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Offlineneuroneuro
Stranger
Registered: 09/30/16
Posts: 2
Last seen: 7 years, 3 months
MS, psilocybin, focus
    #23692989 - 09/30/16 05:03 AM (7 years, 3 months ago)

Hi a newcomer here I'd like to introduce myself and ask a couple of questions, the 'Getting Started' forum doesn't let me post, so I've posted here, I hope you don't mind.

Intro:
I'm a slightly messed up puppy (although not as bad as others). From an early age, maybe 3 years old to about 17 I was subject to a lot of emotional trauma. About 15 I started smoking a bit of weed. From 17 when I moved out of my parents' place (to go to university), I smoked a lot of weed, and was permanently stoned. Lots of vodka too. From the age of 21 I began drinking harder, but stopped the weed. From about 26 cocaine entered my life. I took coke until about 32 and continued daily drinking until about 34 when I was diagnosed with MS after a slow neurological decline and an aggressive flare-up (brain and spinal cord lesions). I was advised to live a healthy life. From then I completely quit alcohol, started eating a more paleo style diet, yoga, pilates, meditation, supplements etc.
Looking back this drug/alcohol fueled carnage was probably a result my emotional trauma. I still have this strange underlying melancholy. I wouldn't say that I'm depressed. Maybe a tiny anxious but nothing too severe. No panic attacks etc.
I used to be a very intelligent, focussed, intuitive person, however the MS, party drugs, a persistent infection, work stress etc must have taken their toll. My MS has stabilised, and I have had no new lesions in a few years with this new healthy life....however my brain is still like treacle.

I have tried lots of supplements and continue to take lots, including:
- Magnesium
- Calcium
- Phosphatidylserine
- Phosphatidylcholine
- Alpha GPC
- 5-HTP
- Vitamin C
- MSM
- Trimethylglycine
- Vitamin B1 (Sulbutiamine and thiamine HCL)
- NAC
- Methylcobalamin (sublingual and topical B12)
- Coffee
- Zinc
- Lots of vitamin D3
- Biotin
- Potassium
- P5P (B6)
- Niacin
- Vitamin E complex
- Vitamin B2
- L-Tyrosine
- L-Carnitine fumerate
- Vape an indica weed before bed
- Tumeric
- MCT oil

I'm also looking at Lion's Mane.

I have tried various Nootropics like Noopept. However I don't want to excite my neurons too much with them so stopped.

The main reason for my post is to ask a few questions about microdosing:
1. Could microdosing shrooms lift this weird melancholy?
2. Could microdosing shrooms increase my focus and attention span? This one is particularly  important to me as I need to provide for my family (wife with quite severe mental health issues and 2 kids).
3. If microdosing enables me to work better am I likely to remember the stuff a week after the dose has worn off?
4. What negatives could you think of?

Many thanks all :smile:
hope to hear from you

NN


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Offlinesubject 13
Stranger


Registered: 08/30/16
Posts: 11
Last seen: 6 years, 3 months
Re: MS, psilocybin, focus [Re: neuroneuro]
    #23697519 - 10/01/16 03:25 PM (7 years, 3 months ago)

There have been a couple good microdosing threads here lately, have a look!
I started mushroom microdoses about a month ago and it's been subtle but positive. A big motivation is cutting through the "brain treacle" as you call it.
I haven't had the drug use history you have and I don't have any serious medical issues.
I don't know if there are any cautions or contraindications with mushrooms and MS.
A few thoughts...
Unless it's really helping with your MS symptoms, I'd suggest try quitting the bedtime weed.
I vaped at bedtime for years and think it eventually led to depression and irritability during the day.
After reading several places that regular caffeine intake can cause serotonin depletion, I'm cutting way back on the coffee too. I use many of the same supplements you do, but several of those are unfamiliar to me, so I can't say how they might interact with psilocybin.
Like you, I'm trying many things at once: quitting bad habits, better diet, supplements, exercise, and microshrooms. The downside is with all the variables, it's hard to say what works.


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OfflinePsychoKinesiS
Alien Resources Manager
Registered: 08/05/11
Posts: 1,444
Last seen: 6 years, 10 months
Re: MS, psilocybin, focus [Re: subject 13]
    #23697744 - 10/01/16 04:57 PM (7 years, 3 months ago)

I recently saw a neurologist as I thought I was neurodegenerating from some kind of virus, but it turns out it was all actually side effects of the various medications I was taking, electrolyte imbalance, B12 deficiency, etc. and quickly resolved once I quit the medications and fixed the imbalances.

He also advised not to take large supplements of individual electrolytes such as calcium, magnesium, etc. unless you have bloodwork showing that you are deficient in those, as you can actually work against yourself and throw off your electrolytes even more.

I would advise not to take nootropics as they are just untested research chemicals with side effects. If you wouldn't takle 25-I-nbome, because it's a research chemical, then you shouldn't take noopept either. I have also found Noopept to cause panic attacks.

I don't think psychedelics will magically help your symptoms and if you use them you may be at risk of a bad trip. You should find the root of your problem, fix it, and then take psychedelics. If you do take psychedeliccs yes they will help you out: by showing you that you have a problem before it catches up to you with aging when it's too late to fix, so you can proactively act on it. However they won't cure it and it won't be pleasant, and the psychological impact might be too much.


--------------------


Edited by PsychoKinesiS (10/01/16 04:59 PM)


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Offlineneuroneuro
Stranger
Registered: 09/30/16
Posts: 2
Last seen: 7 years, 3 months
Re: MS, psilocybin, focus [Re: PsychoKinesiS]
    #23705843 - 10/04/16 06:41 AM (7 years, 3 months ago)

Hi,
Thanks a lot for your advice. I've now reduced to only one cup of coffee a day. The weed is beneficial to my condition, but I will see what happens when I wean myself off. You've got a very good point on serotonin. Interestingly, my serotonin related genes (that convert tryptophan to 5-HTP) are completely broken, so I do need to find a way to maximise it. However due to my broken serotonin system, I was thinking that microdocing psilocybin or LSD may bypass my broken genes and be good agonists to the receptors directly. I'll take maybe 0.05g of dried shrooms just to see any impact. I mean even  an ultra-micro-dose dose could be positive if I pretty much have no serotonin in my system at the moment!
Yes, I've completely halted all nootropics.
I've actually had a B vitamin analysis and am boosting them aggressively as I was deficient in a few.
Thanks again
NN


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OfflineJacksonMetaller
Stranger

Registered: 03/13/11
Posts: 13,361
Last seen: 1 year, 1 month
Re: MS, psilocybin, focus [Re: neuroneuro]
    #23705902 - 10/04/16 07:25 AM (7 years, 3 months ago)

You sound a lot like me. If you don't mind me asking what's the persistent infection? Anyways, if you got the cash you might want to shell it on a good functional medicine doctor who understands this stuff. I emphasize good because not all of them are. After two years of autoimmune neurological problems I finally found someone useful and we've determined they were caused by chronic mold exposure in my home which has probably weakened my immune system as I have evidence of persistent lyme disease as well (which accounts for most of my symptoms as they respond to antibiotics but then relapse on cessation). There's almost always a handful of infections and/or environmental microbial elements behind autoimmune disorders that can be sorted out with the right approach... and a lot of cash... My prognosis right now is very optimistically full remission despite most MD's asserting that autoimmunity is "incurable". Anyways, just thought i'd share because that bullshit is miserable.

As for the microdosing, for me personally this depends on how I'm feeling. I've never microdosed but i have taken full doses and I can say my condition is just too unpredictable to generalize the effects of hallucinogens. Normally when i take them i feel way better, but there are days where i can't even fathom it. It's worth a shot. It definitely gives me the feeling of new purpose which is important when you're sick. Also, curious what you mean by your serotonin genes are "broken". Genes don't really break body-wide like that. You can have variants that make you susceptible to certain things, but all of that is evolutionarily selected for and suggests the environment is the real issue.


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