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Sk8nshram
pigskin footballs



Registered: 11/01/13
Posts: 1,084
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Are mushrooms safe for my co worker to ingest?
#23884202 - 12/01/16 11:03 AM (7 years, 1 month ago) |
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My coworker is in his mid 60's. He's done lsd and mescaline years ago but never tried mushrooms. His blood pressure is high and he is on a pretty large dose of medicine for it. Not sure what drug but I could find out what and dosage if necessary. He wants to try a small amount of mushrooms but wants to make sure it's safe first. He also is a medical marijuana patient.
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Tmethyl
Smear in the shale


Registered: 07/16/12
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Re: Are mushrooms safe for my co worker to ingest? [Re: Sk8nshram]
#23884218 - 12/01/16 11:09 AM (7 years, 1 month ago) |
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A small dose between .5 and 2grams will be completely safe. On higher doses a panic can set in on less experienced trippers and that could affect his BP. You going to be there with him?
-------------------- ¯\_(ツ)_/¯
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AuroraBorealis88
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Re: Are mushrooms safe for my co worker to ingest? [Re: Sk8nshram]
#23884269 - 12/01/16 11:35 AM (7 years, 1 month ago) |
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It is definitely safe but what kind of meds is he taking?
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BANANA.MAN
Turd Ferguson

Registered: 01/11/15
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Re: Are mushrooms safe for my co worker to ingest? [Re: Tmethyl]
#23884315 - 12/01/16 11:59 AM (7 years, 1 month ago) |
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Psychedelics will atleast slightly increase his blood pressure. Weather or not it will be harmful to him i cant say but is BP will increase.
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AuroraBorealis88
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Re: Are mushrooms safe for my co worker to ingest? [Re: BANANA.MAN]
#23884317 - 12/01/16 12:01 PM (7 years, 1 month ago) |
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Psilocybin mushrooms lower blood pressure..
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ergoticmandala



Registered: 06/03/15
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Re: Are mushrooms safe for my co worker to ingest? [Re: AuroraBorealis88]
#23884333 - 12/01/16 12:09 PM (7 years, 1 month ago) |
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you should get him to vape some dmt instead. thats a trip condensed into 15 mins
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ergoticmandala



Registered: 06/03/15
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Re: Are mushrooms safe for my co worker to ingest? [Re: ergoticmandala]
#23884341 - 12/01/16 12:11 PM (7 years, 1 month ago) |
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but yeah im pretty sure he would be fine tripping on shrooms, either way I really don't think his health is in danger
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BANANA.MAN
Turd Ferguson

Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
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Re: Are mushrooms safe for my co worker to ingest? [Re: AuroraBorealis88]
#23884433 - 12/01/16 12:51 PM (7 years, 1 month ago) |
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Quote:
AuroraBorealis88 said: Psilocybin mushrooms lower blood pressure..
Can you link me some proof?
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Sk8nshram
pigskin footballs



Registered: 11/01/13
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Re: Are mushrooms safe for my co worker to ingest? [Re: BANANA.MAN]
#23884466 - 12/01/16 01:09 PM (7 years, 1 month ago) |
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I won't be there with him. He wasn't looking to trip real hard. I was going to start him off with about a half gram of cyanescens. I'll find out what dosage and what medication he is on and report back. I think that at that dosage it should be safe. I've never had mushrooms increase my bp, always the opposite. In fact I have a friend who has very low blood pressure that will pass out on mushrooms because it lowers his bp so much. Pretty scary the first few times. He hit his head on a granite counter once at a party lol. Now if he feels it coming on he just lays down and it's all good. Cubes effect him more than wood lovers too wonder why.
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Sk8nshram
pigskin footballs



Registered: 11/01/13
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Re: Are mushrooms safe for my co worker to ingest? [Re: Sk8nshram]
#23884503 - 12/01/16 01:27 PM (7 years, 1 month ago) |
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So he is on a pretty high dose of his medicines. 100mg of losartan potassium and 12.5mg of hydrochlorothiazide a day. What do yall think I'm not very keen on drug interactions.
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BANANA.MAN
Turd Ferguson

Registered: 01/11/15
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Re: Are mushrooms safe for my co worker to ingest? [Re: BANANA.MAN]
#23884537 - 12/01/16 01:40 PM (7 years, 1 month ago) |
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Quote:
BANANA.MAN said:
Quote:
AuroraBorealis88 said: Psilocybin mushrooms lower blood pressure..
Can you link me some proof?
I looked i into serotonin receptor agonists effect on BP a little more and it appears to be much more complex than increasing or decreasing BP.
serotonin can acctually increase or dcrease blood pressure through different mechanisms for different species.
Quote:
Though selective 5-HT1A receptor agonists can lower heart rate (and arterial blood pressure), 5-HT usually lowers heart rate by eliciting an initial short-lasting hypotension due to bradycardia (von Bezold-Jarisch-like reflex) via 5-HT3 receptors located on sensory vagal nerve endings in the heart. Once this bradycardia reflex is suppressed--for example, during deep anesthesia, vagotomy, or spinal section--5-HT can increase heart rate in different species by a variety of mechanisms. Myocardial 5-HT1-like, 5-HT2, and 5-HT4 receptors appear to be involved in the cat, rat, and pig, respectively.
Check out the whole article if you want OP here is the link. https://www.ncbi.nlm.nih.gov/pubmed/1702484
Btw incase you didnt know, the common method of action between almost all psychedelics (i only count serotonergic haullucinogens that are either tryptamines, phenethtlamines or lysergamides. Others will disagree but many people share my view and my view is the one that makes sense from a chemical and pharmalogical stand point rather than effects which are subjective. But this isnt the thread to get into that) is agonism of 5-HT2a receptors. 5-HT is serotonin.
In conclusion: serotonin receptor agonists can effect BP and heart rate in a variety of ways.
Edited by BANANA.MAN (12/01/16 02:40 PM)
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Thayendanegea
quiet walker



Registered: 02/20/12
Posts: 7,596
Loc: 7 Lodges Nation
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Re: Are mushrooms safe for my co worker to ingest? [Re: BANANA.MAN]
#23884614 - 12/01/16 02:05 PM (7 years, 1 month ago) |
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Like Timethyl said, by keeping the dosage low, he should be ok. I am in my mid 50's and take a low dose of blood pressure meds...have never had any problem...the meds may actually help the vasoconstriction accompanying psychs.
One thing I should mention is that he should have an experienced sitter that could talk him down if anything went south. The paranoia from thought loops or such can definitely cause a rise in bp.
-------------------- Look Deep Into Nature,and Then You Will Understand Everything Better. Albert Einstein
Edited by Thayendanegea (12/01/16 02:07 PM)
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The Blind Ass
Bodhi



Registered: 08/16/16
Posts: 26,658
Loc: The Primordial Mind
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Re: Are mushrooms safe for my co worker to ingest? [Re: Thayendanegea]
#23884639 - 12/01/16 02:17 PM (7 years, 1 month ago) |
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Do not take medical advice from this forum regarding your co worker.
It is irresponsible.
-------------------- Give me Liberty caps -or- give me Death caps
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Sk8nshram
pigskin footballs



Registered: 11/01/13
Posts: 1,084
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Re: Are mushrooms safe for my co worker to ingest? [Re: The Blind Ass]
#23884656 - 12/01/16 02:24 PM (7 years, 1 month ago) |
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Quote:
The Blind Ass said: Do not take medical advice from this forum regarding your co worker.
It is irresponsible.
I am merely using all of my resources to gain insight, information, personal experiences, etc. My co worker will most likely not want to ingest if there is a risk of bp increasing.
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The Blind Ass
Bodhi



Registered: 08/16/16
Posts: 26,658
Loc: The Primordial Mind
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Re: Are mushrooms safe for my co worker to ingest? [Re: Sk8nshram]
#23884663 - 12/01/16 02:25 PM (7 years, 1 month ago) |
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To put it simply, there is a risk. Beyond that I cannot tell you. This is something he should discuss with his family physician in the privacy of the confidential patient/doctor relationship.
-------------------- Give me Liberty caps -or- give me Death caps
Edited by The Blind Ass (12/01/16 02:28 PM)
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Sk8nshram
pigskin footballs



Registered: 11/01/13
Posts: 1,084
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Re: Are mushrooms safe for my co worker to ingest? [Re: The Blind Ass] 1
#23884698 - 12/01/16 02:37 PM (7 years, 1 month ago) |
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Quote:
The Blind Ass said: To put it simply, there is a risk. Beyond that I cannot tell you. This is something he should discuss with his family physician in the privacy of the confidential patient/doctor relationship.
There is a risk every time anyone eats mushrooms. Don't think he will talk to a physician about this. And why must it be in the privacy of the confidential patient/doctor relationship? You're starting to sound a little overbearing here.
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BANANA.MAN
Turd Ferguson

Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
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Re: Are mushrooms safe for my co worker to ingest? [Re: The Blind Ass]
#23884725 - 12/01/16 02:45 PM (7 years, 1 month ago) |
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Quote:
The Blind Ass said: To put it simply, there is a risk. Beyond that I cannot tell you. This is something he should discuss with his family physician in the privacy of the confidential patient/doctor relationship.
First of all most doctors dont know about the method of action of psychedelic drugs. Only people with an interest in psyches ASWELL as a knowledge of pharmacology know.
And just so you know. A family docor is a jack of all trades and a master of none. Thats why we have specialists. They have to study everything in 7 years. They cant focus on one area. Someone who studies just chemistry and pharmacology for 7 years knows their shit (about those 2 topics) better than a family physician.
Second if he is ignorant and doesnt understand that psyches are different than other drugs in many ways then he may be less likely to prescribe you abusable medication that you may have a legitimate medical need for at some point.
I told my doctor that i smoke weed and drink occasionally because he asked. I wouldnt tell him about any drug that is less socially acceptable than weed or alcohol unless i had a problem.
I honestly think i know more about the chemistry and pharmocology of most family physicians who are not into psyches.
I linked a paper that OP can get his info from.
Thats just my 2 cents.
Edited by BANANA.MAN (12/01/16 02:50 PM)
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AuroraBorealis88
Stranger


Registered: 05/06/16
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Re: Are mushrooms safe for my co worker to ingest? [Re: BANANA.MAN]
#23884726 - 12/01/16 02:45 PM (7 years, 1 month ago) |
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Quote:
BANANA.MAN said:
Quote:
AuroraBorealis88 said: Psilocybin mushrooms lower blood pressure..
Can you link me some proof?
All I know is that psilocybin and pot both lower blood pressure which is why people often pass out when mixing weed and shrooms not weed and acid.
I'll try to look for a link but I've also read that psilocybin can momentarily heighten blood pressure as well but it doesn't cause consistent vasoconstriction.
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BANANA.MAN
Turd Ferguson

Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
Last seen: 6 months, 3 days
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Re: Are mushrooms safe for my co worker to ingest? [Re: AuroraBorealis88]
#23884761 - 12/01/16 02:55 PM (7 years, 1 month ago) |
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Quote:
AuroraBorealis88 said:
Quote:
BANANA.MAN said:
Quote:
AuroraBorealis88 said: Psilocybin mushrooms lower blood pressure..
Can you link me some proof?
All I know is that psilocybin and pot both lower blood pressure which is why people often pass out when mixing weed and shrooms not weed and acid.
I'll try to look for a link but I've also read that psilocybin can momentarily heighten blood pressure as well but it doesn't cause consistent vasoconstriction.
Read the link i posted. Its a complex issue.
Serotonin receptor agonists usually cause muscle tension which can increase blood pressure.
I used to have very low BP from abusing weed.
Ive drank beer, inhailed nitrous and smoked weed on the comedown of a shroom trip and i didnt pass out despite my period of low blood pressure. it was fixed by this time though i just feel like its worth mentioning.
I would get a gnarly head rush almost everytime i stood up and i would almost pass out and throw up if i smoked weed on an empty stomach.
On all psyches but mostly shrooms i always feel strong hypertension (increased BP) it makes me cold and my muscles get ridgid.
the hypertension fades after the comeup so it would make sense that it causes temporary hypertension like you said. The link i posted acctually memtions that aswell.
Edited by BANANA.MAN (12/01/16 02:59 PM)
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AuroraBorealis88
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Re: Are mushrooms safe for my co worker to ingest? [Re: BANANA.MAN]
#23885080 - 12/01/16 04:26 PM (7 years, 1 month ago) |
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Ya I saw the link and see how it is a little more complex but even then are you sure it's really that black and white? Why do you think all Serotonin receptor agonists would have the same effect on blood pressure?
Theoretically can't there be a serotonin receptor agonist that lowers BP and another one that heightens it? I mean the fact that they're both serotonin receptor agonists is really the only physiological thing that they inherently have in common.
I always thought LSD heightened blood pressure and mushrooms lowered it  I always thought it was just that simple, I mean apparently it's not that simple and like you stated it's a little complex but roughly speaking I still find it to be true enough most of the time.
We have another thread going on right now where people are talking about the up and down nature of mushroom trips and how dynamic they seem, maybe during different stages of the trip it can have different effects on blood pressure?
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BANANA.MAN
Turd Ferguson


Registered: 01/11/15
Posts: 7,474
Loc: Ontario Canada
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Re: Are mushrooms safe for my co worker to ingest? [Re: AuroraBorealis88]
#23885167 - 12/01/16 04:53 PM (7 years, 1 month ago) |
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Quote:
AuroraBorealis88 said: Ya I saw the link and see how it is a little more complex but even then are you sure it's really that black and white? Why do you think all Serotonin receptor agonists would have the same effect on blood pressure?
Theoretically can't there be a serotonin receptor agonist that lowers BP and another one that heightens it? I mean the fact that they're both serotonin receptor agonists is really the only physiological thing that they inherently have in common.
I always thought LSD heightened blood pressure and mushrooms lowered it  I always thought it was just that simple, I mean apparently it's not that simple and like you stated it's a little complex but roughly speaking I still find it to be true enough most of the time.
We have another thread going on right now where people are talking about the up and down nature of mushroom trips and how dynamic they seem, maybe during different stages of the trip it can have different effects on blood pressure?
Im not saying that at all.
they are both serotonin receptor agonists but that is not the only thing they have in common.
not only are they both serotonin receptor agonists they are both 5-HT2 receptor agonists and even more specifically than that they are both 5-HT2a receptor agonists.
But they do effect other serotonin receptors as well so that could alter the effect on BP im not saying it couldnt. im pretty sure LSD affects more receptors than psilocin so they could have a different effect on BP.
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The Blind Ass
Bodhi



Registered: 08/16/16
Posts: 26,658
Loc: The Primordial Mind
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Re: Are mushrooms safe for my co worker to ingest? [Re: BANANA.MAN]
#23885244 - 12/01/16 05:23 PM (7 years, 1 month ago) |
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Quote:
BANANA.MAN said:
Quote:
The Blind Ass said: To put it simply, there is a risk. Beyond that I cannot tell you. This is something he should discuss with his family physician in the privacy of the confidential patient/doctor relationship.
First of all most doctors dont know about the method of action of psychedelic drugs. Only people with an interest in psyches ASWELL as a knowledge of pharmacology know.
And just so you know. A family docor is a jack of all trades and a master of none. Thats why we have specialists. They have to study everything in 7 years. They cant focus on one area. Someone who studies just chemistry and pharmacology for 7 years knows their shit (about those 2 topics) better than a family physician.
Second if he is ignorant and doesnt understand that psyches are different than other drugs in many ways then he may be less likely to prescribe you abusable medication that you may have a legitimate medical need for at some point.
I told my doctor that i smoke weed and drink occasionally because he asked. I wouldnt tell him about any drug that is less socially acceptable than weed or alcohol unless i had a problem.
I honestly think i know more about the chemistry and pharmocology of most family physicians who are not into psyches.
I linked a paper that OP can get his info from.
Thats just my 2 cents.
-------------------- Give me Liberty caps -or- give me Death caps
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Get Shwifty
I love you guys



Registered: 10/14/15
Posts: 167
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Re: Are mushrooms safe for my co worker to ingest? [Re: ergoticmandala]
#23886327 - 12/02/16 12:06 AM (7 years, 1 month ago) |
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Quote:
ergoticmandala said: you should get him to vape some dmt instead. thats a trip condensed into 15 mins
Dr. Rick Strassman said in his book DMT: The spirit Molecule that the only noticeable health concern he had noticed when performing the DMT trials in the 90s is that some patients experienced elevated blood pressure. This is one of the main reasons I'm not going to allow an older family member to try it. The family member in question is also on blood pressure medication.
Edited by Get Shwifty (12/02/16 12:07 AM)
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