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Offlinemorrowasted
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Dietary Protein, time-restricted eating, and Aging * 2
    #26402654 - 12/27/19 08:18 AM (4 years, 1 month ago)

Dietary Protein and Aging: mTOR, IGF-1, and Tradeoffs


It's worth reading the whole article, it's not too long and is explained in a way most people can understand.



  • A large, powerful musculoskeletal system acts as a buffer against the negative effects of aging.
  • Dietary protein strongly influences muscle protein balance. The amino acid leucine is a key trigger of muscle protein synthesis through its actions on mTORC1.
  • mTORC1 coordinates cell growth and metabolism with prevailing conditions (energy availability, amino acid availability, growth factor signaling, and so on).
  • Generally speaking, lower activities in the mTOR pathway and the insulin/growth hormone/IGF-1 axis are associated with longevity.
  • Calorie and/or amino acid restriction typically prolongs lifespan and healthspan in non-human animals.





A detailed review of the current research on time-restricted eating was just published yesterday:

Effects of Intermittent Fasting on Health, Aging, and Disease



Quote:

How much of the benefit of intermittent fasting is due to metabolic switching and how much is due to weight loss? Many studies have indicated that several of the benefits of intermittent fasting are dissociated from its effects on weight loss. These benefits include improvements in glucose regulation, blood pressure, and heart rate; the efficacy of endurance training; and abdominal fat loss (see Supplementary Section S1).



Intermittent fasting stimulates autophagy and mitophagy while inhibiting the mTOR (mammalian target of rapamycin) protein-synthesis pathway. These responses enable cells to remove oxidatively damaged proteins and mitochondria and recycle undamaged molecular constituents while temporarily reducing global protein synthesis to conserve energy and molecular resources (Fig. 3). These pathways are untapped or suppressed in persons who overeat and are sedentary.






Finally, it appears that the metabolic benefits of amino acid restriction are not gut flora-dependent:

The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome

Quote:

We therefore tested the ability of a LP diet to improve metabolic health following antibiotic ablation of the gut microbiota. We found that a LP diet promotes leanness, increases energy expenditure, and improves glycemic control equally well in mice treated with antibiotics as in untreated control animals. Our results demonstrate that the beneficial effects of a LP diet on glucose homeostasis, energy balance, and body composition are unlikely to be mediated by diet-induced changes in the taxonomic composition of the gut microbiome.




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InvisibleJokeshopbeard
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Registered: 11/30/11
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Re: Dietary Protein, time-restricted eating, and Aging [Re: morrowasted] * 1
    #26402726 - 12/27/19 09:05 AM (4 years, 1 month ago)

Tl;dr - eating plenty meat and building muscles is good for you??


--------------------
Let it be seen that you are nothing. And in knowing that you are nothing... there is nothing to lose, there is nothing to gain. What can happen to you? Something can happen to the body, but it will either heal or it won't. What's the big deal? Let life knock you to bits. Let life take you apart. Let life destroy you. It will only destroy what you are not.
--Jac O'keeffe


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Offlineliving_failure
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Re: Dietary Protein, time-restricted eating, and Aging [Re: Jokeshopbeard]
    #26402752 - 12/27/19 09:27 AM (4 years, 1 month ago)

I always keep skeptical of most scientific studies that are hard to replicate and studies that are based in statistical data.

Genes are what makes you life longer, and even if you are able to live to 120 years, it is high likely that if you are a male, most functions wold be severely damaged ( unable to run, to fight, to fuck, to lift weights and probably have some level of metal disability).


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Invisibletrees
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Registered: 02/08/09
Posts: 9,194
Re: Dietary Protein, time-restricted eating, and Aging [Re: living_failure] * 1
    #26402785 - 12/27/19 09:50 AM (4 years, 1 month ago)

Not really clear what OP is intending to suggest.

Cmon morrowasted. You know we ain't a bunch of scientists accustomed to reading and interpreting scientific jargon. We don't understand if you're showing us scientific literature to suggest we eat meat and intermittently fast on it and also work out a lot and build muscle

I don't know what to think of these scientifically conjured modes of advice. All I know for sure now is that the oldest most clear headed happy people I ever met, never followed science and they smoked and drank and ate whatever they wanted and enjoyed their lives and that is seemingly why they lived so long. To me that is real-much better evidence than some cohort studies grouped with nematode and lab rat stidudies. And I can't help but notice the stories of young professionals who follow specialty diets and routines and they die really early from some freak disease


--------------------


Edited by trees (12/27/19 10:03 AM)


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InvisibleJokeshopbeard
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Re: Dietary Protein, time-restricted eating, and Aging [Re: morrowasted]
    #26402797 - 12/27/19 10:10 AM (4 years, 1 month ago)

Quote:

trees said:
Cmon morrowasted. You know we ain't a bunch of scientists accustomed to reading and interpreting scientific jargon.



That was my thought/feeling on seeing this too. I think for morrow, cause he has a profession/education? closely tied to this kind of work he is able to digest it easily.

However for a layperson this is way too much science talk, and too time consuming.

Think of your audience man!!


--------------------
Let it be seen that you are nothing. And in knowing that you are nothing... there is nothing to lose, there is nothing to gain. What can happen to you? Something can happen to the body, but it will either heal or it won't. What's the big deal? Let life knock you to bits. Let life take you apart. Let life destroy you. It will only destroy what you are not.
--Jac O'keeffe


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Invisiblecannabinated
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Re: Dietary Protein, time-restricted eating, and Aging [Re: Jokeshopbeard]
    #26402967 - 12/27/19 12:23 PM (4 years, 1 month ago)

basically we should only be eating protein when we bulk up


which would be consistent evolutionary with nomadic behavior


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Invisiblecannabinated
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Re: Dietary Protein, time-restricted eating, and Aging [Re: cannabinated]
    #26402969 - 12/27/19 12:24 PM (4 years, 1 month ago)

the nice thing about this typa science is u can google it all


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Invisiblecannabinated
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Re: Dietary Protein, time-restricted eating, and Aging [Re: cannabinated]
    #26402974 - 12/27/19 12:26 PM (4 years, 1 month ago)

ima try keto with salads until i go to the gym next week


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Invisiblecannabinated
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Re: Dietary Protein, time-restricted eating, and Aging [Re: cannabinated]
    #26402975 - 12/27/19 12:28 PM (4 years, 1 month ago)

you dont wanna be exciting cell growth constantly cause it ages u

just cardio n stuff


Edited by cannabinated (12/27/19 12:29 PM)


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Invisibleopenmind
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Registered: 08/03/07
Posts: 13,866
Re: Dietary Protein, time-restricted eating, and Aging [Re: cannabinated] * 3
    #26403003 - 12/27/19 12:56 PM (4 years, 1 month ago)

Why do you always make like 3 or 4 or 5 or more posts in a row instead of just making one single post?

All of that could have easily been said in one single post.




-OM

.


--------------------


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Invisiblecannabinated
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Registered: 01/03/13
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Re: Dietary Protein, time-restricted eating, and Aging [Re: openmind]
    #26403014 - 12/27/19 01:03 PM (4 years, 1 month ago)

im high as fuck dude just ban me start a petition

i had 3 more to add


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Invisiblevinsue
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Re: Dietary Protein, time-restricted eating, and Aging [Re: Jokeshopbeard] * 1
    #26403029 - 12/27/19 01:14 PM (4 years, 1 month ago)

Quote:

Jokeshopbeard said:
Tl;dr - eating plenty meat and building muscles is good for you??



No, getting old is bad for you.:shrug:

:oldman: . . . :peace:


--------------------

"All mushrooms are edible; but some only once." Croatian proverb. BTW ...
  Have You Rated Ythans Mom Yet ?? ... :taser:  ... HERE'S HOW ... (be nice) .  :mod: ... :peace:


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Offlinemorrowasted
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Re: Dietary Protein, time-restricted eating, and Aging [Re: Jokeshopbeard]
    #26404650 - 12/28/19 12:50 PM (4 years, 1 month ago)

Quote:

Jokeshopbeard said:
Tl;dr - eating plenty meat and building muscles is good for you??



No the tldr is more like muscle growth and longevity are counterbalanced by amino acid consumption


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OfflineGaggi
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Re: Dietary Protein, time-restricted eating, and Aging [Re: morrowasted]
    #27782682 - 05/18/22 08:20 AM (1 year, 8 months ago)

How do you cope with gaining muscle mass? I have tried many ways, including proper nutrition, various workouts with regimens, protein shakes and adding protein to the daily diet. Unfortunately for my body, all these methods were not particularly effective. I almost came to terms with this problem when I came across premium peptides, which had a huge impact on my body and it began to transform in a matter of days. Any training brought tremendous results and my muscles began to grow and I began to gain weight. I am pleased that this tool helped me, because I have almost given up. No wonder they say that every body is individual. Peace to all!


Edited by Gaggi (05/19/22 03:40 AM)


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