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Alan Rockefeller
Mycologist

Registered: 03/10/07
Posts: 48,274
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New Paper: Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms
#26635480 - 04/28/20 09:44 PM (3 years, 8 months ago) |
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Today I came across this new paper on the alkaloids in psilocybin mushrooms, published in February 2020.
They suggest that baeocystin might not be psychoactive according to animal and cell culture assays, though Paul Stamets says he tried 10 mg and it did something. "Baeocystin has been detected alongside psilocybin in some varieties of mushrooms in concentrations substantial enough to be potentially physiologically relevant, up to about one-third the relative concentration of psilocybin."
In this study, alkaloids were purified using flash column chromatography and tested for activity using 5-HT2A receptor functional assays.
https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b01061
Full text: https://sci-hub.tw/https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.9b01061
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Mycoactive
Scientist


Registered: 11/20/19
Posts: 185
Last seen: 26 days, 20 hours
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Re: New Paper: Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms [Re: Alan Rockefeller]
#26636360 - 04/29/20 09:22 AM (3 years, 8 months ago) |
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Thanks for sharing! Gartz has also reported effects from baeocystin, although I know some people who are skeptical of his findings.
I'd be curious to get your insights on this. There's a lot of anecdotal evidence to suggest that different species induce different physical and psychological effects. For example, go over to the Pan cultivation thread and you'll find a group of enthusiastic Pan supporters who believe the effects of Panaeolus cyanescens are distinguishable from Psilocybe cubensis, more than can be explained by psilocybin content alone. Still, it's all anecdote, and these sorts of findings have not been validated scientifically.
Even if baeocystin is not active on its own, it's possible that it influences the activity of psilocybin (the study you linked did not test co-application of psilo+baeo). It's also possible that other alkaloids are influencing the experience. Do you have any insights when it comes to different effects from different species (or the same species grown under different parameters)?
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24sevenZed
~Z3D3Z~



Registered: 11/05/16
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Last seen: 3 years, 7 months
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Re: New Paper: Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms [Re: Mycoactive]
#26637336 - 04/29/20 05:55 PM (3 years, 8 months ago) |
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I replied on another thread about this already in Hunting, but if you look down in the paper an interesting observation they made is that norpsilocin - which is just the psilocin analong of baeocystin showed much higher activity in assay than psilocybin and I guess psilocin itself. That is - the monomethylation seems to produce more activity. But somehow, the 4-hydroxy, etc, has to play in as well, because we know (?) from TiHKAL and elsewhere that NMT is seemingly not as potent as DMT:
Quote:
To my knowledge there have been no reports of oral activity of NMT, although its wide availability from botanic sources has encouraged some explorers to assay it. I have had one report that the smoking of 50–100 mg gave visuals that lasted for maybe 15 seconds. The N-hydroxy analogue has been noted as being found in plants, in the “DMT is Everywhere” chapter.
Regardless, I think this paper Is interesting and combined with the beta-Carboline paper suggests a very strong possibility of there eventually being Proof of a wide “spectrum” of effects of psychoactive mushrooms as opposed to the situation we have with cannabis strains right now - where apparently we can’t prove this is not just a placebo effect?
And that is very interesting nowadays as we have people trying to commoditize a standard drug - psilocybin - for therapy. I think eventually we’ll see the pharmacology go much deeper than that.
Edited by 24sevenZed (04/29/20 05:59 PM)
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