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Invisiblefalsereality


Registered: 04/01/13
Posts: 4,112
Harmine stimulates proliferation of human neural progenitors (Study) * 1
    #23904643 - 12/07/16 06:49 PM (7 years, 2 months ago)

Abstract:
Quote:

Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell cultures containing human neural progenitor cells (hNPCs, 97% nestin-positive) derived from pluripotent stem cells. After 4 days of treatment, the pool of proliferating hNPCs increased by 71.5%. Harmine has been reported as a potent inhibitor of the dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A), which regulates cell proliferation and brain development. We tested the effect of analogs of harmine, an inhibitor of DYRK1A (INDY), and an irreversible selective inhibitor of monoamine oxidase (MAO) but not DYRK1A (pargyline). INDY but not pargyline induced proliferation of hNPCs similarly to harmine, suggesting that inhibition of DYRK1A is a possible mechanism to explain harmine effects upon the proliferation of hNPCs. Our findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation in vitro and antidepressant effects in vivo.




Full Study: https://peerj.com/articles/2727/


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OfflineLucisM
Nutritional Yeast

Registered: 03/28/15
Posts: 15,622
Last seen: 2 months, 16 days
Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: falsereality]
    #23904656 - 12/07/16 06:52 PM (7 years, 2 months ago)

Yeah, just saw this, very cool.


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OfflineMorel Guy
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: Lucis]
    #23904664 - 12/07/16 06:53 PM (7 years, 2 months ago)

Harmine is also in tobacco

Try giving tobacco a good rap


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"in sterquiliniis invenitur in stercore invenitur"

In filth it will be found in dung it will be found


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Offlinemusiclover420
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: Morel Guy]
    #23904708 - 12/07/16 07:05 PM (7 years, 2 months ago)

Quote:

Morel Guy said:
Harmine is also in tobacco

Try giving tobacco a good rap




Yes except most people don't eat tobacco which would be very toxic, also who knows if it is in a smokable form or if smoking it is beneficial at all...

Or if there is even a strong enough concentration to to have any effect at all.

The harmalas are very concentrated in syrian rue and caapi and also are the main/ most abundant components.

Not to mention both plants also have harmaline and at least a few other related compounds, Caapi has at least 9-10 I believe half of which are probably MAOI's at least.


--------------------
Don't worry about me, I've got all that I need. And I'm singing my song to the sky

You know how it feels, With the breeze of the sun in your eyes. Not minding that time's passing by

I've got all and more, My smile, just as before. Is all that I carry with me

I talk to myself, I need nobody else. I'm lost and I'm mine, yes I'm free



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OfflineApostle
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Registered: 12/12/09
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: falsereality]
    #23904728 - 12/07/16 07:13 PM (7 years, 2 months ago)

What does this mean exactly?

in simple terms.


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OfflineMorel Guy
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: musiclover420]
    #23904744 - 12/07/16 07:17 PM (7 years, 2 months ago)

I find maoi's make a difference in smoking tobacco.

They say maoi's are the force and DMT is the light.

Never really did dmt.  Plenty of other items.


--------------------
"in sterquiliniis invenitur in stercore invenitur"

In filth it will be found in dung it will be found


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OfflineApostle
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: Morel Guy]
    #23904765 - 12/07/16 07:23 PM (7 years, 2 months ago)

DMT was amazing to me but not as spiritual as shrooms or even lucy.

it was pure euphoria though


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Offlinemusiclover420
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: Apostle]
    #23904804 - 12/07/16 07:32 PM (7 years, 2 months ago)

Quote:

Morel Guy said:
I find maoi's make a difference in smoking tobacco.

They say maoi's are the force and DMT is the light.

Never really did dmt.  Plenty of other items.




MAOI's are the guide is what I have heard.

Quote:

Apostle said:
What does this mean exactly?

in simple terms.




It means they may have found at least part of the mechanism of action that accounts for the positive effects on the brain ayahuasca has.

So now they can hopefully develop less sketchy synthetic antidepressants which can then be compared to aya which will hopefully reveal more info.


--------------------
Don't worry about me, I've got all that I need. And I'm singing my song to the sky

You know how it feels, With the breeze of the sun in your eyes. Not minding that time's passing by

I've got all and more, My smile, just as before. Is all that I carry with me

I talk to myself, I need nobody else. I'm lost and I'm mine, yes I'm free



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OfflineApostle
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Registered: 12/12/09
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: musiclover420]
    #23904810 - 12/07/16 07:33 PM (7 years, 2 months ago)

what positive effects does ayahusca have on the brain?


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Offlinemusiclover420
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: Apostle]
    #23904921 - 12/07/16 07:56 PM (7 years, 2 months ago)

Quote:

Apostle said:
what positive effects does ayahusca have on the brain?




There have been studies showing long term aya users have more balanced brain chemistry, as in their brain has a more healthy balanced chemical content.

This seems like evidence for how harmine/ MAOI's used in aya are beneficial for promoting healthy brain growth.

Also in theory this promoted "proliferation" harmine/ harmalas cause could help repair damaged brains depending on what the issue is and further findings.

Say you have been a longterm alcoholic/ drug abuser, and your brain has been permanently damaged/ altered accordingly. Psychedelic induced neurogenesis could help repair the damaged parts of your brain and promote a more healthy brain chemistry. Now much of this is still just in theory but if you look at how psychedelics can aid addicts it seems very possible further research will validate these possibilities.


--------------------
Don't worry about me, I've got all that I need. And I'm singing my song to the sky

You know how it feels, With the breeze of the sun in your eyes. Not minding that time's passing by

I've got all and more, My smile, just as before. Is all that I carry with me

I talk to myself, I need nobody else. I'm lost and I'm mine, yes I'm free



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OfflineApostle
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: musiclover420]
    #23904930 - 12/07/16 07:57 PM (7 years, 2 months ago)

Do mushrooms not have the same brain healing effects?


thanks for the info so far.


i have been feeling a bit foggy in the brain lately and have been looking to remedy that.


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Offlinemusiclover420
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Re: Harmine stimulates proliferation of human neural progenitors (Study) [Re: Apostle]
    #23904998 - 12/07/16 08:18 PM (7 years, 2 months ago)

Well they probably share some benefits but this research seems to be pointing towards the harmalas adding to the medicinal effects. Oral DMT/ psilocybin probably has its own unique set of benefits and risks. Some tribes make harmala only brews using no DMT/ tryptamines and still manage to have powerful healing experiences :shrug: so clearly they have their own effects.

Harmalas are completely legal so you can buy rue/ caapi online to brew or extract and they even sell pure harmine/harmaline at decent prices (10$/g)

You should consider trying some of both, mushrooms are also greatly potentiated by harmalas so you can concerve both by combining em if your up for it.

Make sure to start low even when using harmalas on thier own and make sure to read up on their proper safety guides, mainly avoid using them if you have been drinking any alcohol or taking any prescription meds/ drugs that may negatively interact. They are best used when you are fully sober and have been eating healthy as they tend to enhance your awareness of your body so eating a lot of them after eating junk food may make you sick.

I took some harmalas with a friend once who decided to make bacon midway through, I warned him it might be hard on his stomach and he could throw up but he ate it anyways. Awhile later he said his stomach was feeling funky but he never through up, meanwhile I could feel my body getting ready to purge all night and I through up eventually even though I hadn't eaten.

For awhile before I started eating kratom regularly I would micro dose 50mg-100mg of harmine/harmaline and get a great uplifting antidepressant effect.

Once I ate like 350mg to see how strong they can be on their own and got really sick, I was stumbling all over feeling shitfaced and sweating buckets. I had been eating poorly so that may be part of why I got sick but too much harmalas alone can be hard on the body. Anyways I was hallucinating super strange abstract lights/ colors, main thing I remember where these pillars of light. They would flash in my peripheral vision like lightning then when I tried to look over they would dissapear only to multiply in the sides of my vision :lol:

Now I don't ever eat more then 250mg which is plenty for MAOI's effects without becoming too intoxicating on their own.

Another time I dabbed a bunch of potent shatter on a solid harmala dose and had some intense hallucinations, I rarely meditate when stoned but the harmalas helped focus me and I had a crazy CEV experience where I could see my heart beating and blood flowing as I breathed and concentrated. It was very interesting too say the least, the high THC dabs got me pretty tweaked out though :tongue2:


--------------------
Don't worry about me, I've got all that I need. And I'm singing my song to the sky

You know how it feels, With the breeze of the sun in your eyes. Not minding that time's passing by

I've got all and more, My smile, just as before. Is all that I carry with me

I talk to myself, I need nobody else. I'm lost and I'm mine, yes I'm free



Edited by musiclover420 (12/07/16 08:23 PM)


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