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Swinette
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Do SSRI's block tripping for every one? *DELETED*
#26466705 - 02/03/20 11:50 AM (3 years, 11 months ago) |
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Post deleted by Swinette
Reason for deletion: answered
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TheStallionMang
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Re: Do SSRI's block tripping for every one? [Re: Swinette] 1
#26466712 - 02/03/20 11:57 AM (3 years, 11 months ago) |
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Everybody and every trip is different. I know someone on SSRIs who seems to be more sensitive to shrooms than I am which seems odd but that's how it is sometimes. Maybe her idea of tripping hard enough is lower than mine but that's ok too.
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Splash_damage
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Re: Do SSRI's block tripping for every one? [Re: Swinette] 1
#26466725 - 02/03/20 12:06 PM (3 years, 11 months ago) |
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There are different types of SSRIs that block different serotonin receptors in your brain. I have been on SSRIs for depression and my brother has been on a plethora of them. It depends on which SSRI you're taking that will effect your trip. I'm really not sure which ones but if you look up the SSRI on wikipedia and go to the pharmacology section you will see which ones bind to and affect reuptake of 5-HT. 5-HT is what psilocybin and LSD bind (or agonize) to so the drugs that affect that receptor are generally what change your trip. If I'm full of shit let me know I'm not a pharmacologist.
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DJ Ed
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Re: Do SSRI's block tripping for every one? [Re: Swinette] 1
#26466965 - 02/03/20 02:56 PM (3 years, 11 months ago) |
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There are lots of factors involved that change the outcome, but the general consensus is that 50% of people on SSRIs will trip, 50% won’t. I believe the percentage of people who don’t trip (properly), though, is much higher. One factor as you say is the brand of SSRI. But they work on the same 5ht2a receptors that psilocin works on. They block serotonin re-uptake by blocking the receptor. So if you think about the science, if they’re blocking the receptors that the psilocin works on; hey presto, no trip. It’s that simple.
But another factor is the length of time you’ve been on the SSRI and at what dosage. I was on 100mg sertraline (Zoloft) for 7 years. It was a full 5 months completely free of SSRIs before I tripped properly, and broke through to that psychedelic headspace.
I would guess somehow that you are very sensitive to psilocin. And further to that, if you ever come off SSRIs, and was free for a while, then that same 3G would send you into hyperspace 👍🏻
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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Sabnock
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Re: Do SSRI's block tripping for every one? [Re: DJ Ed]
#26466987 - 02/03/20 03:10 PM (3 years, 11 months ago) |
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Actually SSRI's work by inhibiting the Serotonin transporter, thereby working as a Serotonin reuptake inhibitor, raising levels of Serotonin in the brain, activating Serotonin receptors, which Psychedelics have to compete with the increase in Serotonin for the binding to and activation of Serotonin receptors. I know MAO-A inhibitors work similarly, in that they inhibit MAO-A which raises Serotonin levels, however, people are still able to "trip" while on an MAO-A inhibitor, so i'm not sure of what makes SSRI's different in that regard, as the end result is the same, Serotonin levels rise, and the Psychedelics have to compete with the Serotonin for Serotonin receptor activation, in fact MAO-A inhibition can actually make things a good bit stronger, not just due to potentiation of the substance, but also due to the increased Serotonin and Noradrenaline increase in the background. I think what makes SSRI's different compared to MAO-A inhibitors, is that SSRI's make Serotonin stay in the synaptic cleft, whereas MAO-A inhibitors merely raise background Serotonin, so say you consume something that raises Serotonin, while on an MAO-A inhibitor the stimulated Serotonergic effects are potentiated, but on SSRI's the substance, in this case Psychedelics, have to forcefully try to displace the Serotonin from the synaptic cleft so that the substance can get through and bind to the receptors, so the MAO-A inhibition doesn't force Serotonin into the synapses which means other things can override it, whereas SSRI's do force Serotonin into the synapses, which means you have to take enough of the substance to overpower the SSRI's grip on the synapses.
I hope that makes sense.
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DJ Ed
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Re: Do SSRI's block tripping for every one? [Re: Sabnock] 1
#26466994 - 02/03/20 03:15 PM (3 years, 11 months ago) |
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Yes it does, actually. So given human variability, these processes will occur to a greater or lesser extent in certain individuals. So the current estimates of 50:50 being able to trip while on SSRIs or not, does seem plausible. My doubts causing me to believe the ratio is actually weighted towards NOT being able to trip while on SSRIs, is after digesting loads of posts on the shroomery. But I suppose though that people wouldn’t post here If they’d been successful!
❤️
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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Ignorantape
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Re: Do SSRI's block tripping for every one? [Re: DJ Ed] 1
#26467258 - 02/03/20 05:49 PM (3 years, 11 months ago) |
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I've been on multiple different SSRI's over the years. Only one of them (can't remember which one) ever affected my capacity to trip. I'd come up just fine but when I'd hit the peak the trip would die and I'd be left with nothing but hours of irritating, minor visuals and no head trip at all. Thankfully those meds didn't work out anyway.
With all the other SSRI's I haven't noticed any affect on my capacity to trip at all. If you enjoyed yourself and got something out of it then I wouldn't worry.
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LogicaL Chaos
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Re: Do SSRI's block tripping for every one? [Re: Swinette]
#26467973 - 02/04/20 06:52 AM (3 years, 11 months ago) |
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This is very interesting. It would appear that newer SSRIs are not blocking the effects of shrooms like the old types did 
The brain is a complex bio-chemical system, therefore everyones reaction to a drug, be it Shrooms or SSRI and unique or different. Just really depends on the persons bio-chemistry
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DJ Ed
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Re: Do SSRI's block tripping for every one? [Re: LogicaL Chaos]
#26468207 - 02/04/20 10:06 AM (3 years, 11 months ago) |
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Hmm good shout, LogicaL Chaos.
But I think peeps could be on bout a new anti-depressant, not a new SSRI.
Is everyone actually referring to SNRIs? See this from google:
serotonin-norepinephrine reuptake inhibitors (SNRIs) such as ansofaxine, nefopam and levomilnacipran
It seems like these work on different 5ht receptors, not just the 5ht2 receptors. There also seem to be new SSRIs, which work on the 5ht1a receptors, not the psilocin 5ht2a receptors.
Maybe there is something in this after all.......
❤️ DJ Ed
-------------------- “It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.” Michael Pollan: How To Change Your Mind “The problem is not to find the answer, it’s to face the answer.” Terence McKenna

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fluorescent
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Re: Do SSRI's block tripping for every one? [Re: Swinette]
#26468712 - 02/04/20 03:09 PM (3 years, 11 months ago) |
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I know someone who's on 50mg of Zoloft, and has had zero problems tripping.
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KD-Grows
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Re: Do SSRI's block tripping for every one? [Re: fluorescent]
#26470280 - 02/05/20 01:04 PM (3 years, 11 months ago) |
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My spouse seems to be able to trip while on Zoloft. He does seem to have reduced effects compared to me, but still reached level 2 on 2.2g and level 3 on 3.5g.
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