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Offlinexpl0de
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New opioid douses pain without being addictive or deadly in primates * 1
    #23611256 - 09/04/16 12:32 PM (7 years, 4 months ago)

http://arstechnica.com/science/2016/09/new-opioid-douses-pain-without-being-addictive-or-deadly-in-primates/

Quote:


In monkeys, the drug is a highly effective pain reliever without downsides.

While the opioid epidemic continues kill more than 40 American every day, researchers and health experts are frantically searching for ways to curtail use of the highly addictive, pain-quenching drugs. In March, the Centers for Disease Control and Prevention even released new guidelines directing doctors to simply refrain from prescribing opioids. But if a new study holds up, the health agency may be able to reverse course.

According to a report in the Proceedings of the National Academy of Sciences, an opioid drug referred to as BU08028 was able to alleviate pain in a dozen monkeys just as well as other opioid painkillers, such as morphine. Yet, unlike every other opioid drug, BU08028 showed no signs of being addictive. Even at high dose—at which other opioid drugs inhibit the respiratory and cardiovascular system, which can be fatal—BU08028 was harmless.

"Based on our research, this compound has almost zero abuse potential and provides safe and effective pain relief," Mei-Chuan Ko, a professor of physiology and pharmacology at Wake Forest Baptist Medical Center and lead author of the study, said in a statement. "This is a breakthrough for opioid medicinal chemistry that we hope in the future will translate into new and safer, non-addictive pain medications."

In pain experiments, which involved dipping monkeys' tails into hot water, BU08028 was a potent pain-killer. A single dose relieved pain for up to 30 hours. Next, in experiments in which the monkeys were trained to self-medicate, BU08028 proved no more habit-forming than a control dose of saline. Scientists forced one group of monkeys to take BU08028, while another group was forced to take morphine. When the drugs were taken away, the monkeys who had taken BU08028 showed no withdrawal symptoms, unlike the monkeys who had blazed on morphine.

BU08028's lack of nasty side-effects may hinge on its dual-action biochemistry. Like other opioids, it controls pain by targeting the nervous system's classic μ-opioid peptide receptors, called MOP receptors. But BU08028 also targets “nonclassical” opioid receptors, called NOP receptors for nociceptin receptors, in the nervous system. These receptor proteins generally don’t interact with opioid drugs, yet they share similarities with the receptors that do. NOP receptors regulate pain, like their MOP counterparts, but they are also involved in a host of other brain functions, such as memory, cardiovascular functions, and anxiety.

“To our knowledge, the present study provides the first functional evidence in nonhuman primates that BU08028 with mixed MOP/NOP agonist activities is an effective and safe analgesic without apparent abuse liability or other opioid-associated side effects,” the authors conclude.

Next, the researchers hope to test BU08028 at treating chronic pain without risks of addiction or overdoses. Regardless of BU08028's fate in subsequent trials, the researchers are hopeful that the strategy of co-activating NOP and MOP receptors will eventually lead to a safer painkiller.




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OfflineLove_spirit
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Registered: 07/18/15
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Re: New opioid douses pain without being addictive or deadly in primates [Re: xpl0de]
    #23611282 - 09/04/16 12:41 PM (7 years, 4 months ago)

Anything that actually removes suffering is addictive.


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InvisibleOgla
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Registered: 02/16/04
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Re: New opioid douses pain without being addictive or deadly in primates [Re: Love_spirit]
    #23611358 - 09/04/16 01:09 PM (7 years, 4 months ago)

theres gonna be alot of upset dopefiends outthere


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InvisibleDark_Star
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Registered: 08/20/04
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Re: New opioid douses pain without being addictive or deadly in primates [Re: Ogla] * 1
    #23611379 - 09/04/16 01:20 PM (7 years, 4 months ago)

It would be awesome if they find an effective painkiller that isn't addictive. I have doubts though. Remember heroin was first touted as a cure for morphine addiction. People still try to tout suboxone as a non-addictive treatment for opioid addiction, despite the fact that anyone who's been on it knows better.


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InvisibleCognitive_Shift
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Re: New opioid douses pain without being addictive or deadly in primates [Re: Dark_Star] * 1
    #23611595 - 09/04/16 02:31 PM (7 years, 4 months ago)

If it's an opiate/opiod habituation will lead to physical dependency which is what makes opiates so notoriously addictive.  This article sounds to good to be true.


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L'enfer est plein de bonnes volontés et désirs


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Offlinemusiclover420
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Re: New opioid douses pain without being addictive or deadly in primates [Re: Cognitive_Shift]
    #23611637 - 09/04/16 02:46 PM (7 years, 4 months ago)

Even if it works as good as they say I wonder how much they will end up charging for it... If it lasts "30 hours" they won't make much $ selling it cheap.


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Don't worry about me, I've got all that I need. And I'm singing my song to the sky

You know how it feels, With the breeze of the sun in your eyes. Not minding that time's passing by

I've got all and more, My smile, just as before. Is all that I carry with me

I talk to myself, I need nobody else. I'm lost and I'm mine, yes I'm free



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Offlinefapjack
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Re: New opioid douses pain without being addictive or deadly in primates [Re: musiclover420]
    #23611924 - 09/04/16 04:40 PM (7 years, 4 months ago)

If anyone is interested on the difference between this and buprenorphine



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Invisibledurian_2008
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Re: New opioid douses pain without being addictive or deadly in primates [Re: fapjack]
    #23611973 - 09/04/16 04:49 PM (7 years, 4 months ago)

:strokebeard: But, what happens to the monkeys' tails?


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OfflineQT3BFLEE
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Re: New opioid douses pain without being addictive or deadly in primates [Re: durian_2008]
    #23612277 - 09/04/16 06:40 PM (7 years, 4 months ago)

Please. Give me a double-blind with hardened heroin addicts already stable on high-dose bupe and then tell me this is a step towards the Holy Grail.


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My Public Key


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Invisiblegrower182
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Re: New opioid douses pain without being addictive or deadly in primates [Re: QT3BFLEE]
    #23612293 - 09/04/16 06:44 PM (7 years, 4 months ago)

So is BU08028 just kratom in pill form?


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Offlinemorrowasted
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Re: New opioid douses pain without being addictive or deadly in primates [Re: grower182]
    #23612344 - 09/04/16 07:01 PM (7 years, 4 months ago)

Opiates that antagonize delta-opioid receptors in addition to agonising mu-opioid receptors, or that do not bind to delta-opioid receptors only to mu-opioid receptors, show promise in mitigating tolerance and thus the physical addiction because opioid-induced tolerance appears to be linked to the upregulation of delta-opioid receptors.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943346/

One promising currently available herbal candidate is Akuammine from Akuamma seeds.


Edited by morrowasted (09/04/16 07:06 PM)


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Offlinemorbiddoctor
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Re: New opioid douses pain without being addictive or deadly in primates [Re: morrowasted]
    #23612857 - 09/04/16 09:36 PM (7 years, 4 months ago)

If opiates kill over 40 people a day, and kratom has killed maybe 40 people ever, how is Kratom worse?


--------------------
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OfflineLuSiD enthusiast
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Re: New opioid douses pain without being addictive or deadly in primates [Re: grower182] * 1
    #23613074 - 09/04/16 10:48 PM (7 years, 4 months ago)

Quote:

grower182 said:
So is BU08028 just kratom in pill form?



Of course not :rofl: if it actually got people off heroin, then that would be a cause for concern and a imminent public health threat with no medical benefits, and we would have to ban it.

I mean, that's just what the DEA has taught me the last few days.:shrug:


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I'm addicted to coke, weed, booze, ludes and speed.
Not LSD, you can't get addicted to LSD, it was built by scientists.

I ain't got no demons that gonna get woke.


In erowid we trust.

Just take your damn pills and don't ask any questions, you'll be fine.


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OfflineLuSiD enthusiast
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Re: New opioid douses pain without being addictive or deadly in primates [Re: morbiddoctor] * 1
    #23613081 - 09/04/16 10:50 PM (7 years, 4 months ago)

Quote:

morbiddoctor said:
If opiates kill over 40 people a day, and kratom has killed maybe 40 people ever, how is Kratom worse?



Don't you get it? If people get off heroin that's bad. We need to get people back on heroin because that's not a public health crisis. Hell they got heroin now with fentanyl analogs so strong they could wipe out entire cities with an 8 ball.

BUY HEROIN, BAN KRATOM, PRAISE THE GREAT LEADERS OF OUR NATION THE DEA!!!


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I'm addicted to coke, weed, booze, ludes and speed.
Not LSD, you can't get addicted to LSD, it was built by scientists.

I ain't got no demons that gonna get woke.


In erowid we trust.

Just take your damn pills and don't ask any questions, you'll be fine.


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Offlinemorbiddoctor
Frilly fungal fruiter
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Re: New opioid douses pain without being addictive or deadly in primates [Re: LuSiD enthusiast]
    #23613658 - 09/05/16 03:31 AM (7 years, 4 months ago)

Of course I get it. These twats and alll related groups are just vouchers for public domineering and slavery. I was just hoping to link the insane kartom  ban to this bs. I've given up hope. There's nothing to do. Let this world crumble so we can rebuild. To hell with those in power,  and a bullet to their heads, please.


--------------------
Trade list Updated 12/20/15

Ranco temperature controller and Wagner steamer for pasteurization in trade list!

I'm looking for eyecatching, colorful, unique and interesting fungi. Not limited to edible or medicinal. Print them when you're on foray and pm me please!


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Invisibletravelleler
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Re: New opioid douses pain without being addictive or deadly in primates [Re: morbiddoctor]
    #23614027 - 09/05/16 08:03 AM (7 years, 4 months ago)

Sounds like the same shit they told everyone when they developed Demerol, which turned out not to be very effective against pain but still causes dependence.  Then again when they came out with Oxycodone and Hydrocodone....  a pain killer safer than morphine with very little withdrawl risk... Riiiiiiight.  Now they got the Suboxone which is a fantastic tool to get people off heroin, right?  Except people who use it find that they can't sleep unless they take the pills... so dependence all over again. 

I can't forsee this new drug will be any different.  It's more than likely a tool of leverage big pharm is using to advance the Kratom and herbal medicine ban agenda. 

a bullet to the head isn't good enough for these shit-heads, they need severe banishment from the Earth...  proceeded by a "difficult interview" with re-education, a lil something they can take to eternity.


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"Whales have deep thoughts"

:sun:Dreams are the fuel of the soul:sun:

:peace:


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OfflineAllGreyThumbs
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Re: New opioid douses pain without being addictive or deadly in primates [Re: fapjack]
    #23614056 - 09/05/16 08:14 AM (7 years, 4 months ago)

Quote:

fapjack said:
If anyone is interested on the difference between this and buprenorphine






So let me guess, they need a new cash cow?  Maybe the patent is expiring?  Because to me it looks like almost exactly the same thing.

Just tack a tiny extra piece on the molecule, tout it as the next miracle drug, and sell it as premium prices, despite being almost exactly the same as something we already have.

I really doubt that they even give a damn about it being better than other options.  They just mixed up a new product is all.


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I only use drugs medicinally.  If I don't my knees hurt from kneeling down.


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Invisibletravelleler
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Re: New opioid douses pain without being addictive or deadly in primates [Re: AllGreyThumbs]
    #23614068 - 09/05/16 08:18 AM (7 years, 4 months ago)

Quote:

AllGreyThumbs said:
Quote:

fapjack said:
If anyone is interested on the difference between this and buprenorphine



Just tack a tiny extra piece on the molecule, tout it as the next miracle drug, and sell it as premium prices, despite being almost exactly the same as something we already have.

I really doubt that they even give a damn about it being better than other options.  They just mixed up a new product is all.





I believe you hit the nail on the head...  It's leverage against Kratom and a false security blanket for lawmakers who might feel otherwise guilty about hindering people in their personal healing process... so now "oh  look here's an amazing "new" drug that does the same thing as kratom!"  and the idiot law men will believe it because they have been programmed en situ to accept "professional opinion" without the burden of proof or legit 3rd party corroboration. 


makes me wanna puke


--------------------




"Whales have deep thoughts"

:sun:Dreams are the fuel of the soul:sun:

:peace:


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Offlinebigbitch
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Re: New opioid douses pain without being addictive or deadly in primates [Re: morrowasted]
    #23614117 - 09/05/16 08:43 AM (7 years, 4 months ago)

Quote:

morrowasted said:
One promising currently available herbal candidate is Akuammine from Akuamma seeds.




That's interesting, I'm always for a more natural route.  I am skeptical of  BU08028 being a miracle drug as well.  It just doesn't seem sensible for big pharma, to push something like that on the market.  They want people to be addicted to addictive drugs, so they can make fat stacks off the addicts.

It would be nice to have something like this available if I'm ever injured badly.  I think the people who take the other opiates for pure recreational use are blind addicts.  It's like cigarettes.  They are addicted to a shitty drug.  I've experimented very lightly with opiates, and cigarettes.  The high and feeling from them isn't even enjoyable.  The only reason to enjoy something like that is because you're an addict.


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Invisibledurian_2008
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Re: New opioid douses pain without being addictive or deadly in primates [Re: morbiddoctor]
    #23615074 - 09/05/16 03:09 PM (7 years, 4 months ago)

Quote:

morbiddoctor said:
If opiates kill over 40 people a day, and kratom has killed maybe 40 people ever, how is Kratom worse?




I'm not a prohibitionist. I have no intention of protecting intelligent, moral people from themselves but believe those with a death wish will use whatever is most convenient, whether it's a plant, a pharm, or research chemical.

I'm seeing potent, black, tarry substances and refined extracts, do not consider myself a fool, am asking whether these things are fool proof.


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