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OnlineBaby_Hitler
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted]
    #26549918 - 03/21/20 10:36 PM (3 years, 10 months ago)

Quote:

morrowasted said:
Quote:

Baby_Hitler said:
Steroids, eh?

What about anabolic steroids, or, for that matter, natural testosterone?



they are talking about corticosteroids. they often use them for pneumonia. methylprednisolone and prednisone





True, though I have heard that this virus is killing more men than women. Could be related. Could just be that more men smoke than women. :shrug:


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: Baby_Hitler]
    #26549935 - 03/21/20 10:49 PM (3 years, 10 months ago)

Quote:

Baby_Hitler said:


True, though I have heard that this virus is killing more men than women. Could be related. Could just be that more men smoke than women. :shrug:



I think it's a combination of social and biological factors. Men work into old age more frequently than women.

If the ACE2 receptor theory turns out to be correct, then it's probably the case that anyone who is genetically predisposed to hypertension because of ACE2 receptor density is also genetically predisposed to COVID19 infection. Men tend to have hypertension more than women because of differences in the renin-angiotensin-aldosterone system which is partially expressed in terms of ACE2 receptor function


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted] * 1
    #26549968 - 03/21/20 11:16 PM (3 years, 10 months ago)

Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.

consuming lectins that bind mannose inhibits cellular entry of SARS-COV because the spike proteins are high in mannose, if I understand correctly. Not sure if this will apply to COVID19


Edited by morrowasted (03/21/20 11:26 PM)


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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted]
    #26549979 - 03/21/20 11:31 PM (3 years, 10 months ago)

I got paratyphoid and got really fucked sick but just sat in my room basically dead. I ate contaminated sushi. spicy tuna rolls that are cheap are made out of a can imported and they straight poisoned an entire restaurant. That shit sucked


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OfflineKizzle
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: CookieCrumbs]
    #26549994 - 03/21/20 11:46 PM (3 years, 10 months ago)

Quote:

CookieCrumbs said:
Quote:

morrowasted said:
https://www.covidactnow.org/

projections of #of deaths and when hospitals will exceed capacity based on various social distancing models

I would be okay with a month long wuhan lockdown at this point




In every state almost all of it seems like it takes barely anything to overload the hospitals.

I think it's so absurd that it took us forever to even kinda acknowledge we had an issue and then got hyper focused on insurance and cost and not.... like the fact that it's all fucked up and severely unprepared to actually take care of us. Struggling to take care of us, actually. Even when things were 'normal.'


And we bickered about costs.

I hate it.



I heard when the hospitals become completely overwhelmed the virus isn't even going to be the biggest killer. It's all the other deadly emergencies that they won't have room for.


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: Kizzle]
    #26550005 - 03/22/20 12:00 AM (3 years, 10 months ago)

You are correct.

Have a relative with a pacemaker?

It's in your best interests that their cardiologist not be forced to work in an ER or ICU, which is what is starting to happen.


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Offlinekoods
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: Kizzle]
    #26550006 - 03/22/20 12:00 AM (3 years, 10 months ago)



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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Invisiblesh4d0ws
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: koods]
    #26550030 - 03/22/20 12:31 AM (3 years, 10 months ago)

Seems in Canada, most of the cases are being found in 20 to 40 year olds



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Edited by sh4d0ws (03/22/20 12:32 AM)


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: sh4d0ws] * 4
    #26550034 - 03/22/20 12:35 AM (3 years, 10 months ago)


Because they are going out. They're working. They're full of hubris. They think their "healthy immune systems" will save them.


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InvisibleballsalsaMDiscord
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: qman] * 1
    #26550045 - 03/22/20 12:50 AM (3 years, 10 months ago)

Quote:

qman said:
Is it safer to have groceries delivered to your home or just go to the store yourself?




delivered.  you can wipe all packaging down with 1:3 bleach/water solution.


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: ballsalsa] * 1
    #26550052 - 03/22/20 01:01 AM (3 years, 10 months ago)

I have a gynecologist friend who had to intubate a patient in the ER today.


It's fucking scary when people are getting intubated by gynecologists.


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Invisiblesh4d0ws
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted] * 1
    #26550053 - 03/22/20 01:02 AM (3 years, 10 months ago)

I dont know if this was posted previously?

Freaky that this was basically predicted...in 2013

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Quote:

The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.




:aghast:


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: sh4d0ws]
    #26550056 - 03/22/20 01:07 AM (3 years, 10 months ago)

Quote:

sh4d0ws said:
I dont know if this was posted previously?

Freaky that this was basically predicted...in 2013

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence.

Quote:

The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations.




:aghast:



this is good stuff thank you


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Invisiblesh4d0ws
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted]
    #26550061 - 03/22/20 01:16 AM (3 years, 10 months ago)

Maybe the chinese found this study though and decided they could create an ultimate bioweapon. And it was released accidentally, or purposefully...but maybe this thing was fucking lab created??

Like they were making this shit humanly transmissible to study it, 7 years ago so... it is possible


Quote:

while public health measures silenced the SARS-CoV outbreak2, recent metagenomics studies have identified sequences of closely related SARS-like viruses circulating in Chinese bat populations that may pose a future threat4,5. However, sequence data alone provides minimal insights to identify and prepare for future pre-pandemic viruses. Therefore, to examine emergence potential of circulating CoVs, we built a chimeric virus that encodes a novel, zoonotic spike protein in the context of a viable CoV backbone. This approach characterized the threat posed by SHC014-CoV spike in primary human airway cells, in vivo, as well as the efficacy of available immune therapeutics. Together, the strategy translates metagenomics data to help predict and prepare for future emergent viruses.




:badtrip:


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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: sh4d0ws]
    #26550070 - 03/22/20 01:32 AM (3 years, 10 months ago)

I don’t get what the big deal is


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NotSheekle said
“if I believed she was 16 I would become unattracted to her”


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Offlinemorrowasted
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: sh4d0ws]
    #26550072 - 03/22/20 01:34 AM (3 years, 10 months ago)

Quote:

sh4d0ws said:
Maybe the chinese found this study though and decided they could create an ultimate bioweapon. And it was released accidentally, or purposefully...but maybe this thing was fucking lab created??

Like they were making this shit humanly transmissible to study it, 7 years ago so... it is possible


Quote:

while public health measures silenced the SARS-CoV outbreak2, recent metagenomics studies have identified sequences of closely related SARS-like viruses circulating in Chinese bat populations that may pose a future threat4,5. However, sequence data alone provides minimal insights to identify and prepare for future pre-pandemic viruses. Therefore, to examine emergence potential of circulating CoVs, we built a chimeric virus that encodes a novel, zoonotic spike protein in the context of a viable CoV backbone. This approach characterized the threat posed by SHC014-CoV spike in primary human airway cells, in vivo, as well as the efficacy of available immune therapeutics. Together, the strategy translates metagenomics data to help predict and prepare for future emergent viruses.




:badtrip:



the fuck are you talking about? The study is specifically saying "hey check out these naturally occurring bat viruses. they look nasty and i bet they could mutate to have human to human transmission"

guess what


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Invisiblesh4d0ws
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: morrowasted]
    #26550093 - 03/22/20 01:59 AM (3 years, 10 months ago)

I'm not saying that this study implies that? Jesus dude.

I'm saying that, it is *possible* that they could have (the chinese government/military/whatever the fuck), at some later date, used this knowledge and the research on the specific sequences in some of the viruses that target the ace2 receptor to find the an especially bad virus, make it humanly transmissible, and ... pass it on to humans, purposefully. Or that they were doing research and the virus escaped - accidentally.

I am not trying to spread conspiracies just a thought,

sorry for offending ya'll :lol:


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Invisiblenooneman
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: sh4d0ws] * 2
    #26550103 - 03/22/20 02:12 AM (3 years, 10 months ago)

So if you actually look at the numbers, it looks like the death rate is normally about 5%, but 10% in italy. Maybe a death rate between 5-10%, perhaps depending on the number of ventilators available. If you just straight up divide the number of deaths in most countries by the number who are ill, you end up generally with 5%.

I just got through day 6, which felt better than days 4-5 most of the time, but occasionally it seemed to flare up and be really bad again. I feel like the amount of oxygen I can get in my system is still pretty low, but it's less painful today most of the time. It almost seems to come and go in waves. When it's bad it gets to the point that I worry about death and dying, but then it seems to gradually go away again. If I exert myself at all, even just like laughing slightly or getting into a show emotionally, I feel like I run out of oxygen and get a lot of pain and tightness in my lungs and can't breathe right. I've actually had to calm myself down after really stupid minor stuff just so it stops hurting and I can breathe right again. Kinda reminds me of the waves of a psychedelic sometimes, but in a bad way.

I'm starting to feel like I'm gonna be alright though, at least when I'm calm and things are going well and it's not so painful, which seems to happen for longer periods of time today than yesterday or the day before.

Thanks for all the wellwishes guys. Stay safe out there. Don't get this shit, you don't want it even if you're young and healthy. It fucking sucks and is painful and shitty, and I probably have the mild version...


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Invisiblesh4d0ws
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: nooneman]
    #26550106 - 03/22/20 02:14 AM (3 years, 10 months ago)

Did you get tested by a nose swab thingy?


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Invisiblenooneman
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Re: Coronavirus 2020 aka Wuhan Coronavirus aka COVID-19 [Re: sh4d0ws]
    #26550107 - 03/22/20 02:24 AM (3 years, 10 months ago)

Mouth swab.

Also keep in mind my timeline might be inaccurate because it's possible that I only noticed my symptoms 5 days ago when they got bad enough to notice.


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