimal's simple tested teks and projects: Wheat Prep 2.0 Acidic Tea Tek Potency Project!
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Ancient Mariner
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Re: Is there any scientific literature on shroom tolerance? [Re: PrimalSoup] 2
#26856258 - 07/31/20 09:02 PM (3 years, 5 months ago) |
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Check google scholar. I only saw one article that deals with tolerance and cross-tolerance of lsd and psilocybin but you have to pay for it. If there's no other answers I'll see what my college database has when I get a library card.
I know you want an objective answer to this but from my experience and others descriptions of their experiences, it seems that tolerance in shrooms is either different for each person and/or different each trip. There are probably a lot of factors that influence tolerance and I wouldn't recommend following that calculator unless your cool with big surprises in dose. If 5 grams was the hardest you ever tripped, I hope you don't do 9.2 grams. That's a big jump. Good thing your checking up on it.
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Azure Essence


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Re: Is there any scientific literature on shroom tolerance? [Re: Ancient Mariner] 1
#26856337 - 07/31/20 09:55 PM (3 years, 5 months ago) |
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The Psychedelics Encyclopedia may have had sections about this, but I haven't had this book in years
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Ancient Mariner
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Re: Is there any scientific literature on shroom tolerance? [Re: Azure Essence] 1
#26856375 - 07/31/20 10:20 PM (3 years, 5 months ago) |
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Really want to get that book when I have time and money.
Turns out I do have access to the database but this is all I can find from credible journals: -Shroom tolerance develops rapidly. -There is cross-tolerance of serotonergic hallucinogens, both selective and non-selective serotonin agonists [mescaline (selective), lsd and shrooms (non-selective)]
The rest is for us to explore. I could figure out a solid answer to this through extensive studies but I don't wanna give rats shrooms unawares. I love the fuckin' critters.
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DJ Ed
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Re: Is there any scientific literature on shroom tolerance? [Re: Ancient Mariner] 1
#26856527 - 08/01/20 12:55 AM (3 years, 5 months ago) |
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I would look first at 1.5x original dose, which would be 7.5g. 9.2g is way too high buddy.
There are various factors that influence an individual’s tolerance. I believe the stronger the first dose, the higher the second dose need to be. The second factor is duration since last trip; 6 days will have rid you of most of your tolerance. The “1.5x to 2x” initial dose is when you’re talking dosing the next day!! Another factor is how frequently you dose; I went through a spell of fortnightly moderate doses of 3.8g. I never felt any tolerance. But if I moved to weekly intervals, the third trip would always be underwhelming.
You have to find out for yourself; mushrooms don’t not tend to follow the scientific rules! But aim towards 1.5x not 2x.
Good luck DJ Ed
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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nooneman


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Re: Is there any scientific literature on shroom tolerance? [Re: napoleon] 3
#26856540 - 08/01/20 01:05 AM (3 years, 5 months ago) |
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Why are all of you guys suddenly so curious about this? I've seen a TON of similar posts recently. If you want to know, why don't you try it and find out?
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DJ Ed
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Re: Is there any scientific literature on shroom tolerance? [Re: nooneman] 1
#26856554 - 08/01/20 01:18 AM (3 years, 5 months ago) |
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Maybe it’s to do with people’s “set” in that lockdown seems to be easing, and people are much more willing to take mushrooms; I’ve really struggled during lockdown with many negative feelings tainting my trips. I have only had one trip, and that was really poor and weak, in the last 3 months.
When my summerhouse is ready, I can can secure myself away from my 15 yearbold daughter for 4 to 6 hours, I too will be looking to “catch up” 
DJ Ed
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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PrimalSoup
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Re: Is there any scientific literature on shroom tolerance? [Re: napoleon] 2
#26857108 - 08/01/20 11:23 AM (3 years, 5 months ago) |
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Quote:
napoleon said: So I've heard 3-5 days, 7-14 days, 2 weeks, 2-4 weeks etc etc
I did 5 grams of cube last week (6 nights ago)and I want to do a 7.5 gram level trip tonight and according to this psychedelic tolerance calculator it says I should do 9.2 grams to reach 7.5 from 5 grams 6 nights prior.
Just curious of any of those studies John Hopkins and others have been doing have touched on psilocybin tolerance?
Oops just read the entire OP. 6 nights is a massive reset. 1.5 times each consecutive daily dosage is what works for me, I reach a plateau after about a week of that at around 5 times the normal dose but after that it stops increasing. To put that in realistic terms it means about 225-250 g of fresh cubes (not PE potency). That can really only be consumed as tea I think. 
The way this works for skipping days is that you figure it backwards - if I skip a day the same dose (tolerance adjusted) will work. Skip two and drop back to 65%. Skip three and use 45% of whatever the previous dose was.
So after a week you'd be good at 7.5 but the only way to find out how your personal biology works is just try it and see. Then you'll know. People differ considerably.
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if you stand too close to the machine it'll start to eat youPrimal's simple tested teks and projects: Wheat Prep 2.0 Acidic Tea Tek Potency Project!
Edited by PrimalSoup (08/01/20 11:36 AM)
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R.I.P.Zappa
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Re: Is there any scientific literature on shroom tolerance? [Re: PrimalSoup] 1
#26857969 - 08/01/20 10:38 PM (3 years, 5 months ago) |
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Alot of vets gave ya good advice here OP. Heres mine for sprinkles on top.  David Nichols ( Heffter Research Institute ) said the rule of thumb is, longer the duration of the substance the longer the tolerance. -DMT 1-2h, psilocybin 7D, Mescaline 2w, LSD 2w roughly for what we call a full reset- that's pretty much the order of shortest too longest tolerance ranges.
Have had no issues with doing mushrooms every three too four days with a 1 gram increase other than getting used to the experience for a couple months straight. One also has to also keep in mind riding the same roller coaster over and over and over looses it's awe factor by getting used to the ropes per-say.
Your gonna have to find out whats works for you. Everyone's metabolism differs and some need less to trip to were other need much more by the draw of evolutionary expressed traits or simple health/preparation.
People can use what ever calculator they want from the internet but I personally take the advice from an expert that has been studying this stuff for over 40 years. You might find what your looking for here, I haven't watched it in a while but he goes over some of the pharmacology in this one. Hope this helps.
-------------------- -The heaviest thing one will ever carry is a thought- -"Like a Blind man In an orgy you gotta feel things out.".- -When we agree about our hallucinations, we call it “reality".- -If you defy authority because your told to, that's no better than blindly trusting authority.- psychonautwiki.org How it should & shouldn't look - NEW CULTIVATORS GUIDE BOD's Easy AF OAT prep tek. Principles of mushroom growing for beginners
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Azure Essence


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Re: Is there any scientific literature on shroom tolerance? [Re: R.I.P.Zappa] 1
#26858601 - 08/02/20 10:49 AM (3 years, 5 months ago) |
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Quote:
R.I.P.Zappa said: David Nichols ( Heffter Research Institute ) said the rule of thumb is, longer the duration of the substance the longer the tolerance. -DMT 1-2h, psilocybin 7D, Mescaline 2w, LSD 2w roughly for what we call a full reset- that's pretty much the order of shortest too longest tolerance ranges.
This is super interesting, something I feel like I've heard or intuitively knew, but glad to see it verified.
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