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Offlinesonoramo
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LSD Overdose Reports (MAPS co-authored journal article) * 6
    #26499510 - 02/23/20 07:49 AM (3 years, 11 months ago)

Seen in Vice, who read it in the Journal of Studies on Alcohol and Drugs


Original post: This Is What Happens When You Take 550 Doses of LSD At Once

Link to journal article: LSD Overdoses: Three Case Reports

This Is What Happens When You Take 550 Doses of LSD At Once
Accidental LSD overdoses are not fun. But for some, they can have a bizarrely beneficial effect.
by Troy Farah
Feb 21 2020, 8:56am

Around 10pm at a summer solstice party somewhere in Canada on June 20, 2000, about 20 people swallowed glasses of water mixed with the powerful psychedelic LSD. A decimal place error caused them to take about 10 times more of the drug than they thought they were getting. For the 12 hours that followed, they would ride out one of the most intense experiences of their lives, one that would change them forever.

Gram for gram, LSD is more powerful than most recreational drugs. While most substances like MDMA or cocaine are active at the milligram scale, the effects of lysergic acid diethylamide manifest at the microgram scale—or one millionth of a gram. An average hit of LSD is 100 micrograms.

A trip can sometimes last 12 hours or more, pumping up heart rate, intensifying colors and sounds, and altering the perception of time. Because the LSD molecule, which mimics serotonin, has a “lid” that locks into serotonin receptors, it can remain there for hours. This is how low concentrations of the drug can be so potent.

Because of this sensitivity, it can be easy to overdose on LSD. But what happens when people take extreme amounts of LSD? This is the subject of a new report co-authored by Mark Haden, the executive director of MAPS Canada and an adjunct professor at the University of British Columbia, which looked at extreme cases of LSD consumption, revealing some bizarre health outcomes.

One of the cases covered in Haden’s study was that of a 15-year-old girl with bipolar disorder. She was one of the 20 people who accidentally OD’d on acid at the summer solstice party in Canada. She took a whopping 1,100 micrograms. For the next six hours, her behavior became erratic. She lay on the floor in the fetal position tightly clenching her arms. Her friends thought she was having a seizure and called an ambulance, although no one was sure if she was actually seizing, lost consciousness or was just lost in the overwhelming experience.

The next morning, her father visited her in the hospital. She told her dad, “It’s over.” He thought she meant the acid trip. She clarified that no, her bipolar illness, which had caused daily manic episodes, seemed to be cured. A week later, her symptoms had still not returned. Doctors followed her progress for over a year, and nearly two decades later, she still hasn’t experienced episodes of depression or mania outside of postpartum depression. Looking back on the overdose, she said it felt like her brain chemistry had somehow been “reset.”

Haden says he was not only amazed that her symptoms resolved, but that such a high dose could ultimately be a positive experience. In his report, published in the Journal of Studies on Alcohol and Drugs, Haden also includes the story of another individual at that infamous solstice party, a 26-year-old woman who only took half a glass (approximately 500 micrograms) of LSD. Unbeknownst to her, she was two weeks pregnant. Yet she experienced no pregnancy complications and her son, now 18 years old, is a perfectly healthy bright young student.

The most remarkable case study included in the report is the 2015 story of a 46-year-old woman, who Haden calls CB, who had chronic pain caused by Lyme disease. CB snorted a line of white powder she thought was cocaine. Fifteen minutes later, she realized something was wrong and called her roommate, who told her what had happened: She had inhaled part of his stash of LSD.


While LSD usually comes in a “blotter” form—tiny pieces of paper dabbed with scentless, clear liquid acid—the drug can also come in a potent white powder form, and is not hard to confuse with other powdered drugs. CB’s roommate weighed the remaining powder and estimated that she had snorted up 55 milligrams—550 times an average dose, enough to get an entire school tripping on acid. It was a rollercoaster mega-trip that would last 34 hours.

The first 12 hours were hellish. She mostly blacked out and vomited frequently, while being looked after by her roommate. For the next 12 hours after that, CB said she felt “pleasantly high,” mostly sat in a chair, “frothing at the mouth, occasionally vocalizing random words and vomiting frequently,” according to Haden’s account.

When the drug finally wore off another 10 hours later, CB felt normal, and her chronic pain had completely disappeared. For seven years she had been taking morphine every day to treat symptoms of Lyme disease. After her LSD overdose, not only had her pain evaporated, she felt no withdrawal symptoms from the opioids she had been taking.

CB stopped taking morphine for five days, and then her pain did return. She then reduced her dose of opioids and started microdosing LSD (taking about a quarter of a typical dose or 25 micrograms) every three days for a few years before completely stopping the morphine in January 2018, again without withdrawal symptoms.

There is some evidence that psychedelics like LSD can treat pain because they are anti-inflammatory drugs, but Haden was surprised it could help with opioid withdrawal symptoms as well. “I heard somebody say that he thought LSD would be good for withdrawals, but I've never seen any evidence of it,” he said. There is almost no evidence LSD may help with bipolar disorder, let alone “cure” it. Ayelet Waldman, author of A Really Good Day, claims microdosing LSD helped manage her mood disorders. A clinical trial in Switzerland is currently recruiting people to look at LSD to treat manic depression. Otherwise, there’s not much there.

CB’s trip isn’t the most intense LSD overdose recorded or even the first time someone mistook LSD for cocaine. In a 1972 report published in the Western Journal of Medicine, four men and four women each snorted two lines of white powder that was acid, not blow. It’s hard to estimate how much they took, but blood samples ranged from 1,000 to 7,000 micrograms per milliliter. That’s about between 260 and 2100 hits of LSD.

Ten minutes later, all of them ended up in the emergency room. Five were comatose, while the others were “extremely hyperactive with severe visual and auditory hallucinations,” according to the report. Three patients stopped breathing and needed to be put on ventilation machines. Other symptoms included diarrhea, vomiting, bleeding, blood clots and fever (the cocaine, which they had also taken, could have caused the bleeding).

All eight patients survived, and fully recovered less than 12 hours later, most with no memory of being admitted to the hospital. The study authors stated that “no apparent psychological or physical ill effects were noted in a year of follow-up examinations of five patients. Most of the patients continue to use LSD intermittently.”

While there’s never been a recorded death from LSD directly, the authors estimated that a lethal dose of LSD would be around 14,000 micrograms. People do sometimes take too much of a psychedelic and stumble into traffic or out of a window. It’s also possible to die from overdosing on drugs like 25I-NBOMe, which often looks like acid blotter, but can be deadly, which underscores the importance of knowing what drug you are ingesting.

Overall, this points to the incredible relative safety of LSD, which is regularly confirmed in clinical trials.

“It's a remarkably safe product. It’s unusual,” Haden said. “Albert Hofmann, [the first scientist to synthesize LSD in 1938], said it was one of the least toxic drugs on the planet and that kind of is consistent with David Nutt’s toxicity data. That’s just another reason why it shouldn’t be criminalized — it’s remarkably non-toxic.”


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OfflineJohnRainyII
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: sonoramo]
    #26500432 - 02/23/20 07:37 PM (3 years, 11 months ago)

That's fascinating.


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InvisibleHolybullshit
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: JohnRainyII]
    #26501001 - 02/24/20 07:17 AM (3 years, 11 months ago)

Amazing.

My then girlfriend, now wife, has a similar story to this involving mushrooms. Her father is schizoaffective/bipolar(pretty severely), when we were young(I think she was 20-21 at the time) she had begun manifesting some of the symptoms and had sought professional help/advice but had yet begun to take any medication(against the doctors advice)...well I was growing mushrooms at the time, and she didn't take them nearly as often or as much as me. But one day I made an extremely strong batch of "tea" that I had filtered well and flavored with kool-aid and a shitload of sugar, to make it easier to consume because she hated the taste...we planned on taking it one night, but I assumed she would wait to dose until I got home from work and did not warn her of its strength and she consumed a very large glass. Needless to say a very intense experience followed. I estimated that she consumed about 15-20 grams worth of mushrooms if not more.

She did have a semi-psychotic experience through portions of the trip, losing touch with reality...I won't get into the details, but any and all mental health issues that she was beginning to experience immediately stopped, since then she has never as much been needed to be prescribed anti-depressants(unlike me), let alone be treated for schizoid symptoms or bipolar and is one of the most stable people I know.


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OfflinePsilosopherr
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Holybullshit]
    #26502022 - 02/24/20 05:58 PM (3 years, 11 months ago)

i'm not quite in the same ballpark but an 11 dried gram mushroom trip cured my depression/suicidal nature forever.

Very interesting article. Wouldn't have guessed that doses that high would have beneficial effects, especially on pain/withdrawal.


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OfflineFailboat
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Psilosopherr]
    #26502475 - 02/25/20 12:42 AM (3 years, 11 months ago)

A fingerprint will set you right. For something more modest a few drops up the nostril is fun.


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OfflineMikeTesserect
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: sonoramo]
    #26502484 - 02/25/20 12:53 AM (3 years, 11 months ago)

ppl just don't fall hard enough when they jump out of windows lol. its not that safe but I don't know shit! I remember I wanted to jump in front of a train during a bad trip to end it. I just had a strong enough mind not to do it. sometimes the brain can learn and reproduce positive experiences ( look up "phantom hand" cases). neurons that wire together even fire together


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Offlinegone-pear-shaped
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: sonoramo]
    #26502553 - 02/25/20 03:45 AM (3 years, 11 months ago)

Is there any reason to think psilocybin could or could not have similarly positive effects at high doses? One piece of evidence is that it's somewhat useful in helping people quit smoking (higher success rate than any other therapy but still low). I wonder if it could be beneficial on a deeper level, or is the duration too short or is it just different than LSD?


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Offlineicetech
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: gone-pear-shaped]
    #26502932 - 02/25/20 10:51 AM (3 years, 11 months ago)

I wish i could take more than i do.. but i'm rationing and afraid of running out :frown:


--------------------


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OfflineFractal420
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: gone-pear-shaped] * 1
    #26502937 - 02/25/20 10:53 AM (3 years, 11 months ago)

Don’t drink random glasses of water with unknown doses. I’m wary ever since I tried some Altoids that ended up in the 300-400 range, my first time taking them I thought it’d be like 100ug, blew me away

Was getting lost in my own house. But was an amazing experience


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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OfflineMikeTesserect
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: gone-pear-shaped]
    #26504288 - 02/26/20 01:56 AM (3 years, 11 months ago)

it sounds stupid, but the brain can "learn" to produce more serotonin after an lsd or psilocybin experience although rare. a spiritual experience would act the same way. the brain will reproduce and reinforce anything conducive to survival no matter how erroneous. don't take this statement seriously


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OfflineDoc9151M
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: MikeTesserect]
    #26504555 - 02/26/20 09:18 AM (3 years, 11 months ago)

The bi-polar part is Interesting,  I personally know some people that suffer from schizophrenia and psychoactive mushrooms made it several times worse or brought it out in those people that didn't know they had it but had family history, most became suicidal but it eventually passed, now they have to take lithium and some other drugs to keep the hallucinations and things under control and this was from a regular dose of 5g dried shrooms.

nausea and vomiting are side effects of high doses of mushrooms or LSD for me and usually happens on the come up, if I puke it ruins the trip so I eat zofran or phenergan before dosing high doses.

edit: word correction, used past instead of passed, duh:facepalm::wow:


--------------------


Psilocybe cubensis data collection thread. please help with this project if you hunt wild cubensis.
https://www.shroomery.org/forums/showflat.php?Cat=0&Number=26513593&page=0&vc=1#26513593


Edited by Doc9151 (02/27/20 02:50 PM)


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OfflineFractal420
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Doc9151]
    #26505829 - 02/27/20 03:12 AM (3 years, 11 months ago)

For me, 5g is more than a regular dose with good cubes

The powder thing makes me feel like it’s more likely to be 1p-lsd or something

And I mean, high doses may help certain conditions in an unknown fashion, but fingerprints imo are not meant for people who want some healing or just wanna trip.

I’ve Always read that regardless of dose, lsd comes down in 12 hrs

I guess it Can have some unexpected positives, but surely negatives too. I get post trip visuals with regular doses, so I bet if I had a thumb print, it’d be like doing 2ce 3x a week, prolly months of post visuals

I could imagine a single megadose tryptamine experience can be good for depression and such though


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



Edited by Fractal420 (02/27/20 03:20 AM)


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OfflineCamwritesgonzo
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: sonoramo]
    #26506657 - 02/27/20 02:42 PM (3 years, 11 months ago)

Am I the only one who finds it a little fucked that people are misplacing or mishandling xtal in a way that other people are doing it thinking they're doing blow? I mean I read about the guy who they said died because he shot up a fat dose of fluff because he thought it was smack, but it's a mite disconcerting that shit like that is still happening. Not to mention all the people who could have been "turned on" if all that sunshine was laid on paper.
Or maybe I'm just behind the times and being cynical.


--------------------
"I've always maintained that reality is for those who can't face drugs."-Tom Waits
"I feel the same way about disco as I feel about herpes."-Hunter S. Thompson
A squid eating dough in a polyethylene bag is fast and bulbous, got me?


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OfflinePsilosopherr
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Camwritesgonzo]
    #26507366 - 02/27/20 10:33 PM (3 years, 11 months ago)

Quote:

Camwritesgonzo said:
Am I the only one who finds it a little fucked that people are misplacing or mishandling xtal in a way that other people are doing it thinking they're doing blow? I mean I read about the guy who they said died because he shot up a fat dose of fluff because he thought it was smack, but it's a mite disconcerting that shit like that is still happening. Not to mention all the people who could have been "turned on" if all that sunshine was laid on paper.
Or maybe I'm just behind the times and being cynical.



Right? Kinda mind blowing. Always makes me think of mia wallace in pulp fiction. Hey an unidentified white powder in a baggie, lets do a fat line. maybe taste a tiny bit first, shyet.

You'd think the first couple people in that group of people would have realized that wasn't coke, then again i've never snorted lsd :lol:

'fuck is fluff slang for? Eh guess i coulda googled that but i already typed it in


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Offlineviraldrome
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Psilosopherr]
    #26507570 - 02/28/20 03:09 AM (3 years, 11 months ago)

All my drugs are clearly labelled. I had a close call when i had a break in and realized some idiot burglar might try to snort a fat line of a potent RC and die, lucky it was hidden they didn't find it. I would probably be liable for that. Even if you think its only you with access and no one will find it, label your drugs, you never know. People have stored anti freeze in a vodka bottle in the fridge and killed people, it's a disaster waiting to happen


--------------------
Lysergamides I have tried so far: 1P-LSD, 1cP-LSD, ALD-52, AL-LAD, LSZ, ETH-LAD, MIPLA, EIPLA, 1cP-AL-LAD


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InvisibleGottaloveacid
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: viraldrome]
    #26507603 - 02/28/20 04:53 AM (3 years, 11 months ago)

This is very interesting information. My little anecdote is I had a 1000ug (or more) trip on LSD, unexpectedly. While the experience was beyond intense and I handled it well, I have borderline personality disorder (came on in the last 2-3 years), which comes with lots of suicidal thoughts and behavior. I will note that I had that experience at 17 years old, and I am 21 now.


--------------------
   
:mushroom2::mushroom2: The greatest story ever told is the story that never ends!:mushroom2::mushroom2:

wubba lubba dub dubstep :gimmebass:


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OfflineFailboat
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Gottaloveacid]
    #26509024 - 02/28/20 11:17 PM (3 years, 11 months ago)

Crystal is commonly mishandled in various ways, and could easily be mistaken for blow. It definitely doesn't last longer when you take more at once, just all of the effects are more pronounced. Eating 550mg would be wild but snorting it sounds like shit yer britches territory...


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OfflineFractal420
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Camwritesgonzo]
    #26509207 - 02/29/20 04:51 AM (3 years, 11 months ago)

Quote:

Camwritesgonzo said:
Am I the only one who finds it a little fucked that people are misplacing or mishandling xtal in a way that other people are doing it thinking they're doing blow? I mean I read about the guy who they said died because he shot up a fat dose of fluff because he thought it was smack, but it's a mite disconcerting that shit like that is still happening. Not to mention all the people who could have been "turned on" if all that sunshine was laid on paper.
Or maybe I'm just behind the times and being cynical.




For sure, who the fuck even has enough LSD crystal to confuse for coke? What is that a quarter in there? I guess now that they’re selling bulk powder lysergamides it’s more in the realm of possibility, but like I said, I think it’s much more likely to be 1p or something than lsd25, for what it’s worth

With real Lucy I mostly just see blotter sales on markets and whatever, not raw powder. That’s more of an rc thing

Not that it matters in terms of potency. But 1p could have other effects at higher doses, possibly. LSD is a chemical that affects Many parts of the brain, whereas psilocybin is mostly concentrated to one area (5ht2/a)


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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OfflineFailboat
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Fractal420]
    #26510561 - 02/29/20 11:10 PM (3 years, 11 months ago)

A crack sack with a gram looks like a crack sack with a gram. The people who are allowed to handle raw are supposed to know well enough not to allow others to make the mistake of taking a bump of crystal. That said sometimes people fuck up. You're not gonna see it on a market, but there's a whole lot out there.


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OfflineFractal420
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Re: LSD Overdose Reports (MAPS co-authored journal article) [Re: Failboat]
    #26511011 - 03/01/20 08:31 AM (3 years, 11 months ago)

i think powder lysergamides like this are likely things like 1p. You’d never hear of a story of someone thinking lsd was coke before they started selling powder 1p and such

Just those two or so accidental ODs from like the 70s or something, when someone thought it was meth and IVed

Maybe back then crystal lsd was around.

Let’s agree that whoever left out a bump of lsd or 1p or whatever, was not an expert who was laying pages. I don’t even treat single blotters like that, they’re never just left out. Everyone knows the heat, light, air thing. Now imagine that it’s just crystal


--------------------
Dreaming of That face again.
It's bright and blue and shimmering.
Grinning wide
And comforting me with it's three warm and wild eyes.

Prying open MY third eye



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