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OfflineJke.b.ro
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What alkaloids are present in fresh magic mushrooms * 1
    #26514923 - 03/03/20 04:23 PM (3 years, 11 months ago)

Ive been wondering what alkaloids, or compounds other than psilocybin, psilocin and baeocystin are in Psilocybe Cubensis mushrooms and if any of them can make a user sick/nauseous. Ive only been having fresh psilocybe cubensis mushrooms and on the come up i get a rather sickly feeling in my stomach and over all feel uncomfortable and cant really enjoy the trip, ive tried drinking ginger tea beforehand and it works a little, i try making tea and lemon tek but i still get the uneasy sickly feeling. Anyone know how i can combat this? Would simply drying my mushrooms help?


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OfflineDoc9151M
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Re: What alkaloids are present in fresh magic mushrooms [Re: Jke.b.ro] * 2
    #26515079 - 03/03/20 05:33 PM (3 years, 11 months ago)

I know what you mean,  in my opinion,  the sick feeling on come up could have something to do with a waxy stinky compound in the mushroom,  I have used 190 proof grain alcohol to extract the active compounds and the stinky waxy stuff is a by product,  of what I don't know,  but the alcohol extraction will contain the active indoles and about 32g of sugar per ounce that can be precipitated in an ice bath leaving the actives suspended in the alcohol. The nausea was absent from the come up after extraction and decoction. I usually reduce the decoction about 75% of the original amount.

When Psilocybe fanaticus was raided by the DEA they poured out an alcohol extraction he had in his freezer,  he noticed it had crystals that he mistook as Psilocybin or psilocin, but it was really the sugars I mentioned above.

In my opinion (I have not completed my studies on this) a double extraction process using ethanol first and then a water extraction will have the highest yields and filtration using a vacuum is needed to obtain crystals, but not many people are willing to risk several ounces/pounds of mushrooms to test this out, the most I have tested at one time is around 100grams and never tried using a buchner funnel under vacuum to filter and clean up the extraction but It is an important step in my opinion.

the sugars extracted are brownish like raw cane sugar with a slight mushroom scent, taste is similar to cane sugar. One day when things calm back down and I have my house back to myself,  then I will use all my lab and pharmacy experience to try for crystals again.


--------------------


Psilocybe cubensis data collection thread. please help with this project if you hunt wild cubensis.
https://www.shroomery.org/forums/showflat.php?Cat=0&Number=26513593&page=0&vc=1#26513593


Edited by Doc9151 (03/03/20 05:33 PM)


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OfflineSubfinder
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Re: What alkaloids are present in fresh magic mushrooms [Re: Doc9151]
    #26515543 - 03/03/20 09:52 PM (3 years, 11 months ago)

That is definitely interesting doc. I've often wondered about what it would take to get psilocybin down to it's purist form. Would be neat if it did crystallize. Is it the right molecular shape to form crystals? Does that even matter?


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OfflineAlan RockefellerM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Subfinder] * 1
    #26515632 - 03/03/20 11:18 PM (3 years, 11 months ago)

Quote:

Subfinder said:
That is definitely interesting doc. I've often wondered about what it would take to get psilocybin down to it's purist form. Would be neat if it did crystallize. Is it the right molecular shape to form crystals? Does that even matter?





Here is a paper that has a good method for extracting pure psilocybin from mushrooms:  https://www.ncbi.nlm.nih.gov/pubmed/28929753

And here are some crystals of pure psilocybin that were generated by using this method:



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OfflineJke.b.ro
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Re: What alkaloids are present in fresh magic mushrooms [Re: Subfinder]
    #26515634 - 03/03/20 11:19 PM (3 years, 11 months ago)

If i could get given a good step by step guide on how to make extract psilocybin or psilocin i can do an extraction with 500+ grams of fresh Psilocybe Cubensis mushrooms and document how i go with it and let you guys know about it


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OfflineAlan RockefellerM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Jke.b.ro] * 3
    #26515641 - 03/03/20 11:29 PM (3 years, 11 months ago)

Quote:

Jke.b.ro said:
If i could get given a good step by step guide on how to make extract psilocybin or psilocin i can do an extraction with 500+ grams of fresh Psilocybe Cubensis mushrooms and document how i go with it and let you guys know about it




That's not going to happen.  You will be given the crystals of the gods tek instead, which doesn't work. 

To do it right, you should extract with methanol, wash with cyclohexane, then use flash column chromatography to separate the alkaloids from the sugars/proteins.  You can use Ehrlich's reagent to test your chromatography fractions to see which ones have the alkaloids you want.  It would be interesting to consume the fractions which don't have the alkaloids to see if they cause nausea or other effects.

Here are some videos on flash chromatography:  https://www.youtube.com/results?search_query=flash+chromatography


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OfflineJke.b.ro
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Re: What alkaloids are present in fresh magic mushrooms [Re: Alan Rockefeller]
    #26515645 - 03/03/20 11:38 PM (3 years, 11 months ago)

Quote:

Alan Rockefeller said:
Quote:

Jke.b.ro said:
If i could get given a good step by step guide on how to make extract psilocybin or psilocin i can do an extraction with 500+ grams of fresh Psilocybe Cubensis mushrooms and document how i go with it and let you guys know about it




That's not going to happen.  You will be given the crystals of the gods tek instead, which doesn't work. 

To do it right, you should extract with methanol, wash with cyclohexane, then use flash column chromatography to separate the alkaloids from the sugars/proteins.  You can use Ehrlich's reagent to test your chromatography fractions to see which ones have the alkaloids you want.  It would be interesting to consume the fractions which don't have the alkaloids to see if they cause nausea or other effects.

Here are some videos on flash chromatography:  https://www.youtube.com/results?search_query=flash+chromatography





If i can get the materials id definitely do it and see what the out come is, i have no problem using excessive amounts of mushrooms due to the fact every time i go out hunting i get over 700 grams fresh, i went out yesterday and today and both times got over 700


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OfflineAlan RockefellerM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Jke.b.ro]
    #26515653 - 03/03/20 11:47 PM (3 years, 11 months ago)

All the materials are available on ebay.


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OfflineLogicaL ChaosM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Alan Rockefeller]
    #26515799 - 03/04/20 03:44 AM (3 years, 11 months ago)

Very cool. Never seen it laid out so simply! :takingnotes:


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OfflineAnglerfishM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Jke.b.ro]
    #26515811 - 03/04/20 04:01 AM (3 years, 11 months ago)

Quote:

Jke.b.ro said:
i try making tea and lemon tek but i still get the uneasy sickly feeling. Anyone know how i can combat this? Would simply drying my mushrooms help?




I used to eat my mushrooms fresh or dried, or make tea, and got a slight sick and uneasy feeling during the onset, however
when the trip hit me the sickness would go away. Recently I've been steeping powdered dry mushrooms in 60% alcohol for
a couple of days before straining and mixing with mango or pineapple juice, and it works very well for me, no sickness
or uneasiness or "body load" of any kind, just pure trippiness and a very gentle onset. I assume that most of the compounds
are extracted into the alcohol, as I still get the same effect per dosage.


--------------------




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OfflineJke.b.ro
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Re: What alkaloids are present in fresh magic mushrooms [Re: Anglerfish]
    #26515851 - 03/04/20 05:00 AM (3 years, 11 months ago)

Quote:

Anglerfish said:
Quote:

Jke.b.ro said:
i try making tea and lemon tek but i still get the uneasy sickly feeling. Anyone know how i can combat this? Would simply drying my mushrooms help?




I used to eat my mushrooms fresh or dried, or make tea, and got a slight sick and uneasy feeling during the onset, however
when the trip hit me the sickness would go away. Recently I've been steeping powdered dry mushrooms in 60% alcohol for
a couple of days before straining and mixing with mango or pineapple juice, and it works very well for me, no sickness
or uneasiness or "body load" of any kind, just pure trippiness and a very gentle onset. I assume that most of the compounds
are extracted into the alcohol, as I still get the same effect per dosage.




Just a question, what type of alcohol do you use/reccomend? I want to be able to enjoy these mushrooms but the sick and uneasyness is making it hard too


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OfflineAnglerfishM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Jke.b.ro]
    #26515862 - 03/04/20 05:12 AM (3 years, 11 months ago)

The one I use is distilled from grains, 60 % alcohol, flavour neutral. It's the only one I've used
as it is the strongest liquor available on the Norwegian market, so I can't really say what would
be better or worse - but it has worked well for me, at least.


--------------------




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OfflineJke.b.ro
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Re: What alkaloids are present in fresh magic mushrooms [Re: Anglerfish]
    #26515888 - 03/04/20 05:39 AM (3 years, 11 months ago)

Would regular 40% alcohol work too? Or not strong enough?


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OfflineAnglerfishM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Jke.b.ro]
    #26515898 - 03/04/20 05:54 AM (3 years, 11 months ago)

I'd guess it works with 40% too but then it probably takes longer time to extract the goods.
Just make sure you grind the mushrooms as finely as possible.


--------------------




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OfflineJke.b.ro
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Re: What alkaloids are present in fresh magic mushrooms [Re: Anglerfish]
    #26515906 - 03/04/20 06:03 AM (3 years, 11 months ago)

Quote:

Anglerfish said:
I'd guess it works with 40% too but then it probably takes longer time to extract the goods.
Just make sure you grind the mushrooms as finely as possible.




Alrighty, might grind up 14g and mix it in with a cup of vodka and leave it for 3-4 day. When i do it ill let you know how i go with the nausea and the experience.


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OfflineAnglerfishM
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Re: What alkaloids are present in fresh magic mushrooms [Re: Jke.b.ro]
    #26515974 - 03/04/20 07:10 AM (3 years, 11 months ago)

Quote:

Jke.b.ro said:
Alrighty, might grind up 14g and mix it in with a cup of vodka and leave it for 3-4 day.




14 grams dried? Best of luck. :mushroom2: :tripnoob:


--------------------




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OfflineDoc9151M
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Re: What alkaloids are present in fresh magic mushrooms [Re: Anglerfish]
    #26516096 - 03/04/20 08:27 AM (3 years, 11 months ago)

you want to use 190 proof everclear grain alcohol

edit: sold at most liquor stores but must be ordered online in some U.S. counties or states.

150 proof will work but the closer to 100% pure food grade alcohol the better the extraction. Bacardi 151 rum will work but grain alcohol is best.

DO NOT USE ISOPROPYL ALCOHOL or denatured alcohol


Edited by Doc9151 (03/04/20 08:33 AM)


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