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OfflineO.T. Oss
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Using psilocybin in a symbiotic relationship to enhance neural networks * 1
    #26694053 - 05/25/20 01:28 AM (3 years, 8 months ago)

Aloha Everyone, I’m kinda new to posting wasn’t sure where to post this monster, so I’m hopeful it will find a audience in the correct thread.
I’ve been thinking a lot lately about language. (I think it’s important to note here that I’ve been reading a lot of Terrance McKenna) I’m sure most everyone here is aware of Mckennas theory of how mushroom consumption in early hominids help evolve language. If your not it’s a fascinating idea, and I would highly recommend looking into it if you think it sounds interesting. The reason I bring it up is because It seems ( to me at least) that some of the neural imaging being done across the globe on people under the influence of pscilocybin show an increased connectivity in neural networks.
https://hopkinspsychedelic.org/
That doesn’t prove mckennas theory but the current research + mckennas theory + a once a month 10g dose brought forth a theory of my own that I would like to share. It’s  on the similarities of beneficial nutrient distribution in root structures & neural networks. In my theory I make the claim that certain Fungi (introduced into our body) can move neurotransmitters around our brain the same way they move nutrients around tree/plant roots. Ive created a video (
) where I show evidence of how this could be possible. The beneficial symbiotic relationship between trees and fungus is similar (at least in my opinion) to what happens in our brain under the influence of psilocybin cubensis, if you take a look at the brain scans (fmri....etc) coming from recent university studies such as the link from Hopkins up above or links readily available at MAPS.org you will see a striking similarity.
    My last trip was incredibly in depth, like I was being given information or blueprint of some kind. It is extremely difficult to bring back coherent ideas from heroic doses yet I have  found if you can write down your ideas pre-trip That you will at the very least be shot out in the right direction. It is this last trip where I was given this idea of our fractal nature. You can see my video here 

Allow me to try an explain and thank you for taking time to read this. Here is a visualization exercise you can do that will better help you understand. Imagine a giant tree, look to the top and slowly move your eyes down the enormous trunk untill you reach the base. Good! Now imagine your in the warm embrace of a magical quicksand that gently lowers you below the ground level so you can see the root system. dont panic this magical quicksand Also infuses your body with oxygen so you do t suffocate! The current root system you see here is very similar to what you would see if you could peer into the human nervous system. (Did anyone see that bodies exhibit that toured around the world a few years back....it’s like that!
To add add an extra dimension think of a world map or globe. You know the one! Look close you can see all the black lines strewn across representing shipping lanes. Maybe you’ve seen a more recent version (I would recommend Dr. Pharag Kannas book) that shows the supply chains of our planets natural resources distribution. Which brings us full circle to the beginning of this post.  Language!  Supply chains move the planets natural resources vital to our life, our neural networks move the rains natural resources vital to our life, the tree roots move natural resources vital to the tree. All three maps...a supply chain map, neural network image, tree/vegetation root structure are uncannily similari if brought to Scale. I’m working on making semi-transparent images that could be laid on top one another that may verify my theory. If so we may be able to learn how to cure brain trauma by streamlining supply chains or help stroke victims by understanding root structure. You may be thinking hmmmmmm what the fuck does that have to do with pscilocybin mushrooms? First off I got this idea from the mushroom, Second the mycelium of several fungi act as an extension of root structures. A symbiotic relationship in which the fungus creates better functional connectivity. Better Functional. Connectivity means healthier trees, better supply chains ,and according to science higher IQ. So please LMK what you think. I would  be grateful to get some constructive criticism on my abstract video
Warm Mahalos
O.T.


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OfflineO.T. Oss
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Re: Using psilocybin in a symbiotic relationship to enhance neural networks [Re: O.T. Oss]
    #26698573 - 05/27/20 04:37 AM (3 years, 7 months ago)

Aloha Everyone
I had an opportunity to polish up the edges of my first Video LMK  what you


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InvisiblefeeversM
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Re: Using psilocybin in a symbiotic relationship to enhance neural networks [Re: O.T. Oss]
    #26698642 - 05/27/20 05:52 AM (3 years, 7 months ago)

Interesting theory.

The similarities between mycelium and neural networks are definitely interesting, as well as the similarity between psilocybin in the mycelium and DMT that is almost certainly in the brain.

One thing I think you're missing in your theory is that it's the mycelial network that exchanges nutrients and enables "communication" between plants and trees. Psilocybin itself isn't involved in that process, but it is the sole catalyst for whatever happens in the brain.

The brain's neural structure is already in place, psilocin binds to selective receptors throughout the body and brain. It doesn't seem to have any sort of regulation effect of other neurotransmitters other than saturating receptors that normally serotonin would bind to.

Meditation has similar effects on the brain when looking at it through scans. The default mode network is toned down by ingesting psychedelics or meditating (and is haywire in schizophrenics). The DMN is a vital area of the brain for processing and filtering sensory input and creating an easy-to-navigate reality with depth and continuity. It also has been described as the generator for the ego, as it plays an enormous role in self-referential thinking and forming a sense of an individual self.

My interpretation of the research is that as your reality-modulating serotonin receptors get saturated by the alien psilocin, the structure is disrupted leading to large abnormalities and novelty in subjective experience. The usual information highway, which runs through the tunnel of the DMN, is avoided and the electrical impulses travel the backroads, linking together brain areas that normally do not communicate. The interesting question to me is a chicken or egg one with the DMN... does the psilocin somehow structurally slow down activity in the DMN, or does it merely trigger a subjective experience that pushes outside the bounds of self-referential thinking and that's what's reflected in the scans?

I actually have a research study written up on stroke recovery and psilocyin, utilizing the neurogenesis and BDNF increase to re-learn ADLs and gain functionality on the effected side. Have to graduate first before bringing up those type of ideas though, unfortunately.


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OfflineO.T. Oss
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Re: Using psilocybin in a symbiotic relationship to enhance neural networks [Re: feevers]
    #26703374 - 05/29/20 03:22 AM (3 years, 7 months ago)

Thank you feeders!
  I appreciate you taking some time to respond. I think your first sentence was the very point I was trying to get across. I'm a little bit jealous because your 29 words may have painted a better picture than my video.

"The similarities between mycelium and neural networks are definitely interesting, as well as the similarity between psilocybin in the mycelium and DMT that is almost certainly in the brain."

As Ive had time to think about it I must agree that my theory, while interesting..... dare I say even beautiful, is both flawed & incomplete. If you will permit me a few moments of your time, I'm confident I can provide you with an interesting exchange, while simultaneously picking your brain to better formulate my understanding....it may take me a moment, however Im hopeful you will enjoy the scenery along the linguistic pathway in-route to idealand.

  On the subject of psilocin binding to the family of 5Ht receptors. Im aware of the closeness in structure between seratonin & psilocin as i am also aware of the key & lock metaphor. Where i can get a bit turned around is in the mechanism of action. Would you say that psilocin acts like a team of highway patrol officers, in hot pursuit of a white bronco making a B-line for the border  rushing to the 5Ht receptors like exits on the freeway, shutting them down as to not let any other traffic get in the way? Or is it more like a bad copy of a key to your front door, you know where it kinda fits but you have to jimmy it a little bit because the slide docent quite release all the way? perhaps its neither...........

The reason I'm asking is about semantics. lets say its the latter in the example above, and If serotonin is a neurotransmitter and its structure is closely related to psilocin, so much so that it causes a transfer of impulse across the synaptic gap, is it not responsible for neurotransmission? Thus making it a neurotransmitter? If its more like the highway patrol then would it be some sort of neurotransmission blocker? This is where the whole incomplete language thing comes into play. (Perhaps it is my lack of understanding) Is it a plant alkaloid, a 5ht agonist, a chemical messenger, the flesh of god, the logos............ THIS IS the roadblock that refuses to allow new knowledge to pass. It matters a lot, not just to make sure that two people in a conversation our actually talking about the same thing, but because whatever label you put on it, what ever word you choose to call it has a radically different thought process or whatever label/word is used is like a pathway leading to a different part of town. If you say " The dog bit Johnny" that has an entirely different meaning than "Johnny bit the dog"  (especially if your Johnny) or if you dial my phone number you get me but if you change 1 number in the sequence you could get someone else on the other side of the planet. By changing one seemingly small variable you can have a radically different outcome............but I digress.

On the chicken and the egg. Im of the opinion that psilocin does slow down the activity in the DMN. It would seem that the metaphorical back roads in which the impulse travel are the highways of old.  More scenic, less traffic, and better restaurants. Also since repetition is the mother of skill, repetition IS the mother of skill, that is if you do something repetitively, like say that repetition is the mother of skill then the person who hears you say may well never forget it. More importantly use of pscilocin to shut down the DMN and constantly take the "backroads" can and will strengthen the connections or newly traveled backroads between  brain centers hence the alleviation of some brain traumas/psychosis/ego issues etc. There are indeed some books to back up the highways of old point of view. Julian jaynes for example wrote a book called "The origins of consciousness in the breakdown of the bicameral mind." In said book he makes the argument that language was, in the not to distant past,  processed in the right hemisphere of the brain, corresponding to where brocas & wernicke's are today on the left. ( The language areas were exactly the same only different.........the book is fascinating. I will PM you a link to my dropbox where you can download it as an mp3) The evidence he gives speaks to the experience of auditory illusions, which are in fact characteristics of both schizophrenics and high dose psilocybin trips and..and..also two groups with abnormal activity in the DMN. As a companion Jaynes book there is another by a gentleman named Ian Mcghilcrest called "The master and his emissary."  It is equally enthralling. He makes the case that the right hemisphere was the king and the left the emissary untill several hundred years ago. He speaks to the creativeness of the renaissance. The artistic beauty of sculpture & verse alike, comparing them to modern day right brain thinkers. The left hemisphere, the analytical side has recently wrestled the authority away in todays environment of what marshall mcluen would call hot mediums..................

I would be stoked to read your paper on stroke recovery and psilocyn. You are right it is unfortunate, but true to bring up talk on psychedelics. It can make only make it difficult to be taken seriously but be career ending.... Thanks for taking time

Warm Mahalos
O.T.


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InvisiblefeeversM
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Re: Using psilocybin in a symbiotic relationship to enhance neural networks [Re: O.T. Oss]
    #26703644 - 05/29/20 07:03 AM (3 years, 7 months ago)

It's pretty much just a structural thing. Once the psilocin passes the blood brain barrier, it will behave largely similar to serotonin and end up at the same receptors. It also interacts to varying degrees with dopamine and adrenergic receptors, as well as serotonin transporters. 5-ht2a is just the primary mode of action, binding to serotonin transporters may leave more psilocin active at the synapse and temporarily reduce reuptake as well which may extend duration.

There's still too much unknown, but it appears the effects come from the addition and not the subtraction. The psilocin doesn't kick serotonin off the receptors, it's only a partial agonist. Serotonin will still have plenty of receptor sites to bind to and serve its function throughout the body/brain. It's whatever signals the unique psilocin molecules catalyzes that appears to cause the subjective experiential changes. To put it metaphorically I'd compare it to a recipe, serotonin is a cake with basic ingredients, psilocin is structurally extremely similar but small differences create an altered experience, such as switching the out some of the sugar in the cake for salt.

Whether or not it's a neurotransmitter is purely semantic, it's not produced in the body so it won't be called one in the literature. DMT however is now being considered as a neurotransmitter because it is found naturally in the body. Kind of like how nicotine is not a neurotranmitter, but after crossing the BBB mimics acetylcholine as its method of action.

As far as the DMN, if I were to take a complete guess I'd say that the prefrontal cortex becomes vastly overstimulated as the psilocin takes hold, and glutamate increases in that area and decreases elsewhere in the brain. Since glutamate is the brain's primary excitatory neurotransmitter, that would cause the effects seen in fMRIs and the subjective experience as those areas of the brain interfere less with transmission of impulses.

It'd make sense that repeated use would strengthen these new pathways for neural communication. The question would be how often would you have to trip to notice any functional difference. It's definitely an area that should be explored.

I have a theory that actually fits with what you said about the "highways of old". It could be that the "monopoly" that the DMN has over our subjective experience is a direct result of evolution. We've undoubtedly evolved over time to see reality in a way that's suited for fitness, not for seeing things as they actually are. It's why we don't see our nose even though it's directly in our field of vision, it's why the blind spot caused by our optic disk gets automatically filled in by our brain, why we can filter out background noise that very much is picked up by our auditory receptors... there are lots of illusion tricks to demonstrate how little "reality" we are actually operating in. I think the physical manifestation of this evolution is the DMN itself, it's the brain areas that have evolved to do this filtering and processing that favors our survival over experiencing reality as it actually is. Drugs and meditation practices that slow the DMN down may give us a slight peek behind the curtain and glimpse into the chaos of something closer to "base reality".


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