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MrDudeMan2222
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Microdosing plus opioids
#26337793 - 11/22/19 09:43 AM (4 years, 2 months ago) |
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Anyone ever microdosed while on opioid pain meds? In my case I'm on tramadol, a fairly mild opioid.
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theRealrollforever
I DID-DENT



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Don’t do it Serotonin syndrome is possible just from tramadol alone and combined with the serotonergic(?) action of psychedelics it could be potentially bad I wouldn’t do it unless someone more knowledgeable can break down how it’s safe
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sunshine said: The order has to be secret and no one is sure.
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GaetanoZ
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In my personal experience I have never encountered any problems mixing low-moderate doses of opioids with mushrooms. I was on methadone maintenance for years and never had any issues with mushrooms or DMT. I can’t really speak for anyone else, but for me it hasn’t caused any problems. If anything it kinda just detracts from the vividness of the experience a bit. Also, since Tramadol has that extra serotonergic action (not present in more traditional/common opioids like morphine or oxycodone) I would be a little more hesitant, but in all likelihood, as long as you just take a minimal amount of opioids, you should be ok, be careful though.
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MrDudeMan2222
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Re: Microdosing plus opioids [Re: GaetanoZ]
#26339037 - 11/22/19 08:31 PM (4 years, 2 months ago) |
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Great advice, friends. Thx.
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Bill_Oreilly
ANIMALS (the RAINBOW SERPENT)


Registered: 11/12/11
Posts: 26,370
Loc: Boston
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Quote:
theRealrollforever said: Don’t do it Serotonin syndrome is possible just from tramadol alone and combined with the serotonergic(?) action of psychedelics it could be potentially bad I wouldn’t do it unless someone more knowledgeable can break down how it’s safe
I highly doubt a microdose with opiates could cause serotonin syndrome.
I am on 42mg methadone per day and have tripped on that for years and never had any problem.
-------------------- Something there is mysteriously formed, Existing before Heaven and Earth, Silent, still, standing alone, unchanging, All-pervading, unfailing, I do not know its name; I call it tao. If forced to give it a name, I call it Great (ta). Being great, it flows out; Flowing out means far-reaching; Being far-reaching, it is said to return. It's just a shot away..
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Universe
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When my dad died I got his hospice meds which included a big bottle of Tramadol. Wife and I took one pill each every 3 or 4 days just to enjoy the feeling. This went on for 6 years until we ran out. During those years I microdosed many times while on a Tram and it was fine. No big deal at all. I like the alertness I felt on Tram and it enhanced the feeling.
The downside for me is that I like to have an orgasm before I go to sleep, either inside my wife or on my own. Especially when I'm on psychedelics. While on Tramadol, that was not possible. No icing on the cake, if you will.
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Bill_Oreilly
ANIMALS (the RAINBOW SERPENT)


Registered: 11/12/11
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Loc: Boston
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Re: Microdosing plus opioids [Re: Universe]
#26339699 - 11/23/19 09:04 AM (4 years, 2 months ago) |
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tramadol is garbage imo
-------------------- Something there is mysteriously formed, Existing before Heaven and Earth, Silent, still, standing alone, unchanging, All-pervading, unfailing, I do not know its name; I call it tao. If forced to give it a name, I call it Great (ta). Being great, it flows out; Flowing out means far-reaching; Being far-reaching, it is said to return. It's just a shot away..
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theRealrollforever
I DID-DENT



Registered: 08/31/13
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Quote:
Bill_Oreilly said:
Quote:
theRealrollforever said: Don’t do it Serotonin syndrome is possible just from tramadol alone and combined with the serotonergic(?) action of psychedelics it could be potentially bad I wouldn’t do it unless someone more knowledgeable can break down how it’s safe
I highly doubt a microdose with opiates could cause serotonin syndrome.
I am on 42mg methadone per day and have tripped on that for years and never had any problem.
tram doesn’t work the same way as typical opioids.
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sunshine said: The order has to be secret and no one is sure.
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Indicabuds420
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Registered: 09/12/19
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Nice to see good advice on here regarding trammy chaps. The serotogenic properties is definitely one thing to take in consideration like said above. It's good to see that a few on here know, because on other forums I usually have to be the first to point that kind of stuff out when comparing opiates.
Please don't do it, just because others do it on morphine etc, is not excuse to do it with Tramadol. Tramadol is a synthetic opiate, not derived from the poppy unlike, codeine, morphine and diamorphine (heroin).
It's not just serotonin syndrome you want to watch out for, it's seizures too. No matter who you are, take enough of them and you WILL have a seizure. Seen it happen a few times. I've got epilepsy myself and wouldn't take it at all. Even when I did take it, which was before I knew more about it, it didn't really even touch me anyway but codeine does.
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Universe
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Quote:
Bill_Oreilly said: tramadol is garbage imo
Maybe that's a good thing. My wife and I did it 2-3 times a week for 6 years and we enjoyed it. When we ran out there were no withdrawals or a craving for more opiates. I think we were growing sick of it by then.
When I take Vicodin it blocks me up and I can't shit the next day. Tramadol never did that.
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openmind
curious


Registered: 08/03/07
Posts: 13,866
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Quote:
theRealrollforever said:
Quote:
Bill_Oreilly said:
Quote:
theRealrollforever said: Don’t do it Serotonin syndrome is possible just from tramadol alone and combined with the serotonergic(?) action of psychedelics it could be potentially bad I wouldn’t do it unless someone more knowledgeable can break down how it’s safe
I highly doubt a microdose with opiates could cause serotonin syndrome.
I am on 42mg methadone per day and have tripped on that for years and never had any problem.
tram doesn’t work the same way as typical opioids.
Yea tram does have a broad spectrum of receptor activity...it does hit on opioid receptors but it touches on a lot of other receptors/systems as well.
With that said though...I still don't feel there is much or any risk of serotonin toxicity resulting from the combination of tram & mushrooms. (from my basic understanding of these things)
Mushrooms are merely serotonin agonists, between the two there is nothing that is causing a release/flood or build up of serotonin.
With the classic psychedelics I don't see how serotonin toxicity can happen. They are serotonergic, but from what I understand classic psychedelics are not causing a release or build up of serotonin anywhere in the body.
Tram itself is something that does interact with a lot of drugs though...it is notorious for causing seizures by itself if dosed too high and/or in combination with other drugs. It has a broad spectrum of activity. Generally speaking tramadol isn't something I would combine with any other drugs just to be on the safe side, but from my basic understanding of these sorts of things I don't see any major inherent risk from taking mushrooms while on a prescribed dose of tramadol....at least no risk for serotonin toxicity.
-OM
.
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Indicabuds420
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Re: Microdosing plus opioids [Re: openmind]
#26340470 - 11/23/19 02:54 PM (4 years, 2 months ago) |
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Suppose that's a point and a thought, the way it affects the serotonin like above said. Shrooms don't deplete it or try stabilise it. I imagine the risk is nothing really compared to taking tramadol with MDMA or antidepressants.
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ZombiWurm
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Registered: 10/15/18
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I take kratom every day. I've microdosed and taken very large doses of many psychoactives while on Kratom and other opiates. It changes the trip a little depending how much you take.
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Bill_Oreilly
ANIMALS (the RAINBOW SERPENT)


Registered: 11/12/11
Posts: 26,370
Loc: Boston
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Re: Microdosing plus opioids [Re: Universe]
#26340948 - 11/23/19 06:29 PM (4 years, 2 months ago) |
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Quote:
Universe said:
Quote:
Bill_Oreilly said: tramadol is garbage imo
Maybe that's a good thing. My wife and I did it 2-3 times a week for 6 years and we enjoyed it. When we ran out there were no withdrawals or a craving for more opiates. I think we were growing sick of it by then.
When I take Vicodin it blocks me up and I can't shit the next day. Tramadol never did that.
Vicodin is garbage too.
But don't take my opinion, after you do heroin then all other opiates besides methadone and fent are pretty much garbage..including tramadol and such
-------------------- Something there is mysteriously formed, Existing before Heaven and Earth, Silent, still, standing alone, unchanging, All-pervading, unfailing, I do not know its name; I call it tao. If forced to give it a name, I call it Great (ta). Being great, it flows out; Flowing out means far-reaching; Being far-reaching, it is said to return. It's just a shot away..
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Universe
Friend


Registered: 05/27/13
Posts: 1,161
Last seen: 11 hours, 42 minutes
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Quote:
Bill_Oreilly said:
Quote:
Universe said:
Quote:
Bill_Oreilly said: tramadol is garbage imo
Maybe that's a good thing. My wife and I did it 2-3 times a week for 6 years and we enjoyed it. When we ran out there were no withdrawals or a craving for more opiates. I think we were growing sick of it by then.
When I take Vicodin it blocks me up and I can't shit the next day. Tramadol never did that.
Vicodin is garbage too.
But don't take my opinion, after you do heroin then all other opiates besides methadone and fent are pretty much garbage..including tramadol and such
If it means having fun while avoiding a life-long opiate addiction that has to be serviced with methadone, I'll stick with the garbage.
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FungiMaster
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Re: Microdosing plus opioids [Re: Universe]
#26342173 - 11/24/19 10:57 AM (4 years, 2 months ago) |
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I was on hella crack and did some morphine. It was pleasant. I took 2 pills and slowly fell asleep with some visuals.
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ZombiWurm
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Re: Microdosing plus opioids [Re: FungiMaster]
#26342499 - 11/24/19 01:22 PM (4 years, 2 months ago) |
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 Hella crack huh?
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