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RatThing
Nuclear Dog



Registered: 09/06/17
Posts: 90
Loc: USA
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Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip
#26570323 - 04/01/20 02:50 AM (3 years, 10 months ago) |
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Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip
Magic mushrooms have hit the news in a big way over the last few years, with a series of highly publicized studies suggesting they may be an effective treatment for depression and other psychological ailments. However, the effects of psychedelic drugs can be unpredictable, with some people finding the experience overwhelmingly scary. To try and address this problem, a psychedelic research and development company is now attempting to create a strain of magic mushroom that only ever causes good trips.
It is well known that the psychoactive effects of hallucinogenic mushrooms are predominantly produced by a molecule called psilocybin, although many of these fungi contain a range of other compounds that may influence the psychedelic experience by interacting with psilocybin – a phenomenon known as the entourage effect.
Little research has been conducted into these other molecules, although a company called CaaMTech has spent the past year or so investigating the properties of several psilocybin analogs, and believes it may have identified one that can completely eliminate bad trips. Speaking to Double Blind, CaaMTech founder Andrew Chadeayne explained that a compound called aeruginascin may well be the key to ensuring a positive mushroom experience.
“We want to come up with a way to at least give people the option of increasing the probability for a euphoric experience versus a dysphoric experience,” he said.
Inspiration for the project came from a paper released in 1989, which analyzed the experiences of a number of people who had inadvertently ingested magic mushrooms. Many of these accidental trippers reported feelings of anxiety, panic, and a “deep dysphoric mood”, although those who had consumed a mushroom species called Inocybe aeruginascens all described extremely positive experiences.
Since I. aeruginascens is the only mushroom known to contain aeruginascin, study author Jochen Gartz concluded that “aeruginascin seems to modify the pharmacological action of psilocybin to give an always euphoric mood during ingestion of the mushrooms.”
Due to the small sample size and lack of proper scientific testing, however, this observation has been widely challenged. Much more research is needed before such definitive statements about the effects of aeruginascin can be made. For one thing, the trimethylammonium structure of aeruginascin means that it is unlikely to pass through the blood-brain barrier, making it seem unlikely that it could possibly be psychoactive.
However, Chadeayne told Double Blind that his company’s latest research – which remains unpublished – has revealed that a metabolite of aeruginascin called 4-OH-TMT does in fact pass the blood-brain barrier and bind to the same serotonin receptors that most psychedelic drugs act upon.
“We’re really the only people in the world to know that this is active at the serotonin receptors,” he said, before explaining that the company won’t be advocating the use of aeruginascin until it has conducted rigorous tests into its safety and efficacy.
And just in case you were thinking of going out and searching for some I. aeruginascens, bear in mind that aeruginascin is similar in structure to a toad venom called bufotenidine, which has been speculated to cause temporary paralysis when ingested in high amounts.
Be cool and wait for the research.
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RogerTheRetard
Overlord

Registered: 07/28/17
Posts: 2,545
Loc: Auckland, NZ
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: RatThing] 3
#26570330 - 04/01/20 02:58 AM (3 years, 10 months ago) |
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I'm not even going to read this, but I just commented to say.
"Magic mushroom that never produces a bad trip" Sounds really really fucking stupid to me.
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 angulospora subaeruginosa subsecotioides tasmaniana    
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Buckomcdoogle
Atypical obsessive.


Registered: 11/27/19
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Last seen: 8 months, 9 days
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: RogerTheRetard] 1
#26570348 - 04/01/20 03:28 AM (3 years, 10 months ago) |
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more like wishful thinking incorporated......
There will always be certain people who simply cannot handle psychedelics.
Be it cannabis, psilocybin or anything else.
Ultimately, the individual and the latent baggage they carry causes a bad trip.
That and the setting.
I firmly believe psychedelics simply magnify your emotions, good and bad.
-------------------- "Nothing is more dangerous to your creativity than comfort and familiarity" "Nihilism is the most basic truth in existence, the only consistency throughout the world, and the universe is chaos and decay" "Logic leads to nihilism"
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RogerTheRetard
Overlord

Registered: 07/28/17
Posts: 2,545
Loc: Auckland, NZ
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: Buckomcdoogle]
#26570349 - 04/01/20 03:29 AM (3 years, 10 months ago) |
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 angulospora subaeruginosa subsecotioides tasmaniana    
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Holybullshit
Stranger
Registered: 01/06/19
Posts: 1,553
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: RogerTheRetard]
#26570548 - 04/01/20 07:33 AM (3 years, 10 months ago) |
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From what I've read TMT analogs are less potent due to the 2-methyl reducing affinity for 5-ht2a, if you couple that with it being a prodrug which might mean not much at all or might mean it acts to introduce the active compound slowly....it might just be like taking a low dose of time released psilocybin, it'd be harder to have a bad trip like that, often the reason people have a bad trip their first time(or first few times) its because they took too much.
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Jimmycapstem
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: Holybullshit]
#26570575 - 04/01/20 07:47 AM (3 years, 10 months ago) |
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You must let go and enjoy the ride in a safe environment...Anyone trying to control the trip has the potential of things going sideways.
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Holybullshit
Stranger
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: Jimmycapstem]
#26570613 - 04/01/20 08:10 AM (3 years, 10 months ago) |
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I don't disagree but that is easier said than done for many people new to psychedelics, a strategy much more likely to end in success is for people to start with low doses to get a feel for what they are in for before taking large doses. Things aren't like to "go sideways" on a low dose.
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tyrannicalrex
Strange R



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Posts: 38,331
Loc: subtropics
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: Holybullshit]
#26571621 - 04/01/20 04:58 PM (3 years, 10 months ago) |
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I'm with buck and holy. I do believe and have read that a "bad trip" is due to an underlying condition already present in the person imbibing. I also believe and have seen low doses being better for many people that have tripped hard and didn't like it. I am a person who ALWAYS tells people to start low and work up. I get frustrated in threads where people say a person should do at least 2-3.5 grams the 1st time. That's crazy to me. I only did 1 gram the 1st couple to first few times. The time I did about 2 or so I had a really anxious come up and for a couple of hours I was really scared.
Edited by tyrannicalrex (04/02/20 07:41 AM)
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Psilosopherr
A psilly goose



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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: tyrannicalrex]
#26571706 - 04/01/20 05:59 PM (3 years, 10 months ago) |
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This OP conflicts with my preconceived notions about psychedelics, I'm going to automatically assume it is wrong
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ReynardTheFox
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: RatThing] 1
#26572850 - 04/02/20 09:06 AM (3 years, 10 months ago) |
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They are literally basing this hypothesis on a small sample size of people who reported inadvertently eating the wrong mushrooms, and the experience they then had, and they noticed that the people who ate mushrooms of this one particular species didn't have any bad trips. It doesn't sound like an awful hypothesis if you were going in totally blind about psychedelics, but if you have any experience at all with these things then you shouldn't hold out too much hope for this research. Sounds like dumb luck to me.
-------------------- "Every actual State is corrupt. Good men must not obey laws too well" - Ralph Waldo Emerson "If I am the devil's child, I will live then, by the devil" - Ralph Waldo Emerson
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Penroc3
hypno toad



Registered: 11/03/02
Posts: 2,807
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: RatThing]
#26573155 - 04/02/20 11:53 AM (3 years, 10 months ago) |
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what are they going to do hand out Xanax and maybe a small dose of seroquell to kill the trip
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BasilBush
Reality Bender



Registered: 11/13/13
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: Penroc3]
#26573411 - 04/02/20 02:18 PM (3 years, 10 months ago) |
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What I do now is take mdma before lsd or shrooms for a guaranteed good trip every time lol.
-------------------- I HUNT MAGIC MUSHROOMS AND MAKE MIND BLOWING TEA, I BUY ROOT BARK OFF THE INTERNET AND EXTRACT DMT, SMOKE MY FRIENDS CHANGA IT TASTES BETTER FOR FREE TRIPPING IS WONDERFUL IT HELPS ME FIND PEACE, SO WILL YOU COME ALONG TO MY NEXT EUPHORIC FEAST. I LOVE MUSHROOMS THEY MUSH UP THE ROOM THERE AINT MUCH ROOM IN HERE SPECIAL GREEN TEA MADE FROM A CACTUS TREE SETS YOUR MIND AND SPIRIT FREE
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supershroomin
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: BasilBush] 1
#26573435 - 04/02/20 02:34 PM (3 years, 10 months ago) |
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I do not see how you can have the "good" without the "bad". They are working off of inherent misunderstandings.
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sk8fast
Tripping skater



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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: supershroomin]
#26574034 - 04/02/20 09:11 PM (3 years, 10 months ago) |
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4-aco-dmt is an analogue that has never given me a bad trip. Mushrooms have never given me a bad trip either but I could see how it could go that way
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sk8fast
Tripping skater



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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: tyrannicalrex]
#26574057 - 04/02/20 09:23 PM (3 years, 10 months ago) |
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Quote:
tyrannicalrex said: I'm with buck and holy. I do believe and have read that a "bad trip" is due to an underlying condition already present in the person imbibing. I also believe and have seen low doses being better for many people that have tripped hard and didn't like it. I am a person who ALWAYS tells people to start low and work up. I get frustrated in threads where people say a person should do at least 2-3.5 grams the 1st time. That's crazy to me. I only did 1 gram the 1st couple to first few times. The time I did about 2 or so I had a really anxious come up and for a couple of hours I was really scared.
Quote:
tyrannicalrex said: I'm with buck and holy. I do believe and have read that a "bad trip" is due to an underlying condition already present in the person imbibing. I also believe and have seen low doses being better for many people that have tripped hard and didn't like it. I am a person who ALWAYS tells people to start low and work up. I get frustrated in threads where people say a person should do at least 2-3.5 grams the 1st time. That's crazy to me. I only did 1 gram the 1st couple to first few times. The time I did about 2 or so I had a really anxious come up and for a couple of hours I was really scared.
People say to eat at least an eighth so you can get the start of psychedelic effects lower dose are more anxiety producing for me because I'm on the verge of a trip and never get it. The first time I ate mushrooms it was 60g fresh and I'm so glad I did. I was only anxious for the first 45min and after it really hits you lose yourself and are not worried just amazed by what you are experiencing. I get anxious everytime I eat mushrooms but it goes away quick unless you don't eat enough it last longer than an hour
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Holybullshit
Stranger
Registered: 01/06/19
Posts: 1,553
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: sk8fast]
#26576769 - 04/04/20 06:59 AM (3 years, 10 months ago) |
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Firstly, you shouldn't extrapolate your own experiences onto the general population. Secondly, if you have never tripped before you don't even know where "the verge" is so you can't be on it and, like pretty much all drugs, the first experience is almost always going to be/seem a lot more powerful than all others after it. This isn't just tolerance, its perception. 1.5 grams is plenty for someone who has never ingested before to experience psychedelic affects, and even with as little as 1 gram of decent shrooms they aren't going to be like "yeah I didn't trip because I didn't take enough" afterwards.
I'm sure part of why you feel anxiety at low doses or on the verge/come up is your anticipation and much anxiety people feel is anxiety they brought with them and isn't intrinsic to the effects at low dosages. Of course many of these drugs can be anxiety inducing, to a point, but they don't become less anxiety inducing at high dosages(quite the opposite).
For many people being ripped from their reality before they are ready is what leads to a bad trip, this can be avoided by beginning with low doses, its as simple as that.
Its like for me with MDMA, I feel intense anxiety during the come up, I don't remember how I felt my first time, but generally when I introduce people to MDMA, people with little to no experience with tryptamines/PEA's, they report feeling no such anxiety...they often can't even distinguish a "come up" from the rest of the experience, they know it started weak and got stronger but there was no magical tipping point, no before and after.
And I recognize that this anxiety has little to do with MDMA itself and originates internally...it might be a common theme among people with psychedelic drugs, because they induce powerful changes in perception, but that's because we are working with a similar psychological framework, but those with no experience don't have a point of reference for such feelings to originate from.
The experience may not be as powerful as they might have been expecting, but I think the odds of it being a positive one will be much higher(that is the goal, right?)
And I think mostly it will be people who do have experience with higher dosages that will feel like they were "missing out" or not getting the "full" benefit, they will be perfectly content with the experience and be more likely to enjoy mushrooms/psychedelics moving forward.
If they have a negative experience because they took too much(especially if they did so because someone else was projecting their own internal anxieties and experiences onto them) and were overwhelmed, that negative experience will be coloring all future sessions(if there are any, they may not wish to repeat it) and can be hard to move past, as it will serve as a distraction during any future experimentation.
It's a high risk low reward scenario, plus even if one were to have a negative experience on a low dose the severity and scale would be greatly reduced and they probably won't be too scared to try it again in the future nor will they have "psychedelic PTSD" skewing their experience during any future sessions. And while we should prepare people for their experience we also need to be careful not to allow our own expectations become their expectations which then control the experience, by doing so we create self-fulfilling prophecies.
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I'm not saying a large dose for first-timers/newbies is even likely to lead to a negative experience, just that is is more likely to...and maybe more importantly the deleterious affects will be much greater and longer lasting from a negative experience at a high dosage vs. a low one.
Starting with low dosages is far more likely to be followed with future positive experiences and I don't think the net benefit of beginning with large dosages(if there is any) is worth risking that future.
Edited by Holybullshit (04/04/20 08:24 AM)
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larry.fisherman
shoulda died already


Registered: 11/03/12
Posts: 36,294
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: RatThing]
#26576961 - 04/04/20 09:44 AM (3 years, 10 months ago) |
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This is pandering. They just want the "hip" crowd to get excited but they are underestimating that crowd. What this is, is another attempted analogue. They want to market it because they will patent it and make money. The good thing would be that it would go through human trials before it hit the market, but the RCs we know have already done that and we don't have to pay a premium for it.
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Buckomcdoogle
Atypical obsessive.


Registered: 11/27/19
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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: larry.fisherman]
#26578739 - 04/05/20 04:53 AM (3 years, 10 months ago) |
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Sometimes the truth isn't easy.
I can only speak for myself, but that brilliant fungal wisdom has been between enlightening, calming and beautiful, to outright terrifying.
Those difficult trips will teach you or at the very least remind you about some very important things, about yourself and the world about you.
It might be easier to just not.
But at the same time it might be beautiful and give you new appreciation for your existence.
"Ignorance is bliss" "nothing worthwhile is easy"
-------------------- "Nothing is more dangerous to your creativity than comfort and familiarity" "Nihilism is the most basic truth in existence, the only consistency throughout the world, and the universe is chaos and decay" "Logic leads to nihilism"
Edited by Buckomcdoogle (04/05/20 04:54 AM)
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Big Bear
Earf Child



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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: Buckomcdoogle]
#26579271 - 04/05/20 11:17 AM (3 years, 10 months ago) |
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A bad trip every now and then is good for the soul. Death and suffering are coming for us all...now what?
-------------------- Need help growing? Ask AMU for hassle free answers. Every year is getting shorter, never seem to find the time...
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Zen999
Zen



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Re: Company Is Trying To Create A Type Of Magic Mushroom That Never Produces A Bad Trip [Re: Big Bear]
#26579316 - 04/05/20 11:39 AM (3 years, 10 months ago) |
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Applause for you brother. Bad trips may be the outcome of inadequate humour/hilarity of the existential situation we all find ourselves. L Try and tell me I'm not some kind of ridiculous caricature of what is possible.balance between not taking oneself too seriously and overwhelming self importance is great I believe it was my brother/father/holy spirit.. oh fuck maybe it was Buddha who cares, some unimportant yet relative person < haha see what I did there? said something that I'm about to misquote but was something along the lines of: the middle path between the two extremes is the road less traveled yet is the only path to salvation. Completely butchered it. But hey fuck you haha. Seriously though people looking to understand will get there eventually and I encourage them to keep consuming knowledge. Time to get mystical everything is cyclical the tree of knowledge is the tree of life. knowledge will lead you back to the path of life for I am the trickster and I was never separate. Just try n compete with my nonsense blathering a fruitless task, do you believe in coincidence?
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