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Offlinesauroman1
Emrys

Registered: 03/22/14
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Saccharomyces cerevisiae (GMO brewing yeast) producing psilocybin
    #26749001 - 06/16/20 01:29 PM (3 years, 7 months ago)

How far away we are from Saccharomyces cerevisiae yeast or other microorganisms producing triptamines like psilocybin and available in markets? Currently only drug they produce is alcohol but there were news quit awhile about GMO yeast producing various drugs such as THC and psilocybin. That would much more efficient, stealthier and cost effective way to produce psychedelic compounds.

https://hightimes.com/news/danish-scientists-modify-yeast-create-psilocybin/


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"You come from realms of unimaginable power and light, and you will return to those realms.” ― Terence McKenna


Edited by sauroman1 (09/03/20 03:27 PM)


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OfflineMycoactive
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Registered: 11/20/19
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Re: Saccharomyces cerevisiae producing psilocybin [Re: sauroman1]
    #26749290 - 06/16/20 03:04 PM (3 years, 7 months ago)

THC can be produced synthetically and biosynthetically in organisms other than Cannabis species. The same is true for psilocybin and Psilocybe/Panaeolus/Gymnopilus/etc. species.

I think a more intriguing question is what is lost when we go from a complex set of molecules produced by an organism to a single molecule. Maybe nothing. Maybe a lot. Anecdotal evidence from members here suggests that there are reliable differences between the psychedelic experiences produced by different psychoactive species of fungi. If true, these differences are almost definitely tied to differences in the molecular makeup of these fungi.

It's tempting to point to one molecule as the cause of the effects produced by consumption of an organism. However, there are usually many molecules produced by these organisms that are structurally similar to the molecule with known psychoactivity. These molecules likely have distinct psychoactive properties that contribute to the overall experience. To replicate such a complex set of psychoactive molecules in an organism like yeast would be difficult and would require a level of understanding that we are still far from achieving.


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Offlinesauroman1
Emrys

Registered: 03/22/14
Posts: 203
Loc: Shangrila
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Re: Saccharomyces cerevisiae producing psilocybin [Re: Mycoactive]
    #26753670 - 06/18/20 08:38 AM (3 years, 7 months ago)

Well difference in psychoactive substances small. Main of this is psilocin and psilocybin which gets converted in body into psilocyn. Mushrooms such as azurescens sure contains baeocystin but what else cubensis contains? Yeast could produce also other psychoactive substances, more research need to be done. Nutritionally speaking brewers yeast is good protein and vitamin B source, great supplement for vegans.

Important thing to consider is also dosage because yeast can produce yeast but it might be too low. Although even small doses could medicinal for depression treatment, nootropic effect and productivity boost.


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"You come from realms of unimaginable power and light, and you will return to those realms.” ― Terence McKenna


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Invisiblepanne cyanne
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Female

Registered: 04/15/20
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Re: Saccharomyces cerevisiae producing psilocybin [Re: sauroman1] * 1
    #26755119 - 06/18/20 05:43 PM (3 years, 7 months ago)

i think the idea is to grow these novel bio forms by the carboy,
and then drop the psil thru chromatography, more / less.

the obvious thing for us to do is lay and wait till someone liberates a culture.
and you know someone will.
and you know once we get it there will be a absolute run on 5 gallon jerry cans like its april 2020 toilet paper.


Edited by panne cyanne (06/18/20 05:44 PM)


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Offlinevinnie boombotz
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Registered: 04/29/19
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Re: Saccharomyces cerevisiae producing psilocybin [Re: panne cyanne]
    #26760171 - 06/20/20 03:55 PM (3 years, 7 months ago)

I got a little Amazon stock for anyone who can exonerate the psilocybin from yeast and send some my way. I also have boxes and boxes of Old Mother Earth magazines which were ahead of their time


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Invisiblepanne cyanne
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Re: Saccharomyces cerevisiae producing psilocybin [Re: vinnie boombotz]
    #26760364 - 06/20/20 05:51 PM (3 years, 7 months ago)

no one should hold their breath on this.
even if the cultures were commonly traded on the web,
my understanding is requires industrial chromatography skill to extract.
good luck on that.
individuals may see this as no obstacle,
to general potential growers, its a total roadblock.


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OfflineInnerWisdom
Male


Registered: 08/09/19
Posts: 1,936
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Re: Saccharomyces cerevisiae producing psilocybin [Re: panne cyanne]
    #26783626 - 06/26/20 04:13 AM (3 years, 6 months ago)

But one doesn't need to extract to consume the psilocybin :hereyougo:
A spoonful of yeast to trip balls. Furthermore you could just put it in tea or bake with it to kill off the yeast.


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OfflineInnerWisdom
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Re: Saccharomyces cerevisiae producing psilocybin [Re: Mycoactive]
    #26783627 - 06/26/20 04:15 AM (3 years, 6 months ago)

In the study that demonstrated how they produced psilocybin with yeast, the yeast also produced various other tryptamines that the mushrooms produce as well with that same enzyme or gene.


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OfflineSoccrates
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Registered: 04/10/19
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Re: Saccharomyces cerevisiae producing psilocybin [Re: InnerWisdom]
    #26794180 - 06/30/20 10:15 AM (3 years, 6 months ago)

Does it produce anything you don't want to consume? I wouldn't think so, but would be good to know. If not, yeah who cares about extraction.

And, to be fair chromatography would only be required if you were after a pure product.

Thee important question, is where do we get this yeast? Someone needs to infiltrate Scott's and get access to their gene splicing technology, then do a big giveaway here. And everywhere. Grow that psilly yeast and then cropdust the countryside with it


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OfflineGreenHorns
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Re: Saccharomyces cerevisiae producing psilocybin [Re: Soccrates]
    #26804195 - 07/04/20 07:53 PM (3 years, 6 months ago)

I heard a presentation at a brewers conference last year and they talked about these GMO strains. Interesting but scary to think about all these GMO beers being brewed if the FDA approves any of them. Id be inclined to believe if someone created a strain that produced psilocybin there would be distillation at the very least involved for a comfortable threshold doses unless you wanted to drink a gallon or more of liquid that might not taste terribly good. From there it would still be a process of extraction similar to just using shrooms for pay dirt. Interesting but as a professional in the beer industry i think its a bad road to go down fucking around with GMO sacc.


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InvisiblebodhisattaMDiscordReddit
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Re: Saccharomyces cerevisiae producing psilocybin [Re: GreenHorns]
    #26804370 - 07/04/20 10:27 PM (3 years, 6 months ago)

Gmo saccharomyces has been around for over 30 years and has made beer. Just not for consumers. Iirc there is gmo saccharomyces used in wine.


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OfflineGreenHorns
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Re: Saccharomyces cerevisiae producing psilocybin [Re: bodhisatta]
    #26804373 - 07/04/20 10:31 PM (3 years, 6 months ago)

What/who is the GMO beer used for? Ill look into it on my own but would love some reading materials if youve got a reference.


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InvisiblebodhisattaMDiscordReddit
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Re: Saccharomyces cerevisiae producing psilocybin [Re: GreenHorns]
    #26804380 - 07/04/20 10:36 PM (3 years, 6 months ago)

Great Britain approved a gmo yeast i think in 95. It had extracellular glucoamylase expression. The reception of gmo made it commercially unviable. The usa has made a boatload of gmo yeast for beer but none is used for commercially available beer. Fuel ethanol uses gmo yeast.


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OfflineGreenHorns
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Re: Saccharomyces cerevisiae producing psilocybin [Re: bodhisatta]
    #26804395 - 07/04/20 10:50 PM (3 years, 6 months ago)

ohhh got it. still very interesting none the less. seemed like a new topic from what i was hearing. they were talking about modifying sacc to obtain certain aromas and flavors. Citrus, fruit, various hop copycats. seemed like cheating to me. thanks for the enlightenment.


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