|
SunFlare
Stranger

Registered: 10/13/17
Posts: 59
Last seen: 1 year, 10 months
|
Mescaline and MDMA Cross Tolerance ?
#26399022 - 12/24/19 11:46 AM (4 years, 1 month ago) |
|
|
I searched the web and most results that come up about this topic are very old...
whats the current science about mdma and mescaline cross tolerance, since mescaline and mdma are both phenethylamines.
my scenario is taking ~200mg mescaline on day 1 and taking 130mg pure mdma 3 nights later.
do you think the mescaline sulfate will crank down the mdma intensity?
did you ever experience a cross tolerance between these 2 substances?
(all my stuff is 100% clean and tested)
|
Pandemoon
Ἧeẍeᾐmeḭsṫeŗ ͛


Registered: 01/28/14 
Posts: 5,844
Loc: Europe
Last seen: 14 seconds
|
Re: Mescaline and MDMA Cross Tolerance ? [Re: SunFlare] 2
#26399136 - 12/24/19 01:10 PM (4 years, 1 month ago) |
|
|
There won't be any noticable tolerance. Both drugs are phenethylamines, yes, but the way they act is different.
200mg of mescaline is a rather low dose. On the other hand, 130mg of mdma is a pretty solid dose if taken all at once. If there was a slight tolerance, the mdma should still work well.
I wouldn't be concerned about and just take it. 
-
|
openmind
curious


Registered: 08/03/07
Posts: 13,866
|
Re: Mescaline and MDMA Cross Tolerance ? [Re: Pandemoon] 1
#26399282 - 12/24/19 02:54 PM (4 years, 1 month ago) |
|
|
Quote:
Pandemoon said: There won't be any noticable tolerance. Both drugs are phenethylamines, yes, but the way they act is different.
200mg of mescaline is a rather low dose. On the other hand, 130mg of mdma is a pretty solid dose if taken all at once. If there was a slight tolerance, the mdma should still work well.
I wouldn't be concerned about and just take it. 
-

Exactly what I was going to say.
There won't be any cross tolerance between the two.
-OM
.
--------------------
|
Psilotyl
נָזִיר


Registered: 08/30/19
Posts: 469
Loc: עולם
|
Re: Mescaline and MDMA Cross Tolerance ? [Re: openmind]
#26399351 - 12/24/19 03:53 PM (4 years, 1 month ago) |
|
|
I’d be willing to bet there is TECHNICALLY some cross tolerance, but it’s probably pretty negligible. Especially given three days in between, I doubt the mescaline will do much or anything at all to mitigate the MDMA.
For me, Mescaline is already quite a “feely” psychedelic. One can certainly see how they’re related pharmacologically as phenethylamine. Both also give you quite a bet of “pep.” Again this makes sense, as both are essentially the main drugs of the “psychedelic amphetamine” class as well.
On mescaline, I always find myself enjoying the effect of rubbing my hands on my legs or arms, or rubbing my feet on a nice carpet lol. The other side of its effects remind me a lot more of LSD than mushrooms. I always seem to find significance and am drawn to the simple “energy” of household objects and things like doors and cabinets are for some reason usually amusing to me. I think many get the same vibe. Aldous Huxley spends a huge part of “The Doors of Perception” just talking about couches and vases, lol. Mescaline is a fun substance for sure. I’m not really a huge fan of MDMA personally, maybe just because I find mescaline so fascinating. It’s interesting that Alexander Shulgin’s whole career was in essence motivated by a mescaline trip, which lead to his discovery/rediscovery of MDMA.
Have fun and be safe!
--------------------
שלום וְאור | PEACE & LIGHT
Edited by Psilotyl (12/24/19 04:05 PM)
|
Korean Jesus



Registered: 11/13/19
Posts: 554
Loc: United States
Last seen: 2 years, 6 months
|
Re: Mescaline and MDMA Cross Tolerance ? [Re: Psilotyl]
#26399405 - 12/24/19 04:32 PM (4 years, 1 month ago) |
|
|
no
|
openmind
curious


Registered: 08/03/07
Posts: 13,866
|
Re: Mescaline and MDMA Cross Tolerance ? [Re: Psilotyl]
#26400538 - 12/25/19 02:25 PM (4 years, 1 month ago) |
|
|
Quote:
Psilotyl said: I’d be willing to bet there is TECHNICALLY some cross tolerance, but it’s probably pretty negligible.
Even though they are both phenethylamines, the mechanism of action of mescaline and MDMA is different so there won't be much of any cross tolerance between the two.
MDMA acts primarily as a releasing agent of monoamine neurotransmitters serotonin, norepinephrine, and dopamine...and it also has some weak agonist activity at serotonin receptors 5-HT1 and 5-HT2.
Mescaline on the other hand acts as an agonist, binding to and activating the serotonin 5-HT2A receptor with a high affinity. (it also touches on and tickles some other serotonin receptors and other systems, but it is mostly just a serotonergic agonist like the other classic psychedelics).
The effects of those two drugs are mediated in different ways, the only "overlap" between the two is how MDMA has some weak affinity for and activity on some of the same receptors that mescaline does. Technically yea there might be some down regulation/very mild tolerance, but since the two drugs are working in different ways I doubt it will be pronounced and noticeable.
IME...I have not noticed any cross tolerance between any of the classic psychedelics and MDMA or MDA.
Quote:
On mescaline, I always find myself enjoying the effect of rubbing my hands on my legs or arms, or rubbing my feet on a nice carpet lol.
Same here.
I too find mescaline to be a VERY "touchy" and tactile experience . That's a specific aspect that mescaline has (for me at least, seems lots of others feel the same as well).
I touch/feel/caress different parts of my body a lot while on mescaline.
I usually take mescaline outdoors/in nature and I always find myself reaching out and touching & feeling different plants & trees & rocks & moss etc etc etc.
Cactus/mescaline is quite a sensual experience for me.
-OM
.
--------------------
|
Psilotyl
נָזִיר


Registered: 08/30/19
Posts: 469
Loc: עולם
|
Re: Mescaline and MDMA Cross Tolerance ? [Re: openmind]
#26401523 - 12/26/19 11:43 AM (4 years, 1 month ago) |
|
|
Your description of mescaline outdoors sounds wonderful OM. I've never done this. My mescaline trips have all just been at my house.
I am going camping soon and was planning to trip shrooms with a friend, but now I might just bring two big arms of San Pedro along instead!
|
|