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OfflineEllis Dee
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Drug abusers crave stimulus AFTER death...
    #23962894 - 12/28/16 02:25 PM (7 years, 1 month ago)

http://www.dailymail.co.uk/health/article-4069560/Drug-abusers-crave-stimulus-death-Study-finds-mutated-protein-deceased-addicts-persists-week.html

Drug abusers still crave the stimulus AFTER death: Researchers discover mutated protein in deceased addicts persists for more than a week

    A protein in the reward center of the brain is modified in drug abusers
    Researchers discovered it was still modified in heroin addicts who had died
    This suggest your body still craves a stimulus even after death
    The protein may stay mutated for months in the living who are recovering

By Stacy Liberatore For Dailymail.com

Published: 19:24 EST, 27 December 2016 | Updated: 12:18 EST, 28 December 2016


Addictive cravings are still persistent after death, finds a new study.

A protein in the reward center of the brain is altered in those suffering from a chemical dependency – it is split off and shortened.

Following numerous autopsies, Austrian researchers found the modified protein in deceased heroin addicts - suggesting cravings for the stimulus continued after their death.

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A protein in the reward center of the brain is altered in those suffering from a chemical dependency – it is split off and shortened. Experts found the modified protein in deceased heroin addicts, which suggests a craving for a stimulus continues after death

The protein, called FosB, is a transcription factor in the brain which, together with other molecules, is involved in so-called signal transduction (transmission of stimuli to the cells).

It is said to convey genetic information between the cells and also determines whether certain genes are activated or not.

FosB is part of the activating protein AP1, which is involved with regulating gene expression in response to a range of stimulus, including stress and bacterial infections.

Due to a constant supply of drugs, such as heroin, FosB turns into DeltaFosB, which is increasingly stimulated in cases of chronic use and even influences growth factors and structural changes (neuronal plasticity) in the brain - approximately in the region where memory is formed.

THE EVIDENCE 

FosB is a protein that transmits stimuli to cells.

When someone abuses drugs, such as heroin, it turns into DeltaFosB, which is increasingly stimulated in cases of chronic use and even influences growth factors and structural changes (neuronal plasticity) in the brain.

The team found the protein was still modified even 9 dies after a heroin addict had died.

Researchers believe the period is much longer in the living who are trying to recover – and it can last for months.


The evidence that the modified protein lingers after death was discovered by the Medical University of Vienna's Department of Forensic Medicine, which examined tissue samples from the nucleus accumbens (an area of the brain) of 15 deceased heroin addicts.

'Using highly sensitive detection methods, DeltaFosB was still detectable nine days after death,' the team explained.


Due to a constant supply of drugs, such as heroin (pictured), FosB turns into DeltaFosB, which is increasingly stimulated in cases of chronic use and even influences growth factors and structural changes in the brain - approximately in the region where memory is formed

Although the mutation of the protein can be identified more than a week after death, researchers believe the period is much longer in the living who are trying to recover – and it can last for months.

They also suggest these results will help advance treatments and management of people with opiate dependencies and heroin addictions, with how to deal with withdrawal being the focus.


FosB turns into DeltaFosB (pictured is mutated FosB in a deseaced herion addict) during drug abuse. Right is FosB in a person who is not suffering from drug dependency


Researches examined tissue samples from the nucleus accumbens (an area of the brain) of 15 deceased heroin addicts. 'Using highly sensitive detection methods, DeltaFosB (pictured) was still detectable nine days after death,' the team explained.


'If the addictive craving persists in the brain for months, it is very important to provide protracted after-care and corresponding psychological support,' said Monika Seltenhammer, a researcher involved in the study.

'Our results show that forensics and forensic medicine can also be of direct benefit to the living,' emphasized Daniele Risser, the lead author.

In a follow-on project to be conducted in collaboration with MedUni Vienna's Institute of Pharmacology and Center for Addiction Research and Science (AddRess) and the objective is now to  further understand the if and how the activation of DeltaFosB can be prevented and how this highly promising starting point can be used to treat the onset of addictive behavior.

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"If the foundations be destroyed, what can the righteous do."-King Solomon

And there was war in heaven: Michael and his angels fought against the dragon; and the dragon fought and his angels,


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Offlinemusiclover420
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Re: Drug abusers crave stimulus AFTER death... [Re: Ellis Dee] * 2
    #23962951 - 12/28/16 02:47 PM (7 years, 1 month ago)

New idea for a sci fi plot, heroin zombies :lol:

The pharma industry could try researching some new techniques for extending peoples lives or keeping a dead body from further decaying and controlling it remotely.


--------------------
Don't worry about me, I've got all that I need. And I'm singing my song to the sky

You know how it feels, With the breeze of the sun in your eyes. Not minding that time's passing by

I've got all and more, My smile, just as before. Is all that I carry with me

I talk to myself, I need nobody else. I'm lost and I'm mine, yes I'm free



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Invisiblenooneman
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Registered: 04/24/09
Posts: 14,566
Loc: Utah
Re: Drug abusers crave stimulus AFTER death... [Re: Ellis Dee]
    #23963377 - 12/28/16 05:35 PM (7 years, 1 month ago)

I wonder how long LSD stays in your body if you die while on LSD. :strokebeard:


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Offlinethehighking
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Re: Drug abusers crave stimulus AFTER death... [Re: nooneman]
    #23963821 - 12/28/16 08:28 PM (7 years, 1 month ago)

I'm sure the spiritual processes will make these chemical ones meaningless


--------------------
"Reality is merely an illusion, albeit a very persistent one" Albert Einstein


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OfflineKonyap

Registered: 06/30/07
Posts: 33,945
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Re: Drug abusers crave stimulus AFTER death... [Re: thehighking]
    #23963863 - 12/28/16 08:44 PM (7 years, 1 month ago)

uhm wouldn't your metabolism speed that up a bit? I mean your living metabolism


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Invisibledemiu5
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Re: Drug abusers crave stimulus AFTER death... [Re: Ellis Dee]
    #23964270 - 12/28/16 11:17 PM (7 years, 1 month ago)

Quote:

9 dies after a heroin addict has died




:flowstone:




when did the dailymail become a reputable or real source?


--------------------
channel your inner Larry David


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InvisibleAdden
I'm a teapot
Registered: 06/04/03
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Re: Drug abusers crave stimulus AFTER death... [Re: Ellis Dee]
    #23964668 - 12/29/16 04:45 AM (7 years, 1 month ago)

:burke:


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OfflineKing Klick
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Re: Drug abusers crave stimulus AFTER death... [Re: musiclover420]
    #23964778 - 12/29/16 07:20 AM (7 years, 1 month ago)

Quote:

musiclover420 said:
New idea for a sci fi plot, heroin zombies :lol:

The pharma industry could try researching some new techniques for extending peoples lives or keeping a dead body from further decaying and controlling it remotely.



Theres movies on it already. At least 2


--------------------
Your god is dead, and I killed him.

When you’re lost, here I am. Forever with your soul



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OfflineOfTheVoid46
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Re: Drug abusers crave stimulus AFTER death... [Re: musiclover420]
    #23965102 - 12/29/16 10:11 AM (7 years, 1 month ago)

Quote:

musiclover420 said:
New idea for a sci fi plot, heroin zombies :lol:

The pharma industry could try researching some new techniques for extending peoples lives or keeping a dead body from further decaying and controlling it remotely.




Literally LOL. I could just picture that now.
Damn zombies better not be pawning my TV for dope is all I got to say :laugh:


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Invisibletravelleler
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Re: Drug abusers crave stimulus AFTER death... [Re: musiclover420]
    #23965124 - 12/29/16 10:20 AM (7 years, 1 month ago)

Quote:

musiclover420 said:
New idea for a sci fi plot, heroin zombies :lol:

The pharma industry could try researching some new techniques for extending peoples lives or keeping a dead body from further decaying and controlling it remotely.





Ahhhh..... you might not realize how close you are to the truth,

NASA is gonna send Heroin Zombies into a Mars simulator in order to make Billions of $$ disappear.  It's a rare form of human sacrifice that keeps the Angels from declaring all out war on the Human Race.  If we can continue to venerate life and death appropriately they will relent in their constant judgment and we will enjoy peace. 


Don't believe me?  Where's Michelle Miscavige?  I'm not sure how much more obvious the truth has to be for people to get a real slap in the face.  Scientology will never be able to get everything they want, that will just never happen.  They think they've invented something, really they've just stumbled upon something the devout have known for longer than the common era. 


This article is actually an eye opener for those of us looking for real answers to the difficult questions. 







Water of life.



Resurrection.


Atonement.


Dungeon Rider.


--------------------




"Whales have deep thoughts"

:sun:Dreams are the fuel of the soul:sun:

:peace:


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OfflineKryptos
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Re: Drug abusers crave stimulus AFTER death... [Re: OfTheVoid46]
    #23965125 - 12/29/16 10:21 AM (7 years, 1 month ago)

Shouldn't the contents of a deceased body persist until you spoil? I.e. Until something *alive* comes along and eats you?

Das ist nicht nur nicht richtig, es ist nicht einmal falsch.


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Invisibletravelleler
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Re: Drug abusers crave stimulus AFTER death... [Re: Kryptos]
    #23965132 - 12/29/16 10:23 AM (7 years, 1 month ago)

Quote:

Kryptos said:
Shouldn't the contents of a deceased body persist until you spoil? I.e. Until something *alive* comes along and eats you?

Das ist nicht nur nicht richtig, es ist nicht einmal falsch.





I think the point is that the protein responsible for drug craving seems to persist LONGER than the others. 

"living hell" might be more than just a metaphor regarding the afterlife


--------------------




"Whales have deep thoughts"

:sun:Dreams are the fuel of the soul:sun:

:peace:


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Offlinerider420
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Re: Drug abusers crave stimulus AFTER death... [Re: Ellis Dee]
    #23965430 - 12/29/16 12:26 PM (7 years, 1 month ago)

Yup Its only drug users who experience life after death. All you other smucks simply cease to exist like we all do every night between falling asleep and when you dream.

Heaven and hell only exists on earth. And heaven is a warm gun and hell is fascist fucks who would put you in jail for trying to go to the only heaven that really exists. Isn't life a joke!

Don't mind me who does not want to go to hell or heaven but just loves the purgatory that is the middle road. ROLMFAO


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Invisibledurian_2008
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Re: Drug abusers crave stimulus AFTER death... [Re: rider420]
    #23965632 - 12/29/16 01:53 PM (7 years, 1 month ago)

Did heroin addicts donate their bodies, formally, or not?

In other words, if you OD, in the wrong time and place, you're gonna become a mad science experiment?

:awesomenod:


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Invisiblenooneman
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Registered: 04/24/09
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Re: Drug abusers crave stimulus AFTER death... [Re: durian_2008]
    #23966085 - 12/29/16 05:04 PM (7 years, 1 month ago)

Probably. But hey, scientists have been experimenting on corpses without the consent of families for hundreds of years. You'll be a part of a long and proud tradition of scientific research and education.


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Invisibletravelleler
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Re: Drug abusers crave stimulus AFTER death... [Re: nooneman]
    #23967460 - 12/30/16 08:05 AM (7 years, 1 month ago)

you can feel pain after death too, sorry if you don't believe it. 

yes if you OD in the wrong place you could end up living in hell for a bit


--------------------




"Whales have deep thoughts"

:sun:Dreams are the fuel of the soul:sun:

:peace:


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InvisibleAdden
I'm a teapot
Registered: 06/04/03
Posts: 39,201
Re: Drug abusers crave stimulus AFTER death... [Re: nooneman]
    #23967494 - 12/30/16 08:39 AM (7 years, 1 month ago)

Quote:

nooneman said:
Probably. But hey, scientists have been experimenting on corpses without the consent of families for hundreds of years. You'll be a part of a long and proud tradition of scientific research and education.




Lol.


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