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InvisibleAsante
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: RebeccaBlack]
    #26558459 - 03/26/20 06:24 AM (3 years, 10 months ago)

I think I may have had a mild case too.

Started with s classic cold, lasted 5 weeks.

I -SO-hope it was that, because I'd have immunity now if is was.


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: RebeccaBlack] * 1
    #26558468 - 03/26/20 06:32 AM (3 years, 10 months ago)



Edited by morrowasted (03/26/20 06:41 AM)


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted] * 2
    #26558518 - 03/26/20 07:29 AM (3 years, 10 months ago)

https://www.nytimes.com/video/nyregion/100000007052136/coronavirus-elmhurst-hospital-queens.html

"We're seeing a lot of our patients who probably had COVID and we didn't realize it"

guy came in for a car accident and they found out he had COVID when running a CT

stay staff in in the NE yall


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted]
    #26558526 - 03/26/20 07:37 AM (3 years, 10 months ago)

nurses are reporting that a lot of hospitals are already making all intubated COVID patients DNR


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Invisibledoctorghosty
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted] * 3
    #26558529 - 03/26/20 07:44 AM (3 years, 10 months ago)

I feel more dread today than I have during this whole thing so far. And i've been feeling a lot of dread. Only thing I can think to do is turn off the news and go look for morels all day so that's exactly what I'll be doing.

Have a lovely day, fellow shroomerites.


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Invisiblekoraks
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: doctorghosty] * 2
    #26558537 - 03/26/20 07:51 AM (3 years, 10 months ago)

Quote:

doctorghosty said:
I feel more dread today than I have during this whole thing so far. And i've been feeling a lot of dread. Only thing I can think to do is turn off the news and go look for morels all day so that's exactly what I'll be doing.

Have a lovely day, fellow shroomerites.



Sounds like a great plan. Have a lovely day, too, and I hope you find some nice ones! And even if you don't, it's good to be outdoors.


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Invisiblesh4d0ws
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: doctorghosty] * 3
    #26558540 - 03/26/20 07:52 AM (3 years, 10 months ago)

enjoy your morel hunting adventure, have a great day man :mushroom2:

I gotta admit - this shit is fucking scary and sad and it definitely isn't easy for it all to sink in.
I had to go to the grocery store yesterday and it's just so dead out there...never seen anything like it in my life. Empty streets. No one out walking. Stores are empty.

It's sad.

I'm really, really glad our province stood up and said fuck this and closed all essential businesses and is doing everything it can to try and stop this virus from spreading too quickly but god damn, it's gonna be a sobering 8 weeks or so.


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Invisiblepsi
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted]
    #26558623 - 03/26/20 08:47 AM (3 years, 10 months ago)

Seems like a few different parties are working on addressing the ventilator supply problem with 3d printing and open source design etc. Volkswagen has expressed interest in making them pending settling on a design, MIT and others have made prototypes, etc.


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: sh4d0ws] * 3
    #26558628 - 03/26/20 08:53 AM (3 years, 10 months ago)

The team of German scientists led by Wölfel et al. proposed the hypothesis that the extension of tropism of the coronavirus is due to the furin cleavage site in the spike protein of SARS-CoV-2.  This cleavage site is not present in SARS-CoV [17, 18] The presence of furins on almost all cell surfaces allow a dramatically increased ability to fuse to host cells, facilitating viral entry even in cells that have low expressions of the ACE2 receptor [26].

The furin cleavage allows efficient virus entry into basically all cell types, making the COVID-19 easily transmissible at rates up to 1,000 times greater than the virulent SARS coronavirus [18]. This is possibly the reason why SARS (2003) infected only 8,000 people worldwide and COVID-19 infected over 120,000 people in one third of the time, even though both coronaviruses cause pneumonia of varying severity.

Cleavage specificity can dictate the tropism and virulence of the virus. The fact that COVID-19 has cleavage sites for furin enzymes renders this virus to be highly pathogenic, with the capacity to replicate in MULTIPLE tissues and organs due to how furins are utilized and distributed in the human body [27]. 

Furin-like cleavage in human coronaviruses have been associated with the development of neurological diseases where the invasiveness and efficient establishment of lower pathogenicity can result in persistent infection of the central nervous system [28].  Thus it was not a surprise when in early March of 2020, doctors from Beijing Ditan Hospital affiliated to Capital Medical University, a designated institution for COVID-19 treatment, showed for the first time that COVID-19 can attack the human central nervous system, causing symptoms of encephalitis [29].

The presence of furin enzymes on all cell surfaces cleaves and activates the SARS-CoV-2 in a wide range of tissues and organs. Activated SARS-CoV-2 then unleashes NLRP3 inflammasomes, initiating a flurry of immune reactions that can result in deadly cytokine storms...

Inflammasomes are an integral part of our innate immune system.  Inflammasomes sense pathogens, danger associated molecular patterns (DAMPs) as well as biological crystals including urate and cholesterol. The activation of inflammasomes releases proinflammatory cytokines interleukin (IL)‑1β and IL‑18. 

Recently, the NLRP3 inflammasome has been identified as key to the induction of ADRS/ALI [33, 40].  Interleukin 1 beta (IL-1β) is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome because the initiation of hypoxemia (below normal oxygen levels in blood)  is induced by IL-1β signaling [38]. The production of IL-1β is tightly controlled and is dependent upon NLRP3 inflammasome activation [39] . 

A study published in June 2019 demonstrated that high level activation of NLRP3 inflammasome is essential for the induction and development of cytokine storms and multi-organ dysfunctions in a streptococcal toxic shock-like syndrome model [34].  How are NLRP3 inflammasomes connected to the SARS-CoV-2 coronavirus?
...

The most current structure models of all mature peptides of SARS-CoV-2 generated by the C-I-TASSER pipeline [68] clearly shows that SARS-CoV-2, responsible for the COVID-19 disease encodes BOTH ORF3a AND E protein viroporins [69]....


The NLRP3 inflammasome is now recognized as a target for melatonin!

The fact that the pro-inflammatory cytokine storm effects are induced by the activation of NLRP3 inflammasomes, the ability of melatonin to INHIBIT NLRP3 inflammasome elevates this powerful molecule to a truly unique position in the fight against COVID-19.  This also means that if a patient, regardless of age, has adequate melatonin, the infectiousness of COVID-19 will be greatly reduced, and the chances of developing ARDS/ALI significantly diminished. 

Melatonin is the reason why children under the age of 9 seldom exhibit severe symptoms. In fact, children may exhibit mild or even no symptoms at all, even though they have been infected by SARS-CoV-2 [73].  How significant is the difference in melatonin production between children, adults and the elderly?

For most people, peak melatonin production is between the hours of 2 am to 3 am.  The maximum melatonin levels measured in healthy adults between the ages of 65 to 70 years appeared to be around 49.3 picograms/ml (pg/ml).  Adults more than 75 years of age only have maximum production levels of 27.8 pg/ml [74]. 

Young children, on the other hand, have extremely high melatonin levels, compared to adults.  The maximum levels recorded for children showed a decline as age increased. Children between the ages of 1 to 5 had peak melatonin at 325 pg/ml, while those between the ages of 5 to 11 already declined to 133 pg/ml [76]. 

Compared to healthy adult seniors, a young child can easily have TEN TIMES the amount of peak melatonin levels.  But even then, the actual physiological concentration is extremely low. How much is one picogram, exactly?

To give you some perspective, most melatonin supplements are around 3 to 5 mg per capsule or tablet.  One milligram equals 1,000,000,000 picograms. That is why the physiological dosage generally recommended for melatonin supplementation is around 0.3 milligram [75]. 

The fact that young children have such high melatonin levels explains why they show very mild symptoms after COVID-19 infections.

Melatonin is a potent inhibitor of NLRP3 inflammasomes..


The binding of SARS-CoV-2 to ACE2 exposes patients with CVD to higher risk for pneumonia and increased severity of symptoms. Reports showed that in China, among COVID-19 patients with severe symptoms, 58% had hypertension, 25% had heart disease and 44% had arrhythmia [55].  Fatality data released by China’s NHC showed 35% of patients who died from SARS-CoV-2 infection had a history of hypertension, while 17% had a history of coronary heart disease [56]. 

NLRP3 inflammasomes are also one of the primary reasons why COVID-19 causes cardiovascular complications.  The increased production of pro-inflammatory cytokines interleukin-1β and interleukin-18 from the activation of inflammasomes can induce a signal transduction cascade of strong immune responses that speeds disease progression in CVD.  Inflammasomes are now definitively associated with the progression of atherosclerosis, myocardial infarction and heart failure [70]...



https://www.evolutamente.it/covid-19-pneumonia-inflammasomes-the-melatonin-connection/


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted] * 5
    #26558650 - 03/26/20 09:04 AM (3 years, 10 months ago)



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InvisibleShroomerInTheRye
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted]
    #26558677 - 03/26/20 09:17 AM (3 years, 10 months ago)

My dad is 70 with a heart problem and I can't get him to stay inside and social distance.  I'm about ready to send my brother and nephew to his house to sit on him or duct tape him to the sofa.


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted] * 2
    #26558678 - 03/26/20 09:18 AM (3 years, 10 months ago)

Welp, you guys.


It's time for me to turn off the internet


:sad:


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Invisibletyrannicalrex
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: doctorghosty] * 1
    #26558690 - 03/26/20 09:25 AM (3 years, 10 months ago)

Great advice doc. I'll be in my hot tub in a bit, then heading to the mountain cabin until sunday. No internet or cell phone service there actually. We could get the net, but we only go out there a few times a year. I am VERY fortunate to have something like this and someone who shares it with me.


Morrow: great posts! Your education paid off big time. Is there a possibility that I could have had it around nov-dec last year? My mate got the flu shot before thanksgiving and within 2 weeks he developed a dry cough and flu like symptoms. I got it a week or so later. Dry cough, hardly any taste, felt really weird and unlike any cold or flu I ever had. Lasted about 1 month or so.

Mate has respiratory issues and one night he had to go to the ER and they gave him breathing treatments to get his oxygen up. He was panicking and could not breathe or catch his breath well. It was scary.


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Offlinekoods
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: tyrannicalrex]
    #26558776 - 03/26/20 09:58 AM (3 years, 10 months ago)

More than 5000 people are hospitalized in New York State with covid


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NotSheekle said
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OfflineTripsurfer
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: tyrannicalrex]
    #26558781 - 03/26/20 09:59 AM (3 years, 10 months ago)

My partner and I also had some weird lung-cold earlier this year. My mom got it too

We all noticed a distinct feeling of congestion in the lower lungs. Normally our colds are way higher up in the airways

Lasted forever too. Kids hardly suffered anything


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Ach en wee ben ik de klos, met mijn boog schoot ik een albatros...

A philosopher is a person who knows less and less about more and more, until he knows nothing about everything.



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OfflineRebeccaBlack
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: Tripsurfer]
    #26558783 - 03/26/20 10:01 AM (3 years, 10 months ago)

WTF!

We got 1000+ cases in Montreal. My friend's mom has cough and shortness of breath. His sister his a flight attendant. She called the hospital to get tested and they said they don't test if you haven't travelled.

I'm sure this thing is rampant in Montreal already.


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InvisiblefeeversM
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: tyrannicalrex] * 1
    #26558790 - 03/26/20 10:03 AM (3 years, 10 months ago)

Hopefully they make an antibody test available soon so people will know whether they had it already or not. I definitely had some symptoms, but there are lots of things that cause those same symptoms.


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Invisiblepsi
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: RebeccaBlack] * 2
    #26558796 - 03/26/20 10:03 AM (3 years, 10 months ago)

Quote:

Daijo said:
She called the hospital to get tested and they said they don't test if you haven't travelled.




Shows how much you can trust the numbers.


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InvisibleAsante
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: Asante]
    #26558797 - 03/26/20 10:04 AM (3 years, 10 months ago)





Meanwhile in Holland :sad:



Tuesday 382 (March 10, 2020)
Wednesday: 503 (+121)
Thursday: 614 (+111)
Friday: 804 (+190)
Saturday: 959 (+155)
Sunday: 1135 (+176)
Monday: 1413 (+287)(March 16)
Tuesday: 1708 (+295)
Wednesday: 2051 (+343)
Thursday 2460 (+409)
Friday 2994 (+534)
Saturday 3631 (+637)
Sunday 4202 (+571)
Monday 4749 (+547)(March 23)
Tuesday 5560 (+811)
Wednesday 6412 (+852)
Thursday 7431 (+1019)


Today's the first day of +1000 documented cases in my tiny country. We're now at the level Italy was at not too long ago when everybgody lamented Italy. But, the number of 4 digit countries is increasing and the number of 5 digit countries is increasing too.

TODAY THE WORLD GOES OVER 500,000 CASES.


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Offlinekoods
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: RebeccaBlack]
    #26558798 - 03/26/20 10:04 AM (3 years, 10 months ago)

Let’s be clear here: if you were sick over a month  ago and you don’t live in the Nee York area and hadn’t travelled the chances that you had covid is nearly zero


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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