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InvisibleZombi3
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Eating mushrooms while taking an SSRI?
    #26620278 - 04/22/20 03:24 PM (3 years, 9 months ago)

Hey Boomtown I need your advice again!

My good friend I just learned is taking 10mg Escitalopram (SSRI) daily. And his girlfriend is taking Venlafaxine (SNRI) not sure what dose she takes.

Obviously these will interact with mushrooms.

Well it’s my buddies girlfriends birthday coming up next week so I mailed them a half ounce of mushrooms because he asked for them.
This was before he told me they’re both on anti-depressants...

Now what’s the protocol for tripping SAFELY if you take an SSRI / SNRI daily?
Do you need to skip your medication the day before and the day of the trip?
Do you immediately resume your medication after the come down or do you wait until the next day?

I don’t want my friend to get hurt.
What are the harm reduction protocols in this scenario?

Thank you so much Shroomery!


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Offlinepoisoned
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Re: Eating mushrooms while taking an SSRI? [Re: Zombi3]
    #26620393 - 04/22/20 04:10 PM (3 years, 9 months ago)

This is anecdotal and definitely not a medical advice. 2 of my friends that were taking SSRI had very reduced effects from mushrooms. Not sure which ones they took and what were the doses, but they both had reduced effects by 50% at least.


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Invisiblenooneman
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Re: Eating mushrooms while taking an SSRI? [Re: Zombi3]
    #26620407 - 04/22/20 04:13 PM (3 years, 9 months ago)

It's safe to trip while on an SSRI, you'll just have reduced effects/have to take more. Because SSRI withdrawal can be pretty serious, I'd recommend just telling them to take more than they normally would and to expect reduced effects.


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InvisibleBlazer420
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Re: Eating mushrooms while taking an SSRI? [Re: nooneman] * 2
    #26620910 - 04/22/20 07:49 PM (3 years, 9 months ago)

SSRI's are just dumb in the first place. you need 2 open up your mind, not crust it over with bullshit meds.


--------------------
~ I used to get high on life, until I realized life was cut with morons ~
* You need 2 wake up and smell the music! *
-We are all computer data in a materialistic world-
|Sometimes you have to lose yourself, to find anything|


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InvisibleShr00mEater
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Re: Eating mushrooms while taking an SSRI? [Re: Blazer420]
    #26621045 - 04/22/20 09:06 PM (3 years, 9 months ago)

:rolleyes:


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InvisibleThe Blind Ass
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Re: Eating mushrooms while taking an SSRI? [Re: Blazer420] * 1
    #26621060 - 04/22/20 09:15 PM (3 years, 9 months ago)

Quote:

Blazer420 said:
SSRI's are just dumb in the first place. you need 2 open up your mind, not crust it over with bullshit meds.



Having your mind so open your brain falls out isn’t good either.

Plus, you don’t know if someone is on meds legitimately or not through a friend of theirs posting about it online, so take care.

I see your point and agree sometimes, but just saying.  :thumbup:


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OfflinePsion
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Re: Eating mushrooms while taking an SSRI? [Re: The Blind Ass]
    #26621088 - 04/22/20 09:33 PM (3 years, 9 months ago)

::edit:: maybe no risk of serotonin syndrome, see below response

unfortunately the protocol for safe tripping with SSRIs and psychs is to not mix the two. for one thing, they tend to blunt the effects of shrooms - which defeats the entire purpose of the trip. for another, there's a small chance of serotonin syndrome risk if you mix the two, especially if you're doing heroic doses.

due to SSRIs having rather long half-lives, you generally have to let them taper off for about 5 half-lives, which usually takes about 2 weeks or so. obviously... this can be rather difficult for someone going through depression, so this is something to discuss with them, and perhaps plan out if possible. maybe set aside a good time/days off, have the day planned out with a relaxing music playlist ready, cleaned room, no big stressful events coming up like exams to worry about, etc.

essentially, have all the set and settings ready, so that the trip is a blast.


Edited by Psion (04/23/20 02:39 AM)


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InvisibleBlazer420
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Re: Eating mushrooms while taking an SSRI? [Re: The Blind Ass] * 1
    #26621180 - 04/22/20 10:46 PM (3 years, 9 months ago)

Quote:

The Blind Ass said:
Quote:

Blazer420 said:
SSRI's are just dumb in the first place. you need 2 open up your mind, not crust it over with bullshit meds.



Having your mind so open your brain falls out isn’t good either.

Plus, you don’t know if someone is on meds legitimately or not through a friend of theirs posting about it online, so take care.

I see your point and agree sometimes, but just saying.  :thumbup:




I've dealt with the devil of SSRI meds myself and I can vouch that its better to have your mind open than closed off by SSRI meds. Just saying :super:

I took myself off of the SSRI meds before they could fully take me over by the zombified affects it gives. Waited a good 2 months before taking a psychedelic and never looked back on any SSRI meds. If you want to keep taking those zombie pills by all means do it.

But do not think that psychedelics will help you whilst on SSRI meds, because you are doing the opposite in terms of healing with those things.

Just my honest opinion.


--------------------
~ I used to get high on life, until I realized life was cut with morons ~
* You need 2 wake up and smell the music! *
-We are all computer data in a materialistic world-
|Sometimes you have to lose yourself, to find anything|


Edited by Blazer420 (04/22/20 10:47 PM)


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OfflineDJ Ed
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Re: Eating mushrooms while taking an SSRI? [Re: Psion]
    #26621270 - 04/23/20 12:11 AM (3 years, 9 months ago)

Whoa, whoa, whoa, Psion!

You can’t mention serotonin syndrome in relation to SSRIs and mushrooms without backing it up with evidence!

I have heard of no link between the two. I think you may be confusing mushrooms with harmalas.

Please provide evidence or retract your comment....

Mush love
DJ Ed


--------------------
“It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.”
Michael Pollan: How To Change Your Mind

“The problem is not to find the answer, it’s to face the answer.”
Terence McKenna



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OfflineRyan_Spalding2727
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Re: Eating mushrooms while taking an SSRI? [Re: DJ Ed]
    #26621353 - 04/23/20 02:05 AM (3 years, 9 months ago)

Just wanted to take a moment to say FUCK SSRI’s! And yes, in my experience they dull the effects substantially. And just a side note- I’ve been doing ketamine infusions for depression for a bit now, and if it is accessible to either of your friends, I’d definitely recommend they look into it to see if it could be right for them.


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InvisibleBlazer420
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Re: Eating mushrooms while taking an SSRI? [Re: DJ Ed]
    #26621358 - 04/23/20 02:11 AM (3 years, 9 months ago)

Quote:

DJ Ed said:
Whoa, whoa, whoa, Psion!

You can’t mention serotonin syndrome in relation to SSRIs and mushrooms without backing it up with evidence!

I have heard of no link between the two. I think you may be confusing mushrooms with harmalas.

Please provide evidence or retract your comment....

Mush love
DJ Ed



:whathesaid:


--------------------
~ I used to get high on life, until I realized life was cut with morons ~
* You need 2 wake up and smell the music! *
-We are all computer data in a materialistic world-
|Sometimes you have to lose yourself, to find anything|


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OfflinePsion
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Re: Eating mushrooms while taking an SSRI? [Re: Blazer420]
    #26621376 - 04/23/20 02:37 AM (3 years, 9 months ago)

I guess it was SSRIs and MAOIS i was thinking of, like syrian rue - oral dmt wouldn't be a good idea if you're on SSRIs for this reason, since you'd be doing SSRIs with an MAOI there.

still, you'd be getting iffy results on SSRIs and psychs, which kind of defeats the purpose of using psychs to treat depression.


Edited by Psion (04/23/20 02:42 AM)


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Offlinepoisoned
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Re: Eating mushrooms while taking an SSRI? [Re: Psion]
    #26621384 - 04/23/20 02:46 AM (3 years, 9 months ago)

I know people from both sides of SSRI experience. Some people really get dulled out, but it really helps some other people. So, evaluate your dose and evaluate the effects on yourself. Get off if you feel they're bad for you, but keep going if you feel they're helping you.

We're all wired in different ways.


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OfflineDJ Ed
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Re: Eating mushrooms while taking an SSRI? [Re: Psion] * 1
    #26621594 - 04/23/20 06:13 AM (3 years, 9 months ago)

Thought so dude. I’ve been looking recently into Syrian rue with mushrooms, and noted the link to serotonin syndrome. Which is potentially fatal. Didn’t want innocent folk thinking there was a potential for death from mushroom use, when it is generally considered one of the safest drugs on the planet.

Yes, maybe fact check me on this, but SSRIs and psilocin, both work on the same 5HT-2a brain receptors. So guess what happens if you take psilocin while an SSRI is already doing its job and blocking the 5HT-2a receptors.....

EDIT: should have added, it took me being completely free from SSRIs (after 7 years, sertraline, 100mg) for 5 months before I had a proper trip.

EDIT #2: should also have added, for people recommending don’t take your SSRI that day. If you remember it took 4 to 6 weeks before the SSRIs originally started working for you, consider whether they would be sufficiently out of your brain after a few hours not taking your pill?


--------------------
“It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.”
Michael Pollan: How To Change Your Mind

“The problem is not to find the answer, it’s to face the answer.”
Terence McKenna



Edited by DJ Ed (04/23/20 06:17 AM)


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InvisibleShr00mEater
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Re: Eating mushrooms while taking an SSRI? [Re: DJ Ed]
    #26621830 - 04/23/20 08:41 AM (3 years, 9 months ago)

a couple of wiki links for OP to read thru and get an idea what everyone is talking about.

harmala alkaloids are considered RIMAs, so, not as dangerous as the majority of pharmaceutical MAOIs

Maoi

Serotonin Syndrome isn’t quite as deadly as it sounds either.

Serotonin Syndrome

Caution is always going to be my advice for mixing drugs. But, I am also pretty sure your friends will do what they want to anyway. They might want to have an experienced sitter... or about 30 minutes into the trip, they will prob end up calling an ambulance thinking they are dying.

Maybe, have them do their own research and make their own choices? you can’t be responsible for everyone else, and I would hate you to feel that way if something bad did happen.


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InvisibleThe Blind Ass
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Re: Eating mushrooms while taking an SSRI? [Re: Shr00mEater]
    #26621857 - 04/23/20 08:55 AM (3 years, 9 months ago)

It can be quite dangerous actually.


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Invisibleacidgoofy
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Re: Eating mushrooms while taking an SSRI? [Re: The Blind Ass]
    #26622067 - 04/23/20 11:03 AM (3 years, 9 months ago)



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InvisibleShr00mEater
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Re: Eating mushrooms while taking an SSRI? [Re: The Blind Ass]
    #26622141 - 04/23/20 11:36 AM (3 years, 9 months ago)

Quote:

The Blind Ass said:
It can be quite dangerous actually.




In case you are looking for an argument in regards to serotonin syndrome, I purposely used the word “deadly”.

Quote:

Upon the discontinuation of serotonergic drugs, most cases of serotonin syndrome resolve within 24 hours




And don’t take this as my vote for everyone mixing ssri and maois for good times. You are right, it CAN be dangerous.

What I am saying is, hyperbolic fear mongering is not much of a solution for inadequate knowledge of a subject. I am recommending OPs friends do their own research and make their own decisions.

So far on this thread, the opinions seem divided between breaking a doctors orders and skipping/stopping meds completely, or taking extra shrooms to compensate, or not taking shrooms at all.

How are these opinions less dangerous, or more helpful to OPs friends, than me posting wiki links and recommending personal research and responsibility?

I had a bunch more typed up, but when I went posted it I was going from LTE to WiFi..... and it deleted the last half :mad:


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OfflineGoodDoctor06
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Re: Eating mushrooms while taking an SSRI? [Re: acidgoofy]
    #26622149 - 04/23/20 11:41 AM (3 years, 9 months ago)

'not dangerous.  Serotonin syndrome is theoretical only and I don't see it in my ER.  It takes a lot to have a psychedelic experience.  This is why we are using Ketamine more than Psilocybin for treatment resistant depression and PSTD. If you're worried have some benzos and Haldol on standby.


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OfflineInfraredRick
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Re: Eating mushrooms while taking an SSRI? [Re: GoodDoctor06]
    #26622292 - 04/23/20 12:51 PM (3 years, 9 months ago)

I take 150mg setraline daily. It works great for me, going off it is a huge risk due to major depression, unspecified. I just take double the dose of rooms compared to people not on a heavy dose of SSRIs. I still trip for hours and feel great for days after. These days I use only PE, 5 grams and I chat with the trees who are dancing for me. Plenty of OEV, no interest in going deeper.

People who dismiss or wholly advise against SSRIs are ignorant.


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