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Offlinemorrowasted
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Why inflammation causes depression * 3
    #26354629 - 11/30/19 08:49 PM (4 years, 1 month ago)

It has long been known that depressed patients have lower CSF levels of serotonin. More recently, it has been discovered that patients with depression usually have high biomarkers for inflammatory compunds like TNF-a. TNF-a induces an enzyme called IDO, which is part of the kynurenine pathway. The end product of the kynurenine pathway is nicotinamide (which is used throughout the citric acid cycle for ATP production). This is because the reduced oxygen delivery to the cell resulting from inflammation increases cellular energy demand.

The kynurenine pathway is essentially tryptophan -> quinolinic acid -> NAD.

Tryptophan is also used to produce serotonin (and therefore melatonin as well).

The body prioritizes energy production over mood. Essentially, the body uses as much tryptophan as it needs to to keep up with NAD demands and whatever is left over gets used to produce serotonin. Thus, inflammation causes tryptophan to be shunted away from the serotonin pathway.


Edited by morrowasted (11/30/19 10:52 PM)


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Offlinemorrowasted
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Re: Why inflammation causes depression [Re: morrowasted]
    #26354640 - 11/30/19 09:01 PM (4 years, 1 month ago)

Then why do antibiotics make depression worse?

Aromatic amino acids like tryptophan cannot be produced by the human body. They can, however, be produced by gut bacteria. Therefore antibiotics reduce tryptophan availability. Pesticides like glyphosate function as antibiotics.


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OfflineDorfnob
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Re: Why inflammation causes depression [Re: morrowasted]
    #26354653 - 11/30/19 09:13 PM (4 years, 1 month ago)

So I legit have a presentation due the 4th on inflammatory disease wanna whip something up for me? also
I think I'm going to go more in depth with symptoms now that you brought up a good link between the two.


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Offlinemorrowasted
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Re: Why inflammation causes depression [Re: Dorfnob]
    #26354663 - 11/30/19 09:19 PM (4 years, 1 month ago)

Quote:

Dorfnob said:
So I legit have a presentation due the 4th on inflammatory disease wanna whip something up for me? also
I think I'm going to go more in depth with symptoms now that you brought up a good link between the two.



I have schoolwork of my own. Good luck


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OfflineJBaker
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Re: Why inflammation causes depression [Re: morrowasted]
    #26354672 - 11/30/19 09:28 PM (4 years, 1 month ago)

im on Zoloft for serotonin deficiency, thkning I need dopamine too


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dark blue balloon, way high up in the sky, and it just can't speed up, being yourself and feeling content is way better than grasping for things that won't ever happen


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Invisiblecannabinated
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Re: Why inflammation causes depression [Re: JBaker]
    #26354694 - 11/30/19 09:45 PM (4 years, 1 month ago)



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Invisiblecannabinated
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Re: Why inflammation causes depression [Re: cannabinated]
    #26354697 - 11/30/19 09:45 PM (4 years, 1 month ago)

whats the deal with nicotinamide riboside eh


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Offlinemorrowasted
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Re: Why inflammation causes depression [Re: cannabinated]
    #26354738 - 11/30/19 10:23 PM (4 years, 1 month ago)

Quote:

cannabinated said:
whats the deal with nicotinamide riboside eh



preliminary studies suggest it may be good for longevity


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Offlinemorrowasted
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Re: Why inflammation causes depression [Re: JBaker] * 2
    #26354751 - 11/30/19 10:33 PM (4 years, 1 month ago)

Quote:

JBaker said:
im on Zoloft for serotonin deficiency, thkning I need dopamine too



or maybe, you know, look into the root causes of your problem.


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OfflineJBaker
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Re: Why inflammation causes depression [Re: morrowasted]
    #26354752 - 11/30/19 10:35 PM (4 years, 1 month ago)

nerve pain :sonofawebitch:


--------------------
dark blue balloon, way high up in the sky, and it just can't speed up, being yourself and feeling content is way better than grasping for things that won't ever happen


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Offlinemorrowasted
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Re: Why inflammation causes depression [Re: JBaker]
    #26354764 - 11/30/19 10:44 PM (4 years, 1 month ago)

no. just... no.


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Offlineyeah
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Re: Why inflammation causes depression [Re: morrowasted]
    #26354765 - 11/30/19 10:44 PM (4 years, 1 month ago)

How conclusive is it that sugar causes inflammation?


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Offlinemorrowasted
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Re: Why inflammation causes depression [Re: yeah]
    #26354777 - 11/30/19 10:56 PM (4 years, 1 month ago)

Quote:

yeah said:
How conclusive is it that sugar causes inflammation?



I'm not sure about the overall effect but within the context of this metabolic pathway, quite the opposite is true, actually. In the same way that inflammation induces TDO to metabolize tryptophan into kyurenine, low blood sugar levels and cortisol induce an enzyme called TDO that does the same thing.

Many people crave carbohydrates as the evening approaches, and it's been speculated that this is because the body needs to make some melatonin. Putting a bunch of sugar in your body slows down the kyurenine pathway so that more tryptophan is available to make melatonin.

there may be other factors that cause sugar to produce inflammatory cytokines but I'm not familiar with them


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Invisiblecannabinated
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Re: Why inflammation causes depression [Re: morrowasted]
    #26354794 - 11/30/19 11:23 PM (4 years, 1 month ago)

Quote:

morrowasted said:
Quote:

cannabinated said:
whats the deal with nicotinamide riboside eh



preliminary studies suggest it may be good for longevity



coo


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Offlineyeah
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Re: Why inflammation causes depression [Re: morrowasted]
    #26355245 - 12/01/19 09:43 AM (4 years, 1 month ago)

Quote:

morrowasted said:
Quote:

yeah said:
How conclusive is it that sugar causes inflammation?



I'm not sure about the overall effect but within the context of this metabolic pathway, quite the opposite is true, actually. In the same way that inflammation induces TDO to metabolize tryptophan into kyurenine, low blood sugar levels and cortisol induce an enzyme called TDO that does the same thing.

Many people crave carbohydrates as the evening approaches, and it's been speculated that this is because the body needs to make some melatonin. Putting a bunch of sugar in your body slows down the kyurenine pathway so that more tryptophan is available to make melatonin.

there may be other factors that cause sugar to produce inflammatory cytokines but I'm not familiar with them




Cool, thanks. I eat mad sugar.

CBD - does it toxify the liver? And how does it compare to NSAID's?


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OfflineDorfnob
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Re: Why inflammation causes depression [Re: yeah]
    #26355443 - 12/01/19 11:53 AM (4 years, 1 month ago)

do you have a link to an article you got your info?
I found a study, quite interesting I really like how psychs help battle inflammation and depression


Edited by Dorfnob (12/01/19 04:07 PM)


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OfflineFungiMaster
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Re: Why inflammation causes depression [Re: Dorfnob]
    #26355951 - 12/01/19 05:26 PM (4 years, 1 month ago)

Depression can be cured with a short stint of cocaine use. It engalrges the serotonin receptors.


--------------------


https://tinyurl.com/wjuxagb


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InvisibleYangSupporter
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Re: Why inflammation causes depression [Re: FungiMaster]
    #26355986 - 12/01/19 05:49 PM (4 years, 1 month ago)

Ever since I started with fish oil, tumeric and a few other supplements my depression got noticeably better.


--------------------
https://youtu.be/cTsEzmFamZ8


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Offlinemorrowasted
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Re: Why inflammation causes depression [Re: YangSupporter]
    #26356271 - 12/01/19 09:03 PM (4 years, 1 month ago)

Quote:

YangSupporter said:
Ever since I started with fish oil, tumeric and a few other supplements my depression got noticeably better.



raw turmeric? be careful with the imported bulk spice, a lot of it is intentionally contaminated with a form of lead that makes the orange look brighter and more appealing. I used to use it every day and when I stopped I actually felt better. raw turmeric is too expensive for me to use like that

Quote:


do you have a link to an article you got your info?
I found a study, quite interesting I really like how psychs help battle inflammation and depression






This info was pieced together from my textbooks, wikipedia articles, examine.com, etc. You can look up any of the individual facts though, you'll find that it's all true.

Quote:

It has long been known that depressed patients have lower CSF levels of serotonin.



https://www.ncbi.nlm.nih.gov/pubmed/6172023

Quote:

More recently, it has been discovered that patients with depression usually have high biomarkers for inflammatory compunds like TNF-a



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687935/
Quote:

TNF-a induces an enzyme called IDO, which is part of the kynurenine pathway. The end product of the kynurenine pathway is nicotinamide (which is used throughout the citric acid cycle for ATP production).



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC305266/


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Invisiblecannabinated
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Re: Why inflammation causes depression [Re: morrowasted]
    #26356287 - 12/01/19 09:23 PM (4 years, 1 month ago)

time to grow turmeric


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