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jsncrs
DYEL


Registered: 01/16/14
Posts: 1,170
Loc: Mars
Last seen: 3 years, 7 months
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How are new organic psychoactive compounds discovered?
#23769075 - 10/25/16 06:26 AM (7 years, 3 months ago) |
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I've always wondered this, thought here would be the best place to ask. How do people discover new psychoactive compounds in plants? I know a majority would be due to history of ritualistic use. But is there some scientific method of Analysis that a plant can be put through? Or is it basically just random taste testing?
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ellomello
XP



Registered: 08/11/08
Posts: 2,423
Loc: babilonUSA
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Re: How are new organic psychoactive compounds discovered? [Re: jsncrs]
#23769138 - 10/25/16 07:10 AM (7 years, 3 months ago) |
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Cool subject! i'd guess most are like you said from documented ritual use. Then from extracts of plants to concentrate those effects.
Ancient people would sometimes watch animals to see what they eat, and how they reacted.
There is chemistry, where you can take a known compound, move around some atoms and you have a new compound.
Alexander Shulgin is an example of someone creating thousands of new compounds.
Computers are used to come up with new compounds based on like idk science or something.
-------------------- PAY NO ATTENTION TO THE MAN BEHIND THE CURTAIN get back to the garden
some came singing, some come to play, some come for keeping the dark away
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Mostly_Harmless
wyrd bið ful aræd



Registered: 05/12/09
Posts: 5,043
Loc: Perfidious Albion
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Re: How are new organic psychoactive compounds discovered? [Re: ellomello]
#23769154 - 10/25/16 07:23 AM (7 years, 3 months ago) |
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Shulgin sharing some thoughts
Quote:
One has to be reasonably competent in chemistry, in botany and in pharmacology, all at the same time. If you hope to identify new alkaloids in a plant, you have to take a decade or two, to synthesize reference samples of a few hundred tetrahydroisoquinolines with one through four oxygens on the aromatic ring, with any or all of them having methyl ethers or methylenedioxy ethers attached. And then each of these should be modified from the di-H material to the N-methyl, the 1-methyl or the N, 1-dimethyl homologues. And let's make all the N-oxides. Then the preparation of the dihydro and the aromatic analogues will triple the number of spectra posted up there on the wall.
http://www.cognitiveliberty.org/shulgin/blg/2005/01/juuls-giant-cactus-aka-jewels-giant.html
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mandrin13
Stranger


Registered: 07/08/14
Posts: 1,111
Loc: Socal
Last seen: 2 months, 7 days
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Re: How are new organic psychoactive compounds discovered? [Re: Mostly_Harmless]
#23769168 - 10/25/16 07:38 AM (7 years, 3 months ago) |
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g-o-o-g-l-e
-------------------- Even Jesus got stoned.
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DualWieldRake
Stranger


Registered: 07/17/16
Posts: 1,115
Loc: Zone 8b
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Re: How are new organic psychoactive compounds discovered? [Re: mandrin13]
#23769244 - 10/25/16 08:36 AM (7 years, 3 months ago) |
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finger dip method
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jsncrs
DYEL


Registered: 01/16/14
Posts: 1,170
Loc: Mars
Last seen: 3 years, 7 months
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Re: How are new organic psychoactive compounds discovered? [Re: DualWieldRake]
#23770568 - 10/25/16 04:19 PM (7 years, 3 months ago) |
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I'm currently reading Pikhal which is what lead me to ask this question Shulgin lived such a cool life
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ferrel_human
stone eater



Registered: 06/26/09
Posts: 16,320
Loc: Texas
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Re: How are new organic psychoactive compounds discovered? [Re: Mostly_Harmless]
#23770599 - 10/25/16 04:27 PM (7 years, 3 months ago) |
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Quote:
Mostly_Harmless said: Shulgin sharing some thoughts
Quote:
One has to be reasonably competent in chemistry, in botany and in pharmacology, all at the same time. If you hope to identify new alkaloids in a plant, you have to take a decade or two, to synthesize reference samples of a few hundred tetrahydroisoquinolines with one through four oxygens on the aromatic ring, with any or all of them having methyl ethers or methylenedioxy ethers attached. And then each of these should be modified from the di-H material to the N-methyl, the 1-methyl or the N, 1-dimethyl homologues. And let's make all the N-oxides. Then the preparation of the dihydro and the aromatic analogues will triple the number of spectra posted up there on the wall.
http://www.cognitiveliberty.org/shulgin/blg/2005/01/juuls-giant-cactus-aka-jewels-giant.html
Now does this guy know how to party or what?
-------------------- Nature is my church and walking through it is gospel. It tells no lies and reveals all to those who look, and listen, closely. -Karode
 Looking for Mimosa tenuiflora seeds. Buttons for trade
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jimmyBbuffet
Registered: 02/20/16
Posts: 558
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Re: How are new organic psychoactive compounds discovered? [Re: ferrel_human]
#23771741 - 10/25/16 10:37 PM (7 years, 3 months ago) |
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Yup, Sasha was THE MAN. There's a podcast called "the psychedelic salon" with a few of his lectures. Very entertaining.
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Herbgrower12
Stranger


Registered: 08/07/14
Posts: 531
Last seen: 3 years, 7 months
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Re: How are new organic psychoactive compounds discovered? [Re: jimmyBbuffet]
#23774200 - 10/26/16 06:15 PM (7 years, 3 months ago) |
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Just tell a couple high school kids its "weed" and check the obituaries a few days after. LOL.
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