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Offlineichugwindex
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Been "microdosing" daily for over a month AMA * 1
    #23899828 - 12/06/16 12:40 PM (7 years, 1 month ago)

I've been "microdosing" on a 3rd of a gram of cubes (daily) for a little over a month. Since then I have been able to retain more information, have more self confidence, my anxiety is turned way down and I've had the motivation to work out whenever. More people should be doing this! So ya ask me anything that's on topic.


Edited by ichugwindex (12/06/16 12:43 PM)


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Offlinesunshine
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Re: Been "microdosing" daily for over a month AMA [Re: ichugwindex]
    #23899840 - 12/06/16 12:44 PM (7 years, 1 month ago)

I used legal herbs a lot which is like microdosing, for the most part, expect for a few of the herbs that really work wonders.


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlineichugwindex
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Re: Been "microdosing" daily for over a month AMA [Re: sunshine]
    #23899848 - 12/06/16 12:46 PM (7 years, 1 month ago)

Herbs? Yerbamate? Ganja?


--------------------
Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.


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Offlinesunshine
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Re: Been "microdosing" daily for over a month AMA [Re: ichugwindex]
    #23899856 - 12/06/16 12:49 PM (7 years, 1 month ago)

HAHA.  Ganja is a legal herb now.  I tried over 150 herbs to find the good ones.  I almost died a few times.  I have heard they are mainly outlawed in parts of Europe now.


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlineichugwindex
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Re: Been "microdosing" daily for over a month AMA [Re: sunshine]
    #23899888 - 12/06/16 01:06 PM (7 years, 1 month ago)

My question is which herbs


--------------------
Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.


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InvisibleThayendanegea
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Re: Been "microdosing" daily for over a month AMA [Re: ichugwindex]
    #23899927 - 12/06/16 01:23 PM (7 years, 1 month ago)

Been thinking about doing this ...I have tried microdosing on occasion, just not on a daily basis though....do you dose more than once a day?


--------------------
Look Deep Into Nature,and Then You Will Understand Everything Better.

Albert Einstein


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Offlineichugwindex
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Re: Been "microdosing" daily for over a month AMA [Re: Thayendanegea]
    #23899938 - 12/06/16 01:28 PM (7 years, 1 month ago)

Just 1 time a day. I take 0.33 of a gram with breakfast. You should try it man! Especially if you have lots of cubes just sitting around.


--------------------
Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.


Edited by ichugwindex (12/06/16 01:29 PM)


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Offlinesunshine
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Re: Been "microdosing" daily for over a month AMA [Re: ichugwindex]
    #23899977 - 12/06/16 01:49 PM (7 years, 1 month ago)

It's too dangerous.  You're better off not trying herbs.  If you read a lot about drugs, you will find something.  Some of them are very dangerous.  Some people died of kidney failure at some type of clinic using herbs and they banned most of them in parts of Europe, I understand!


--------------------
One Love True Indeed.  Have Good Trips.  Mike/sunshine's mom.


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Offlineichugwindex
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Re: Been "microdosing" daily for over a month AMA [Re: Thayendanegea]
    #23899988 - 12/06/16 01:53 PM (7 years, 1 month ago)

I feel like the background noise of life is turned down. Like it lifts the cloud of stress/self doubt thats lingering in the back of my mind. Really my only concern is if prolonged consumption of the alkaloids could be bad for my physical health. I have no idea if thats a legit concern to have or not.


--------------------
Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.


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InvisibleThayendanegea
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Re: Been "microdosing" daily for over a month AMA [Re: ichugwindex]
    #23900025 - 12/06/16 02:06 PM (7 years, 1 month ago)

I have a lot of wild ovoids (pretty potent) and have felt effects from just eating a single mushroom...just haven't strung any days together yet...I think I may give it a try tomorrow morning.

Do you think it affects your sleep habits at all?


--------------------
Look Deep Into Nature,and Then You Will Understand Everything Better.

Albert Einstein


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Invisiblesudly
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Re: Been [Re: ichugwindex]
    #23900112 - 12/06/16 02:32 PM (7 years, 1 month ago)

I'm all for micro-dosing psilocybin but daily seems too much even at such low doses.
I have tried it for a few weeks with 0.3g once every 2-3 days so that eventually I could sustain myself without them.

I'm going to see if Prazosin(aplha blocker) helps because it acts in the same way as magic mushrooms by stimulating and inhibiting regions of the sympathetic nervous system.

Quote:

Psilocybin = sympathomimetic, (of a drug) producing physiological effects characteristic of the sympathetic nervous system by promoting the stimulation of sympathetic nerves.




Quote:

Prazosin = Prazosin is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD).

sympatholytic = (of a drug) antagonistic to or inhibiting the transmission of nerve impulses in the sympathetic nervous system.





Edited by sudly (12/06/16 02:39 PM)


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Offlineflickedbic
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Re: Been "microdosing" daily for over a month AMA [Re: ichugwindex]
    #23900186 - 12/06/16 02:59 PM (7 years, 1 month ago)

Quote:

Really my only concern is if prolonged consumption of the alkaloids could be bad for my physical health.




This is a valid concern.  I like to microdose occasionally, 2x a week, but never daily; and never for an extended amount of time, as this may damage the heart valves:

https://www.reddit.com/r/DrugNerds/comments/2mqqww/psilocin_and_5ht2b_agonism_induced_cardiotoxicity/


--------------------
Favorite entheogen experiences in descending order:
1)Combo of oral DMT + smoked Bufotenine
2)Amanita (urine drank twice)
3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose)
4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators)
5)Salvia (need to try quid)


All readable matter in the above post is ficticious... any similarities to real life are purely coincidental.

Blessing.


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Invisiblesudly
Darwin's stagger


Registered: 01/05/15
Posts: 10,810
Re: Been "microdosing" daily for over a month AMA [Re: flickedbic]
    #23900261 - 12/06/16 03:28 PM (7 years, 1 month ago)

If it's microdosing it's probably not a concern.
Quote:

However, these drugs differ enormously in their half life. Psilocin has a half life of around 2.5 hours following oral psilocybin administration, while cabergoline has a half life of ~65 hours (from the prescribing information), so it will be exposed to cardiac fibroblasts for around 25X as long as psilocin. Extrapolating a very long stretch, a weekly mushroom trip is probably not going to cause cardiotoxicity.




Once every 2-3 days is so that you don't solely rely on psilocybin and can develop your own sense of comfort.


--------------------
I am whatever Darwin needs me to be.



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Offlineichugwindex
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Re: Been "microdosing" daily for over a month AMA [Re: flickedbic]
    #23900316 - 12/06/16 03:42 PM (7 years, 1 month ago)

I really could not summize anything conclusive from that link. Maybe I should stop doing DAILY though idk


--------------------
Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.


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Offlineflickedbic
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Re: Been "microdosing" daily for over a month AMA [Re: sudly]
    #23900317 - 12/06/16 03:43 PM (7 years, 1 month ago)

Quote:

Alright, final data review on known 5-HT2b agonists causing cardiopathies vs psilocybin. I've been trying to find a drug closer to psilocin in terms of its dosage and resulting plasma concentration relative to its EC 50 for the 5-HT2b receptor, and also one that's only a partial agonist. Bromocriptine (...) (shows) a strong relationship between cumulative dose and risk of developing valvular heart disease.

How do these dosages correlate to the pharmalocologically relevant plasma concentrations? A 7.5 mg dose of bromocriptine results in a maximal plasma concentration of 1.3 ug/L, which equates to 2 nM. 25 mg peaks at 2.4 ug/L, or 3.7 nM. Its half life is 4.83 hours, 2-fold longer than psilocin.

Bromocriptine appears to be able to induce cardiac valvulopathies at concentrations far below the EC 50 (around 50x lower). This would suggest that a 5-HT2b agonist of similar efficacy would also be able to induce valvulopathies at similarly low concentrations. Psilocin's EC-50 of 58 nM means that it could be cardiotoxic at chronic concentrations 1nM. Psilocin shows a peak serum concentration of 8.2 ng/ml, or 40 nM after administration of 15.7 mg (/70kg) psilocybin. Assuming linear dose vs plasma concentration, 0.5 mg of psilocybin would reach the equivalent plasma concentration of bromocriptine in the high dosage study, that's equivalent to 100mg dried P. cubensis assuming 0.5% concentration.

People who report microdosing with mushrooms take more than this much. 




If he's right you should definitely stop doing it daily IMO, ichugwindex. 


--------------------
Favorite entheogen experiences in descending order:
1)Combo of oral DMT + smoked Bufotenine
2)Amanita (urine drank twice)
3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose)
4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators)
5)Salvia (need to try quid)


All readable matter in the above post is ficticious... any similarities to real life are purely coincidental.

Blessing.


Edited by flickedbic (12/06/16 03:48 PM)


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Offlineichugwindex
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Re: Been "microdosing" daily for over a month AMA [Re: flickedbic]
    #23900358 - 12/06/16 04:02 PM (7 years, 1 month ago)

If he is right this is sad news indeed. I've been the happiest I've been in my whole life from daily microdosing and I would hate to have to stop. I've never been so motivated/energized/perceptive so this makes me sad to have to end it.


--------------------
Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.


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Invisiblesudly
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Registered: 01/05/15
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Re: Been [Re: ichugwindex]
    #23900370 - 12/06/16 04:08 PM (7 years, 1 month ago)

Quote:

'Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose–effect study'

"Despite the possibility of a short-lasting moderate elevation of blood pressure, in healthy humans without pre-existing medical conditions, no cardiovascular complications must be expected from administration of PY(psilocybin)"
http://www.maps.org/research-archive/w3pb/2004/2004_Hasler_20465_2.pdf




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Offlineichugwindex
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Re: Been [Re: sudly]
    #23900466 - 12/06/16 04:37 PM (7 years, 1 month ago)

Wait so..Im having trouble seeing where you stand on the subject. I'm not trying to be an ass or anything.


--------------------
Only hope can give rise to the emotion we call despair. But it is nearly impossible for a man to try to live without hope, so I guess that leaves Man no choice but to walk around with despair as his companion.


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OfflineBANANA.MAN
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Re: Been [Re: sudly]
    #23900472 - 12/06/16 04:40 PM (7 years, 1 month ago)

Quote:

sudly said:
I'm all for micro-dosing psilocybin but daily seems too much even at such low doses.
I have tried it for a few weeks with 0.3g once every 2-3 days so that eventually I could sustain myself without them.

I'm going to see if Prazosin(aplha blocker) helps because it acts in the same way as magic mushrooms by stimulating and inhibiting regions of the sympathetic nervous system.

Quote:

Psilocybin = sympathomimetic, (of a drug) producing physiological effects characteristic of the sympathetic nervous system by promoting the stimulation of sympathetic nerves.




Quote:

Prazosin = Prazosin is a sympatholytic drug used to treat high blood pressure, anxiety, and posttraumatic stress disorder (PTSD).

sympatholytic = (of a drug) antagonistic to or inhibiting the transmission of nerve impulses in the sympathetic nervous system.







Psychedelics are serotonin receptor agonists. The drug You are talking about is an antagonist. Agonists activate receptors and antagonists block them.


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Offlineflickedbic
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Re: Been [Re: sudly]
    #23900481 - 12/06/16 04:42 PM (7 years, 1 month ago)

The question is of cumulative, especially daily, dosage.  That study you shared had only four doses given, all of which were spaced out at least two weeks apart.  It does not address the issue.


--------------------
Favorite entheogen experiences in descending order:
1)Combo of oral DMT + smoked Bufotenine
2)Amanita (urine drank twice)
3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose)
4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators)
5)Salvia (need to try quid)


All readable matter in the above post is ficticious... any similarities to real life are purely coincidental.

Blessing.


Edited by flickedbic (12/06/16 05:13 PM)


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