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OfflineBlabble40
Scorpio

Registered: 11/11/14
Posts: 1,182
Last seen: 1 year, 28 days
Psychedelics and inflammation
    #26372320 - 12/10/19 04:16 AM (4 years, 1 month ago)

I’m wondering your thoughts on this. Inflammation is a response to damage, generally, so while a sign of something bad, is considered good as a sign of healing. Psychedelics also can have a response to inflammation by healing inflamed areas faster. This is seen as a physical connection to the mental, as a reminder of keeping you grounded and to form a connection with the body, while some focus purely on the mind aspects of it. There’s more to the inner and outer life than thoughts and expression.


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OfflineK3yBoardC0WBoy
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Registered: 07/19/19
Posts: 158
Last seen: 3 years, 6 months
Re: Psychedelics and inflammation [Re: Blabble40]
    #26372338 - 12/10/19 04:36 AM (4 years, 1 month ago)

More effective then big farma at less duration


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OfflineSocrateshroom
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Registered: 09/05/18
Posts: 1,840
Loc: Westworld
Last seen: 17 days, 10 hours
Re: Psychedelics and inflammation [Re: Blabble40]
    #26372565 - 12/10/19 07:40 AM (4 years, 1 month ago)

Quote:

Blabble40 said:
I’m wondering your thoughts on this. Inflammation is a response to damage, generally, so while a sign of something bad, is considered good as a sign of healing. Psychedelics also can have a response to inflammation by healing inflamed areas faster. This is seen as a physical connection to the mental, as a reminder of keeping you grounded and to form a connection with the body, while some focus purely on the mind aspects of it. There’s more to the inner and outer life than thoughts and expression.




I think we need to be careful ascribing properties that may be unproven to psychedelics. I haven't scoured the data so there might be research studies about psychedelics physically having an effect on inflammation but I believe what you are suggesting is the notion that a mind-body connection can be effective at naturally "commanding" your body to reduce specific aspects of the inflammatory response (there is some evidence that a person can "will" a reduction in their pain or inflammation, suggesting the power of the mind in these matters).

Do psychedelics have chemical properties that, irregardless of our willpower, reduce inflammation? Perhaps, but we need either some evidence in that field or research. I believe there is a growing field of evidence showing that the combination of the various chemicals in marijuana (or even specific chemicals like THC or CBD alone) are chemically effective for treating inflammation. But this research is almost nonexistent with psychedelics due to the illegality of the substances.


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InvisiblefeeversM
Male

Registered: 12/28/10
Posts: 8,546
Loc: Flag
Re: Psychedelics and inflammation [Re: Socrateshroom] * 1
    #26373814 - 12/10/19 07:23 PM (4 years, 1 month ago)

Quote:

Overall, psychedelics regulate inflammatory pathways via novel mechanisms, and may represent a new and exciting treatment strategy for several inflammatory disorders 



https://www.ncbi.nlm.nih.gov/m/pubmed/30102081/


Quote:

As reviewed by Nichols et al. (2017), it is now known that serotonergic-acting psychedelics, including psilocybin, have anti-inflammatory effects and may have efficacy in treating some inflammatory diseases. 



https://www.sciencedirect.com/science/article/pii/S0028390818302296

Quote:

Antiinflammatory effects may hold promise for efficacy in treatment of inflammation-related nonpsychiatric as well as potentially for psychiatric disorders. 



https://www.ncbi.nlm.nih.gov/m/pubmed/28019026/

Quote:

Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular proliferation, and cell survival via activating NF-κB and mitogen-activated protein kinases.




https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500993/


MAPS: Hallucinogens and Spontaneous Healing (a section with some inflammation. content.)
https://maps.org/news-letters/v21n1/v21n1-21to22.pdf


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OfflinePrimalSoup
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Registered: 11/17/09
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Re: Psychedelics and inflammation [Re: feevers] * 1
    #26373889 - 12/10/19 08:11 PM (4 years, 1 month ago)

:themoreyouknow: :havesomescience: :solidnod:


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Invisibleredgreenvines
irregular verb
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Registered: 04/08/04
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Re: Psychedelics and inflammation [Re: feevers]
    #26373901 - 12/10/19 08:14 PM (4 years, 1 month ago)

both ae personal journeys, both can affect your loved ones too, but inflammation often involves doctors as well.

I don't know how to deal with all the auto immune inflammations my family has attracted, but we steer clear of hundreds of allergens etc.

does my psychedelic use reduce my inflammatory nature, maybe, but maybe it affects my family the other way... that I am tripping nearby?


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OfflineCountHTML
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I'm a teapot

Registered: 06/24/18
Posts: 557
Loc: Maine
Last seen: 2 years, 2 months
Re: Psychedelics and inflammation [Re: redgreenvines]
    #26373915 - 12/10/19 08:22 PM (4 years, 1 month ago)

I suspect that positive and life-affirming psychedelic experiences may reduce overall inflammation for a brief period corresponding to the degree to which they alleviate stress. Of course, this cannot be said definitively or ascribed without actual evidence. Look's like Feevers is in the know on a lot of promising research on this.

Speaking as someone with several chronic inflammatory conditions coupled with depression, the week following a trip is just filled with superb clarity and a vacation from negative thinking patterns, which I tend to attribute to a general reduction in inflammation. Or inflammation reduces in response to the positive experience which compounds the on improvement to my psycho-emotional state, if that makes sense.

All of this is, of course, in the realm of speculation and observed personal experience and exists outside of the realm of science and should not be taken as any such claims.


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OfflineVibe_Enthusiast
Mushroom Technician
I'm a teapot


Registered: 10/16/18
Posts: 2,420
Loc: GPS signal lost.. Flag
Last seen: 18 days, 23 hours
Re: Psychedelics and inflammation [Re: CountHTML]
    #26374465 - 12/11/19 06:35 AM (4 years, 1 month ago)

Wish the fucking things were just legal so we can really study the other huge side effects mushrooms may have.. who fucking knows what else these are capable of.


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OfflineSocrateshroom
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Registered: 09/05/18
Posts: 1,840
Loc: Westworld
Last seen: 17 days, 10 hours
Re: Psychedelics and inflammation [Re: feevers]
    #26374490 - 12/11/19 07:03 AM (4 years, 1 month ago)

Quote:

feevers said:
Quote:

Overall, psychedelics regulate inflammatory pathways via novel mechanisms, and may represent a new and exciting treatment strategy for several inflammatory disorders 



https://www.ncbi.nlm.nih.gov/m/pubmed/30102081/


Quote:

As reviewed by Nichols et al. (2017), it is now known that serotonergic-acting psychedelics, including psilocybin, have anti-inflammatory effects and may have efficacy in treating some inflammatory diseases. 



https://www.sciencedirect.com/science/article/pii/S0028390818302296

Quote:

Antiinflammatory effects may hold promise for efficacy in treatment of inflammation-related nonpsychiatric as well as potentially for psychiatric disorders. 



https://www.ncbi.nlm.nih.gov/m/pubmed/28019026/

Quote:

Classical psychedelics are psychoactive substances, which, besides their psychopharmacological activity, have also been shown to exert significant modulatory effects on immune responses by altering signaling pathways involved in inflammation, cellular proliferation, and cell survival via activating NF-κB and mitogen-activated protein kinases.




https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500993/


MAPS: Hallucinogens and Spontaneous Healing (a section with some inflammation. content.)
https://maps.org/news-letters/v21n1/v21n1-21to22.pdf




:cheers:

Thanks for the info!


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InvisibleGreen_Hands
The Great Devourer
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Registered: 05/21/05
Posts: 625
Loc: Old World
Re: Psychedelics and inflammation [Re: Socrateshroom]
    #26374505 - 12/11/19 07:17 AM (4 years, 1 month ago)

Not directly part of topic but still, there is connection.

Seratonin role in wound healing


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OfflineK3yBoardC0WBoy
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Registered: 07/19/19
Posts: 158
Last seen: 3 years, 6 months
Re: Psychedelics and inflammation [Re: Green_Hands]
    #26390040 - 12/19/19 04:40 AM (4 years, 1 month ago)

Those of us who have experience in this area know the answer


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InvisiblePrimal Glitch
literally just vibing
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Registered: 05/06/07
Posts: 4,854
Loc: 🌎 Flag
Re: Psychedelics and inflammation [Re: K3yBoardC0WBoy]
    #26390041 - 12/19/19 04:44 AM (4 years, 1 month ago)

:threadmonitor:


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Offlinefluorescent
Unexpected.
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Registered: 06/30/17
Posts: 157
Last seen: 22 days, 3 hours
Re: Psychedelics and inflammation [Re: Blabble40]
    #26390284 - 12/19/19 08:41 AM (4 years, 1 month ago)

Anecdotal evidence, n=1, and all that, but I know someone (actually not me) who has suffered with low back pain and sciatica. For a period of time they were microdosing mushrooms (approx 125mg every other day for around 6 months) and experienced significant relief. Then, following a macrodose and continuation of microdosing, they experienced >90% relief of their back pain symptoms including nearly 100% relief of sciatic pain. The individual has been unable to continue microdosing due to circumstances, but continues to experience reduced discomfort relative to pre macrodose levels.


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