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Anonymous #1

Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone)
    #23798940 - 11/03/16 08:03 PM (7 years, 3 months ago)

I doubt it, but figured I'd ask...

I have a few 8mg sub film strips and I'm weening myself down on dosage.
The 8mg strips are a pain to cut down to 1 and 1/2 mgs, none the less 1/4 mgs...

I want some 2mg strips so I can cut them down for the lower doses easier.

Can I take the 8mg strips to the pharmacy and "trade" them for 2mg ones?

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Anonymous #2

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #1]
    #23799175 - 11/03/16 09:38 PM (7 years, 3 months ago)

Why didnt you just call and ask?

Answer is no, though. That would be the same as bringing any other prescription drug in and trying to trade it for a lesser dose. They legally cant do that for you.

Consult your doctor or whoever.

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Anonymous #2

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #2]
    #23799177 - 11/03/16 09:38 PM (7 years, 3 months ago)

Oh and its hella easy to cut those suboxone strips. I dont see the problem

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Anonymous #1

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #2]
    #23799185 - 11/03/16 09:43 PM (7 years, 3 months ago)

Not really man...

Getting it down to 1/8 strip is easy enough (1 mg), but after that, it's really tough to get 1/2 mgs and I wanna get down to 1/4 mg... That's near impossible..

Cutting that little strip in to 32 pieces.. Easy? :lol:

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Anonymous #3

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #1] * 1
    #23799749 - 11/04/16 04:49 AM (7 years, 3 months ago)

:underage:

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Anonymous #4

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #3]
    #23799780 - 11/04/16 05:30 AM (7 years, 3 months ago)

powder the tablet, dissolve it in water and then :

https://psychonautwiki.org/wiki/Volumetric_liquid_dosing

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Anonymous #5

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #4]
    #23804808 - 11/05/16 09:14 PM (7 years, 3 months ago)

Quote:

Anonymous #4 said:
powder the tablet, dissolve it in water and then :

https://psychonautwiki.org/wiki/Volumetric_liquid_dosing




He has strips not tablets, which dont dissolve good enouth to use volumetrics accurately.

I used to fold them in half and cut on the crease for the larger doses, and when it got to small to do that take a razor and cut it in half
  It usually worked out well becouse once you get less than 0.25g reduceing the dose by half every day worked well (for myself)

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Anonymous #1

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #3]
    #23806817 - 11/06/16 02:29 PM (7 years, 3 months ago)

Quote:

Anonymous #3 said:
:underage:



What about this is :underage:  ?

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Anonymous #6

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #1]
    #23823133 - 11/11/16 02:03 PM (7 years, 3 months ago)

It should dissolve just fine I would think, I remember them dissolving on my tongue when I took one back in the day. Even if they don't dissolve though it should extract the suboxone from the strip. I would either do that or go back to the dr.

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Anonymous #7

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #6]
    #23905193 - 12/07/16 09:20 PM (7 years, 2 months ago)

Strips dissolve just fine in water, ppl shoot them. An easy way of splitting a strip is just folding a crease and it tears perfect on the line, no cutting. You can even snort strips, an eighth dissolved in a few drops of water on a spoon and snorted will do you as good as a half.

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Anonymous #1

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #7]
    #23905251 - 12/07/16 09:42 PM (7 years, 2 months ago)

Shooting them makes the naloxone active and precipitates withdrawal.

And I don't see how snorting would have a better bioavailability than sublingual.

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Anonymous #4

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #1]
    #23905489 - 12/07/16 11:16 PM (7 years, 2 months ago)

Why would he do either if hes tapering off :facepalm:

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Anonymous #7

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #4]
    #23905910 - 12/08/16 06:50 AM (7 years, 2 months ago)

Quote:

Anonymous #1 said:
Shooting them makes the naloxone active and precipitates withdrawal.

And I don't see how snorting would have a better bioavailability than sublingual.



Have you tried either? Don't knock it till you try it. All I know is I know plenty of ppl who will only shoot them, and I can't get shit off a half sublingual but an eighth or less snorted does me right
Quote:

Anonymous #4 said:
Why would he do either if hes tapering off :facepalm:



More for less, did I say it was a good idea for him to do? Just making the point they dissolve just fine :facepalm::facepalm::facepalm:
If I got down to trying to split 8th's sublingual I'd just fkn quit anyway. BTW the naloxone is just in there as a marketing gimmick, the half life is only 1-2 hours compared to the Bup of 24+

Edited by Anonymous (12/08/16 07:07 AM)

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Anonymous #1

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #7]
    #23908031 - 12/08/16 06:34 PM (7 years, 2 months ago)

It's a gimmick, yeah, but it'll still precipitate withdrawal for an opiod dependant person.
It's not active any other way than IV

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Anonymous #7

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #1]
    #23908118 - 12/08/16 07:02 PM (7 years, 2 months ago)

The precipitated withdrawal is actually due to the bup itself being a partial antagonist, unless like you said and IV'd
Quote:


Precipitated withdrawal can occur when an antagonist (or partial antagonist, such as buprenorphine) is administered to a patient dependent on full agonist opioids. Due to Buprenorphine’s high affinity but low intrinsic activity at the mu receptor, the partial antagonist displaces agonist opioids from the mu receptors, without activating the receptor to an equivalent degree, resulting in a net decrease in agonist effect, thus precipitating a withdrawal syndrome.


It is a common misconception that the Naloxone in Suboxone initiates precipitated withdrawal. This is false. The Naloxone can only initiate precipitated withdrawal if injected into a person tolerant to opioids. Taken sublingually the Naloxone has virtually no effect.


- NAABT

May be a dumb question, but you taper as far as you can have you thought about keeping kratom around for the rough days OP?  Even though you are used to the sub it will still take the edge off, help with cravings, rest ect.

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Anonymous #4

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #7]
    #23908864 - 12/08/16 11:43 PM (7 years, 2 months ago)

buprenorphine is a partial agonist not an antagonist. Also theres no such thing as a "partial antagonist" lol

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Anonymous #7

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #4]
    #23909126 - 12/09/16 04:34 AM (7 years, 2 months ago)

People have referred to it as either, is the glass half full or half empty, is a zebra black with white stripes or white with black stripes.  buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. Also a partial agonist can occupy receptors not activating them, acting like an antagonist, so maybe you could call it a partial antagonist or partial agonist whatever floats your boat :smile:
https://www.naabt.org/faq_answers.cfm?ID=5


Edited by Anonymous (12/09/16 09:14 AM)

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Anonymous #4

Re: Likely a dumb question, but can I swap drugs at a pharmacy? (want lower doses of Suboxone) [Re: Anonymous #7]
    #23918467 - 12/12/16 02:20 AM (7 years, 2 months ago)

Quote:

Anonymous #7 said:
People have referred to it as either, is the glass half full or half empty, is a zebra black with white stripes or white with black stripes. 




Quote:

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist.




https://en.wikipedia.org/wiki/Agonist



There cant ever be something like a partial antagonist. Its completely impossible since an antagonist implies 0% receptor activation. At 1% it would be a partial agonist and at -1% it would be a partial inverse agonist.

Quote:


buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor.



Yes

Quote:


Also a partial agonist can occupy receptors not activating them, acting like an antagonist





Yes this is a phenomenon called functional selectivity. Receptors of the same subtype can be connected to different signaling pathways.

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