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Multispore culture is the least difficult method of obtaining a viable if not absolutely pure strain. In the germination of such a multitude of spores, one in fact creates many strains, some incompatible with others each potentially different in the manner and degree to which they fruit under artificial conditions. This mixture of strains can have a limiting effect on total yields, with the less productive strains inhibiting the activity of more productive ones. In general, strains created from spores have a high probability of resembling their parents. If those parents have been domesticated and fruit well under labrotory conditions, their progeny can be expected to behave similarly. In contrast, cultures from wild specimens may fruit poorly in an artificial environment. Just as with wild plants, strains of wild mushrooms must be selectively developed.

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