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Invisibletyrannicalrex
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Registered: 04/24/03
Posts: 38,323
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Re: What to expect from a molly comedown? [Re: Nymphaea] * 1
    #26687731 - 05/22/20 09:33 AM (3 years, 8 months ago)

Check this out:

It might be beneficial to ingest cannabis after a roll.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824821/

TH levels were also measured in animals pretreated with the CB1 receptor antagonist AM251 and the CB2 receptor antagonist AM630 receiving THC and MDMA and housed at 26±1°C (Fig. 7c). THC did not prevent MDMA-induced hyperthermia in mice treated with AM251. Conversely, AM630 did not modify the ability of THC to prevent MDMA-induced hyperthermia (Table 2).

Finally, TH levels were evaluated in CB1, CB2 and double CB1/CB2 knockout mice administered with THC and MDMA (Fig. 7b). Vehicle-treated CB1, CB2 and double CB1–CB2 knockout mice showed similar TH levels than wild-type mice. In contrast, THC prevented MDMA-induced hyperthermia in wild-type and CB2 knockout mice, but it was unable to prevent MDMA-induced DA terminal loss in mice deficient in the CB1 and CB1–CB2 receptor. In conclusion, THC protects against MDMA-induced DA axonal degeneration through the activation of CB1 receptor.


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