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OfflineMushroomAreTheKey
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Can you Od on pure psilocybin?
    #23603210 - 09/01/16 11:27 PM (7 years, 4 months ago)

Ik you can't od on shrooms but pure psilocybin?


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Invisibleruaware

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. [Re: MushroomAreTheKey]
    #23603215 - 09/01/16 11:29 PM (7 years, 4 months ago)

.


Edited by ruaware (12/06/16 02:26 AM)


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OfflineMushroomAreTheKey
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Re: Can you Od on pure psilocybin? [Re: ruaware]
    #23603233 - 09/01/16 11:36 PM (7 years, 4 months ago)

I was being serious, it is a chemical.


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OfflineNature Boy
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Re: Can you Od on pure psilocybin? [Re: MushroomAreTheKey]
    #23603646 - 09/02/16 03:46 AM (7 years, 4 months ago)

Actually, yes.  Death as a result I consider an "OD."  It's EXCEEDINGLY rare, but there is one reported, well documented death from psilocybin.  This is the only one I actually believe.  Other deaths involved co-morbid conditions that probably contributed in some way.  Not this one:

From Erowid:  One death (commented on by Lim, Wasywich, and Roygrok) was reportedly the result of "neurological sequelae (somnolence and convulsions) 6-8 h after ingestion of an unknown quantity of magic-mushrooms". Post-mortem toxicology revealed very high plasma psilocin concentration (4000 mg/L).

Gerault A, Picart D. "Intoxication mortelle a la suite de la consommoation volontaire et en groupe de champignons hallucinogenes". Bull Soc Mycol France 1996;112: 1-14.

N.B.


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All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               


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OfflineFilterhead462
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Re: Can you Od on pure psilocybin? [Re: Nature Boy]
    #23603881 - 09/02/16 07:15 AM (7 years, 4 months ago)

Quote:

Nature Boy said:
Actually, yes.  Death as a result I consider an "OD."  It's EXCEEDINGLY rare, but there is one reported, well documented death from psilocybin.  This is the only one I actually believe.  Other deaths involved co-morbid conditions that probably contributed in some way.  Not this one:

From Erowid:  One death (commented on by Lim, Wasywich, and Roygrok) was reportedly the result of "neurological sequelae (somnolence and convulsions) 6-8 h after ingestion of an unknown quantity of magic-mushrooms". Post-mortem toxicology revealed very high plasma psilocin concentration (4000 mg/L).

Gerault A, Picart D. "Intoxication mortelle a la suite de la consommoation volontaire et en groupe de champignons hallucinogenes". Bull Soc Mycol France 1996;112: 1-14.

N.B.



Man the trip that guy would have been on before he died must have been fucked!


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OfflineThe Mycologist
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Re: Can you Od on pure psilocybin? [Re: Filterhead462]
    #23603915 - 09/02/16 07:37 AM (7 years, 4 months ago)

You can od on anything really. But its harder to od on psilocybin than on water. It takes more than 10 times a regular does to kill a mouse so I wouldn't stress. Its basically impossible.


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OfflineNature Boy
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Re: Can you Od on pure psilocybin? [Re: Filterhead462]
    #23603972 - 09/02/16 08:20 AM (7 years, 4 months ago)

Quote:

Filterhead462 said:
Man the trip that guy would have been on before he died must have been fucked!




Actually, victim was a woman.

N.B.


--------------------
All submitted posts under this user name are works of pure fiction or outright lies.  Any information, statement, or assertion contained therein should be considered pure unadulterated bullshit.  Note well:  Sorry, but I do not answer PM's unless you are a long-time trusted friend.  If you have a question, ask it in the appropriate thread.

                                                                               


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OfflineOccazn
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Re: Can you Od on pure psilocybin? [Re: MushroomAreTheKey]
    #23604545 - 09/02/16 12:40 PM (7 years, 4 months ago)

No


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Offlineendogenous
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Re: Can you Od on pure psilocybin? [Re: Nature Boy]
    #23606933 - 09/03/16 04:37 AM (7 years, 4 months ago)

Quote:

Nature Boy said:
Actually, yes.  Death as a result I consider an "OD."  It's EXCEEDINGLY rare, but there is one reported, well documented death from psilocybin.  This is the only one I actually believe.  Other deaths involved co-morbid conditions that probably contributed in some way.  Not this one:

From Erowid:  One death (commented on by Lim, Wasywich, and Roygrok) was reportedly the result of "neurological sequelae (somnolence and convulsions) 6-8 h after ingestion of an unknown quantity of magic-mushrooms". Post-mortem toxicology revealed very high plasma psilocin concentration (4000 mg/L).

Gerault A, Picart D. "Intoxication mortelle a la suite de la consommoation volontaire et en groupe de champignons hallucinogenes". Bull Soc Mycol France 1996;112: 1-14.

N.B.




4 GRAMS of Psilocybin per LITER of blood???!!!

There's 4.7 to 5.5 liters of blood in the human body. So that means they're claiming this person had a minimum of 18.8 GRAMS of Psilocybin total.

Quote:

AlexandrSupertramp said:
I found this quote on the Psilocybin article on Wikipedia, "A typical recreational dosage is 10–50 mg psilocybin, which is roughly equivalent to 10–50 grams of fresh mushrooms, or 1–5 grams of dried mushrooms."


  -- https://www.shroomery.org/forums/showflat.php/Number/15799988#15799988

According to that - 1 gram of fresh Mushrooms has 1 mg of Psilocybin. Now this person supposedly had 18.8 grams of Psilocybin. That would equal 18,800 grams of fresh Mushrooms.

You're talking about 41.5 POUNDS OF FRESH MUSHROOMS (or 4.15 POUNDS of dry.)

Uuummmm. I would say the claim sounds slightly incorrect?


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Offlineendogenous
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Re: Can you Od on pure psilocybin? [Re: endogenous]
    #23606956 - 09/03/16 05:15 AM (7 years, 4 months ago)

I just looked up the wiki article and the current article says that Psilocybin is 1% of the weight of the Mushroom. That would mean that 1 gram has 10 mg of Psilocybin. That's 1880 grams of fresh (or 4.15 pounds). That would be 188 grams of dry or 6.6 ounces.

I realize that the actual amounts vary - this was supposedly for Cubensis. Maybe Hofmann has this information somewhere?


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The Day of the Lord has come like a thief in the night. -- It is there but no one knows it.


Edited by endogenous (09/03/16 05:37 AM)


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Offlinecube talk
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Re: Can you Od on pure psilocybin? [Re: endogenous]
    #23607002 - 09/03/16 06:16 AM (7 years, 4 months ago)

Quote:

endogenous said:
Quote:

Nature Boy said:
Actually, yes.  Death as a result I consider an "OD."  It's EXCEEDINGLY rare, but there is one reported, well documented death from psilocybin.  This is the only one I actually believe.  Other deaths involved co-morbid conditions that probably contributed in some way.  Not this one:

From Erowid:  One death (commented on by Lim, Wasywich, and Roygrok) was reportedly the result of "neurological sequelae (somnolence and convulsions) 6-8 h after ingestion of an unknown quantity of magic-mushrooms". Post-mortem toxicology revealed very high plasma psilocin concentration (4000 mg/L).

Gerault A, Picart D. "Intoxication mortelle a la suite de la consommoation volontaire et en groupe de champignons hallucinogenes". Bull Soc Mycol France 1996;112: 1-14.

N.B.




4 GRAMS of Psilocybin per LITER of blood???!!!

There's 4.7 to 5.5 liters of blood in the human body. So that means they're claiming this person had a minimum of 18.8 GRAMS of Psilocybin total.

Quote:

AlexandrSupertramp said:
I found this quote on the Psilocybin article on Wikipedia, "A typical recreational dosage is 10–50 mg psilocybin, which is roughly equivalent to 10–50 grams of fresh mushrooms, or 1–5 grams of dried mushrooms."


  -- https://www.shroomery.org/forums/showflat.php/Number/15799988#15799988

According to that - 1 gram of fresh Mushrooms has 1 mg of Psilocybin. Now this person supposedly had 18.8 grams of Psilocybin. That would equal 18,800 grams of fresh Mushrooms.

You're talking about 41.5 POUNDS OF FRESH MUSHROOMS (or 4.15 POUNDS of dry.)

Uuummmm. I would say the claim sounds slightly incorrect?





well... assuming it SOMEHOW isn't:

I would say that 4.15 pounds COULD be fatal


geesh


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OfflineNature Boy
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Re: Can you Od on pure psilocybin? [Re: endogenous]
    #23607011 - 09/03/16 06:22 AM (7 years, 4 months ago)

I seem to remember a story of a contemporary of Timothy Leary who died on the premises of his retreat at Millbrook from psilocybin - but it was the pure powder, not mushrooms.  The OP did specify "pure psilocybin" and it IS available as a purely synthetic product.

I'll see if I can dig up the info.

BTW...Just looked at the original article in french.  The mushroom in question which was consumed to the point of fatality was Psilocybe semilanceata.  Have no idea what its psilocybin content is.  It may be the french version of political bullshit...but I have no way to judge.

EDIT:  HOLY SHIT.  I found his (it was a he!) toxicology report!  here it is:

TOXICOLOGICAL ANALYSIS

We have looked for the usual toxins in the blood and urine samples, in the kidney and in the liver.

Blood, urine and gastric content : The GC analysis of ethanol, alcohol and other volatile substances was negative. Barbiturates, benzodiazepins, tricyclic antidepressives, paracetamol, cannabinoïds, opiates and cocaine were not revealed in the urine by an immuno technique (EMIT) and salicylates by colorimetric technique : negative. Carbon monoxyde, paraquat and chlorinated solvents were negative, so was the amanitins of methanol extracts from the gastric content by TLS. The detection of blood cholinesterases was normal. Thus, it can not be a organophosphorated pesticide poisoning. Finally, we tried to systematically detect foreign substances in the body by HPLC and mass spectrometry. Nothing was detected on acid, neutral and basic extracts.

Kidney and liver:

A fragment of each organ was hydrolyzed by `subtilisin',. The obtained liquid was extracted from acid, neutral and basic environment by dichloromethan. After an azote controlled evaporation, the dry residue was extracted by methanol. The organic extracts were analyzed by HPLC and mass spectrometry. No abnormal substances were found.

Study and measurement of hallucinogenic indolic components:

This was performed on methanolic extracts from the gastric content, blood and hydrolysats from kidney and liver. We tried to detect halucinogenic indolic components and especially psilocybin and psilocin. Psilocybin rapidly hydrolyses in the body to create psilocin which is the biologically active substance. This hydrolysis is performed in the ratio 100 / 72, depending on each molecular weight. We found psilocin but no psilocybin, not even in the gastric content, which confirmed the rapid hydrolysis because of the high acidity of the gastric juice. HPLC was the method used to determine the quantification combined with fluorometric detection since mass spectrometry is less effective on this kind of chemical because the weight spectra show a very low density molecular ion (5, 15, 16, 33, 36). A psilocybin standard was used for the quantification. The psilocin was extracted through the hydrolysis at 37°C of this psilocybin by alkaline phosphatase in pH 7 Tris 1M buffer overnight.

Results :

- blood : 4 micrograms/ml of psilocin - gastric content : only trace amounts of psilocin, which were not easily measurable because of all the impurities we could not correctly eliminate. - kidney and liver : failed because of an unidentified chemical interfering with psilocin

Nothing found in the literature could help us interpreting these results. Furthermore, the blood used was drawn 36 hours after the death, thus, the results can not be applied to the living. However, this proved that psilocybin containing mushrooms were ingested.

Note it is 4 MICROgrams.  Erowid had it at 4 MILLIGRAMS.  Evidently a typo (common).

N.B.


Edited by Nature Boy (09/03/16 06:39 AM)


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Offlineendogenous
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Re: Can you Od on pure psilocybin? [Re: Nature Boy]
    #23608603 - 09/03/16 04:29 PM (7 years, 4 months ago)

OK. 4 ugs is 1 million times less than 4 grams.

Did you mean to say that Erowid had it at 4 mgs? Your other post said they had it at 4000 mg/liter of blood.

Just looked up the article. They did say 4000mgs/liter.
Incident: Anonymous Female, 1996 #
One death (commented on by Lim, Wasywich, and Roygrok) was reportedly the result of "neurological sequelae (somnolence and convulsions) 6-8 h after ingestion of an unknown quantity of magic-mushrooms". Post-mortem toxicology revealed very high plasma psilocin concentration (4000 mg/L).
Gerault A, Picart D. "Intoxication mortelle a la suite de la consommoation volontaire et en groupe de champignons hallucinogenes". Bull Soc Mycol France 1996;112: 1-14.
   
-- https://erowid.org/plants/mushrooms/mushrooms_death.shtml

That would be 1.88 grams of fresh Mushrooms and .188 gms of dry (using wikipedias 1% claim).

According to the Shroomery Calculator, ( https://www.shroomery.org/6257/Magic-Mushroom-Dosage-Calculator ) 5.9 grams of Semilanceata is "level 1" -- i.e. -- very mild. So these people are claiming that a MICRODOSE (1.88 gms) caused this person's death!!!!

It's another case of obvious nonsense (to put it euphemistically).


Edited by endogenous (09/03/16 04:53 PM)


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Offlineendogenous
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Re: Can you Od on pure psilocybin? [Re: endogenous]
    #23608714 - 09/03/16 05:10 PM (7 years, 4 months ago)

Incidentally, the Shroomery Calculator says that there's .839 mgs of Psilocybin per gram of fresh Semilanceata. So that's back to the original wiki article that had it as 1 mg per gram or .1%. That would mean the amount of fresh Mushrooms was .188 grams!!


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The Day of the Lord has come like a thief in the night. -- It is there but no one knows it.


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Offlineendogenous
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Re: Can you Od on pure psilocybin? [Re: endogenous]
    #23610026 - 09/04/16 01:48 AM (7 years, 4 months ago)

Albert Hofmann says that the dried Mushrooms contain 0.2 to 0.4% of Psilocybin and that Psilocin is only in trace amounts. -- "The Botany And Chemistry Of Hallucinogens" p.45


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