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Offlinemctaveesh
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Registered: 04/01/16
Posts: 1,118
Last seen: 2 months, 12 days
Re: other psychedelics [Re: AuroraBorealis88]
    #23900503 - 12/06/16 04:49 PM (7 years, 1 month ago)

Some people claim Salvia gives them Psychedelic effects.

I would assume that it being a K-Opioid agonist, it would have some kind of Psychedelic effect, even if it's very different than Serotonin Psychedelics.

Maybe it works for some but yeah, most people say they don't like it much. I've never done it so I can't say.


OP, how about weed edibles?

Weed is very introspective for me if I smoke a good bit and keep it at once or twice a week.
Edibles are very Psychedelic, but even with smoking, you can get pretty deep if you smoke a lot of good weed with low tolerance.

Can you do weed?


--------------------

LogicaL Chaos said:
"humans are like cubes, lots of strains but cubes a cube. Not much difference really."


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Offlineflickedbic
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Re: other psychedelics [Re: AuroraBorealis88]
    #23900839 - 12/06/16 06:25 PM (7 years, 1 month ago)

Quote:

ECG abnormalities in the form of tachycardia, myocardial ischaemia and aberrant intraventricular conduction. It was
also stated that long-term exposure to PSI and PEA exerts a crucial effect on the energy heart muscle metabolism, which has been reflected in the complex changes in the myocardial profile of purine concentrations. These abnormalities corresponded with degenerative changes in cardiomyocyte mitochondria observed on histopathological and electron microscopy examinations



https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=61834


--------------------
Favorite entheogen experiences in descending order:
1)Combo of oral DMT + smoked Bufotenine
2)Amanita (urine drank twice)
3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose)
4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators)
5)Salvia (need to try quid)


All readable matter in the above post is ficticious... any similarities to real life are purely coincidental.

Blessing.


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OfflineMarkosheehan
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Re: other psychedelics [Re: AuroraBorealis88]
    #23902415 - 12/07/16 07:18 AM (7 years, 1 month ago)

most people i have shown this to have not responded with a response  like that


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OfflineAuroraBorealis88
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Registered: 05/06/16
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Re: other psychedelics [Re: Markosheehan]
    #23902755 - 12/07/16 10:12 AM (7 years, 1 month ago)

That's because most people don't have balls and don't know how to think realistically.

Oh ya not to mention even with LSD there's no evidence of users suffering heart complications. If these things can really damage the heart valves with any reasonable amount of use then we would have seen it in the long term effects of people who have used them.

We already know the major long term effects of all traditional psychedelics and heart problems are not one of them.
These studies seem fishy and I would be interested to know who even funded them.
I'd also be interested in finding out how they narrowed it down to the 5-HTP2b receptors..
What makes them think that's it? They used mostly SSRIs for these studies it seems and they don't even know how SSRIs work. Why are they assuming it's just an affinity for the receptor? All of these drugs interact differently with the receptors and how exactly they do interact is still a mystery.

I have a really hard time believing mushrooms in anyway physically damage the body or brain especially the heart valves and not because I'm biased but because I actually use logic.
All these studies were, were basically speculation and it still sounds like utter bullshit.
Also from the looks of it they were only able to actually prove it with SSRIs and MDMA which....ya no shit.
MDMA is an amphetamine and no it doesn't surprise me it should actually be expected.


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Offlineflickedbic
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Re: other psychedelics [Re: AuroraBorealis88]
    #23902993 - 12/07/16 11:22 AM (7 years, 1 month ago)

Quote:

If these things can really damage the heart valves with any reasonable amount of use then we would have seen it(...)



I dont think long-term everyday or every-other-day dosing is reasonable use.

Quote:

All these studies were, were basically speculation(...) they were only able to actually prove it with SSRIs and MDMA(...)



That giving rats sub-psychedelic doses every other day produces ECG abnormalities in the form of tachycardia, myocardial ischaemia and aberrant intraventricular conduction is not speculation, and they didn't use MDMA or a SSRI; they proved it using psilocin.


--------------------
Favorite entheogen experiences in descending order:
1)Combo of oral DMT + smoked Bufotenine
2)Amanita (urine drank twice)
3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose)
4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators)
5)Salvia (need to try quid)


All readable matter in the above post is ficticious... any similarities to real life are purely coincidental.

Blessing.


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OfflineAuroraBorealis88
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Registered: 05/06/16
Posts: 5,871
Last seen: 5 years, 2 months
Re: other psychedelics [Re: flickedbic]
    #23903052 - 12/07/16 11:41 AM (7 years, 1 month ago)

https://www.reddit.com/r/DrugNerds/comments/2mqqww/psilocin_and_5ht2b_agonism_induced_cardiotoxicity/

^In this? This is what I was referring to as well as the other one the OP linked earlier that talked about SSRIs.


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Offlineflickedbic
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Re: other psychedelics [Re: AuroraBorealis88]
    #23903323 - 12/07/16 01:08 PM (7 years, 1 month ago)

Yes, the study I'm talking about is provided about halfway down the thread that you've just linked.


--------------------
Favorite entheogen experiences in descending order:
1)Combo of oral DMT + smoked Bufotenine
2)Amanita (urine drank twice)
3)Mushrooms > Achuma 16"+cid(still need higher dose Achuma)> Cid (still need high dose)
4)Morning Glory-HBWR (+cumin, cinnamon aldehyde adducts) > Methyl chavicol (need more activators)
5)Salvia (need to try quid)


All readable matter in the above post is ficticious... any similarities to real life are purely coincidental.

Blessing.


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Invisiblenooneman
Male

Registered: 04/24/09
Posts: 14,564
Loc: Utah
Re: other psychedelics [Re: Markosheehan]
    #23903463 - 12/07/16 01:47 PM (7 years, 1 month ago)

All classic psychedelics affect 5HT2A. That is in fact the definition of a classic psychedelic is that it has action at 5HT2A. If you're looking for something with no action at 5HT2A, then by definition you are not looking for a psychedelic.


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OfflineMarkosheehan
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Re: other psychedelics [Re: AuroraBorealis88]
    #23903635 - 12/07/16 02:25 PM (7 years, 1 month ago)

Quote:

AuroraBorealis88 said:
Oh ya not to mention even with LSD there's no evidence of users suffering heart complications. If these things can really damage the heart valves with any reasonable amount of use then we would have seen it in the long term effects of people who have used them.





i know they have been around for a long time but when ever i look up studies on the physical affects of shrooms i find absolutely nothing. people only seem interested in the pyscoactive affects and how it affects depression etc can you link  anything on this??


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OfflineAuroraBorealis88
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Re: other psychedelics [Re: Markosheehan]
    #23904991 - 12/07/16 08:16 PM (7 years, 1 month ago)

Link anything on what? The physical side effects of shrooms? Ha there are none.

Some people talk about long term changes in blood pressure occasionally but that's all I've heard and I don't think it's confirmed.
Mushrooms don't even affect your heart rate so I don't see how it can even affect the heart valves at all at least in any notable way, after all when your heart rate changes that means the speed at which the heart valves are opening and closing move faster since that's what a heart beat is. It isn't the actual contraction of the muscles in the heart it's actually just the valves being opened and then closed again due to a rise in ventricular pressure after the cells are depolarized (electrically charged). So for a drug like MDMA or LSD which speeds up the heart rate I can see how they might have an effect after seriously strenuous use. And I mean like really strenuous use.

I'm not necessarily saying a drug has to affect your heart rate to have any effect on the heart valves but that would be the first place I'd look. I don't know if the heart valves can be affected in any other way but then again I wouldn't be surprised.


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OfflineMarkosheehan
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Re: other psychedelics [Re: AuroraBorealis88]
    #23905693 - 12/08/16 02:19 AM (7 years, 1 month ago)

how come when i measure my blood pressure on a trip it has gone up then and how do you know there are no phsyical affects if there is nothing examinationg it. and also the someone died from shrooms from cardiac arrest . i know they had had a heart transplant but it was years ago  so how does it have no affect,  also the person did other things to  elevate there heart rate e.g execise, orgasims but shrooms made them die.


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OfflineAuroraBorealis88
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Re: other psychedelics [Re: Markosheehan]
    #23906168 - 12/08/16 09:34 AM (7 years, 1 month ago)

How do you know shrooms made them die? Mother fucker had a weak heart so who knows what it was plus he already had a transplant.

I never said it doesn't affect the heart I said it doesn't change the heart rate.
I don't know why you measured your blood pressure getting higher because it definitely doesn't consistently do that, shrooms more often than not create vasodilation which decreases blood pressure. That's why people often pass out when they mix it with pot which also causes vasodilation.


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OfflineMarkosheehan
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Re: other psychedelics [Re: AuroraBorealis88]
    #23906336 - 12/08/16 10:46 AM (7 years, 1 month ago)

he had be fine for years since the transplant  and 2 weeks prevoius he had been to the doctor who had said his heart is absolutely fine the guy did other things to aggregate his heart like i already mentioned e.g panic, exercise orgasims but none of these killed him but he took shrooms and on no other drugs he died and well there must be something very wrong with my body cause i have measured it twice and both have been substantially higher as well as measuring my friends which was higher.


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OfflineAuroraBorealis88
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Re: other psychedelics [Re: Markosheehan]
    #23908161 - 12/08/16 07:17 PM (7 years, 1 month ago)

Dude fuck the guy I don't give a shit lol :lol:

Who knows what it was. People have cardiac arrests all the time, someone's bound to have it happen on shrooms. How do you know they didn't mess up the heart transplant that day?

You sound way too paranoid. You're over here complaining about mushrooms and heart valves like there's some kind of real risk involved.
THERE ISN'T

I can guarantee you almost everything we use everyday is probably worse for the heart than mushrooms. There's no evidence of even long term users having heart problems so just drop it man.


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