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Offlineklhouse
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Registered: 12/12/15
Posts: 671
Loc: SE Virginia
Last seen: 4 years, 1 month
Psychedelics not working? * 1
    #26390631 - 12/19/19 12:15 PM (4 years, 1 month ago)

I know it is common knowledge about certain drugs like antidepressants dampening your high. I have not been able to catch a good trip in a long time. I took 5 grams of my own mushrooms (so I know what I'm dealing with) and nothing happened. I gave same batch to others, they tripped balls. One person even questioned if I laced shrooms with acid. So they were effective. Then I took 9 grams of same batch. Nothing happened.

It also took me tremendous amounts of quality wax to get me a weak THC high.

Same thing happened with acid tabs. My friends took one tab and tripped great. I took one, nothing happened. Ended up taking four, maybe felt a little something.

Anyway, I was listening to a podcast about trying to legalize psychedelics for depression and the guy mentioned that this stuff works on Serotonin 2a receptor. I went home and googled it. Turns out that the first thing mentioned that blocks this action is TRAZODONE. I have been prescribed this for sleep, so I didn't think of it as an problem.

I quit Trazodone a week ago, and my THC highs have improved greatly. I'm gonna try a psychedelic trip here in about a week.

Trazodone is a 5 HT 2A ANTOGONIST. (against) Does anyone know if a 5 ht 2a AGONIST (PRO, or HELPER) would help a psychedelic trip?

https://en.wikipedia.org/wiki/5-HT2A_receptor
Here is an easy to read article.


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Shroomery mycologist definitely know their shit. :wink:


Knowledge talks. Wisdom listens.


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OfflineMorel Guy
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Registered: 01/23/13
Posts: 15,577
Last seen: 4 years, 30 days
Re: Psychedelics not working? [Re: klhouse]
    #26390642 - 12/19/19 12:22 PM (4 years, 1 month ago)

5ht2a antagonist is anti-psychotic in action/effect.

5ht2a is thought to be the most active.  LSD is a powerful agonist of 5ht2a.

I'd also try to lay off the wax.


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"in sterquiliniis invenitur in stercore invenitur"

In filth it will be found in dung it will be found


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Invisibleacidgoofy
Freak


Registered: 05/14/17
Posts: 192
Loc: Germany
Re: Psychedelics not working? [Re: Morel Guy]
    #26390702 - 12/19/19 01:06 PM (4 years, 1 month ago)

pretty crazy, I think you should try different stuff until something works for you.


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“What you seek is seeking you” Rumi


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OfflineDJ Ed
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Registered: 09/04/16
Posts: 2,326
Loc: UK Flag
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Re: Psychedelics not working? [Re: klhouse]
    #26390844 - 12/19/19 02:57 PM (4 years, 1 month ago)

I came off 7 years on SSRIs to replace them with pysilocybin mushrooms. I read loads and loads before the first dose. Including drug interactions. It seems 50:50 will trip when they are still on SSRIs but the other half need to be off. For a small few, yes ME, you have to be completely off them. My first few trips were very weak. I got CEVs but that was about it. And the room grew then shrunk and the mood / colours changed. I increase dose up to at one point 8.5g dried cubensis golden teachers with weak effects. Then after 6 months off the SSRIs I took about 5g dried liberty caps (very strong mushroom) and had a real trip. At last I got an anti-depressant effect! Unfortunately the next day one of my labradors died in the woods, bled to death in my arms; I was seriously upset and fucked up for bout 10 months 😫

But my point, sir, is it might take you some time to get a proper trip. Build up your doses slowly, and take care my friend.

Mush love, m y thoughts are with you,
DJ Ed


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“It’s like when you see a mountain lion,” he suggested. “If you run, it will chase you. So you must stand your ground.”
Michael Pollan: How To Change Your Mind

“The problem is not to find the answer, it’s to face the answer.”
Terence McKenna



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OnlineLogicaL ChaosM
Ascension Energy & Alien UFOs
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Registered: 05/12/07
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Re: Psychedelics not working? [Re: klhouse]
    #26391829 - 12/20/19 03:17 AM (4 years, 1 month ago)

Thats why its important to identifily ANY prescribed drugs you are taking. Its not just antidepressants (TRAZODONE is a antidepressant btw) that dampen the psychedelic effect, antipsychotics and Benzos do as well.

Also, there is a period of "detoxing" where the prescribed drug does still affect the psychedelic effect. Usually lasts about 2 - 4 weeks or so from what Ive read.   


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