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Offlinemorrowasted
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Re: Hydroxychloroquine sulfate [Re: feevers]
    #26900879 - 08/26/20 03:53 PM (3 years, 5 months ago)

Negative lol

Though wine is my drink of choice if i am partaking these days. Not for health reasons though😑


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OfflineHamHead
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Re: Hydroxychloroquine sulfate [Re: morrowasted]
    #26901007 - 08/26/20 05:13 PM (3 years, 5 months ago)

Quote:

morrowasted said:
Please read my post, HamHead.




Remdesivir has not been approved to treat coronavirus or COVID-19. However, the US Food and Drug Administration (FDA) has authorized emergency use of remdesivir in adults and children who are hospitalized with COVID-19.

Remdesivir has not been approved to treat coronavirus or COVID-19. It is not yet known if remdesivir is an effective treatment for any condition.

Readers are cautioned that Remdesivir is not an approved treatment for coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2, but rather, is being investigated for and is currently available under an FDA emergency use authorization (EUA) for the treatment of severe COVID-19 in hospitalized patients.

Side effects include:

Randomized, double-blind, placebo-controlled trial in hospitalized adults with severe COVID-19 in China: Adverse events (e.g., constipation, hypoalbuminemia, hypokalemia, anemia, thrombocytopenia, increased total bilirubin concentrations) reported in 66 or 64% of patients who received remdesivir or placebo, respectively. Serious adverse events reported in 18 or 26%, respectively, and drug discontinued because of adverse events in 12 or 5%, respectively.

Phase 3, adaptive, randomized, placebo-controlled trial in hospitalized adults with mild/moderate or severe COVID-19 (NCT04280705; ACTT-1): Serious adverse events (e.g., cardiac events, respiratory distress or failure, acute kidney injury, hypotension) reported in 21% in remdesivir group and 27% in placebo group; grade 3 or 4 adverse events occurred in 29% in remdesivir group and 33% in placebo group. Most common nonserious grade 3 or greater adverse events in remdesivir group were anemia or decreased hemoglobin concentrations (8%); acute kidney injury, decreased eGFR or Clcr, or increased Scr (7%); pyrexia (5%); hyperglycemia or increased blood glucose concentrations (4%); and increased ALT and/or AST concentrations (4%); these were reported in 3–9% of patients in placebo group.

Phase 3, randomized, open-label trial in hospitalized adults with severe COVID-19 (NCT04292899; GS-US-540-5773; SIMPLE-Severe): Adverse events reported in 70 or 74% of patients who received a 5- or 10-day remdesivir regimen, respectively; serious adverse events (e.g., respiratory distress or failure, septic shock) reported in 21 or 35%, respectively, and grade 3 or greater adverse events reported in 30 or 43%, respectively. Drug discontinued because of adverse events in 4% of patients in 5-day group and 10% of patients in 10-day group. All-cause mortality at day 28 was 10 or 13% in the 5- or 10-day group, respectively. Most common adverse events overall were nausea (10 or 9%), acute respiratory failure (6 or 11%), increased ALT concentrations (6 or 8%), and constipation (7% in both groups),

Cohort of 53 hospitalized patients in manufacturer's compassionate-use program: Adverse events (e.g., increased hepatic enzymes, diarrhea, rash, renal impairment, hypotension) reported in 60% of patients; serious adverse events (e.g., multiple organ dysfunction syndrome, septic shock, acute kidney injury, hypotension) reported in 23%; drug discontinued because of adverse events in 8% of patients

The approval status of VEKLURY varies worldwide. In countries where VEKLURY has not been approved by the regional health authority, VEKLURY is an investigational drug, and the safety and efficacy of VEKLURY have not been established. VEKLURY has not been approved by the U.S. Food and Drug Administration (FDA) for any use.

https://www.drugs.com/history/remdesivir.html

FDA StatusRemdesivir
Remdesivir Approval Status
Reviewed by Judith Stewart, BPharm. Last updated on Aug 11, 2020.

FDA Approved: No
Generic name: remdesivir
Company: Gilead Sciences, Inc.
Treatment for: COVID-19
Remdesivir is an investigational nucleotide analog antiviral in development as a potential treatment for hospitalized patients with severe COVID-19.

Remdesivir is authorized in the United States for use under an Emergency Use Authorization (EUA) only for the treatment of patients with suspected or laboratory-confirmed SARS-CoV-2 infection and severe COVID-19.
In August 2020, Gilead announced the submission of a New Drug Application (NDA) to the FDA for Veklury (remdesivir). The filing was supported by data from two randomized, open-label, multi-center Phase 3 clinical studies conducted by Gilead, and the Phase 3 randomized, placebo-controlled study conducted by the National Institute of Allergy and Infectious Diseases (NIAID). These studies demonstrated that treatment with Veklury led to faster time to recovery compared with placebo and that a 5-day or 10-day treatment duration led to similar clinical improvement. Across studies, Veklury was generally well-tolerated in both the 5-day and 10-day treatment groups, with no new safety signals identified.

https://www.gilead.com/remdesivir

Remdesivir is an investigational drug that has not been approved by the FDA for any use. It is not yet known if remdesivir is safe and effective for the treatment of COVID-19.

So, after a little digging, it seems Remdesivir is not a FDA approved drug for any treatment.

Yet, an FDA approved drug, HCQ, is getting heat.

Why are you using a drug that isn't approved?

Remdesivir must be administered intravenously.

HCQ is taken in pill form, in outpatient settings.

Remdesivir is reserved for those who are hospitalised.

HCQ is a preventive prophylaxis preventing people from becoming severely infected amd then hospitalized, which is why health care workers take HCQ, to prevent them from viral spread.


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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InvisiblebodhisattaMDiscordReddit
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Re: Hydroxychloroquine sulfate [Re: HamHead]
    #26901012 - 08/26/20 05:17 PM (3 years, 5 months ago)

Every healthcare worker I know thinks HCQ is bullshit so who's taking it. Bible belt doctor's that believe in stolen pagan traditions, symbols, and values?


--------------------
:whyyy:


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OfflineHamHead
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Re: Hydroxychloroquine sulfate [Re: bodhisatta]
    #26901021 - 08/26/20 05:22 PM (3 years, 5 months ago)

Quote:

bodhisatta said:
Every healthcare worker I know thinks HCQ is bullshit so who's taking it. Bible belt doctor's that believe in stolen pagan traditions, symbols, and values?




Check other countries.

https://www.bahrain-confidential.com/coronavirus-therapeutic-medication-in-bahrain-proved-effective/

President of the Supreme Council of Health (SCH) Lt. General Dr Shaikh Mohammed bin Abdullah Al Khalifa, the Head of the National Taskforce to Combat Coronavirus (COVID-19), has affirmed that the therapeutic protocol of the Kingdom of Bahrain which uses Hydroxychloroquine (HCQ) medication in treating COVID-19-infected cases has proved its effectiveness.

He said the Kingdom is one of the first countries that used the medication, pointing out its success in alleviating the symptoms of the virus and reducing its complications.

The SCH President noted that the Kingdom of Bahrain used Hydroxychloroquine on February 26, 2020, after detecting the first COVID-19 case two days before.

He pointed out that the National Taskforce to Combat COVID-19 decided to use the medication to treat the cases according to the experience of the countries which achieved remarkable success in curing the coronavirus-infected cases, like China and South Korea where the recovery indices rose remarkably.

The SCH President affirmed that Hydroxychloroquine is used as the main cure for diseases like Malaria, rheumatoid arthritis and lupus. It proved to be very effective in alleviating virus-related symptoms, pneumonia, pain and fever, he added, pointing out that applying the therapeutic protocol depends on the pathological case.

Source: BNA


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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Offlinemorrowasted
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Re: Hydroxychloroquine sulfate [Re: HamHead] * 1
    #26901043 - 08/26/20 05:39 PM (3 years, 5 months ago)

Quote:


So, after a little digging, it seems Remdesivir is not a FDA approved drug for any treatment.

Yet, an FDA approved drug, HCQ, is getting heat.

Why are you using a drug that isn't approved?

Remdesivir must be administered intravenously.

HCQ is taken in pill form, in outpatient settings.

Remdesivir is reserved for those who are hospitalised.

HCQ is a preventive prophylaxis preventing people from becoming severely infected amd then hospitalized, which is why health care workers take HCQ, to prevent them from viral spread.



hcq isnt approved for covid19. The way FDA approval works is that a drug is approved to treat a specific disease. It is a misunderstanding to simply think of a drug as being an FDA approved drug or not an FDA approved drug without respect to a given disease.

We use remdesivir because we have plenty of it and it works. It will receive approval. The process takes at least 6 months

We havent given anyone hydroxychloroquine for outpatient use to treat covid. Maybe they do it in other countries where their hospital space, personnel and resources are more limited and they are less concerned about being sued for malpractice, but we only gave it to people if they were in the hospital. The reason for this is that we discovered quickly that it was unwise to give people hcq without putting them on telemetry- a type of continuous ekg monitoring. If a patient were to suffer a fatal dysrhythmia at home, they could easily sue the hospital since the literature on using hcq for covid indicates that patients should be on telemetry. Even one of the lit reviews you posted from India agreed with that practice, though you appeared not to notice, even though it said so right in the part you copied and pasted.

You have stated both that the indications for HCQ, in your mind, are people with mild illness "unworthy of hospitalization" and prophylaxis. First you were advocating for general population prophylaxis but you appear to have narrowed the scope of your claim, presumably after reading and understanding my explanations of the logistical reasons that a prophylactic strategy could never be implemented at the scale of the general population for a drug like hcq. I have just explained to you that we do not give it for outpatient use because it is too dangerous and it leaves the hospital open to malpractice suits. I heard of some doctors taking it in the beginning of the pandemic, but I dont hear about any of that going on anymore. We have a pretty effective prophylactic called wearing PPE. It has worked for me and most healthcare workers I know. Taking hcq long term can have a variety of chronic health consequences. I personally would not choose to take it even if it were allowed. Some of the hospitals here are testing other prophylactics intended for use among healthcare workers like PUL047, which is an inhaled chemical that prevents respiratory infections in general. I do not think that it will be in general use even if it is found to be effective though, because masks are much cheaper and they work just fine when used properly

Countries like bahrain use hcq because they dont have any other options. Doctors there would be trying remdesivir in a heartbeat if they could get their hands on it. Unlike hcq, remdesivir was designed specifically to treat this kind of virus.

You can cherry pick your countries if you want. South korea's fda equivalent already approved remdesivir. I have seen it suggested that it may not work quite as well in asian populations, but i cant say. It could easily be the case that certain adian countries, china in particular, simply dont want to admit that drugs of american origin might be superior to whatever they are using. I dont know though


Edited by morrowasted (08/26/20 05:54 PM)


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Re: Hydroxychloroquine sulfate [Re: HamHead]
    #26901045 - 08/26/20 05:40 PM (3 years, 5 months ago)

HCQ isn’t really prescribed for malaria anymore. Most areas have resistant mosquitoes


--------------------
NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Re: Hydroxychloroquine sulfate [Re: koods]
    #26901064 - 08/26/20 05:49 PM (3 years, 5 months ago)

Bahrain:tryingnottodie:


--------------------
:whyyy:


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OfflineHamHead
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Re: Hydroxychloroquine sulfate [Re: morrowasted]
    #26901074 - 08/26/20 05:55 PM (3 years, 5 months ago)

Quote:

morrowasted said:
Quote:


So, after a little digging, it seems Remdesivir is not a FDA approved drug for any treatment.

Yet, an FDA approved drug, HCQ, is getting heat.

Why are you using a drug that isn't approved?

Remdesivir must be administered intravenously.

HCQ is taken in pill form, in outpatient settings.

Remdesivir is reserved for those who are hospitalised.

HCQ is a preventive prophylaxis preventing people from becoming severely infected amd then hospitalized, which is why health care workers take HCQ, to prevent them from viral spread.



hcq isnt approved for covid19. The way FDA approval works is that a drug is approved to treat a specific disease. It is a misunderstanding to simply think of a drug as being and FDA approved drug or not an FDA approved drug without respect to a given disease.

We use remdesivir because it works. It will receive approval. The process takes at least 6 months

We havent given anyone hydroxychloroquine for outpatient use to treat covid. Maybe they do it in other countries where their hospital space, personnel and resources are more limited and they are less concerned about being sued for malpractice, but we only gave it to people if they were in the hospital. The reason for this is that we discovered quickly that it was unwise to give people hcq without putting them on telemetry- a type of continuous ekg monitoring. If a patient were to suffer a fatal dysrhythmia at home, they could easily sue the hospital since the literature on using hcq for covid indicates that patients should be on telemetry. Even one of the lit reviews you posted from India agreed with that practice, though you appeared not to notice, even though it said so right in the part you copied and pasted.

You have stated both that the indications for HCQ, in your mind, are people with mild illness "unworthy of hospitalization" and prophylaxis. I have just explained to you that we do not give it for outpatient use because it is too dangerous and it leaves the hospital open to malpractice suits. I heard of some doctors taking it in the beginning of the pandemic, but I dont hear about any of that going on anymore. We have a pretty effective prophylactic called wearing PPE. It has worked for me and most healthcare workers I know. Taking hcq long term can have a variety of chronic health consequences. I personally would not choose to take it even if it were allowed. Some of the hospitals here are testing other prophylactics intended for use among healthcare workers like PUL047, which is an inhaled chemical that prevents respiratory infections in general. I do not think that it will be in general use even if it is found to be effective though, because masks are much cheaper and they work just fine when used properly




Remdesivir is not approved to treat any illness. Meaning, FDA has not approved Remdesivir.

HCQ is an FDA approved drug. If you want me to paste when it was approved by FDA, I will.

My point here should be obvious. We are using a drug with no FDA approval, under emergency use authorization. Otherwise, since Remdesivir isn't approved to treat any illness, without that EUA, Remdesivir would not be being used for anything, as it is not approved to.

After thinking about it, seems to me like Gilead, through their request for EAU, is looking for an illness for which to gain approval for.

:shrug:

Makes sense, since Remdesivir is not approved, why not attempt to push it through approval during a pandemic.

HCQ is an FDA approved drug to treat malaria.

It went through it's processes and gained approval. Again, I can go look this shit up if you don't want to.

So, again I ask, why is a drug that is not approved to treat ANY illness, being used while FDA approved HCQ, has show effectiveness at prevention, is being rejected by US and some others, while those who are using HCQ have shown effectiveness?

And thanks for clarification that HCQ was not given to your paitents in out paitent settings and as you say, only used in hospitalized paitents. It makes a difference, you don't see it working because you are always in a hospital setting.


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


Edited by HamHead (08/26/20 05:58 PM)


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Re: Hydroxychloroquine sulfate [Re: HamHead]
    #26901082 - 08/26/20 06:03 PM (3 years, 5 months ago)

Quote:

After thinking about it, seems to me like Gilead, through their request for EAU, is looking for an illness for which to gain approval for.




It was definitely an orphaned drug when it didn’t show much promise for Ebola, but they lucked out with Covid. It’s not that great, and I’m sure someone is tweaking the molecule for better results. Remdesivir has been shown to be safe because they ran trials for Ebola, so proving efficacy was the main hurdle.


--------------------
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Re: Hydroxychloroquine sulfate [Re: HamHead]
    #26901096 - 08/26/20 06:08 PM (3 years, 5 months ago)

and here's another problem with Remdesivir.

What other drugs did you say were given within that 'everything in between' statement?

How do you know it's Remdesivir that's working and not one of those other, in between drugs like corticosteroids?

It's difficult to tell what works when so many medicines are being given all at once.

While HCQ+zinc with an optional antibiotics such as azithromycin is simple and is being proven safe, like it was many years ago when HCQ went through it's own trials to even be an FDA approved drug.

Seems Gilead may be paying to push Remdesivir through, or maybe NIAID and Dr. Fauci are funding Remdesivir trials now?


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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OfflineHamHead
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Re: Hydroxychloroquine sulfate [Re: koods]
    #26901098 - 08/26/20 06:11 PM (3 years, 5 months ago)

Quote:

koods said:
Quote:

After thinking about it, seems to me like Gilead, through their request for EAU, is looking for an illness for which to gain approval for.




It was definitely an orphaned drug when it didn’t show much promise for Ebola, but they lucked out with Covid. It’s not that great, and I’m sure someone is tweaking the molecule for better results. Remdesivir has been shown to be safe because they ran trials for Ebola, so proving efficacy was the main hurdle.





You don't read thoroughly, do you?

Second coat of paste.


Cohort of 53 hospitalized patients in manufacturer's compassionate-use program: Adverse events (e.g., increased hepatic enzymes, diarrhea, rash, renal impairment, hypotension) reported in 60% of patients; serious adverse events (e.g., multiple organ dysfunction syndrome, septic shock, acute kidney injury, hypotension) reported in 23%; drug discontinued because of adverse events in 8% of patients

And I don't think Gilead lucked out with Remdesivir being a Covid treatment. I think they saw an opportunity to push their drug that had not been approved yet, through these covid trials, seeking approval, because it's useless for anything else.


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


Edited by HamHead (08/26/20 06:20 PM)


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Re: Hydroxychloroquine sulfate [Re: koods] * 1
    #26901110 - 08/26/20 06:17 PM (3 years, 5 months ago)

Talking to this guy is like talking to a brick wall.

We use remdesivir because it works and people are dying. It will be approved. Because it works. We arent gonna stop saving lives we can potentially save just because the fda hasnt signed off on it yet.

And I say again, fda approval of drugs is for specific conditions. Oxycontin is an fda approved drug to treat certain kinds of pain. That doesnt make it any safer to use for treating drug addiction than suboxone. Suboxone is a much better drug to give to addicts. It was a better drug to give to addicts than morphine before it was ever approved by the fda. In the same way, remdesivir is a much better drug to give to covid patients even though it hasnt been approved by the fda yet. We give unapproved drugs to cancer patients all the time. We do it for the same reason- we want to save their lives, and we tried other things and they didnt work.

People dont magically get sicker because we hospitalize them. If someone isnt sick enough to benefit from hospitalization, they arent sick enough to need either hcq or remdesivir.

This is really not complicated at all. I went to great lengths in that post to explain everything you could possibly need to know about why we use remdesivir and not hcq. Just go back and read the post. If you still dont understand, read it again. The answer to every single question you have asked since i posted it is contained inside that post. The only reason things remain unclear to you is that you are operating woth misunderstandings about how the fda works, what hospitalization entails, and how medicine in general is practiced.


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Re: Hydroxychloroquine sulfate [Re: morrowasted]
    #26901123 - 08/26/20 06:25 PM (3 years, 5 months ago)

Quote:

morrowasted said:
Talking to this guy is like talking to a brick wall.

We use remdesivir because it works and people are dying. It will be approved. Because it works. We arent gonna stop saving lives we can potentially save just because the fda hasnt signed off on it yet.

And I say again, fda approval of drugs is for specific conditions. Oxycontin is an fda approved drug to treat certain kinds of pain. That doesnt make it any safer to use for treating drug addiction than suboxone. Suboxone is a much better drug to give to addicts. It was a better drug to give to addicts than morphine before it was ever approved by the fda. In the same way, remdesivir is a much better drug to give to covid patients even though it hasnt been approved by the fda yet. We give unapproved drugs to cancer patients all the time. We do it for the same reason- we want to save their lives, and we tried other things and they didnt work.

People dont magically get sicker because we hospitalize them. If someone isnt sick enough to benefit from hospitalization, they arent sick enough to need either hcq or remdesivir.

This is really not complicated at all. I went to great lengths in that post to explain everything you could possibly need to know about why we use remdesivir and not hcq. Just go back and read the post. If you still dont understand, read it again. The answer to every single question you have asked since i posted it is contained inside that post. The only reason things remain unclear to you is that you are operating woth misunderstandings about how the fda works, what hospitalization entails, and how medicine in general is practiced.





Yeah, I read it, and you keep saying you are trying HCQ in hospitalized people.

I keep saying, as other countries are showing, that early treatment with HCQ is showing great benefits, but you won't admit that because you and your hospital are invested in Remdesivir, like many other hospitals are doing, under guidance of NIAID.

Millions of doses of HCQ are prescribed annually. Why would doctors prescribe such a dangerous drug, millions of times over if they knew it was dangerous? For decades, HCQ has been used safely, why now has it become more dangerous?

Perhaps doctors who don't prescribe HCQ, don't know how to use it.


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


Edited by HamHead (08/26/20 06:30 PM)


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Re: Hydroxychloroquine sulfate [Re: HamHead]
    #26901128 - 08/26/20 06:27 PM (3 years, 5 months ago)

you realize yall could be studying pharmacology instead of creating a rift between retards


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Re: Hydroxychloroquine sulfate [Re: cannabinated]
    #26901129 - 08/26/20 06:28 PM (3 years, 5 months ago)

ok im done for the night


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Re: Hydroxychloroquine sulfate [Re: cannabinated] * 1
    #26901141 - 08/26/20 06:39 PM (3 years, 5 months ago)

So the key is early treatment for something you very well may not even know you have in the early stages, and the research says that it kind of maybe might possibly sort of in theory help an unknown percentage of people possibly maybe have less severe cases, so long as you also ignore all the research suggesting the opposite.

Should we all wake up and take some antimalarials and antibiotics with our morning coffee every day? Don't forget the zinc

And why is no one talking about bleach? Bleach is a potent antiviral in in-vitro clinical trials. I saw it on Google Scholar.

:mindblown:


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Re: Hydroxychloroquine sulfate [Re: feevers]
    #26901155 - 08/26/20 06:57 PM (3 years, 5 months ago)

Quote:

feevers said:
So the key is early treatment for something you very well may not even know you have in the early stages, and the research says that it kind of maybe might possibly sort of in theory help an unknown percentage of people possibly maybe have less severe cases, so long as you also ignore all the research suggesting the opposite.

Should we all wake up and take some antimalarials and antibiotics with our morning coffee every day? Don't forget the zinc

And why is no one talking about bleach? Bleach is a potent antiviral in in-vitro clinical trials.

:mindblown:




Is this supposed to be funny?

I'll entertain you though.

https://internetprotocol.co/hype-news/2020/04/14/a-detailed-coronavirus-treatment-plan-from-dr-zelenko/

:specialralph:


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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OfflineHamHead
Hard Ass Motherfucker
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Registered: 03/17/15
Posts: 6,107
Loc: Galactic sector ZZ9 Plura...
Last seen: 2 years, 8 months
Re: Hydroxychloroquine sulfate [Re: HamHead]
    #26901352 - 08/26/20 09:26 PM (3 years, 4 months ago)

Oh, something interesting just ran across my eyeballs.

https://wattsupwiththat.com/2020/08/24/hydroxychloroquine-in-covid-19-treatment-actual-usage-in-the-usa/

"From late March to early May, about 150,000 US patients received HCQ for COVID-19. HHS OSE found 97 adverse reports22 of all kinds (misspelled as 347 in the FDA Memorandum17) associated with HCQ and chloroquine during that period.

This study shows that Remdesivir was widely used in March-April before its emergency approval on May 1. Surprisingly, its usage throughout the epidemic was, on average, 70% of the HCQ usage. It sharply declined in the last third of June, possibly on disappointing clinical results23 and evidence of liver toxicity24, but resumed at the nearly previous level in July.

Still reading through, Cherry picked this one for me, she's down there sucking my big toe clean.

Study Limitations
There are limitations usual for studies based on a population survey. Most values in the Summary spreadsheet are computed from small sample sizes. Other limitations are mentioned in subsection Processing.

Conclusions
Patients’ side statistical information about the use of hydroxychloroquine for COVID-19 patients was collected. Using it, this study has found:

HCQ was used for the treatment of COVID-19 in the US since January 2020. From January to August 16, 13.5% of COVID-19 patients ages 40+ were prescribed Hydroxychloroquine in the US.
The New England and Middle Atlantic census divisions suffered from the largest COVID-19 mortality and accounted for most COVID-19 deaths from mid-March through mid-June. They also had the lowest utilization of HCQ (average 6.1% for patients ages 40+) in the matching period early March — late May.
Everywhere in the US, prescription of the HCQ nearly ceased in the last third of May but resumed in June and has been fluctuating around 16% for patients ages 40+.
The raw responses data is attached. It can be mined further, especially when combined with publicly available statistics on the COVID-19 hospitalizations, deaths, tests, infection cases, and how many days pass from the first COVID-19 symptoms and the start of HCQ based treatment. Eventually, more data would allow testing hypotheses:

Early HCQ-based treatment of adults of all ages with COVID-19 symptoms correlates with decreased COVID-19  infection and/or hospitalizations cases 10-20 days later25.
Early HCQ-based treatment of ages 40+ with COVID-19 symptoms correlates with decreased COVID-19 deaths and/or ICU admissions 20-35 days later.
No Competing Interests
The author declares no competing interest.

No funding was provided for this work.

All relevant ethical guidelines have been followed."

Interesting how remdesivir caused liver toxicity.

Anything else causing liv. . .

:tryingnottodie:


Edited by HamHead (08/26/20 09:31 PM)


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OfflineIce9
3X Ban Lotto Champion
I'm a teapot User Gallery


Registered: 03/20/14
Posts: 11,232
Loc: daterapeville,USA
Last seen: 26 minutes, 13 seconds
Re: Hydroxychloroquine sulfate [Re: HamHead] * 1
    #26901363 - 08/26/20 09:36 PM (3 years, 4 months ago)

From your study:

All three surveys were conducted using SurveyMonkey. Each survey was sent to the general US population. Each survey asked the respondent the following:

Whether he or she knew anybody diagnosed with or treated for COVID-19. Depending on the answer, the response was assigned weight from 1.0 (personal knowledge, friends, or family) to 0.2 (second-hand knowledge) or disqualified at all. Qualified respondents were asked to provide information about a single case best known to them.
The age bracket of the patient was selected from the options <40, 40-49, 50-59, 60-69, 70+.
When the treatment took place.
Which of the following drugs were prescribed or recommended:
Hydroxychloroquine (Plaquenil)

Ibuprofen (Advil)

Acetaminophen (Paracetamol, Tylenol)

Remdesivir

Other

emphasis mine, this article could  maybe get in a pay to play Chinese journal but yeah, it's methodology is utter useless trash, rendering any and all conclusions to be utter useless trash.

I know you have the time and the will, teach yourself how to understand the methodology of various studies (see Morrowind's great post for the type of studies you'll be looking at) and you will be better equipped to determine for yourself whether you should post a quote or an article based on its absolute scientific merits.

Otherwise you just keep showing the shroomery your whole ass to be  laughed at, its gotten so embarrassing I find myself feeling bad for you.


--------------------
The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore, all progress depends on the unreasonable man. -- George Brenard Shaw


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OfflineHamHead
Hard Ass Motherfucker
Male


Registered: 03/17/15
Posts: 6,107
Loc: Galactic sector ZZ9 Plura...
Last seen: 2 years, 8 months
Re: Hydroxychloroquine sulfate [Re: Ice9]
    #26901381 - 08/26/20 09:55 PM (3 years, 4 months ago)

https://wattsupwiththat.com/2020/07/05/hypothesis-restrictions-on-hydroxychloroquine-contribute-to-the-covid-19-cases-surge/

Interesting stuff there. I doubt anyone clicks these things.

Whatever you say Ice9.

Keep calling studies teash until legitimate clinical trials are completed.

We'll see who's right about HCQ in a few months.

HCQ trials are still running, without EAU, while remdesivir needed it's emergency use authorization because Gilead is aware Remdesivir causes liver toxicity.

Care to comment morrowasted? There's letters here I don't quite understand, something about levels being elevated?

Here, look!

https://link.springer.com/article/10.1007%2Fs12072-020-10077-3

Our observation supports previous findings obtained in healthy volunteers (Gilead Sciences, data on file) and COVID-19 patients treated with RDV [4, 5], suggesting this antiviral may cause hepatocellular injury. In our patients, this adverse effect neither progressed to severe liver damage nor induced liver failure, although none had a prior chronic liver disease. Although SARS-CoV-2 infection can cause aminotransferase elevation per se, 4 of our 5 patients had normal or slightly elevated AST/ALT levels at RDV treatment start, suggesting a direct role of RDV in hepatocellular toxicity. Despite the overall low number of patients treated, we observed a clear trend of bilirubin elevation with LPV/r and ALT/AST elevation with RDV. Our observation suggests RDV can be used with close monitoring of liver function tests and with caution in subjects with prior liver disease.


What's all that stuff mean? Looks like they're using many drugs, recognize any of them? How can they tell what's working and what isn't?

:rush:


--------------------
The Italian researchers’ findings, published by the INT’s scientific magazine Tumori Journal, show 11.6% of 959 healthy volunteers enrolled in a lung cancer screening trial between September 2019 and March 2020 had developed coronavirus antibodies well before February.

https://www.reuters.com/article/us-health-coronavirus-italy-timing-idUSKBN27V0KF

This online first version has been peer-reviewed, accepted and edited,  but not formatted and finalized with corrections from authors and proofreaders

https://www.icandecide.org/


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