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John Stossel
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Psilocybin and Lexapro
#26686108 - 05/21/20 04:57 PM (3 years, 8 months ago) |
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If someone takes 5mg Lexapro daily for 14 days, would they be safe taking 2g of psilocybin mushrooms? Serotonin syndrome appears to be a concern for those taking high dosages of both mushrooms and lexapro, but considering the fairly low doses of both of these drugs, I would assume there is little to no risk of this happening. If not, how long would one have to discontinue the use of 5mg Lexapro before taking psilocybin?
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dizzy_simmons
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I wouldn’t recommend discontinuing your medication to trip. It takes a long time to actually take effect for one thing, and it can be VERY uncomfortable to suddenly stop taking it.
-------------------- UNDO YOUR DOMESTICATION Looking for: ***The Land of the Free*** Ps. caerulipes Ps. cubensis Ps. cyanescens Ps. ovoideocystidiata Pan. cinctulus Pan. cyanescens
Edited by dizzy_simmons (05/21/20 05:46 PM)
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John Stossel
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So what would be a good dose for a first timer on ssris?
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dizzy_simmons
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I can’t recommend it, but if you insist, you should at least peruse Erowid’s SSRI experiences.
-------------------- UNDO YOUR DOMESTICATION Looking for: ***The Land of the Free*** Ps. caerulipes Ps. cubensis Ps. cyanescens Ps. ovoideocystidiata Pan. cinctulus Pan. cyanescens
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alephdog
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If it is being used for major depression, yeah there are ways to get off of it WITH YOUR DOCTOR'S AWARENESS. You can generally treat depression with magnesium, green tea, turmeric or a similar personalized combination.
If it's being used as an adjunctive to address a wider range of symptoms, it might be trickier. You might be out of luck. You can still enjoy cannabis and salvia (in moderation) but I doubt you'll be getting high on DMT, shrooms or LSD.
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DJ Ed
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After 14 days, it’s possible the SSRIs haven’t even started to work. Stop taking them for 14 days then go adventuring 
There is no link between psilocybin, SSRIs, and serotonin syndrome
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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C12ShroomMan
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Re: Psilocybin and Lexapro [Re: DJ Ed]
#26689042 - 05/22/20 08:08 PM (3 years, 8 months ago) |
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I've been on 20mg about a year (6'5 260) Around 2g dose was a nice re-introduction for me. Left me wanting more, stronger but also more of the same would be good too
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CocaineBuffet
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Quote:
C12ShroomMan said: I've been on 20mg about a year (6'5 260) Around 2g dose was a nice re-introduction for me. Left me wanting more, stronger but also more of the same would be good too 
Interesting I am about the same height and weight on the same amount of Lexapro. I have been curious about it but I know I got some shit in my life to get a hold on before doing it.
OP is on the lowest dose of the medication (they dont make pills less than 5mg of it unless you break those in half or quarters).
I was told by my doctor if you go more than 1 day without taking it (cold turkey not tapering) you just have the absolute worst headache in your life. 5mg is an introductory dose of the SSRI though so it would be easy for OP. Just anecdotal information.
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The Blind Ass
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I recall the party line with some of the SSRI’s back in the early 2000s being that it takes up to 4 weeks to build up to a medically significant level... Back in 2008 or around that time I was prescribed Lexapro, I took it for less than a month and then quit taking it without a taper.
I had some “brain zaps” and that worried me bc I didn’t really know what that was indicative of, so that easily turned into a persistent background anxiety because I imagined that could be the sign, or start of seizures..
I like to think that Brain Zaps feel like you momentarily step onto one of those transporters from Star Trek that deconstructs & then rematerializes all the atoms in your body . I used to call it “phase shifting” , but really it’s just the brain & body returning to equilibrium. That’s the best way I can put it; However, they only lasted for a brief moment in time and then passed, but they were persistent in that they kept reoccurring throughout the day - it took about a week or two for that to stop.
After that - Everything went back to whatever “normal” was for me at the time . Just wanted to share my experience of that with you OP.
-------------------- Give me Liberty caps -or- give me Death caps
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DJ Ed
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This is the point people with SSRIs, even the experts don’t know what cause the brain zaps etc, because they simply have no long term safety data on SSRIs. SSRIs have passed the minimum FDA safety processes to get them to market. Do some research, Big Pharma do not have any long term data on ssri use.
Scary shit. Now dude, you got the brain zaps after a month; I was on high dose of sertraline for 7 years. I tapered off from 100mg to 0mg in under 4 weeks.....but I don’t suggest anybody else do the same without doing your research first. Ok, these are dangerous. Brian zaps, amongst many other withdrawals, were horrendous
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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John Stossel
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Re: Psilocybin and Lexapro [Re: DJ Ed]
#26690500 - 05/23/20 02:10 PM (3 years, 8 months ago) |
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Learning a lot from the discussion on this, thanks a lot guys. I have been off the Lexapro for about 3 or 4 days now and have experienced no noticeable side effects, especially not brain zaps. Gonna wait a week or two from now to try the mushrooms!
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DJ Ed
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Good luck dude. You’ll know when your brain is clear of the medication; the trip will be amazing and rewarding. Your afterglow will make you feel better than any medication......
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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Seeker604


Registered: 11/30/20
Posts: 331
Loc: United States
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I've been on 5mg of Lexapro daily for over a year now, and I typically trip 2 or 3 times a year. I've had no bad experiences - in fact the few effects of tripping I didn't care for like anxiety or racing thoughts - are noticeably absent now, while all the enjoyable experiences remain.
I also found this article that made me think of this thread so here you go:
https://mugglehead.com/popular-antidepressant-escitalopram-and-psilocybin-can-be-taken-together-safely-study/
Peace & Light,
Seeker604
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epilectric
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Re: Psilocybin and Lexapro [Re: Seeker604]
#28150012 - 01/21/23 04:49 AM (1 year, 7 days ago) |
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SSRIs can and do reduce the effects of psychedelics
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Seeker604


Registered: 11/30/20
Posts: 331
Loc: United States
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Quote:
epilectric said: SSRIs can and do reduce the effects of psychedelics
Nobody in this thread is negating that. I shared the study above to help put to rest peoples' concern about safety combining psilocybin and Lexapro.
Again, I can confirm it's been my experience since starting Lexy that my mushroom trips are more enjoyable as anxiety and scattered lines of thought are no longer present at low or high doses. I've also tripped on LSD twice since starting my Lexy treatment (not for depression but for anxiety and helping control my blood pressure); and while I needed 1 or 2 hits more than I normally would without the Lexy in my system, those trips were equally beautiful and engaging.
Peace & Light,
Seeker604
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Northerner
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Re: Psilocybin and Lexapro [Re: Seeker604] 1
#28150743 - 01/21/23 02:55 PM (1 year, 7 days ago) |
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The OP made this thread and then left 2 years ago guys.
Probably not going to be reading your posts.
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The nearest we ever come to knowing truth is when we are witness to paradox.
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Seeker604


Registered: 11/30/20
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Loc: United States
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That doesn't mean other people don't find the information useful.
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Northerner
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Re: Psilocybin and Lexapro [Re: Seeker604]
#28150833 - 01/21/23 04:34 PM (1 year, 7 days ago) |
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It just looked like you were talking to the OP, guiding them to a link, which was why I pointed that out.
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The nearest we ever come to knowing truth is when we are witness to paradox.
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