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OfflineZeroHart
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Could this be related to PE being so potent ?
    #26340820 - 11/23/19 05:37 PM (4 years, 2 months ago)



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OfflineZeroHart
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Re: Could this be related to PE being so potent ? [Re: ZeroHart]
    #26340823 - 11/23/19 05:38 PM (4 years, 2 months ago)

The psychotropic effects of Psilocybe “magic” mushrooms are caused by the L-tryptophan-derived alkaloid psilocybin. Despite their significance, the secondary metabolome of these fungi is poorly understood in general. Our analysis of four Psilocybe species identified harmane, harmine, and a range of other L-tryptophan-derived β-carbolines as their natural products, which was confirmed by 1D and 2D NMR spectroscopy. Stable-isotope labeling with 13C11-L-tryptophan verified the β-carbolines as biosynthetic products of these fungi. In addition, MALDI-MS imaging showed that β-carbolines accumulate toward the hyphal apices. As potent inhibitors of monoamine oxidases, β-carbolines are neuroactive compounds and interfere with psilocybin degradation. Therefore, our findings represent an unprecedented scenario of natural product pathways that diverge from the same building block and produce dissimilar compounds, yet contribute directly or indirectly to the same pharmacological effects.


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OfflineMorel Guy
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Re: Could this be related to PE being so potent ? [Re: ZeroHart]
    #26340844 - 11/23/19 05:45 PM (4 years, 2 months ago)

Care to clear that up?

How is this related to MAOI?  Cause those I don't like.  Might explain some of the residual side effects.

In that case I'd suspect some other peyote alkaloids than mescaline as having maoi effects.


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"in sterquiliniis invenitur in stercore invenitur"

In filth it will be found in dung it will be found


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OfflineZeroHart
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Re: Could this be related to PE being so potent ? [Re: Morel Guy]
    #26341011 - 11/23/19 06:57 PM (4 years, 2 months ago)

The way I'm reading it, there is an active mushroom or four that produce MAOIs. Could PE's mutation be causing a larger amount of these secondary metabolomes?


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OfflineMorel Guy
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Re: Could this be related to PE being so potent ? [Re: ZeroHart]
    #26341025 - 11/23/19 07:08 PM (4 years, 2 months ago)

I'm not surprised yet sorta am surprised.

Rhodiola Rosea has a moai effect.


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"in sterquiliniis invenitur in stercore invenitur"

In filth it will be found in dung it will be found


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