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Offlinepslyke
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Registered: 06/12/10
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Re: Viral outbreak in China [Re: TheFakeSunRa]
    #26630690 - 04/26/20 08:09 PM (3 years, 9 months ago)

The ground glass opacity clearly appearing in lesions of asymptomatic Covid-19 patients is concerning. What percentage of these individuals will resolve unremarkably versus those that go on to develop pulmonary fibrosis; or perhaps in some cases 'idiopathic' pulmonary fibrosis, because they won't even know they were ever Covid-19 positive.


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"What appears impenetrable to us does exist, manifesting itself in the deepest wisdom and the most radiant beauty" Einstein

"The conservatives of 70 years ago would be outraged at what has come to pass. It embodies everything they took up arms for to defeat"Asante


:kratom:


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InvisibleTheFakeSunRa
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Registered: 03/01/05
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Re: Viral outbreak in China [Re: pslyke]
    #26630870 - 04/26/20 09:53 PM (3 years, 9 months ago)

Quote:

pslyke said:
The ground glass opacity clearly appearing in lesions of asymptomatic Covid-19 patients is concerning. What percentage of these individuals will resolve unremarkably versus those that go on to develop pulmonary fibrosis; or perhaps in some cases 'idiopathic' pulmonary fibrosis, because they won't even know they were ever Covid-19 positive.




Fibrosis is a word that should scare the living fuck out of anyone.


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[quote]Asante said:
You constantly make posts thatr fling middle school insults at people you don't like mixed in with maladjusted psychopathic comments about wanting to beat up the other poster with a crowbar.

You know how shit you are, you just don't give a fuck for precisely that reason.

I disendorse you.[/quote]


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: TheFakeSunRa] * 1
    #26631542 - 04/27/20 07:00 AM (3 years, 9 months ago)



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Offlineviraldrome
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Re: Viral outbreak in China [Re: morrowasted]
    #26631555 - 04/27/20 07:14 AM (3 years, 9 months ago)

Quote:

morrowasted said:
This new evidence shows nicotine might prevent smokers from contracting the coronavirus




I'm glad its not pot because can you imagine preachy med pot enthusiasts if pot prevented coronavirus? I'm not starting smoking cigs again as much as I miss those cigarette breaks


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Lysergamides I have tried so far: 1P-LSD, 1cP-LSD, ALD-52, AL-LAD, LSZ, ETH-LAD, MIPLA, EIPLA, 1cP-AL-LAD


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OfflineNorthernerM
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Re: Viral outbreak in China [Re: viraldrome] * 1
    #26631565 - 04/27/20 07:24 AM (3 years, 9 months ago)

That's a massive stab in the dark that nicotine has anything to do with coronavirus resistance. There's 1000s of chemicals in cigarette smoke, many of them super deadly and far more likely to take out a virus.

In fact the linked study doesn't even mention nicotine, only smoking.


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The nearest we ever come to knowing truth is when we are witness to paradox.


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: Northerner] * 2
    #26631652 - 04/27/20 08:21 AM (3 years, 9 months ago)

Quote:

Northerner said:
That's a massive stab in the dark that nicotine has anything to do with coronavirus resistance. There's 1000s of chemicals in cigarette smoke, many of them super deadly and far more likely to take out a virus.

In fact the linked study doesn't even mention nicotine, only smoking.



There is a proposed biochemical mechanism for it, specifically involving nicotine. Scientists are curious enough about it that they are running clinical trials with nicotine, and have banned the online sale of it in the country conducting said trial.

Smoking, Vaping, and COVID19 hospitalization

:shrug:

I'm not gonna encourage anyone to start smoking. I personally vape nicotine, have on and off for like 6 or 7 years. Never liked cigs much. I also wouldn't discourage a patient from trying nicotine patches as a prophylactic right now tbh


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InvisibleShroomerInTheRye
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Re: Viral outbreak in China [Re: morrowasted]
    #26631699 - 04/27/20 08:47 AM (3 years, 9 months ago)

Can you explain how the immunomodulation properties of nicotine affect COVID to a regular person?  I believe that’s what the article said helped.


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:nyan: <-- Clicky Clicky


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: ShroomerInTheRye] * 1
    #26631725 - 04/27/20 08:56 AM (3 years, 9 months ago)

I'm not sure about immunomodulation and dont have time to read further atm. My understanding is that it simply reduces the density/availability of the receptor to which COVID19 binds in order to gain entry into the cell.


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OfflineRebeccaBlack
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Re: Viral outbreak in China [Re: morrowasted]
    #26631730 - 04/27/20 08:58 AM (3 years, 9 months ago)

That's what I got from what I read too. Competition for ACE2 binding


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Offlinekoods
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Re: Viral outbreak in China [Re: RebeccaBlack] * 2
    #26631742 - 04/27/20 09:02 AM (3 years, 9 months ago)

I just saturated my receptors


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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InvisiblefeeversM
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Re: Viral outbreak in China [Re: koods]
    #26631912 - 04/27/20 10:39 AM (3 years, 9 months ago)

This study suggests a negative impact:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083240/
Quote:

although further research is warranted as the weight of the evidence increases, with the limited available data, and although the above results are unadjusted for other factors that may impact disease progression, smoking is most likely associated with the negative progression and adverse outcomes of COVID-19.




Not sure about nicotine without smoking though, but since it constricts blood vessels and messes with circulation, and elevates cortisol it's not really something I'm looking to try out. Someone I know that vapes constantly got slammed pretty hard with COVID, so it's definitely no magic shield.


MA is now reporting a 7% hospitalization rate for positive cases. Much better than the 1 in 5 that was being reported a while back.

Also Mass General is reporting that the current tests are wrong 33% of the time.


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: feevers]
    #26631948 - 04/27/20 11:06 AM (3 years, 9 months ago)

That study is from march :shrug: we are always encouraged to look at the most recent data.

A quick scan suggests that that is about covid19 sevrity among hospitalized patients. The new data is based on mass testing rather  than being limited to hospitalized patients and shows that the percentage of covid positive patients who smoke is consistently lower than the percentage of the population who smokes.


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OfflineBANANA.MAN
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Re: Viral outbreak in China [Re: morrowasted]
    #26632033 - 04/27/20 11:52 AM (3 years, 9 months ago)

Quote:

morrowasted said:
This new evidence shows nicotine might prevent smokers from contracting the coronavirus



Quote:

morrowasted said:
Quote:

Northerner said:
That's a massive stab in the dark that nicotine has anything to do with coronavirus resistance. There's 1000s of chemicals in cigarette smoke, many of them super deadly and far more likely to take out a virus.

In fact the linked study doesn't even mention nicotine, only smoking.



There is a proposed biochemical mechanism for it, specifically involving nicotine. Scientists are curious enough about it that they are running clinical trials with nicotine, and have banned the online sale of it in the country conducting said trial.

Smoking, Vaping, and COVID19 hospitalization

:shrug:

I'm not gonna encourage anyone to start smoking. I personally vape nicotine, have on and off for like 6 or 7 years. Never liked cigs much. I also wouldn't discourage a patient from trying nicotine patches as a prophylactic right now tbh



I didnt think they would a ctually look into nicotine as a treatment even if further research showed its protective qualities. im pleasently surprised.

Tobacco is obviously bad in alot of ways but people are way too biased against it.

I just really wanted all the people who said with no evidence that smoking worsens covid 19 to be wrong just because i knew that even if they were right they just pulled that statement out of their ass rather than basing it on data. I did not expect them to be this wrong though.


So if I quit smoking right now would my ACE 2 receptors beggin to upregulate again, increasing my risk to the point of a non smoker's but still leave me with damaged lungs from smoking? because that would mean the logical choice would be to not quit smoking until covid isnt a threat anymore. What do you think about that morro? not asking for medical advice just thinking out loud here.


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InvisibleTheStallionMang
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Re: Viral outbreak in China [Re: BANANA.MAN]
    #26632047 - 04/27/20 12:04 PM (3 years, 9 months ago)

Current US cases: 1,000,015

I thought drump said we'd be a zero cases in no time :shrug:


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Invisiblecannabinated
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Registered: 01/03/13
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Re: Viral outbreak in China [Re: TheStallionMang] * 1
    #26632054 - 04/27/20 12:07 PM (3 years, 9 months ago)



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Offlinesusurrador
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Re: Viral outbreak in China [Re: TheStallionMang]
    #26632064 - 04/27/20 12:12 PM (3 years, 9 months ago)

Oh jeeze, I hope word of that doesn't get out.

Improper dose of nicotine will kill you in very small amounts.

It's also used as an insecticide.

I saw a murder mystery once where a woman stole some of the nicotine pesticide from her landscaper and laced the inside of a condom with it then boned a guy and killed him.

Far fetched, but that shit can really kill you in too high a dose.

Every once in a while you hear about some tourist dying in the lands of ayahuasca down South because they drank tobacco tea to purge and either they were too sensitive or the tea was too strong.

I think like 100mg could probably kill a 200lb person.


--------------------
"If it doesn't work, you can always hit him with it."



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Invisiblepirate-blues
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Re: Viral outbreak in China [Re: BANANA.MAN] * 3
    #26632068 - 04/27/20 12:15 PM (3 years, 9 months ago)

Nursing home update(in case anyone else is interested in seeing how this plays out).

Grandma's still fine, but she is thoroughly bewildered by any kind of technology whatsoever, so the staff's(heroic)efforts of setting up a video call are unfortunately not working out.

Total cases = 19

3 fatalities - all residents who were in their late 80's and 90's.
5 staff members infected - 4 are recovered and now back at work, 1 was just found on Friday and has been at home in isolation since. No status on the number of recovered residents, if any.

There are two clusters on campus, and I expect more cases to be announced. Facility sends out pre-recorded calls every other day. Pretty much just waiting for the day where we get a call about gram showing symptoms, but so far both clusters are away from her wing - which is locked down tight and has RN's literally living in the ward. I expect that we will see more essential professions that will begin to lock down, like the PPE factor workers - probably meat plants, power plants, etc.


I want to send them flowers and chocolate and all of my love and thanks, but I don't want to accidentally expose anyone to the virus. And I don't want to go into a store even geared up until I get a blood test that rules out a tb infection, or until my dad's case is confirmed as latent/inactive. I'll have to give them a call and see if there is a safe way to do something nice, or something they might need that can be donated or whatever.


edit:

for comparison, at nearby nursing homes, the state is bringing in the National Guard because it's getting so bad - case numbers in the hundreds. Primarily at care homes that were already having issues with quality of care.


Edited by pirate-blues (04/27/20 02:07 PM)


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InvisiblefeeversM
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Re: Viral outbreak in China [Re: morrowasted]
    #26632069 - 04/27/20 12:15 PM (3 years, 9 months ago)

Quote:

morrowasted said:
That study is from march :shrug: we are always encouraged to look at the most recent data.

A quick scan suggests that that is about covid19 sevrity among hospitalized patients. The new data is based on mass testing rather  than being limited to hospitalized patients and shows that the percentage of covid positive patients who smoke is consistently lower than the percentage of the population who smokes.




To be fair it looked like the statistics from the articles you posted were from March as well, there's just not a lot of data yet. The numbers claimed in France were varying pretty wildly, one study claimed 4.4% of current COVID patients were smokers while the larger study was saying double that.

In MA close to half of the deaths and serious cases are people in nursing homes/LTC, and the vast majority of hospitalizations are people 60+ with other health conditions. How many of them are still smoking? People who are immunocompromised or have a variety of other chronic conditions are less likely to smoke and are the most likely to end up hospitalized. Those who do smoke and are hospitalized have worse outcomes according to the current data.  There's also going to be an unknown percentage of people who misreport their smoking status because it can raise future life and health insurance premiums, personally I'll never say I smoke or drink to a doctor unless it reasonably could make any difference.

There's too much grey area to trust those kind of numbers to actually mean anything, from what I'm seeing at least. They pretty much just throw the statistics out there as-is without much real context or addressing the other variables.

The ACE2 connection is definitely interesting, but seems speculative at best right now, like all of the other miracle cures and preventatives we've seen crash and burn over the last 2 months. Hopefully I'm wrong though, I've been looking for an excuse to buy a sleeve of some nice swedish snus. Withdrawing from anything while your body is fighting off a deadly virus (if you were to be hospitalized with no nicotine) doesn't seem like it'd be wise either way though.


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OnlinePatlal
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Re: Viral outbreak in China [Re: feevers]
    #26632246 - 04/27/20 02:05 PM (3 years, 9 months ago)

3000000 cases!


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Offlinekoods
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Re: Viral outbreak in China [Re: Patlal] * 3
    #26632257 - 04/27/20 02:11 PM (3 years, 9 months ago)

The president of Tyson’s food, a major meat producer in the US, is warning that the food supply chain is crumbling.


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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