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Markosheehan
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Registered: 09/01/16
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vasoconstriction and getting sick
#23986002 - 01/06/17 08:37 AM (7 years, 24 days ago) |
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why do people get severe vasoconstriction on lsd. also why do people get sick when they eat shrooms. i understand that there is chitin and cellulose which make it hard to digest but people even get sick when they take pure psilocybin. why is this does anyone know and why doesnt it happen on lsd
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Kush_Zombie
smug piece of shit



Registered: 10/22/14
Posts: 4,793
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Re: vasoconstriction and getting sick [Re: Markosheehan]
#23986033 - 01/06/17 08:57 AM (7 years, 24 days ago) |
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I don't get sick on shrooms and vasoconstriction has never been bad enough for me to really notice it
-------------------- How to get started in bulk: Presto 23-Quart Pressure Cooker BOD's Simple as FUCK Still Air Box PastyWhyte's Easy Agar Tek Munchauzen's Cultivation Video Series How EvilMushroom666 Prepares His Grains (I use jars with Synthetic Filter Discs) What is G2G? (Grain-to-Grain) Damion5050's Coir Tek (I use 5.5 - 6 quarts of water instead of 4. Also ignore step 13 and ignore the monotub completely. The only purpose of this tek is to show you how to make a simple substrate. I also add gypsum to it but not necessary) Spitball's Monotub Tek (A liner isn't necessary but is useful) Use 6500k lights throughout the whole process. When you wake up, turn the light on. When you go to sleep turn the light off. It's as simple as that.
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connectedcosmos
Neti Neti



Registered: 02/07/15
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Loc: The Pathless Path
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Re: vasoconstriction and getting sick [Re: Kush_Zombie]
#23986191 - 01/06/17 10:23 AM (7 years, 24 days ago) |
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It's like the pharmakinetics and pharmacology of the actual chemical compounds and the mechanisms and actions it has on your body,
I think
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 54. The true nature of things is to be known personally , through the eyes of clear illumination and not through a sage : what the moon exactly is , is to be known with one's own eyes ; can another make him know it?
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AuroraBorealis88
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Re: vasoconstriction and getting sick [Re: Markosheehan]
#23986495 - 01/06/17 01:01 PM (7 years, 24 days ago) |
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I've NEVER gotten sick from mushrooms and don't...really understand how you could unless you were allergic. I mean I know people "do" supposedly but I just don't understand it. I'm not sure why you would still continue to use a drug if it made you feel sick. But then again I'm kind of a hypocrite for this because alcohol has made me feel plenty sick and I've continued to use it. I just see booze as completely different though so that's why. It isn't vehicle for spiritual enlightenment like psilocybin is.
They make me feel extremely healthy, literally the opposite of sick. I don't know what the hell vasoconstriction would even feel like. I didn't even find out psychedelics cause vasoconstriction until just recently in fact.
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AuroraBorealis88
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Re: vasoconstriction and getting sick [Re: Markosheehan]
#23986496 - 01/06/17 01:04 PM (7 years, 24 days ago) |
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Quote:
Markosheehan said: but people even get sick when they take pure psilocybin.
Wait are you referring to people getting runny noses from psilocybin? Is that what you mean by sick? Yea that's not being sick, a runny nose is a normal physiological effect of psilocybin. If that's what you were referring to.
It also causes yawning, watery eyes and salivation.
Edited by AuroraBorealis88 (01/06/17 01:06 PM)
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openmind
curious


Registered: 08/03/07
Posts: 13,866
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Re: vasoconstriction and getting sick [Re: Markosheehan]
#23986558 - 01/06/17 01:38 PM (7 years, 24 days ago) |
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Quote:
Markosheehan said: why do people get severe vasoconstriction on lsd. also why do people get sick when they eat shrooms. i understand that there is chitin and cellulose which make it hard to digest but people even get sick when they take pure psilocybin. why is this does anyone know and why doesnt it happen on lsd
Severe vasoconstriction is not common at all with LSD, sure some folks do sometimes experience some constriction to a degree...but certainly not on the level of being "severe" .
As for people getting sick on mushrooms, by "sick" I'm assuming you mean nauseated/puking? Like you mentioned, chitin can't be digested by the stomach which can cause stomach aches & pains and/or nausea & puking for some people.
As for why some people get sick when the chitin/mushrooms material isn't in the equation (if they made a tea, or an extract of some sort)....Psilocin (and maybe psilocybn) likely have affinity for certain serotonin receptors that are all through out the stomach/gut/digestive track (pretty sure all the classic psychedelics do to a certain extent)...And when psilocin finds its way into the receptor it can cause a stomach load/nausea (this is why a stomach load/puking on pure mescaline still happens, I believe mescaline has even higher affinity for these receptors in the gut which is why it's notorious for having a stomach load/nausea).
And another reason...purely psychosomatic. A person's own anxiety or worries about things can totally manifest physically as nausea and a body load in general.
Another reason could simply be a "shock" to the serotonin system....a proper dose of any sort of serotonergic drug can cause one to become a bit nauseated during the initial come up.
And this does happen to some folks on LSD when a high enough dose is taken....feeling nauseated during the come up and letting out a purge is not at all unheard of when a heavy dose is taken. I have a couple friends that have puked when they took a solid dose of L.
Personally.....Sometimes LSD does give me some noticeable though rather mild vasoconstriction, other time there's virtually zero body load/constriction and I feel like I'm floating/airy, my body feels like bliss in the wind....More often than not it's not that bad, and again, no where near the point of being severe.
In regards to mushrooms.....after a decade of working with mushrooms I have only puked from them once (a few months ago, after smoking a lot of syrian rue while tripping). I've had a mild load on the stomach from them several times over the past decade, last time I made a tea my friend and I both had a bit of a load on the stomach (it was relatively mild for me and dissipated after about 60 to 90 minutes after drinking)....But generally speaking, more often than not, they don't really bother my stomach at all.
-OM
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Mike4aco
Soy el pinche guey



Registered: 11/28/15
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Re: vasoconstriction and getting sick [Re: openmind]
#23986616 - 01/06/17 02:05 PM (7 years, 24 days ago) |
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Everytime I eat 14 grams or more i throw up but then again. When I eat 2 mg + of lsd I also throw up. Maybe for me its because its such a large amount. I would assume that the same would be true for anyone regardless if the doses are the same size, what is going to be large for your particular body to handle is what my main point is, is that it will probably cause some distress. However doesn't necessarily need to cause vomiting
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BANANA.MAN
Turd Ferguson


Registered: 01/11/15
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Re: vasoconstriction and getting sick [Re: Markosheehan]
#23987010 - 01/06/17 04:27 PM (7 years, 24 days ago) |
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Quote:
Markosheehan said: why do people get severe vasoconstriction on lsd. also why do people get sick when they eat shrooms. i understand that there is chitin and cellulose which make it hard to digest but people even get sick when they take pure psilocybin. why is this does anyone know and why doesnt it happen on lsd
Psychedelics are serotonin receptor agonists. When ingested orally they bind to the serotonin receptors in the gut which control the muscles in the digestive tract.
I can eat non active mushrooms and not get nauseous at all. I dont think chittin contributes to the nausea. Even if there is a slightly observable effect i bet its insignificant compared the the activated serotonin receptors.
Vasocontriction is also a side effect of serotonergic activity.
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Cstpa

Registered: 07/19/15
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Last seen: 7 years, 24 days
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Re: vasoconstriction and getting sick [Re: Markosheehan]
#23987031 - 01/06/17 04:35 PM (7 years, 24 days ago) |
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I experienced vasoconstriction on lsd for the first time recently. it is like a dull headache, or a rubber band around the brain. I remember closing my eyes near the end of the trip and envisioning my veins throbbing :o
I think it has to do with diet. And caffeine. I took 200mg of l-theanine and a polar pop soda. And didn't eat/drink throughout the trip. But also an added theory to why this happened to me is because I recently finished my time of the month and believe my iron levels were low. idk if it works like that tho. have to research.
this was like 6 days ago and I'm still feeling it. Or the memory of the pain. Tryina to take care of myself for now.
Stay hydrated ! Apparently you can take ibuprofen with lsd to avoid vasoconstriction?
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AuroraBorealis88
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Re: vasoconstriction and getting sick [Re: openmind]
#23987641 - 01/06/17 08:04 PM (7 years, 24 days ago) |
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Quote:
openmind said: ..Psilocin (and maybe psilocybn) likely have affinity for certain serotonin receptors that are all through out the stomach/gut/digestive track (pretty sure all the classic psychedelics do to a certain extent)...And when psilocin finds its way into the receptor it can cause a stomach load/nausea (this is why a stomach load/puking on pure mescaline still happens, I believe mescaline has even higher affinity for these receptors in the gut which is why it's notorious for having a stomach load/nausea).
Hmm interesting, I've only heard of this happening with LSD. I wasn't totally sure if it happened with other psychedelics or not.
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BANANA.MAN
Turd Ferguson


Registered: 01/11/15
Posts: 7,474
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Last seen: 6 months, 2 days
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Quote:
AuroraBorealis88 said:
Quote:
openmind said: ..Psilocin (and maybe psilocybn) likely have affinity for certain serotonin receptors that are all through out the stomach/gut/digestive track (pretty sure all the classic psychedelics do to a certain extent)...And when psilocin finds its way into the receptor it can cause a stomach load/nausea (this is why a stomach load/puking on pure mescaline still happens, I believe mescaline has even higher affinity for these receptors in the gut which is why it's notorious for having a stomach load/nausea).
Hmm interesting, I've only heard of this happening with LSD. I wasn't totally sure if it happened with other psychedelics or not.
All psychedelics are serotonin receptor agonists. Thatd why mescaline causes nausea too. Most if not all psychedelics have the potential to Cause nausea.
Edited by BANANA.MAN (01/06/17 09:02 PM)
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AuroraBorealis88
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Re: vasoconstriction and getting sick [Re: BANANA.MAN]
#23987714 - 01/06/17 08:41 PM (7 years, 23 days ago) |
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Yeah I knew they were all serotonin receptor agonists but I didn't really know about the gut thing.
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