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sudly
Darwin's stagger


Registered: 01/05/15
Posts: 10,810
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Agonist activate receptors(stimulation) which eventually leads to numbing(inhibition).
I'm advocating for a microdose of psilocybin once every 3 days. Psilocybin has a low toxicity(LD-50) and is physically safe in those regards.
@flickedbic Do you have anything better than a reddit blog to support the claim of cardiovascular risks associated with the use of psilocybin?
This is not an adequate reference.
Quote:
My concern is that frequent psilocybin use may result in slight valvular fibrosis which has not been detected yet in users.
-------------------- I am whatever Darwin needs me to be.
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flickedbic
Sojourner



Registered: 03/21/11
Posts: 4,673
Loc: Fractalic Fabric
Last seen: 12 hours, 43 minutes
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Re: Been [Re: sudly]
#23900585 - 12/06/16 05:14 PM (7 years, 1 month ago) |
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The thread links a study done in mice using "every other day" dosing: Quote:
http://old.imp.lodz.pl/nowy_pttox/abstracts/streszcz07/Borowiak%20ABSTRACT.pdf (...) shows significant ECG abnormalities in rats (...) here's what hamilton morris had to say about this (above) study: "Like most animal tox studies the dosing regimen does not accurately reflect "normal" patterns of human use, it would be very unusual for anyone to ingest psilocin every other day for 12 weeks, though what is impressive about the study you linked is the very low dose of psilocin administered, which would actually be sub-psychedelic if dosed equivalently in humans.
I certainly do think it's possible for long term, frequent, or high dose use of some psychedelics and empathogens to cause heart valve damage. This is probably more of a concern for people who consume large quantities of 6-APB, DOB or similar high affinity full agonists of 5HT2B, but psilocin could also be a concern if it were used very frequently. So...yeah, don't ingest psilocin everyday would be the takeaway I suppose. "
-------------------- Favorite entheogen experiences in descending order: 1)Combo of oral DMT + smoked Bufotenine 2)Amanita (urine drank twice) 3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose) 4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators) 5)Salvia (need to try quid)
All readable matter in the above post is ficticious... any similarities to real life are purely coincidental. Blessing.
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BANANA.MAN
Turd Ferguson


Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
Last seen: 6 months, 3 days
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Re: Been [Re: sudly]
#23900662 - 12/06/16 05:34 PM (7 years, 1 month ago) |
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Quote:
sudly said: Agonist activate receptors(stimulation) which eventually leads to numbing(inhibition).
I'm advocating for a microdose of psilocybin once every 3 days. Psilocybin has a low toxicity(LD-50) and is physically safe in those regards.
@flickedbic Do you have anything better than a reddit blog to support the claim of cardiovascular risks associated with the use of psilocybin?
This is not an adequate reference.
Quote:
My concern is that frequent psilocybin use may result in slight valvular fibrosis which has not been detected yet in users.
What do you mean? When an agonist is bound to a receptor it also blocks it the way an antagonist does but it also stinulates the receptor. Once it is removed by the body the receptor is available again. Maybe i dont understand what you mean.
OP have you found that you need to take it eveyday to get the positive effects?
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Bill_Oreilly
ANIMALS (the RAINBOW SERPENT)


Registered: 11/12/11
Posts: 26,370
Loc: Boston
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Re: Been [Re: sudly]
#23900665 - 12/06/16 05:35 PM (7 years, 1 month ago) |
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Quote:
sudly said: Agonist activate receptors(stimulation) which eventually leads to numbing(inhibition).
I'm advocating for a microdose of psilocybin once every 3 days. Psilocybin has a low toxicity(LD-50) and is physically safe in those regards.
@flickedbic Do you have anything better than a reddit blog to support the claim of cardiovascular risks associated with the use of psilocybin?
This is not an adequate reference.
Quote:
My concern is that frequent psilocybin use may result in slight valvular fibrosis which has not been detected yet in users.
Doesnt microdosing every 3 days defeat the purpose? doesnt that give the mushrooms time to exit the body thus wasting the drug and not doing anything for the mind in that situation?
-------------------- Something there is mysteriously formed, Existing before Heaven and Earth, Silent, still, standing alone, unchanging, All-pervading, unfailing, I do not know its name; I call it tao. If forced to give it a name, I call it Great (ta). Being great, it flows out; Flowing out means far-reaching; Being far-reaching, it is said to return. It's just a shot away..
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nooneman


Registered: 04/24/09
Posts: 14,564
Loc: Utah
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Microdosing is pointless and stupid.
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sudly
Darwin's stagger


Registered: 01/05/15
Posts: 10,810
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That's better, although it is a light hearted critique. A faster heart rate and reduced blood flow may result from excessive use of psilocybin.
@BANANA.MAN Stimulation over time leads to a numbing effect. E.g. Working out
As for OP, once every three days is so that you don't rely on psilocybin to be productive or proactive. Imagine it like a spotter at the gym, it's helpful for a boost but you shouldn't rely solely on them to get you through it.
-------------------- I am whatever Darwin needs me to be.
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ichugwindex
Dex



Registered: 06/04/16
Posts: 4,613
Loc: ¯\_(ツ)_/¯
Last seen: 11 months, 2 days
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Quote:
BANANA.MAN
OP have you found that you need to take it eveyday to get the positive effects?
I'm not sure since I've been taking it daily and this is my first attempt at it. Im sure I'll find out in the coming days though since it would seem daily dosing is unhealthy
-------------------- Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.
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BANANA.MAN
Turd Ferguson


Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
Last seen: 6 months, 3 days
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Re: Been [Re: sudly]
#23900799 - 12/06/16 06:13 PM (7 years, 1 month ago) |
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Im assuming you mean receptor down regulation (when receptors disappear) thats not why microdosing has benefits. It comes from the activation of the receptors not the downregulation of them. Everybody i have talked to says that microdosing has no effect on tolerence to full sized doses. Ive even heard people say they coild microdose and trip later that week. My friend also says he gets some positive effects from just one single microdose. Anyway thats not the point of the thread.
Op please update us if you experiment some more. I think ill try a .5 of cubes sometime because a .3 didnt seem to help me and im not willing to microdose more than 2 or 3 times a week because i would rather teip once in a while.
Edited by BANANA.MAN (12/06/16 06:14 PM)
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ichugwindex
Dex



Registered: 06/04/16
Posts: 4,613
Loc: ¯\_(ツ)_/¯
Last seen: 11 months, 2 days
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I will report back. Tomorrow will be first day without dosing in a little over a month so it should be interesting. Haven't decided if I should slow down to every other day or maybe 2 times a week
-------------------- Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.
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sudly
Darwin's stagger


Registered: 01/05/15
Posts: 10,810
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I'm not talking about tolerance I'm talking about psilocybins inhibitory effects on the sympathetic nervous system which is responsible for regulating the fight or flight response.
It's a benefit because it allows us to act more human like without the distracting interference of gut feelings and intuition. Psilocybin allows us to take the time to focus on our experiences.
-------------------- I am whatever Darwin needs me to be.
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ichugwindex
Dex



Registered: 06/04/16
Posts: 4,613
Loc: ¯\_(ツ)_/¯
Last seen: 11 months, 2 days
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Quote:
nooneman said: Microdosing is pointless and stupid.
I would like to know why you feel this way. In the one month I have been doing this I feel like it has improved my life considerably
-------------------- Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.
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Kinshino
Restful Soul



Registered: 03/11/13
Posts: 1,122
Loc: 5th Dimension
Last seen: 8 months, 5 days
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I've been planning on microdosing. Was thinking to do .2 of penis envies every three days. How do you consume them? You said with breakfast, do you blend it in a smoothie or somethin? Would you think it would help people who suffer from depression?
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BANANA.MAN
Turd Ferguson


Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
Last seen: 6 months, 3 days
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Quote:
Kinshino said: I've been planning on microdosing. Was thinking to do .2 of penis envies every three days. How do you consume them?
Psilocin microdoses are best taken rectally imo
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sudly
Darwin's stagger


Registered: 01/05/15
Posts: 10,810
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Quote:
The mechanisms of action of the hallucinogens lysergic acid (LSD) and psilocybin (magic mushrooms) are complex, with various effects on serotonergic, dopaminergic, and adrenergic receptors. These drugs have mild adrenergic effects, producing manifestations of sympathetic arousal such as dilated pupils, sinus tachycardia, hypertension, and hyper-reflexia. Cardiovascular complications are rarely serious, although the potential for arrhythmias and myocardial infarction exist. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1121066/
-------------------- I am whatever Darwin needs me to be.
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ichugwindex
Dex



Registered: 06/04/16
Posts: 4,613
Loc: ¯\_(ツ)_/¯
Last seen: 11 months, 2 days
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Quote:
Kinshino said: I've been planning on microdosing. Was thinking to do .2 of penis envies every three days. How do you consume them? You said with breakfast, do you blend it in a smoothie or somethin? Would you think it would help people who suffer from depression?
Rectally. Daily. Jk I just break them up a but like you would with some ganja and drink them down. It's really not too unpleasant with such a small amount or sometimes I do make a shake with some whey protein and toss em in the blender. Honestly if it was an option for me I would grind them to a powder and put it in gell capsules
-------------------- Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.
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sudly
Darwin's stagger


Registered: 01/05/15
Posts: 10,810
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I did gel capsules once and they're great for microdosing, they fit 0.2g in each. Otherwise a mouthful of fruit juice or cordial makes tiny pieces of shrooms easy to swallow.
-------------------- I am whatever Darwin needs me to be.
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Kinshino
Restful Soul



Registered: 03/11/13
Posts: 1,122
Loc: 5th Dimension
Last seen: 8 months, 5 days
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Quote:
ichugwindex said:
Quote:
Kinshino said: I've been planning on microdosing. Was thinking to do .2 of penis envies every three days. How do you consume them? You said with breakfast, do you blend it in a smoothie or somethin? Would you think it would help people who suffer from depression?
Rectally. Daily. Jk I just break them up a but like you would with some ganja and drink them down. It's really not too unpleasant with such a small amount or sometimes I do make a shake with some whey protein and toss em in the blender. Honestly if it was an option for me I would grind them to a powder and put it in gell capsules
Okay, thanks!
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ZacksJourney
STRANGLER



Registered: 05/02/16
Posts: 543
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I always feel like microdosing has so much to offer and heal, and yet we barely speak of it.
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ALL MUSHROOMS ARE EDIBLE, some are just only edible once. Trade List
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Get Shwifty
I love you guys



Registered: 10/14/15
Posts: 167
Last seen: 8 months, 18 days
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I am also microdosing this week. Feels good man.
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PlantManBee
undifferentiated



Registered: 11/17/16
Posts: 360
Last seen: 1 year, 6 months
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Have you tried microdosing less often and it didn't work? Because I'd think the best thing to do, in any case, would be to aim for the smallest does that still had the positive effect.
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