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Offlinemorrowasted
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Re: Viral outbreak in China [Re: morrowasted] * 1
    #26585069 - 04/07/20 09:12 PM (3 years, 9 months ago)

https://www.scientificamerican.com/article/new-coronavirus-drug-shows-promise-in-animal-tests1/


EIDD-2801 inhibits the coronavirus’s self-copying operations in a manner that is different from remdesivir. While remdesivir brings that replication process to a full stop, EIDD-2801 introduces mutations—mistakes—into the virus’s RNA as it makes copies so that the viral RNA becomes so damaged that it cannot infect cells. Another feature of the drug is that it is able to work against a host of other RNA viruses. Thus, it could serve as a multipurpose antiviral, much in the way some antibiotics can work against a wide variety of bacteria. In several preclinical studies, researchers from multiple labs have shown that EIDD-2801 was effective against several strains of influenza, as well as the viruses for respiratory syncytial virus and the viruses for chikungunya, Venezuelan equine encephalitis and Eastern equine encephalitis—all microbes that intermittently pop up in different parts of the world and produce widespread sickness in their wake.

The compound may be initially beneficial as a “prophylaxis [that] health care workers can take to prevent an infection,” says Wayne Holman, co-founder of Miami-based Ridgeback Biotherapeutics, which has licensed the drug from Emory’s nonprofit biotech company Drug Innovation Ventures at Emory (DRIVE). Another potential use of EIDD-2801 might be to protect uninfected nursing home residents and workers if an outbreak occurs inside a facility. Holman says the wider goal is to have an oral pill that can be taken twice a day by patients at home early in the course of the disease to prevent it from progressing to hospitalization, mechanical ventilation or death.



Article also states that remdesivir human trial results will be back by end of this month


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: morrowasted] * 2
    #26585082 - 04/07/20 09:21 PM (3 years, 9 months ago)

interesting general info about chloroquine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/

Quote:

Because chloroquine is an established lysosomal targeting agent [12], [13], [24], we examined intracellular zinc distribution after treatment of A2780 cells with chloroquine and zinc. As shown in Figure 4, chloroquine induced accumulation of intracellular zinc ions primarily in the lysosomes,






this is why some people are saying quercetin may also help, because it also causes zinc to move into the cell

https://www.ncbi.nlm.nih.gov/pubmed/25050823

Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model.
Quote:



Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, transporting zinc cations through the plasma membrane. To prove this hypothesis, herein, we have demonstrated the capacity of QCT and epigallocatechin-gallate to rapidly increase labile zinc in mouse hepatocarcinoma Hepa 1-6 cells as well as, for the first time, in liposomes. In order to confirm that the polyphenols transport zinc cations across the plasma membrane independently of plasma membrane zinc transporters, QCT, epigallocatechin-gallate, or clioquinol (CQ), alone and combined with zinc, were added to unilamellar dipalmitoylphosphocholine/cholesterol liposomes loaded with membrane-impermeant FluoZin-3. Only the combinations of the chelators with zinc triggered a rapid increase of FluoZin-3 fluorescence within the liposomes, thus demonstrating the ionophore action of QCT, epigallocatechin-gallate, and CQ on lipid membrane systems. The ionophore activity of dietary polyphenols may underlay the raising of labile zinc levels triggered in cells by polyphenols and thus many of their biological actions




Edited by morrowasted (04/07/20 09:29 PM)


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OfflineRebeccaBlack
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Re: Viral outbreak in China [Re: morrowasted]
    #26585149 - 04/07/20 09:53 PM (3 years, 9 months ago)

I'm really confused as to how chelators can do anything to vitamin C, chemistry-wise.


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: RebeccaBlack]
    #26585154 - 04/07/20 09:58 PM (3 years, 9 months ago)

Quote:

Daijo said:
I'm really confused as to how chelators can do anything to vitamin C, chemistry-wise.




unsure, I've never heard of it either, but that is what wikipedia said. my guess is that some of the AA is bound to the metals that are getting excreted but I honestly dont know

Quote:

The chelating process also removes vital nutrients such as vitamins C and E, therefore these must be supplemented.[12]




The source they have on that claim is some BS magazine called "Mothering" though so...


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Offlinekoods
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Re: Viral outbreak in China [Re: morrowasted]
    #26585191 - 04/07/20 10:22 PM (3 years, 9 months ago)

Quote:

Article also states that remdesivir human trial results will be back by end of this month




If it were truly promising we’d know already.


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InvisibleballsalsaMDiscord
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Re: Viral outbreak in China [Re: morrowasted]
    #26585197 - 04/07/20 10:27 PM (3 years, 9 months ago)

I read a paper about PEGylated zinc nanoparticles back in Jan but I can't find it now.


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: koods]
    #26585199 - 04/07/20 10:30 PM (3 years, 9 months ago)

Quote:

koods said:
Quote:

Article also states that remdesivir human trial results will be back by end of this month




If it were truly promising we’d know already.



I'm just gonna wait for the study to come out :shrug: the truth will be revealed. Ima say this though, if I get severe COVID19, fuck the studies. i'm not waiting for them to finish, and neither are the docs that apparently blowing up gilead trying to get access to this drug. personally- load me up. carpet bomb it. hydroxychloroquine, vitamin c, remdesivir, zinc, all those interleukin and tnf-a inhibitors.


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: morrowasted] * 1
    #26585210 - 04/07/20 10:39 PM (3 years, 9 months ago)

it's honestly gonna suck in a way if the real numbers come in way under the models because numbnuts are going to interpret that as the CDC was lying to us rather than these social control measures actually worked. next time they have to do this they are going to throw a tantrum- "it wasnt even necessary last time"


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Offlineinsanegrain
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Re: Viral outbreak in China [Re: morrowasted]
    #26585214 - 04/07/20 10:41 PM (3 years, 9 months ago)

Finally got to restock on some tp. I was hoping all the panic buying would be done by now. I dread going to the store with all these panic buyers hoarding everything.

Ps. I see so many people using PPE incorrectly, it is infuriating.


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: insanegrain]
    #26585217 - 04/07/20 10:44 PM (3 years, 9 months ago)

Quote:

insanegrain said:
Finally got to restock on some tp. I was hoping all the panic buying would be done by now. I dread going to the store with all these panic buyers hoarding everything.

Ps. I see so many people using PPE incorrectly, it is infuriating.



I use PPE 'incorrectly' when I am just out in public. I  have 2 boxes of gloves. can't afford to do it "properly". me wearing the same gloves doesn't protect you from whatever is on my gloves, but it stops me from picking my nose or rubbing my eye. that does about 90% of the job


i found 12 rolls of TP at the dollar store 2 days ago


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InvisibleThe Blind Ass
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Re: Viral outbreak in China [Re: morrowasted]
    #26585232 - 04/07/20 10:56 PM (3 years, 9 months ago)

Quote:

morrowasted said:
Quote:

Tantrika said:

I'm worried that once word gets out, orange juice will be even more difficult to come by than it already has become
QQ



only suckers source vitamin C from oranges. peppers are where it's at




My man.


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OfflineRebeccaBlack
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Re: Viral outbreak in China [Re: morrowasted] * 1
    #26585235 - 04/07/20 10:58 PM (3 years, 9 months ago)

The mask on my face is enough to remind me not to touch my mouth, nose or eyes. I'd much rather see people wash their hands rather than use gloves, but hey.

I'm guessing chelators must not pick up all chelation positions possible on metals. Metals may be chelated by both vitamin C and the chelator during excretion.

Do you know a commonly used chelator I could check the structure of?


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: RebeccaBlack]
    #26585243 - 04/07/20 11:02 PM (3 years, 9 months ago)

Quote:

Daijo said:
The mask on my face is enough to remind me not to touch my mouth, nose or eyes. I'd much rather see people wash their hands rather than use gloves, but hey.

I'm guessing chelators must not pick up all chelation positions possible on metals. Metals may be chelated by both vitamin C and the chelator during excretion.

Do you know a commonly used chelator I could check the structure of?



https://en.wikipedia.org/wiki/Deferoxamine

this is the only one I've ever seen/used IRL


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OfflineRebeccaBlack
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Re: Viral outbreak in China [Re: morrowasted]
    #26585248 - 04/07/20 11:08 PM (3 years, 9 months ago)

That looks like it can wrap around metals leaving no place for vitamin c, but they could both be partially bound. Who knows :shrug:

Where does that 0.3% death rate people talk about come from? What math makes it to that low % ?


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Offlinemorrowasted
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Re: Viral outbreak in China [Re: RebeccaBlack]
    #26585254 - 04/07/20 11:11 PM (3 years, 9 months ago)

Quote:

Where does that 0.3% death rate people talk about come from? What math makes it to that low % ?



I have no idea what you're talking about. You mean people are claiming a CFR of 0.3? If so that means we have way more cases than we think we do. I hope that is the case but I doubt it.


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OfflineRebeccaBlack
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Re: Viral outbreak in China [Re: morrowasted]
    #26585267 - 04/07/20 11:20 PM (3 years, 9 months ago)

That would compare deaths to cases. But people say death rate, not fatality rate. It's better to compare outcomes (deaths versus deaths + recoveries)


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Offlineviraldrome
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Re: Viral outbreak in China [Re: morrowasted] * 1
    #26585280 - 04/07/20 11:38 PM (3 years, 9 months ago)

Quote:

morrowasted said:

only suckers source vitamin C from oranges. peppers are where it's at




I half expect someone here to invent a vitamin C extraction tek


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Edited by viraldrome (04/08/20 03:02 AM)


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Invisiblesh4d0ws
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Re: Viral outbreak in China [Re: viraldrome] * 2
    #26585362 - 04/08/20 01:12 AM (3 years, 9 months ago)

peppers are delicious no need for extraction

:stoned:


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OfflineLogicaL ChaosM
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Re: Viral outbreak in China [Re: sh4d0ws]
    #26585375 - 04/08/20 01:22 AM (3 years, 9 months ago)

But Vit C IV must be IV'd for it to fight againist the Coronavirus (apparently).


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InvisibleMadMuncher
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Re: Viral outbreak in China [Re: viraldrome]
    #26585383 - 04/08/20 01:28 AM (3 years, 9 months ago)

Quote:

viraldrome said:
Quote:

morrowasted said:

only suckers source vitamin C from oranges. peppers are where it's at




I have expect someone here to invent a vitamin C extraction tek




1 cup of prepared rose hips equals the vitamin c content of 144 oranges


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